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公开(公告)号：US20060188957A1
公开(公告)日：2006-08-24
申请号：US11245950
申请日：2005-10-07
申请人： Lih-Ling Lin , Jennifer Chen , Andrea Schievella , James Graham
发明人： Lih-Ling Lin , Jennifer Chen , Andrea Schievella , James Graham
IPC分类号： C12P21/06 , C07H21/04 , C07K14/715 , C07K16/30
CPC分类号： C07K14/4743 , A61K38/00 , C07K14/47 , C07K16/24 , C07K2317/34
摘要： Novel TNF receptor death domain (“TNF-R1-DD”) ligand proteins are disclosed. Polynucleotides encoding the TNF-R1-DD ligand protein are also disclosed, along with vectors, host cells, and methods of making the TNF-R1-DD ligand protein. Pharmaceutical compositions containing the TNF-R1-DD ligand protein, methods of treating inflammatory conditions, and methods of inhibiting TNF-R death domain binding are also disclosed. Methods of identifying inhibitors of TNF-R death domain binding and inhibitors identified by such methods are also disclosed.
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公开(公告)号：US5852173A
公开(公告)日：1998-12-22
申请号：US533901
申请日：1995-09-26
IPC分类号： C12N15/09 , A61K38/00 , A61K45/00 , A61K48/00 , A61P29/00 , C07K14/47 , C07K14/715 , C07K16/24 , C12N1/19 , C12N5/10 , C12N15/12 , C12P21/02 , C07K14/52 , C12N15/10
CPC分类号： C07K14/4743 , C07K14/47 , C07K16/24 , A61K38/00 , C07K2317/34
摘要： Novel TNF receptor death domain ("TNF-R1-DD") ligand proteins are disclosed. Polynucleotides encoding the TNF-R1-DD ligand protein are also disclosed, along with vectors, host cells, and methods of making the TNF-R1-DD ligand protein. Pharmaceutical compositions containing the TNF-R1-DD ligand protein, methods of treating inflammatory conditions, and methods of inhibiting TNF-R death domain binding are also disclosed. Methods of identifying inhibitors of TNF-R death domain binding and inhibitors identified by such methods are also disclosed.
摘要翻译： 公开了新型TNF受体死亡结构域（“TNF-R1-DD”）配体蛋白。 还公开了编码TNF-R1-DD配体蛋白的多核苷酸以及载体，宿主细胞和制备TNF-R1-DD配体蛋白的方法。 还公开了含有TNF-R1-DD配体蛋白质的药物组合物，治疗炎性病症的方法和抑制TNF-R死亡结构域结合的方法。 还公开了鉴定TNF-R死亡结构域结合抑制剂的方法和通过这些方法鉴定的抑制剂。
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3.发明授权公开(公告)号：US07109307B2
公开(公告)日：2006-09-19
申请号：US09989350
申请日：2001-11-20
IPC分类号： C07K16/28
CPC分类号： C07K14/4743 , A61K38/00 , C07K14/47 , C07K16/24 , C07K2317/34
摘要： Novel TNF receptor death domain (“TNF-R1-DD”) ligand proteins are disclosed. Polynucleotides encoding the TNF-R1-DD ligand protein are also disclosed, along with vectors, host cells, and methods of making the TNF-R1-DD ligand protein. Pharmaceutical compositions containing the TNF-R1-DD ligand protein, methods of treating inflammatory conditions, and methods of inhibiting TNF-R death domain binding are also disclosed. Methods of identifying inhibitors of TNF-R death domain binding and inhibitors identified by such methods are also disclosed.
摘要翻译： 公开了新型TNF受体死亡结构域（“TNF-R1-DD”）配体蛋白。 还公开了编码TNF-R1-DD配体蛋白的多核苷酸以及载体，宿主细胞和制备TNF-R1-DD配体蛋白的方法。 还公开了含有TNF-R1-DD配体蛋白质的药物组合物，治疗炎性病症的方法和抑制TNF-R死亡结构域结合的方法。 还公开了鉴定TNF-R死亡结构域结合抑制剂的方法和通过这些方法鉴定的抑制剂。
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公开(公告)号：US5948638A
公开(公告)日：1999-09-07
申请号：US839031
申请日：1997-04-23
IPC分类号： C12N15/09 , A61K38/00 , A61K45/00 , A61K48/00 , A61P29/00 , C07K14/47 , C07K14/715 , C07K16/24 , C12N1/19 , C12N5/10 , C12N15/12 , C12P21/02 , C12N15/10
CPC分类号： C07K14/4743 , C07K14/47 , C07K16/24 , A61K38/00 , C07K2317/34
摘要： Novel TNF receptor death domain ("TNF-R1-DD") ligand proteins are disclosed. Polynucleotides encoding the TNF-R1-DD ligand protein are also disclosed, along with vectors, host cells, and methods of making the TNF-R1-DD ligand protein. Pharmaceutical compositions containing the TNF-R1-DD ligand protein, methods of treating inflammatory conditions, and methods of inhibiting TNF-R death domain binding are also disclosed. Methods of identifying inhibitors of TNF-R death domain binding and inhibitors identified by such methods are also disclosed.
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公开(公告)号：US5843675A
公开(公告)日：1998-12-01
申请号：US602228
申请日：1996-02-15
IPC分类号： C12N15/09 , A61K38/00 , A61K45/00 , A61K48/00 , A61P29/00 , C07K14/47 , C07K14/715 , C07K16/24 , C12N1/19 , C12N5/10 , C12N15/12 , C12P21/02 , G01N33/53 , C07K14/705
CPC分类号： C07K14/4743 , C07K14/47 , C07K16/24 , A61K38/00 , C07K2317/34
摘要： Novel TNF receptor death domain ("TNF-R1-DD") ligand proteins are disclosed. Polynucleotides encoding the TNF-R1-DD ligand protein are also disclosed, along with vectors, host cells, and methods of making the TNF-R1-DD ligand protein. Pharmaceutical compositions containing the TNF-R1-DD ligand protein, methods of treating inflammatory conditions, and methods of inhibiting TNF-R death domain binding are also disclosed. Methods of identifying inhibitors of TNF-R death domain binding and inhibitors identified by such methods are also disclosed.
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公开(公告)号：US20090092613A1
公开(公告)日：2009-04-09
申请号：US12069735
申请日：2008-02-11
IPC分类号： A61K39/395 , C12N15/11 , C12N5/06 , C12P21/04 , C07K14/00 , C12Q1/68 , A61K38/16 , C07K16/18 , G01N33/566
CPC分类号： C07K14/4743 , A61K38/00 , C07K14/47 , C07K16/24 , C07K2317/34
摘要： Novel TNF receptor death domain (“TNF-R1-DD”) ligand proteins are disclosed. Polynucleotides encoding the TNF-R1-DD ligand protein are also disclosed, along with vectors, host cells, and methods of making the TNF-R1-DD ligand protein. Pharmaceutical compositions containing the TNF-R1-DD ligand protein, methods of treating inflammatory conditions, and methods of inhibiting TNF-R death domain binding are also disclosed. Methods of identifying inhibitors of TNF-R death domain binding and inhibitors identified by such methods are also disclosed.
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公开(公告)号：US5891675A
公开(公告)日：1999-04-06
申请号：US839032
申请日：1997-04-23
IPC分类号： A61K38/00 , C07K14/47 , C07K16/24 , C12N15/12 , C07K14/705
CPC分类号： C07K14/4743 , C07K14/47 , C07K16/24 , A61K38/00 , C07K2317/34
摘要： Novel TNF receptor death domain ("TNF-R1-DD") ligand proteins are disclosed. Polynucleotides encoding the TNF-R1-DD ligand protein are also disclosed, along with vectors, host cells, and methods of making the TNF-R1-DD ligand protein. Pharmaceutical compositions containing the TNF-R1-DD ligand protein, methods of treating inflammatory conditions, and methods of inhibiting TNF-R death domain binding are also disclosed. Methods of identifying inhibitors of TNF-R death domain binding and inhibitors identified by such methods are also disclosed.
摘要翻译： 公开了新型TNF受体死亡结构域（“TNF-R1-DD”）配体蛋白。 还公开了编码TNF-R1-DD配体蛋白的多核苷酸以及载体，宿主细胞和制备TNF-R1-DD配体蛋白的方法。 还公开了含有TNF-R1-DD配体蛋白质的药物组合物，治疗炎性病症的方法和抑制TNF-R死亡结构域结合的方法。 还公开了鉴定TNF-R死亡结构域结合抑制剂的方法和通过这些方法鉴定的抑制剂。
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8.发明授权公开(公告)号：US06322972B1
公开(公告)日：2001-11-27
申请号：US09185258
申请日：1998-11-02
IPC分类号： C12Q168
CPC分类号： C07K14/4743 , A61K38/00 , C07K14/47 , C07K16/24 , C07K2317/34
摘要： Novel TNF receptor death domain (“TNF-R1-DD”) ligand proteins are disclosed. Polynucleotides encoding the TNF-R1-DD ligand protein are also disclosed, along with vectors, host cells, and methods of making the TNF-R1-DD ligand protein. Pharmaceutical compositions containing the TNF-R1-DD ligand protein, methods of treating inflammatory conditions, and methods of inhibiting TNF-R death domain binding are also disclosed. Methods of identifying inhibitors of TNF-R death domain binding and inhibitors identified by such methods are also disclosed.
摘要翻译： 公开了新型TNF受体死亡结构域（“TNF-R1-DD”）配体蛋白。 还公开了编码TNF-R1-DD配体蛋白的多核苷酸以及载体，宿主细胞和制备TNF-R1-DD配体蛋白的方法。 还公开了含有TNF-R1-DD配体蛋白质的药物组合物，治疗炎性病症的方法和抑制TNF-R死亡结构域结合的方法。 还公开了鉴定TNF-R死亡结构域结合抑制剂的方法和通过这些方法鉴定的抑制剂。
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公开(公告)号：US5712381A
公开(公告)日：1998-01-27
申请号：US698551
申请日：1996-08-15
CPC分类号： C07K14/4743 , C07K14/47 , C07K16/24 , A61K38/00 , C07K2317/34
摘要： Novel TNF receptor death domain ("TNF-R1-DD") ligand proteins are disclosed. Polynucleotides encoding the TNF-R1-DD ligand protein are also disclosed, along with vectors, host cells, and methods of making the TNF-R1-DD ligand protein. Pharmaceutical compositions containing the TNF-R1-DD ligand protein, methods of treating inflammatory conditions, and methods of inhibiting TNF-R death domain binding are also disclosed. Methods of identifying inhibitors of TNF-R death domain binding and inhibitors identified by such methods are also disclosed.
摘要翻译： 公开了新型TNF受体死亡结构域（“TNF-R1-DD”）配体蛋白。 还公开了编码TNF-R1-DD配体蛋白的多核苷酸以及载体，宿主细胞和制备TNF-R1-DD配体蛋白的方法。 还公开了含有TNF-R1-DD配体蛋白质的药物组合物，治疗炎性病症的方法和抑制TNF-R死亡结构域结合的方法。 还公开了鉴定TNF-R死亡结构域结合抑制剂的方法和通过这些方法鉴定的抑制剂。
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10.发明授权TNF receptor death domain ligand proteins and method to identify inhibitors of ligand binding 失效TNF受体死亡域配体蛋白和鉴定配体结合抑制剂的方法
公开(公告)号：US5849501A
公开(公告)日：1998-12-15
申请号：US494440
申请日：1995-06-19
IPC分类号： A61K38/00 , C07K14/47 , C07K16/24 , C12N15/12 , G01N33/566 , C07K14/475 , C07K14/71
CPC分类号： C07K16/24 , C07K14/47 , C07K14/4743 , A61K38/00 , C07K2317/34
摘要： Novel TNF receptor death domain ("TNF-R1-DD") ligand proteins are disclosed. Polynucleotides encoding the TNF-R1-DD ligand protein are also disclosed, along with vectors, host cells, and methods of making the TNF-R1-DD ligand protein. Pharmaceutical compositions containing the TNF-R1-DD ligand protein, methods of treating inflammatory conditions, and methods of inhibiting TNF-R death domain binding are also disclosed. Methods of identifying inhibitors of TNF-R death domain binding and inhibitors identified by such methods are also disclosed.
摘要翻译： 公开了新型TNF受体死亡结构域（“TNF-R1-DD”）配体蛋白。 还公开了编码TNF-R1-DD配体蛋白的多核苷酸以及载体，宿主细胞和制备TNF-R1-DD配体蛋白的方法。 还公开了含有TNF-R1-DD配体蛋白质的药物组合物，治疗炎性病症的方法和抑制TNF-R死亡结构域结合的方法。 还公开了鉴定TNF-R死亡结构域结合抑制剂的方法和通过这些方法鉴定的抑制剂。
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