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    Anti-IGF-IR and/or anti-insulin/IGF-I hybrid receptors antibodies and uses thereof
    1.
    发明授权
    Anti-IGF-IR and/or anti-insulin/IGF-I hybrid receptors antibodies and uses thereof 有权
    抗IGF-1R和/或抗胰岛素/ IGF-I杂合受体抗体及其用途

    公开(公告)号：US08101180B2

    公开(公告)日：2012-01-24

    申请号：US12388534

    申请日：2009-02-19

    申请人： Liliane Goetsch ,  Nathalie Corvaia ,  Alain Duflos ,  Jean-Francois Haeuw ,  Olivier Leger ,  Alain Beck

    发明人： Liliane Goetsch ,  Nathalie Corvaia ,  Alain Duflos ,  Jean-Francois Haeuw ,  Olivier Leger ,  Alain Beck

    IPC分类号： A61K39/00 ,  A61K39/395 ,  A61K51/10 ,  G01N33/53 ,  G01N33/574 ,  G01N33/561 ,  G01N33/557 ,  G01N33/566

    CPC分类号： A61K47/6805 ,  C07K2317/732

    摘要： The present invention relates to novel antibodies capable of binding specifically to the human insulin-like growth factor I receptor (IGF-IR) and/or the insulin/IGF-I hybrid receptor (hybrid-R) and/or capable of specifically inhibiting the tyrosine kinase activity of said IGF-IR and/or hybrid-R, especially monoclonal antibodies of murine, chimeric and humanized origin, as well as the amino acid and nucleic acid sequences coding for these antibodies. The invention likewise comprises the use of these antibodies as a medicament for the prophylactic and/or therapeutic treatment of cancers overexpressing IGF-IR and/or hybrid-R or any pathology connected with the overexpression of said receptor as well as in processes or kits for diagnosis of illnesses connected with the overexpression of the IGF-IR and/or hybrid-R. The invention finally comprises products and/or compositions comprising such antibodies in combination with anti-EGFR antibodies and/or compounds and/or anti-cancer agents or agents conjugated with toxins and their use for the prevention and/or the treatment of certain cancers.

    摘要翻译： 本发明涉及能够特异性结合人胰岛素样生长因子I受体（IGF-1R）和/或胰岛素/ IGF-I杂合受体（杂合-R）和/或能够特异性抑制 所述IGF-1R和/或杂种-R，特别是鼠，嵌合和人源化起始的单克隆抗体以及编码这些抗体的氨基酸和核酸序列的酪氨酸激酶活性。 本发明同样包括使用这些抗体作为用于预防和/或治疗过度表达IGF-1R和/或杂合-R的癌症或与所述受体的过度表达相关的任何病理学以及在用于 诊断与IGF-1R和/或杂合体R的过表达相关的疾病。 本发明最终包括包含抗体与抗EGFR抗体和/或化合物和/或与毒素缀合的抗癌剂或试剂的组合的产品和/或组合物及其用于预防和/或治疗某些癌症的用途。

    NOVEL ANTI-IGF-IR AND/OR ANTI-INSULIN/IGF-I HYBRID RECEPTORS ANTIBODIES AND USES THEREOF
    3.
    发明申请
    NOVEL ANTI-IGF-IR AND/OR ANTI-INSULIN/IGF-I HYBRID RECEPTORS ANTIBODIES AND USES THEREOF 有权
    新型抗IGF-1R和/或抗胰蛋白胨/ IGF-I混合受体抗体及其用途

    公开(公告)号：US20110014122A1

    公开(公告)日：2011-01-20

    申请号：US12388534

    申请日：2009-02-19

    申请人： Liliane GOETSCH ,  Nathalie Corvaia ,  Alain Duflos ,  Jean-Francois Haeuw ,  Olivier Leger ,  Alain Beck

    发明人： Liliane GOETSCH ,  Nathalie Corvaia ,  Alain Duflos ,  Jean-Francois Haeuw ,  Olivier Leger ,  Alain Beck

    IPC分类号： A61K49/00 ,  C07K16/00 ,  A61K39/395 ,  A61P35/00 ,  C12N5/071 ,  C12N5/09 ,  C40B30/04

    CPC分类号： A61K47/6805 ,  C07K2317/732

    摘要： The present invention relates to novel antibodies capable of binding specifically to the human insulin-like growth factor I receptor (IGF-IR) and/or the insulin/IGF-I hybrid receptor (hybrid-R) and/or capable of specifically inhibiting the tyrosine kinase activity of said IGF-IR and/or hybrid-R, especially monoclonal antibodies of murine, chimeric and humanized origin, as well as the amino acid and nucleic acid sequences coding for these antibodies. The invention likewise comprises the use of these antibodies as a medicament for the prophylactic and/or therapeutic treatment of cancers overexpressing IGF-IR and/or hybrid-R or any pathology connected with the overexpression of said receptor as well as in processes or kits for diagnosis of illnesses connected with the overexpression of the IGF-IR and/or hybrid-R. The invention finally comprises products and/or compositions comprising such antibodies in combination with anti-EGFR antibodies and/or compounds and/or anti-cancer agents or agents conjugated with toxins and their use for the prevention and/or the treatment of certain cancers.

    摘要翻译： 本发明涉及能够特异性结合人胰岛素样生长因子I受体（IGF-1R）和/或胰岛素/ IGF-I杂合受体（杂合-R）和/或能够特异性抑制 所述IGF-1R和/或杂种-R，特别是鼠，嵌合和人源化起始的单克隆抗体以及编码这些抗体的氨基酸和核酸序列的酪氨酸激酶活性。 本发明同样包括使用这些抗体作为预防和/或治疗过度表达IGF-1R和/或杂合-R的癌症或与所述受体的过度表达相关的任何病理学以及用于 诊断与IGF-1R和/或杂合体R的过表达相关的疾病。 本发明最终包括包含抗体与抗EGFR抗体和/或化合物和/或与毒素缀合的抗癌剂或试剂的组合的产品和/或组合物及其用于预防和/或治疗某些癌症的用途。

    Novel anti-IGF-IR and/or anti-insulin/IGF-I hybrid receptors antibodies and uses thereof
    4.
    发明申请
    Novel anti-IGF-IR and/or anti-insulin/IGF-I hybrid receptors antibodies and uses thereof 有权
    新型抗IGF-1R和/或抗胰岛素/ IGF-I杂合体受体抗体及其用途

    公开(公告)号：US20050249730A1

    公开(公告)日：2005-11-10

    申请号：US11012353

    申请日：2004-12-16

    申请人： Liliane Goetsch ,  Nathalie Corvaia ,  Alain Duflos ,  Jean-Francois Haeuw ,  Olivier Leger ,  Alain Beck

    发明人： Liliane Goetsch ,  Nathalie Corvaia ,  Alain Duflos ,  Jean-Francois Haeuw ,  Olivier Leger ,  Alain Beck

    IPC分类号： A61K47/48 ,  A61K39/395 ,  C07K16/30

    CPC分类号： A61K47/6805 ,  C07K2317/732

    摘要： The present invention relates to novel antibodies capable of binding specifically to the human insulin-like growth factor I receptor (IGF-IR) and/or the insulin/IGF-I hybrid receptor (hybrid-R) and/or capable of specifically inhibiting the tyrosine kinase activity of said IGF-IR and/or hybrid-R, especially monoclonal antibodies of murine, chimeric and humanized origin, as well as the amino acid and nucleic acid sequences coding for these antibodies. The invention likewise comprises the use of these antibodies as a medicament for the prophylactic and/or therapeutic treatment of cancers overexpressing IGF-IR and/or hybrid-R or any pathology connected with the overexpression of said receptor as well as in processes or kits for diagnosis of illnesses connected with the overexpression of the IGF-IR and/or hybrid-R. The invention finally comprises products and/or compositions comprising such antibodies in combination with anti-EGFR antibodies and/or compounds and/or anti-cancer agents or agents conjugated with toxins and their use for the prevention and/or the treatment of certain cancers.

    摘要翻译： 本发明涉及能够特异性结合人胰岛素样生长因子I受体（IGF-1R）和/或胰岛素/ IGF-I杂合受体（杂合-R）和/或能够特异性抑制 所述IGF-1R和/或杂种-R，特别是鼠，嵌合和人源化起始的单克隆抗体以及编码这些抗体的氨基酸和核酸序列的酪氨酸激酶活性。 本发明同样包括使用这些抗体作为用于预防和/或治疗过度表达IGF-1R和/或杂合-R的癌症或与所述受体的过度表达相关的任何病理学以及在用于 诊断与IGF-1R和/或杂合体R的过表达相关的疾病。 本发明最终包括包含抗体与抗EGFR抗体和/或化合物和/或与毒素缀合的抗癌剂或试剂的组合的产品和/或组合物及其用于预防和/或治疗某些癌症的用途。

    Method for the treatment of psoriasis comprising novel anti-IGF-IR antibodies
    5.
    发明申请
    Method for the treatment of psoriasis comprising novel anti-IGF-IR antibodies 审中-公开
    用于治疗牛皮癣的方法，其包含新的抗IGF-1R抗体

    公开(公告)号：US20080063639A1

    公开(公告)日：2008-03-13

    申请号：US11783666

    申请日：2007-04-11

    申请人： Liliane Goetsch ,  Nathalie Corvaia ,  Olivier Leger ,  Alain Duflos ,  Jean-Francois Haeuw ,  Alain Beck ,  Yann Duflos

    发明人： Liliane Goetsch ,  Nathalie Corvaia ,  Olivier Leger ,  Alain Duflos ,  Jean-Francois Haeuw ,  Alain Beck ,  Yann Duflos

    IPC分类号： A61K39/395 ,  A61P17/06

    CPC分类号： A61K47/6805 ,  C07K2317/732

    摘要： The present invention relates to a method for the prevention or for the treatment of psoriasis comprising administering to a patient in need thereof an effective amount of an isolated antibody, or one of its functional fragments, capable of binding to the human insulin-like growth factor I receptor IGF-IR. The present invention is also directed to said method wherein a second compound selected from the compounds capable of specifically inhibiting the attachment of the EGF to the human epidermal growth factor receptor EGFR, such as an isolated anti-EGFR antibody, or a functional fragment thereof, is administered to the patient in addition to the anti-IGR-IR antibody.

    摘要翻译： 本发明涉及一种预防或治疗牛皮癣的方法，包括向有需要的患者施用有效量的能够结合人类胰岛素样生长因子的分离抗体或其功能片段之一 I受体IGF-1R。 本发明还涉及所述方法，其中选自能够特异性抑制EGF与人表皮生长因子受体EGFR（例如分离的抗EGFR抗体或其功能片段）附着的化合物的第二化合物， 除了抗IGR-IR抗体外还施用于患者。

    Anti-IGF-IR and/or anti-insulin/IGF-I hybrid receptors antibodies and uses thereof
    6.
    发明授权
    Anti-IGF-IR and/or anti-insulin/IGF-I hybrid receptors antibodies and uses thereof 有权
    抗IGF-1R和/或抗胰岛素/ IGF-I杂合受体抗体及其用途

    公开(公告)号：US07553485B2

    公开(公告)日：2009-06-30

    申请号：US11012353

    申请日：2004-12-16

    申请人： Liliane Goetsch ,  Nathalie Corvaia ,  Alain Duflos ,  Jean-Francois Haeuw ,  Olivier Leger ,  Alain Beck

    发明人： Liliane Goetsch ,  Nathalie Corvaia ,  Alain Duflos ,  Jean-Francois Haeuw ,  Olivier Leger ,  Alain Beck

    IPC分类号： A61K39/00 ,  C07K16/00

    CPC分类号： A61K47/6805 ,  C07K2317/732

    摘要： The present invention relates to novel antibodies capable of binding specifically to the human insulin-like growth factor I receptor (IGF-IR) and/or the insulin/IGF-I hybrid receptor (hybrid-R) and/or capable of specifically inhibiting the tyrosine kinase activity of said IGF-IR and/or hybrid-R, especially monoclonal antibodies of murine, chimeric and humanized origin, as well as the amino acid and nucleic acid sequences coding for these antibodies. The invention likewise comprises the use of these antibodies as a medicament for the prophylactic and/or therapeutic treatment of cancers overexpressing IGF-IR and/or hybrid-R or any pathology connected with the overexpression of said receptor as well as in processes or kits for diagnosis of illnesses connected with the overexpression of the IGF-IR and/or hybrid-R. The invention finally comprises products and/or compositions comprising such antibodies in combination with anti-EGFR antibodies and/or compounds and/or anti-cancer agents or agents conjugated with toxins and their use for the prevention and/or the treatment of certain cancers.

    摘要翻译： 本发明涉及能够特异性结合人胰岛素样生长因子I受体（IGF-1R）和/或胰岛素/ IGF-I杂合受体（杂合-R）和/或能够特异性抑制 所述IGF-1R和/或杂种-R，特别是鼠，嵌合和人源化起始的单克隆抗体以及编码这些抗体的氨基酸和核酸序列的酪氨酸激酶活性。 本发明同样包括使用这些抗体作为用于预防和/或治疗过度表达IGF-1R和/或杂合-R的癌症或与所述受体的过度表达相关的任何病理学以及在用于 诊断与IGF-1R和/或杂合体R的过表达相关的疾病。 本发明最终包括包含抗体与抗EGFR抗体和/或化合物和/或与毒素缀合的抗癌剂或试剂的组合的产品和/或组合物及其用于预防和/或治疗某些癌症的用途。

    Novel anti-IGF-IR antibodies and uses thereof
    9.
    发明申请
    Novel anti-IGF-IR antibodies and uses thereof 有权
    新型抗IGF-1R抗体及其用途

    公开(公告)号：US20050084906A1

    公开(公告)日：2005-04-21

    申请号：US10735916

    申请日：2003-12-16

    申请人： Liliane Goetsch ,  Nathalie Corvaia ,  Olivier Leger ,  Alain Duflos ,  Jean-Francois Haeuw ,  Alain Beck

    发明人： Liliane Goetsch ,  Nathalie Corvaia ,  Olivier Leger ,  Alain Duflos ,  Jean-Francois Haeuw ,  Alain Beck

    IPC分类号： A61K47/48 ,  G01N33/53 ,  C07K16/26

    CPC分类号： A61K47/6805 ,  C07K2317/732 ,  Y10S425/81

    摘要： The present invention relates to novel antibodies capable of binding specifically to the human insulin-like growth factor I receptor IGF-IR and/or capable of specifically inhibiting the tyrosine kinase activity of said IGF-IR receptor, especially monoclonal antibodies of murine, chimeric and humanized origin, as well as the amino acid and nucleic acid sequences coding for these antibodies. The invention likewise comprises the use of these antibodies as a medicament for the prophylactic and/or therapeutic treatment of cancers overexpressing IGF-IR or any pathology connected with the overexpression of said receptor as well as in processes or kits for diagnosis of illnesses connected with the overexpression of the IGF-IR receptor. The invention finally comprises products and/or compositions comprising such antibodies in combination with anti-EGFR antibodies and/or compounds and/or anti-cancer agents or agents conjugated with toxins and their use for the prevention and/or the treatment of certain cancers.

    摘要翻译： 本发明涉及能够特异性结合人类胰岛素样生长因子I受体IGF-1R和/或能够特异性抑制所述IGF-1R受体的酪氨酸激酶活性的新型抗体，特别是鼠，嵌合体的单克隆抗体， 人源化，以及编码这些抗体的氨基酸和核酸序列。 本发明同样包括使用这些抗体作为用于预防和/或治疗过度表达IGF-1R的癌症或与所述受体的过度表达相关的任何病理学以及用于诊断与所述受体相关的疾病的过程或试剂盒 IGF-1R受体的过度表达。 本发明最终包括包含抗体与抗EGFR抗体和/或化合物和/或与毒素缀合的抗癌剂或试剂的组合的产品和/或组合物及其用于预防和/或治疗某些癌症的用途。

    Anti-IGF-IR antibodies and uses thereof
    10.
    发明授权
    Anti-IGF-IR antibodies and uses thereof 有权
    抗IGF-1R抗体及其用途

    公开(公告)号：US08168410B2

    公开(公告)日：2012-05-01

    申请号：US13037734

    申请日：2011-03-01

    申请人： Liliane Goetsch ,  Nathalie Corvaia ,  Olivier Leger ,  Alain Duflos ,  Jean-François Haeuw ,  Alain Beck

    发明人： Liliane Goetsch ,  Nathalie Corvaia ,  Olivier Leger ,  Alain Duflos ,  Jean-François Haeuw ,  Alain Beck

    IPC分类号： C12P19/34 ,  C12N15/00 ,  C12N15/13 ,  C07H21/04 ,  C07K16/28

    CPC分类号： A61K47/6805 ,  C07K2317/732 ,  Y10S425/81

    摘要： The present invention relates to novel antibodies capable of binding specifically to the human insulin-like growth factor I receptor IGF-IR and/or capable of specifically inhibiting the tyrosine kinase activity of said IGF-IR receptor, especially monoclonal antibodies of murine, chimeric and humanized origin, as well as the amino acid and nucleic acid sequences coding for these antibodies. The invention likewise comprises the use of these antibodies as a medicament for the prophylactic and/or therapeutic treatment of cancers overexpressing IGF-IR or any pathology connected with the overexpression of said receptor as well as in processes or kits for diagnosis of illnesses connected with the overexpression of the IGF-IR receptor. The invention finally comprises products and/or compositions comprising such antibodies in combination with anti-EGFR antibodies and/or compounds and/or anti-cancer agents or agents conjugated with toxins and their use for the prevention and/or the treatment of certain cancers.

    摘要翻译： 本发明涉及能够特异性结合人类胰岛素样生长因子I受体IGF-1R和/或能够特异性抑制所述IGF-1R受体的酪氨酸激酶活性的新型抗体，特别是鼠，嵌合体的单克隆抗体， 人源化，以及编码这些抗体的氨基酸和核酸序列。 本发明同样包括使用这些抗体作为用于预防和/或治疗过度表达IGF-1R的癌症或与所述受体的过度表达相关的任何病理学以及用于诊断与所述受体相关的疾病的过程或试剂盒 IGF-1R受体的过度表达。 本发明最终包括包含抗体与抗EGFR抗体和/或化合物和/或与毒素缀合的抗癌剂或试剂的这些抗体及其用于预防和/或治疗某些癌症的用途的产品和/或组合物。