利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

855 条记录 (耗时 0.035 秒)

    Anti-IGF-IR antibodies and uses thereof
    2.
    发明授权
    Anti-IGF-IR antibodies and uses thereof 有权
    抗IGF-1R抗体及其用途

    公开(公告)号：US08168410B2

    公开(公告)日：2012-05-01

    申请号：US13037734

    申请日：2011-03-01

    申请人： Liliane Goetsch ,  Nathalie Corvaia ,  Olivier Leger ,  Alain Duflos ,  Jean-François Haeuw ,  Alain Beck

    发明人： Liliane Goetsch ,  Nathalie Corvaia ,  Olivier Leger ,  Alain Duflos ,  Jean-François Haeuw ,  Alain Beck

    IPC分类号： C12P19/34 ,  C12N15/00 ,  C12N15/13 ,  C07H21/04 ,  C07K16/28

    CPC分类号： A61K47/6805 ,  C07K2317/732 ,  Y10S425/81

    摘要： The present invention relates to novel antibodies capable of binding specifically to the human insulin-like growth factor I receptor IGF-IR and/or capable of specifically inhibiting the tyrosine kinase activity of said IGF-IR receptor, especially monoclonal antibodies of murine, chimeric and humanized origin, as well as the amino acid and nucleic acid sequences coding for these antibodies. The invention likewise comprises the use of these antibodies as a medicament for the prophylactic and/or therapeutic treatment of cancers overexpressing IGF-IR or any pathology connected with the overexpression of said receptor as well as in processes or kits for diagnosis of illnesses connected with the overexpression of the IGF-IR receptor. The invention finally comprises products and/or compositions comprising such antibodies in combination with anti-EGFR antibodies and/or compounds and/or anti-cancer agents or agents conjugated with toxins and their use for the prevention and/or the treatment of certain cancers.

    摘要翻译： 本发明涉及能够特异性结合人类胰岛素样生长因子I受体IGF-1R和/或能够特异性抑制所述IGF-1R受体的酪氨酸激酶活性的新型抗体，特别是鼠，嵌合体的单克隆抗体， 人源化，以及编码这些抗体的氨基酸和核酸序列。 本发明同样包括使用这些抗体作为用于预防和/或治疗过度表达IGF-1R的癌症或与所述受体的过度表达相关的任何病理学以及用于诊断与所述受体相关的疾病的过程或试剂盒 IGF-1R受体的过度表达。 本发明最终包括包含抗体与抗EGFR抗体和/或化合物和/或与毒素缀合的抗癌剂或试剂的这些抗体及其用于预防和/或治疗某些癌症的用途的产品和/或组合物。

    Method and apparatus for manufacturing plate-like structure
    4.
    发明授权
    Method and apparatus for manufacturing plate-like structure 失效
    制造板状结构的方法和装置

    公开(公告)号：US08057214B2

    公开(公告)日：2011-11-15

    申请号：US12552049

    申请日：2009-09-01

    申请人： Ryoichi Takahashi ,  Masatoshi Sakurai

    发明人： Ryoichi Takahashi ,  Masatoshi Sakurai

    IPC分类号： B29C59/02

    CPC分类号： G11B5/855 ,  B29C59/022 ,  B29C2059/023 ,  B29L2017/005 ,  Y10S425/81 ,  Y10S977/887 ,  Y10T156/1039

    摘要： A method for manufacturing a plate-like structure, the method including a step of transferring concave and convex patterns on a master to a surface of a transferred substrate by sandwiching the master provided with the concave and convex patterns and the transferred substrate, between a press surface of a hollow cylindrical upper and a press surface of a lower mold, and pressurizing central parts of the upper and lower molds to apply pressure to the master and the transferred substrate, wherein a compressive load imposed on inner peripheral portions of the upper and lower molds is blocked and distributed toward outer peripheries of the upper and lower molds.

    摘要翻译： 一种板状结构体的制造方法，其特征在于，包括以下步骤：通过将具有所述凹凸图案和所转印的基板的所述母体夹在压印机之间，将母版上的凹凸图案转印到转印基板的表面上 中空圆柱形上表面和下模的压制表面，并且对上模和下模的中心部分加压，以向主转台和转印基板施加压力，其中施加在上下的内周部分上的压缩载荷 模具被封闭并分布到上模和下模的外周。

    Pattern drawing method, method of manufacturing a master disk for manufacturing information recording media, and method of manufacturing an information recording medium
    5.
    发明授权
    Pattern drawing method, method of manufacturing a master disk for manufacturing information recording media, and method of manufacturing an information recording medium 失效
    图案绘制方法，制造用于制造信息记录介质的母盘的方法，以及制造信息记录介质的方法

    公开(公告)号：US07938990B2

    公开(公告)日：2011-05-10

    申请号：US11033138

    申请日：2005-01-12

    申请人： Yoshikazu Soeno

    发明人： Yoshikazu Soeno

    IPC分类号： B29D11/00 ,  G11B11/00

    CPC分类号： G11B5/855 ,  B82Y10/00 ,  B82Y40/00 ,  H01J37/3174 ,  H01J2237/20214 ,  H01J2237/20228 ,  H01J2237/3175 ,  Y10S425/81

    摘要： A pattern drawing apparatus which is capable of reducing manufacturing costs of information recording media. A partial drawing process is executed in response to output of a reference signal, for drawing, after being on standby for a predetermined standby time period, pattern segments, which are obtained by dividing patterns forming a servo pattern in the direction of the width of the patterns, by irradiation of a resin layer with an electron beam. A drawing position-changing process is executed for changing the irradiation position of the electron beam on the resin, toward a center of rotation of a substrate or away from the center of rotation, within a range of the effective drawing width of the electron beam. These processes are executed a plurality of times to draw an exposure pattern on the resin layer.

    摘要翻译： 能够降低信息记录介质的制造成本的图形绘制装置。 响应于参考信号的输出执行部分绘图处理，用于在预定的待机时间段待机之后绘制图案片段，其是通过在宽度方向上划分形成伺服图案的图案而获得的图案片段 通过用电子束照射树脂层的图案。 执行绘图位置改变处理，以在电子束的有效绘制宽度的范围内改变树脂上的电子束的照射位置，朝向基底的旋转中心或者远离旋转中心。 执行这些处理多次以在树脂层上绘制曝光图案。

    Method of manufacturing a composite disc structure and apparatus for performing the method
    6.
    发明授权
    Method of manufacturing a composite disc structure and apparatus for performing the method 有权
    复合盘结构的制造方法及其制造方法

    公开(公告)号：US07918957B2

    公开(公告)日：2011-04-05

    申请号：US11031167

    申请日：2005-01-07

    申请人： Ellis E. Kern ,  William R. Mueller

    发明人： Ellis E. Kern ,  William R. Mueller

    IPC分类号： B29D11/00

    CPC分类号： G11B7/265 ,  B29C65/48 ,  B29C66/45 ,  B29D17/005 ,  B29K2033/12 ,  B29K2069/00 ,  B29L2009/00 ,  B29L2017/005 ,  G11B7/24038 ,  Y10S425/81 ,  Y10T156/17

    摘要： A method of making composite discs continuously, including forming for each disc a first, a second layer, and a third support layer, each support layer being disc shaped and having a first surface with information indicia. An information layer is added to each support layers respectively. The said first and third support layers are positioned in a facing relationship, with the first and third information layers being adjacent. The third support layer is then separated from the third information layer, which thus remains attached to the first support layer. The first and second support layers are then joined. These steps are performed on a manufacturing line with conveyor belts transferring the support layers from station to station.

    摘要翻译： 一种连续制造复合盘的方法，包括为每个盘形成第一，第二层和第三支撑层，每个支撑层是盘形的并且具有带有信息标记的第一表面。 信息层分别添加到每个支撑层。 所述第一和第三支撑层以面对的关系定位，第一和第三信息层相邻。 然后将第三支撑层与第三信息层分离，从而保持附着到第一支撑层。 然后连接第一和第二支撑层。 这些步骤在具有从站到站传送支撑层的传送带的生产线上执行。

    Mold structure
    8.
    发明授权
    Mold structure 失效
    模具结构

    公开(公告)号：US07850441B2

    公开(公告)日：2010-12-14

    申请号：US11946198

    申请日：2007-11-28

    申请人： Toshihiro Usa ,  Kenji Ichikawa ,  Kazunori Komatsu

    发明人： Toshihiro Usa ,  Kenji Ichikawa ,  Kazunori Komatsu

    IPC分类号： B29D17/00

    CPC分类号： G03F7/0002 ,  B82Y10/00 ,  B82Y40/00 ,  G11B5/743 ,  G11B5/855 ,  Y10S425/81

    摘要： There is provided a mold structure containing a substrate, and a plurality of convex portions formed in the shape of concentric circles at predetermined intervals on one surface of the substrate, wherein a cross-sectional shape of the convex portions with respect to a radial direction of the concentric circles is such that a middle width M of each of the convex portions with respect to a heightwise direction is greater than a width T of a top portion of each of the convex portions with respect to the radial direction of the concentric circles.

    摘要翻译： 提供了一种包含基板的模具结构和在基板的一个表面上以预定间隔形成为同心圆形的多个凸部，其中凸部相对于基板的径向的横截面形状 同心圆使得每个凸部相对于高度方向的中间宽度M相对于同心圆的径向方向大于每个凸部的顶部的宽度T。

    Production method and production apparatus of optical disc
    9.
    发明授权
    Production method and production apparatus of optical disc 有权
    光盘的生产方法和生产设备

    公开(公告)号：US07842202B2

    公开(公告)日：2010-11-30

    申请号：US12087232

    申请日：2006-12-27

    申请人： Naoto Ozawa ,  Masahiro Nakamura ,  Takayuki Suzuki

    发明人： Naoto Ozawa ,  Masahiro Nakamura ,  Takayuki Suzuki

    IPC分类号： G11B7/26

    CPC分类号： G11B7/266 ,  B29C65/1406 ,  B29C65/1435 ,  B29C65/1454 ,  B29C65/1483 ,  B29C65/4845 ,  B29C65/521 ,  B29C65/524 ,  B29C65/78 ,  B29C66/1122 ,  B29C66/345 ,  B29C66/452 ,  B29C66/65 ,  B29C66/71 ,  B29C66/93441 ,  B29C66/93451 ,  B29C66/939 ,  B29C66/9392 ,  B29L2017/005 ,  Y10S425/81 ,  B29C65/00 ,  B29K2069/00

    摘要： In order to control a warp of a disc substrate so as to be a desired level, an optical disc production method includes: a step of supplying resin on the disc substrate; a step of mounting the disc substrate on an inside diameter portion of a turntable after supplying the resin; a step of providing an air-gap between an outside diameter portion of the turntable and a portion of the disc substrate that is not mounted; a step of extending the resin by spinning; and a curing step of curing the resin while spinning the disc substrate mounted on the inside diameter portion of the turntable, wherein in the step of extending the resin, a negative pressure is affected on a portion of the disc substrate that is not mounted, and in the curing step, the warp is controlled by curing the resin on the spinning disc substrate while maintaining effect of the negative pressure.

    摘要翻译： 为了将盘基板的翘曲控制在期望的水平，光盘的制造方法包括：在盘基片上供给树脂的步骤; 在提供树脂之后将盘基片安装在转盘的内径部分上的步骤; 在转台的外径部分和未安装的盘基片的一部分之间设置气隙的步骤; 通过纺丝延长树脂的步骤; 以及固化步骤，在旋转安装在转台的内径部分上的盘基片的同时固化树脂，其中在延伸树脂的步骤中，在未安装的盘基片的一部分上影响负压，以及 在固化步骤中，通过固化旋转盘基片上的树脂同时保持负压的作用来控制翘曲。