Antifungal proteins and methods for their use
    10.
    发明授权
    Antifungal proteins and methods for their use 有权
    抗真菌蛋白及其使用方法

    公开(公告)号:US06573361B1

    公开(公告)日:2003-06-03

    申请号:US09732210

    申请日:2000-12-07

    IPC分类号: A61K3800

    摘要: A novel protein was isolated from Fusarium culmorum and characterized. The protein, termed FCWP1, demonstrated significant antifungal activity against several fungal species. Mutations in proteolytic consensus sequences contained within FCWP1 improved the stability of its antifungal activity. In addition, a class of proteins related to FCWP1 was identified and characterized. This class is made up of ribosomal proteins and displayed similar values for pI and molecular weight. A representative number of proteins from this class were tested and found to have significant antifungal activities. The antifungal proteins disclosed herein are useful in controlling fungal infections in plants. Transgenic plants may be produced that are more resistant to fungal infections relative to non-transgenic plants of the same species. Alternatively, the proteins may be applied to plants exogenously.

    摘要翻译: 从镰刀菌中分离出一种新的蛋白质并进行了表征。 称为FCWP1的蛋白质表现出对几种真菌物种的显着抗真菌活性。 FCWP1中包含的蛋白水解共有序列的突变改善了其抗真菌活性的稳定性。 此外,鉴定和表征了一类与FCWP1相关的蛋白质。 该类由核糖体蛋白质组成,显示出与pI和分子量相似的值。 测试了来自该类别的代表性的蛋白质,并发现其具有显着的抗真菌活性。本文公开的抗真菌蛋白质可用于防治植物中的真菌感染。 可以产生相对于相同物种的非转基因植物更能抵抗真菌感染的转基因植物。 或者,蛋白质可以外源地施用于植物。