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18 条记录 (耗时 0.03 秒)

    NIGHT SIGHT AND METHOD OF MAKING THE SAME
    3.
    发明申请
    NIGHT SIGHT AND METHOD OF MAKING THE SAME 审中-公开
    夜景及其制作方法

    公开(公告)号：US20110113671A1

    公开(公告)日：2011-05-19

    申请号：US12942742

    申请日：2010-11-09

    申请人： Eugene J. Pochapsky ,  Paul Maxin ,  William Welsh

    发明人： Eugene J. Pochapsky ,  Paul Maxin ,  William Welsh

    IPC分类号： F41G1/32 ,  B23P11/00

    CPC分类号： G02B23/12 ,  F41G1/32 ,  Y10T29/49826

    摘要： A night sight includes a notched bottom portion, permitting the use of a large objective lens for maximized light gathering capability while also permitting the night sight to be mounted with its center line relatively close to the center line of the barrel of the weapon with which it is used. This configuration permits the night sight to be mounted so that its center line is the same as the center line of a daytime telescopic sight used in conjunction with the night sight. The night sight includes a focusing assembly having decreased sensitivity to tilt or decenter, and a collimator mounted within a spherical bearing so that the collimator may be precisely aligned during assembly of the night sight. The night sight thereby ensures that an image viewed through the night sight appears to originate from the same angle as that with which the image entered the objective lens, and further resists a need to compensate for parallax during aiming.

    摘要翻译： 夜视包括凹口的底部部分，允许使用大型物镜以获得最大的聚光能力，同时还允许夜视安装其中心线相对靠近武器枪管的中心线 用来。 该配置允许安装夜视，使得其中心线与与夜视相结合的白天望远镜的中心线相同。 夜视包括具有降低的对倾斜或偏心的灵敏度的聚焦组件和安装在球面轴承内的准直器，使得准直仪可以在组装夜视期间精确对准。 因此，夜视可以确保通过夜景观看的图像似乎源自与图像进入物镜的角度相同的角度，并且进一步抵抗在瞄准期间补偿视差的需要。

    Opiate analogs selective for the delta-opioid receptor
    4.
    发明申请
    Opiate analogs selective for the delta-opioid receptor 审中-公开
    鸦片类似物对δ-阿片受体有选择性

    公开(公告)号：US20070105884A1

    公开(公告)日：2007-05-10

    申请号：US11507955

    申请日：2006-08-22

    申请人： William Welsh ,  Seong Yu ,  Anil Nair

    发明人： William Welsh ,  Seong Yu ,  Anil Nair

    IPC分类号： A61K31/485 ,  C07D489/02

    CPC分类号： C07D471/10 ,  C07D498/08

    摘要： Novel compounds which selectively bind to the δ-opioid receptor have been designed. These compounds have greater selectivity, improved water (blood) solubility, and enhanced therapeutic value as analgesics. Because agonists with selectivity for the δ-opioid receptor have shown promise in providing enhanced analgesis without the addictive properties, the compounds of the present invention are better than morphine, naltrindole (NTI), spiroindanyloxymorphone (SIOM), and other known μ-opioid receptor selectors as analgesics.

    摘要翻译： 已经设计了选择性结合δ-阿片受体的新型化合物。 这些化合物具有更大的选择性，改善的水（血液）溶解度，并且作为镇痛药具有增强的治疗价值。 由于对δ-阿片样物质受体具有选择性的激动剂显示出提供增强镇痛而没有上瘾性质的希望，本发明的化合物比吗啡，纳曲酮（NTI），螺茚二氧基吗啡（SIOM）和其他已知的μ-阿片受体 选择剂作为镇痛药。

    Glutamate receptor modulators and therapeutic agents
    5.
    发明申请
    Glutamate receptor modulators and therapeutic agents 有权
    谷氨酸受体调节剂和治疗剂

    公开(公告)号：US20130150416A1

    公开(公告)日：2013-06-13

    申请号：US13507097

    申请日：2012-06-02

    申请人： Richard D. Wood ,  William Welsh

    发明人： Richard D. Wood ,  William Welsh

    IPC分类号： C07C235/56 ,  C07C271/02 ,  C07D277/58 ,  C07D317/34 ,  C07D207/16

    CPC分类号： C07C235/56 ,  C07C235/64 ,  C07C255/58 ,  C07C271/02 ,  C07C271/44 ,  C07C271/56 ,  C07D207/16 ,  C07D277/46 ,  C07D277/58 ,  C07D317/34

    摘要： The present invention discloses methods of modulating the activity of Group I mGluRs using a defined class of benzamide compounds. In one embodiment, methods of modulating the activity of mGluR1 are provided. In another embodiment, methods of modulating the activity of mGluR5 are provided. In still another embodiment, methods of simultaneously modulating the activities of both mGluR1 and mGluR5 are provided. The present invention also provides methods of treating diseases or disorders which are mediated in full or in part by Group I mGluRs using one or more compounds belonging to the defined class of benzamide compounds. The present invention further provides methods of preventing diseases or disorders which are mediated in full or in part by Group I mGluRs using one or more compounds belonging to the defined class of compounds.

    摘要翻译： 本发明公开了使用确定类型的苯甲酰胺化合物调节I组mGluR的活性的方法。 在一个实施方案中，提供调节mGluR1活性的方法。 在另一个实施方案中，提供调节mGluR5活性的方法。 在另一个实施方案中，提供了同时调节mGluR1和mGluR5的活性的方法。 本发明还提供了使用一种或多种属于所定义类型的苯甲酰胺化合物的化合物来治疗全部或部分由I组mGluR介导的疾病或病症的方法。 本发明还提供了使用一种或多种属于所定类化合物的化合物来预防全部或部分由I组mGluR介导的疾病或病症的方法。

    Active force generation system for minimizing vibration in a rotating system
    6.
    发明申请
    Active force generation system for minimizing vibration in a rotating system 有权
    用于最小化旋转系统中的振动的主动力产生系统

    公开(公告)号：US20050079056A1

    公开(公告)日：2005-04-14

    申请号：US10685215

    申请日：2003-10-14

    申请人： William Welsh

    发明人： William Welsh

    IPC分类号： B64C27/00 ,  F16F15/14 ,  F16F15/36 ,  B63H1/00

    CPC分类号： F16F15/145 ,  B64C27/001 ,  B64C2027/004 ,  F16F15/36 ,  Y10S416/50

    摘要： A method and device for reducing vibratory noise in a system with an integral rotating member includes independently operable drive means for controlling the angular velocity of at least two masses. Control signals manipulate the drive means to allow each mass to rotate at optimal speed, direction and phase for reducing the noise induced in the system by the rotating member.

    摘要翻译： 一种用于减小具有整体旋转构件的系统中的振动噪声的方法和装置包括用于控制至少两个质量的角速度的独立可操作的驱动装置。 控制信号操纵驱动装置以允许每个质量块以最佳速度，方向和相位旋转，以减少由旋转构件在系统中引起的噪声。

    Method of use of pharmaceutical formulations for the treatment of apicomplexan diseases in animals
    7.
    发明申请
    Method of use of pharmaceutical formulations for the treatment of apicomplexan diseases in animals 审中-公开
    药物制剂用于治疗动物中的复合物疾病的方法

    公开(公告)号：US20130324555A1

    公开(公告)日：2013-12-05

    申请号：US13904063

    申请日：2013-05-29

    申请人： Richard Delarey Wood ,  Rima McLeod ,  Ernest Mui ,  Alina Fomovska ,  William Welsh

    发明人： Richard Delarey Wood ,  Rima McLeod ,  Ernest Mui ,  Alina Fomovska ,  William Welsh

    IPC分类号： C07C235/64 ,  C07C271/50 ,  C07D295/192

    CPC分类号： C07C235/64 ,  A61K31/167 ,  A61K31/24 ,  A61K31/357 ,  A61K31/401 ,  A61K31/426 ,  C07C271/50 ,  C07D295/192

    摘要： The present invention is directed to the method of use of effective pharmaceutical formulations for the treatment of diseases caused by apicomplexan parasites, said formulation comprised of a salicylanilide or salicylanilide derivative, disclosed herein, alone or in combination with one or more other active or excipient pharmaceutical substances. The present invention is further directed to the method of use of effective pharmaceutical formulations for the treatment of diseases caused by apicomplexan parasites, said formulation comprised of a combination of salicylanilides or salicylanilide derivatives, disclosed herein. The present invention is further directed to the method of use of effective pharmaceutical formulations for the treatment of diseases caused by apicomplexan parasites, said formulation comprised of a combination of salicylanilides or salicylanilide derivatives, disclosed herein, further comprised of one or more active or excipient pharmaceutical substances.

    摘要翻译： 本发明涉及使用有效的药物制剂来治疗由复合顶寄生虫引起的疾病的方法，所述制剂由本文公开的水杨酰苯胺或水杨酰苯胺衍生物单独或与一种或多种其它活性或赋形剂药物组合 物质 本发明进一步涉及使用有效的药物制剂来治疗由复合物寄生虫引起的疾病的方法，所述制剂由本文公开的水杨酰苯胺或水杨酰苯胺衍生物的组合组成。 本发明进一步涉及使用有效的药物制剂来治疗由副复合寄生虫引起的疾病的方法，所述制剂由本文公开的水杨酰苯胺或水杨酰苯胺衍生物的组合组成，还包含一种或多种活性或赋形剂药物 物质

    OPIOID RECEPTOR ACTIVE COMPOUNDS
    8.
    发明申请
    OPIOID RECEPTOR ACTIVE COMPOUNDS 失效
    阿片受体活性化合物

    公开(公告)号：US20080070964A1

    公开(公告)日：2008-03-20

    申请号：US11857193

    申请日：2007-09-18

    申请人： William Welsh ,  Seong Yu ,  Anil Nair

    发明人： William Welsh ,  Seong Yu ,  Anil Nair

    IPC分类号： A61K31/4196 ,  A61P25/04 ,  C07D249/08

    CPC分类号： C07D249/08 ,  A61K31/4196 ,  C07D249/14

    摘要： The invention provides compounds of formula I: wherein R1 to R4 and n have any of the meanings defined in the specification and their pharmaceutically acceptable salts. The invention also provides pharmaceutical compositions comprising a compound of formula I, processes for preparing compounds of formula I, intermediates useful for preparing compounds of formula I, and therapeutic methods for treating pain and treating other conditions which involve, for example, binding opioid receptors using compounds of formula I.

    摘要翻译： 本发明提供式I化合物：其中R 1至R 4和n具有说​​明书中定义的任何含义及其药学上可接受的盐。 本发明还提供包含式I化合物的药物组合物，制备式I化合物的方法，可用于制备式I化合物的中间体，以及用于治疗疼痛和治疗其它病症的治疗方法，所述治疗方法涉及例如使用 式I化合物。

    Systems and methods for microarray data analysis
    10.
    发明申请
    Systems and methods for microarray data analysis 审中-公开
    用于微阵列数据分析的系统和方法

    公开(公告)号：US20060271300A1

    公开(公告)日：2006-11-30

    申请号：US10565417

    申请日：2004-07-29

    申请人： William Welsh ,  Ming Ouyang ,  Paul Lioy ,  Panos Georgopoulos

    发明人： William Welsh ,  Ming Ouyang ,  Paul Lioy ,  Panos Georgopoulos

    IPC分类号： G06F19/00

    CPC分类号： G06K9/6226 ,  G16B25/00 ,  G16B40/00

    摘要： Clustering is routinely applied in the exploratory analysis of microarray data. Missing entries arise from blemishes on the microarrays. The present invention provides a new method, and computer program and/or computer product thereof to impute missing values. The method involves the steps of clustering microarray data by partitioning the data into a select number of clusters, wherein each data point is iteratively moved from one cluster to another, until two consecutive iterations have resulted in the same partition pattern; obtaining a select number of estimates of the data in the clusters by probabilistic interference; and averaging the select number of estimates to obtain missing values in the microarray data. The method is superior to other imputation models as measured by root mean squared errors.

    摘要翻译： 在微阵列数据的探索性分析中常规应用聚类。 缺少的条目是由微阵列上的瑕疵产生的。 本发明提供了一种新的方法，以及计算机程序和/或计算机产品来估算缺失值。 该方法包括通过将数据分割成选定数量的簇来聚类微阵列数据的步骤，其中每个数据点被迭代地从一个簇移动到另一簇，直到两个连续的迭代已经得到相同的分区模式; 通过概率干扰获得集群中的数据的选择数量的估计; 并对所选择的估计数进行平均以获得微阵列数据中的缺失值。 该方法优于通过均方根误差测量的其他插补模型。