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    Composition containing a radioactive component for treatment of vessel wall
    4.
    发明授权
    Composition containing a radioactive component for treatment of vessel wall 失效
    含有用于治疗血管壁的放射性成分的组合物

    公开(公告)号：US5873811A

    公开(公告)日：1999-02-23

    申请号：US782542

    申请日：1997-01-10

    申请人： Lixiao Wang ,  Roger N. Hastings

    发明人： Lixiao Wang ,  Roger N. Hastings

    IPC分类号： A61B17/22 ,  A61F2/00 ,  A61F2/82 ,  A61K38/17 ,  A61K51/00 ,  A61K51/12 ,  A61M29/02 ,  A61M36/04 ,  A61N5/10 ,  A61P9/08

    CPC分类号： A61F2/82 ,  A61K51/1279 ,  A61K51/1282 ,  A61M25/104 ,  A61N5/1002 ,  A61B2017/22002 ,  A61F2002/30448 ,  A61F2220/005 ,  A61M2025/105 ,  A61M29/02

    摘要： A method and composition for inhibiting restenosis. The composition includes an adhesive or polymeric material having a radioactive component dispersed therethrough. A biologically compatible adhesive including a radioactive material is applied to a vessel region where inhibition of restenosis is desired in a preferred method. In one composition, the radioactive material is admixed with the adhesive. In another composition, the radioactive material is chemically bonded to a polymeric adhesive. The adhesive is preferably cured in place. The radioactive material has a preferred half life of less than six months. In one method, the application of adhesive is followed by stent placement, leaving radioactive adhesive extending beyond both stent ends. The application can include forcing adhesive from a double walled balloon having a porous outer wall.

    摘要翻译： 用于抑制再狭窄的方法和组合物。 该组合物包括具有分散在其中的放射性组分的粘合剂或聚合材料。 将包含放射性物质的生物相容性粘合剂施用于在优选方法中需要抑制再狭窄的血管区域。 在一种组合物中，放射性物质与粘合剂混合。 在另一种组合物中，放射性物质化学键合到聚合物粘合剂上。 粘合剂优选在适当的地方固化。 放射性物质的半衰期优选少于6个月。 在一种方法中，粘合剂的应用之后是支架放置，留下放射性粘合剂延伸超过两个支架末端。 该应用可以包括从具有多孔外壁的双壁球囊迫使粘合剂。

    Method for percutaneous coronary artery bypass
    7.
    发明授权
    Method for percutaneous coronary artery bypass 失效
    经皮冠状动脉搭桥方法

    公开(公告)号：US06253769B1

    公开(公告)日：2001-07-03

    申请号：US09391112

    申请日：1999-09-07

    申请人： Daniel M. LaFontaine ,  Kent D. Harrison ,  Charles L. Euteneuer ,  Roger N. Hastings ,  Lixiao Wang

    发明人： Daniel M. LaFontaine ,  Kent D. Harrison ,  Charles L. Euteneuer ,  Roger N. Hastings ,  Lixiao Wang

    IPC分类号： A61B1900

    CPC分类号： A61F2/82 ,  A61B17/32053 ,  A61B2017/00243 ,  A61B2017/00252 ,  A61B2017/1135 ,  A61B2017/306 ,  A61B2090/3929 ,  A61B2090/3945 ,  A61B2090/3958 ,  A61F2/06 ,  A61F2/064 ,  A61F2/90 ,  A61F2/958 ,  A61F2250/0098 ,  Y10S623/902

    摘要： A percutaneous system for bypassing a restriction in an artery of a mammal having an aorta includes providing a graft having a body portion with a first end, a second end and a lumen therebetween. First and second expandable stents are provided at the first and second ends of the graft, respectively. Apertures are formed in the artery, distal of the restriction, and in the aorta and the graft is inserted between the apertures. At least a portion of the first stent is inserted through the aperture in the artery and the stent is deployed to connect the first end of the graft within the artery. The second stent is positioned such that a first expandable portion is outside the aorta and a second expandable portion is within the aorta. The first and second expandable portions of the second stent are expanded to have outer diameters at least as large as the aperture in the aorta to anchor the first end of the graft in the aorta such that the lumen in the graft communicates with the aorta and the artery.

    摘要翻译： 用于绕过具有主动脉的哺乳动物的动脉中的限制的经皮系统包括提供具有主体部分的移植物，其具有第一端，第二端和内腔。 第一和第二可扩张支架分别设置在移植物的第一和第二端。 孔径形成在动脉的远端，在主动脉的远侧，移植物插入孔之间。 第一支架的至少一部分插入通过动脉中的孔，并且支架被展开以将移植物的第一端连接在动脉内。 第二支架定位成使得第一可膨胀部分在主动脉外侧，第二可膨胀部分在主动脉内。 第二支架的第一和第二可膨胀部分被扩张以具有至少与主动脉中的孔相同的外径，以将移植物的第一端锚定在主动脉中，使得移植物中的内腔与主动脉连通，并且 动脉。

    Drug Coated Balloon Catheters for Nonvascular Strictures
    9.
    发明申请
    Drug Coated Balloon Catheters for Nonvascular Strictures 审中-公开
    用于非血管狭窄的药物涂层气球导管

    公开(公告)号：US20150273117A1

    公开(公告)日：2015-10-01

    申请号：US14438327

    申请日：2013-10-14

    申请人： Lixiao WANG ,  Urotronic, Inc.

    发明人： Lixiao Wang

    IPC分类号： A61L29/16 ,  A61L29/08

    摘要： Embodiments of the present invention provide a method for treatment of nonvascular body lumen strictures such as benign prostatic hyperplasia (BPH), urethral strictures, ureteral strictures, prostate cancer, esophageal strictures, sinus strictures, biliary tract strictures, asthma and chronic obstructive pulmonary disease (COPD). The method involves delivering, preferably via drug coated balloon catheters, of anti-inflammatory and anti-proliferative drugs (rapamycin or paclitaxel and their analogues) and one or more additives.

    摘要翻译： 本发明的实施方案提供了一种用于治疗诸如良性前列腺增生（BPH），尿道狭窄，输尿管狭窄，前列腺癌，食管狭窄，窦狭窄，胆道狭窄，哮喘和慢性阻塞性肺病的非血管性体腔狭窄的方法 COPD）。 该方法优选通过药物涂覆的气囊导管递送抗炎和抗增殖药物（雷帕霉素或紫杉醇及其类似物）和一种或多种添加剂。