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    SURFACE PLASMON RESONANCE COMPATIBLE CARBON THIN FILMS
    1.
    发明申请
    SURFACE PLASMON RESONANCE COMPATIBLE CARBON THIN FILMS 有权
    表面等离子体共混碳薄膜

    公开(公告)号：US20090141376A1

    公开(公告)日：2009-06-04

    申请号：US12037332

    申请日：2008-02-26

    申请人： Lloyd M. Smith ,  Matthew R. Lockett ,  Michael R. Shortreed ,  Robert M. Corn ,  Stephen Weibel ,  Robert J. Hamers ,  Bin Sun

    发明人： Lloyd M. Smith ,  Matthew R. Lockett ,  Michael R. Shortreed ,  Robert M. Corn ,  Stephen Weibel ,  Robert J. Hamers ,  Bin Sun

    IPC分类号： G02B5/04 ,  G01N21/55 ,  H01J49/00 ,  B32B38/00 ,  B05D5/06 ,  C23C14/34

    CPC分类号： G01N21/553 ,  G02B5/04

    摘要： SPR-compatible substrates for high density microarray fabrication and analyses are provided. Novel carbon-on-metal thin film substrate architecture permits the integration of surface plasmon resonance detection with photolithographically fabricated biomolecule arrays for the analysis of biomolecular interactions. The utility of the technology is shown in the analysis of specific DNA-DNA, DNA-RNA and DNA-protein binding interactions. These new substrates may be used to determine the secondary structure of RNA molecules, to probe the sequence-specific binding kinetics and affinity of proteins and small molecules, and as substrates for small-molecule combinatorial chemistry platforms for drug discovery applications.

    摘要翻译： 提供了用于高密度微阵列制造和分析的SPR兼容基板。 新的碳 - 金属薄膜基板架构允许将表面等离子体共振检测与光刻制造的生物分子阵列整合以用于生物分子相互作用的分析。 该技术的实用性在特异性DNA-DNA，DNA-RNA和DNA-蛋白结合相互作用的分析中显示。 这些新的底物可用于确定RNA分子的二级结构，以探测序列特异性结合动力学和蛋白质和小分子的亲和力，以及作为用于药物发现应用的小分子组合化学平台的底物。

    DEVICE AND METHOD FOR DETECTION AND MONITORING OF COUGH
    3.
    发明申请
    DEVICE AND METHOD FOR DETECTION AND MONITORING OF COUGH 有权

    公开(公告)号：US20210153773A1

    公开(公告)日：2021-05-27

    申请号：US16854641

    申请日：2020-04-21

    申请人： Edward T. Wei ,  Bin Sun ,  Zhengrong Tang

    发明人： Edward T. Wei ,  Bin Sun ,  Zhengrong Tang

    IPC分类号： A61B5/08 ,  A61B5/00 ,  A61B7/00 ,  A61B5/01 ,  A61K31/194

    摘要： Cough is a common experience and the most frequent reason why an individual seeks a visit to a physician. The prevalence of cough is about 10+% of the population. Cough is a manifestation of many aerodigestive tract disorders and especially consequential for serious lower airway diseases such as respiratory infections, chronic obstructive pulmonary disease (COPD) and asthma because increased coughing leads to emergency room visits and hospitalization. There is a need for methods to oversee coughing frequency in certain patients. Traditionally, all automated cough monitors have used cough sound as the signal for the measurement of cough. In the present invention movements of the diaphragm muscle, recorded by a motion sensor placed above the xiphoid process, are used for counting coughs. A device for such recordings is described and data were collected. This method is validated by using citric acid spray to trigger cough sounds and to show that the provoked acoustic signal is matched by the electronic signals from the movement sensors. The xiphoid process is a unique anatomical landmark for the non-acoustic detection of cough.

    Process for ammoximation of carbonyl compounds
    8.
    发明授权
    Process for ammoximation of carbonyl compounds 有权
    羰基化合物氨肟化方法

    公开(公告)号：US07408080B2

    公开(公告)日：2008-08-05

    申请号：US10448282

    申请日：2003-05-30

    申请人： Wei Wu ,  Bin Sun ,  Yongxiang Li ,  Shibiao Cheng ,  Enquan Wang ,  Shuzhong Zhang

    发明人： Wei Wu ,  Bin Sun ,  Yongxiang Li ,  Shibiao Cheng ,  Enquan Wang ,  Shuzhong Zhang

    IPC分类号： C07C249/04

    CPC分类号： C07C251/48 ,  C07C249/04 ,  C07C251/38 ,  C07C251/42 ,  C07C2601/08 ,  C07C2601/14

    摘要： The present invention discloses a process for the ammoximation of carbonyl compounds, wherein a reaction in a liquid reaction system comprising a carbonyl compound, ammonia and hydrogen peroxide is carried out in the presence of a sillicon-containing catalyst, characterized in that a liquid silicon-containing assistant is added to the reaction system so that the silicon concentration in the system reaches a range of between 0.1 and 10000 ppm. In the process according to the present invention, the deactivation of catalyst due to dissolution of silicon in the catalyst can be reduced, thus lifetime of the catalyst extended and the stable operation time elongated.

    摘要翻译： 本发明公开了一种羰基化合物的肟化方法，其中在含有硅基催化剂的催化剂存在下进行包含羰基化合物，氨和过氧化氢的液体反应体系中的反应，其特征在于， 加入到反应体系中，使得体系中的硅浓度达到0.1〜10000ppm的范围。 在根据本发明的方法中，可以减少由于硅在催化剂中的溶解导致的催化剂的失活，从而延长催化剂的寿命并延长稳定的操作时间。