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公开(公告)号：US20110263611A1
公开(公告)日：2011-10-27
申请号：US13178277
申请日：2011-07-07
申请人： Lon T. Spada , Jane Guo Shiah , Patrick Hughes , Thomas C. Malone , Gerald W. Devries , Jeffrey L. Edelman , Julie A. Wurster
发明人： Lon T. Spada , Jane Guo Shiah , Patrick Hughes , Thomas C. Malone , Gerald W. Devries , Jeffrey L. Edelman , Julie A. Wurster
IPC分类号： A61K31/496 , A61P27/06 , A61K31/5377 , A61P27/02
CPC分类号： C07D213/82 , A61K9/0051 , A61K31/44 , A61K31/4436 , A61K31/4439 , A61K31/444 , A61K31/4545 , A61K31/496 , A61K31/5377 , A61K31/541 , A61K47/34 , C07D401/06 , C07D401/14 , C07D405/06 , C07D405/14 , C07D409/06 , C07D413/06 , C07D417/06 , Y02A50/401
摘要： The present invention relates to drug delivery systems comprising ocular implant, which include organic molecules, capable of modulating tyrosine kinase signal transduction in order to regulate, modulate and/or inhibit abnormal cell proliferation, in combination with a polymer, which polymer serves to control, modify, modulate and/or slow the release of the therapeutic component into the environment of the eye in which said composite is placed.
摘要翻译： 本发明涉及药物递送系统，其包括眼部植入物，其包括能够调节酪氨酸激酶信号转导以调节，调节和/或抑制异常细胞增殖的有机分子，所述聚合物用于控制聚合物， 改变，调节和/或缓慢释放治疗组分到其中放置所述复合物的眼睛的环境中。
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公开(公告)号：US08143410B2
公开(公告)日：2012-03-27
申请号：US12319356
申请日：2009-01-05
申请人： Lon T. Spada , Jane Guo Shiah , Patrick Hughes , Thomas C. Malone , Gerald W. Devries , Jeffrey L. Edelman , Julie A. Wurster
发明人： Lon T. Spada , Jane Guo Shiah , Patrick Hughes , Thomas C. Malone , Gerald W. Devries , Jeffrey L. Edelman , Julie A. Wurster
IPC分类号： C07D211/72 , C07D241/00 , A61K31/50 , A61K31/44
CPC分类号： C07D213/82 , A61K9/0051 , A61K31/44 , A61K31/4436 , A61K31/4439 , A61K31/444 , A61K31/4545 , A61K31/496 , A61K31/5377 , A61K31/541 , A61K47/34 , C07D401/06 , C07D401/14 , C07D405/06 , C07D405/14 , C07D409/06 , C07D413/06 , C07D417/06 , Y02A50/401
摘要： The present invention relates to drug delivery systems comprising ocular implant, which include organic molecules, capable of modulating tyrosine kinase signal transduction in order to regulate, modulate and/or inhibit abnormal cell proliferation, in combination with a polymer, which polymer serves to control, modify, modulate and/or slow the release of the therapeutic component into the environment of the eye in which said composite is placed.
摘要翻译： 本发明涉及药物递送系统，其包括眼部植入物，其包括能够调节酪氨酸激酶信号转导以调节，调节和/或抑制异常细胞增殖的有机分子，所述聚合物用于控制聚合物， 改变，调节和/或缓慢释放治疗组分到其中放置所述复合物的眼睛的环境中。
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公开(公告)号：US20090286773A1
公开(公告)日：2009-11-19
申请号：US12380493
申请日：2009-02-26
申请人： Lon T. Spada , Jane Guo Shiah , Patrick Hughes , Thomas C. Malone , Gerald W. DeVries , Jeffrey L. Edelman , Julie A. Wurster , Xialing Guo , Sougato Boral
发明人： Lon T. Spada , Jane Guo Shiah , Patrick Hughes , Thomas C. Malone , Gerald W. DeVries , Jeffrey L. Edelman , Julie A. Wurster , Xialing Guo , Sougato Boral
IPC分类号： A61K31/404 , A61K31/454 , A61K31/5377 , A61K31/496 , A61K31/541 , A61P27/00
CPC分类号： C07D405/04 , A61K9/0051 , A61K9/5031 , A61K31/397 , A61K31/404 , A61K31/41 , A61K31/454 , A61K31/496 , A61K31/5377 , A61K31/541 , A61K45/06 , C07D213/82 , C07D401/06 , C07D401/14 , C07D405/06 , C07D405/14 , C07D409/06 , C07D413/06 , C07D413/14 , C07D417/06
摘要： The present invention relates to drug delivery systems comprising ocular implant, which include organic molecules, capable of modulating tyrosine kinase signal transduction in order to regulate, modulate and/or inhibit abnormal cell proliferation, in combination with a polymer, which polymer serves to control, modify, modulate and/or slow the release of the therapeutic component into the environment of the eye in which said composite is placed.
摘要翻译： 本发明涉及药物递送系统，其包括眼部植入物，其包括能够调节酪氨酸激酶信号转导以调节，调节和/或抑制异常细胞增殖的有机分子，所述聚合物用于控制聚合物， 改变，调节和/或缓慢释放治疗组分到其中放置所述复合物的眼睛的环境中。
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公开(公告)号：US20120238558A9
公开(公告)日：2012-09-20
申请号：US12380493
申请日：2009-02-26
申请人： Lon T. Spada , Jane Guo Shiah , Patrick Hughes , Thomas C. Malone , Gerald W. DeVries , Jeffrey L. Edelman , Julie A. Wurster , Xialing Guo , Sougato Boral
发明人： Lon T. Spada , Jane Guo Shiah , Patrick Hughes , Thomas C. Malone , Gerald W. DeVries , Jeffrey L. Edelman , Julie A. Wurster , Xialing Guo , Sougato Boral
IPC分类号： A61K31/404 , A61P27/00 , A61K31/496 , A61K31/541 , A61K31/454 , A61K31/5377
CPC分类号： C07D405/04 , A61K9/0051 , A61K9/5031 , A61K31/397 , A61K31/404 , A61K31/41 , A61K31/454 , A61K31/496 , A61K31/5377 , A61K31/541 , A61K45/06 , C07D213/82 , C07D401/06 , C07D401/14 , C07D405/06 , C07D405/14 , C07D409/06 , C07D413/06 , C07D413/14 , C07D417/06
摘要： The present invention relates to drug delivery systems comprising ocular implant, which include organic molecules, capable of modulating tyrosine kinase signal transduction in order to regulate, modulate and/or inhibit abnormal cell proliferation, in combination with a polymer, which polymer serves to control, modify, modulate and/or slow the release of the therapeutic component into the environment of the eye in which said composite is placed.
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公开(公告)号：US20090196906A1
公开(公告)日：2009-08-06
申请号：US12319356
申请日：2009-01-05
申请人： Lon T. Spada , Jane Guo Shiah , Patrick Hughes , Thomas C. Malone , Gerald W. DeVries , Jeffrey L. Edelman , Julie A. Wurster
发明人： Lon T. Spada , Jane Guo Shiah , Patrick Hughes , Thomas C. Malone , Gerald W. DeVries , Jeffrey L. Edelman , Julie A. Wurster
IPC分类号： A61F2/14 , A61K31/44 , A61K31/444 , A61K31/4439 , A61K31/4436 , A61K31/5377 , A61K31/496 , A61K31/541 , A61K31/4545
CPC分类号： C07D213/82 , A61K9/0051 , A61K31/44 , A61K31/4436 , A61K31/4439 , A61K31/444 , A61K31/4545 , A61K31/496 , A61K31/5377 , A61K31/541 , A61K47/34 , C07D401/06 , C07D401/14 , C07D405/06 , C07D405/14 , C07D409/06 , C07D413/06 , C07D417/06 , Y02A50/401
摘要： The present invention relates to drug delivery systems comprising ocular implant, which include organic molecules, capable of modulating tyrosine kinase signal transduction in order to regulate, modulate and/or inhibit abnormal cell proliferation, in combination with a polymer, which polymer serves to control, modify, modulate and/or slow the release of the therapeutic component into the environment of the eye in which said composite is placed.
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公开(公告)号：US08455656B2
公开(公告)日：2013-06-04
申请号：US12380493
申请日：2009-02-26
申请人： Lon T. Spada , Jane Guo Shiah , Patrick Hughes , Thomas C. Malone , Gerald W. Devries , Jeffrey L. Edelman , Julie A. Wurster , Xialing Guo , Sougato Boral
发明人： Lon T. Spada , Jane Guo Shiah , Patrick Hughes , Thomas C. Malone , Gerald W. Devries , Jeffrey L. Edelman , Julie A. Wurster , Xialing Guo , Sougato Boral
IPC分类号： A61K31/40 , A61F9/007 , C07D213/00
CPC分类号： C07D405/04 , A61K9/0051 , A61K9/5031 , A61K31/397 , A61K31/404 , A61K31/41 , A61K31/454 , A61K31/496 , A61K31/5377 , A61K31/541 , A61K45/06 , C07D213/82 , C07D401/06 , C07D401/14 , C07D405/06 , C07D405/14 , C07D409/06 , C07D413/06 , C07D413/14 , C07D417/06
摘要： The present invention relates to drug delivery systems comprising ocular implant, which include organic molecules, capable of modulating tyrosine kinase signal transduction in order to regulate, modulate and/or inhibit abnormal cell proliferation, in combination with a polymer, which polymer serves to control, modify, modulate and/or slow the release of the therapeutic component into the environment of the eye in which said composite is placed.
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公开(公告)号：US08383825B2
公开(公告)日：2013-02-26
申请号：US13178277
申请日：2011-07-07
申请人： Lon T. Spada , Jane Guo Shiah , Patrick Hughes , Thomas C. Malone , Gerald W. Devries , Jeffrey L. Edelman , Julie A. Wurster
发明人： Lon T. Spada , Jane Guo Shiah , Patrick Hughes , Thomas C. Malone , Gerald W. Devries , Jeffrey L. Edelman , Julie A. Wurster
IPC分类号： C07D211/72 , A61K31/44 , A61K31/50
CPC分类号： C07D213/82 , A61K9/0051 , A61K31/44 , A61K31/4436 , A61K31/4439 , A61K31/444 , A61K31/4545 , A61K31/496 , A61K31/5377 , A61K31/541 , A61K47/34 , C07D401/06 , C07D401/14 , C07D405/06 , C07D405/14 , C07D409/06 , C07D413/06 , C07D417/06 , Y02A50/401
摘要： The present invention relates to drug delivery systems comprising ocular implant, which include organic molecules, capable of modulating tyrosine kinase signal transduction in order to regulate, modulate and/or inhibit abnormal cell proliferation, in combination with a polymer, which polymer serves to control, modify, modulate and/or slow the release of the therapeutic component into the environment of the eye in which said composite is placed.
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公开(公告)号：US07749530B2
公开(公告)日：2010-07-06
申请号：US12317469
申请日：2008-12-23
申请人： Lon T. Spada , Jane Guo Shiah , Patrick Hughes , Thomas C. Malone , Gerald W. DeVries , Jeffrey L. Edelman , Julie A. Wurster , Wendy M. Blanda
发明人： Lon T. Spada , Jane Guo Shiah , Patrick Hughes , Thomas C. Malone , Gerald W. DeVries , Jeffrey L. Edelman , Julie A. Wurster , Wendy M. Blanda
IPC分类号： A61K31/404
CPC分类号： A61K9/204 , A61K9/0051 , A61K31/404 , C07D209/34 , C07D401/12 , C07D403/12 , C07D405/12 , C07D409/12 , C07D413/12 , C07D417/12 , C07D495/04 , C07D513/04 , C40B40/04 , Y10S514/954
摘要： The present invention relates to drug delivery systems comprising ocular implant, which include organic molecules, capable of modulating tyrosine kinase signal transduction in order to regulate, modulate and/or inhibit abnormal cell proliferation, in combination with a polymer, which polymer serves to control, modify, modulate and/or slow the release of the therapeutic component into the environment of the eye in which said composite is placed.
摘要翻译： 本发明涉及药物递送系统，其包括眼部植入物，其包括能够调节酪氨酸激酶信号转导以调节，调节和/或抑制异常细胞增殖的有机分子，所述聚合物用于控制聚合物， 改变，调节和/或缓慢释放治疗组分到其中放置所述复合物的眼睛的环境中。
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公开(公告)号：US20090208557A1
公开(公告)日：2009-08-20
申请号：US12317469
申请日：2008-12-23
申请人： Lon T. Spada , Jane Guo Shiah , Patrick Hughes , Thomas C. Malone , Gerald W. DeVries , Jeffrey L. Edelman , Julie A. Wurster , Wendy M. Blanda
发明人： Lon T. Spada , Jane Guo Shiah , Patrick Hughes , Thomas C. Malone , Gerald W. DeVries , Jeffrey L. Edelman , Julie A. Wurster , Wendy M. Blanda
IPC分类号： A61F2/00 , A61K31/403 , A61K31/4965 , A61K31/4427 , A61K31/53
CPC分类号： A61K9/204 , A61K9/0051 , A61K31/404 , C07D209/34 , C07D401/12 , C07D403/12 , C07D405/12 , C07D409/12 , C07D413/12 , C07D417/12 , C07D495/04 , C07D513/04 , C40B40/04 , Y10S514/954
摘要： The present invention relates to drug delivery systems comprising ocular implant, which include organic molecules, capable of modulating tyrosine kinase signal transduction in order to regulate, modulate and/or inhibit abnormal cell proliferation, in combination with a polymer, which polymer serves to control, modify, modulate and/or slow the release of the therapeutic component into the environment of the eye in which said composite is placed.
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公开(公告)号：US08512738B2
公开(公告)日：2013-08-20
申请号：US11119001
申请日：2005-04-29
申请人： Jeffrey L. Edelman , Patrick M. Hughes , Thomas C. Malone , Gerald W. De Vries , Joan-En Chang-Lin , Jane Guo Shiah , Thierry Nivaggioli , Lon T. Spada , Wendy M. Blanda
发明人： Jeffrey L. Edelman , Patrick M. Hughes , Thomas C. Malone , Gerald W. De Vries , Joan-En Chang-Lin , Jane Guo Shiah , Thierry Nivaggioli , Lon T. Spada , Wendy M. Blanda
IPC分类号： A61F2/14
CPC分类号： A61K9/0051 , A61F9/0017 , A61K9/204 , A61K31/404 , A61K31/454 , A61K31/5377 , A61K47/34
摘要： Biocompatible intraocular implants include a tyrosine kinase inhibitor and a biodegradable polymer that is effective to facilitate release of the tyrosine kinase inhibitor into the vitreous of an eye for an extended period of time. The therapeutic agents of the implants may be associated with a biodegradable polymer matrix, such as a matrix that is substantially free of a polyvinyl alcohol. The implants can be placed in an eye to treat or reduce the occurrence of one or more ocular conditions, such as posterior ocular conditions.
摘要翻译： 生物相容性眼内植入物包括酪氨酸激酶抑制剂和可生物降解的聚合物，其有效促进酪氨酸激酶抑制剂延长一段时间的眼睛玻璃体。 植入物的治疗剂可以与可生物降解的聚合物基质相关，例如基本上不含聚乙烯醇的基质。 植入物可以放置在眼睛中以治疗或减少一种或多种眼部病症如眼后病症的发生。
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