公开(公告)号：US20090286773A1

公开(公告)日：2009-11-19

申请号：US12380493

申请日：2009-02-26

申请人： Lon T. Spada ,  Jane Guo Shiah ,  Patrick Hughes ,  Thomas C. Malone ,  Gerald W. DeVries ,  Jeffrey L. Edelman ,  Julie A. Wurster ,  Xialing Guo ,  Sougato Boral

发明人： Lon T. Spada ,  Jane Guo Shiah ,  Patrick Hughes ,  Thomas C. Malone ,  Gerald W. DeVries ,  Jeffrey L. Edelman ,  Julie A. Wurster ,  Xialing Guo ,  Sougato Boral

IPC分类号： A61K31/404 ,  A61K31/454 ,  A61K31/5377 ,  A61K31/496 ,  A61K31/541 ,  A61P27/00

CPC分类号： C07D405/04 ,  A61K9/0051 ,  A61K9/5031 ,  A61K31/397 ,  A61K31/404 ,  A61K31/41 ,  A61K31/454 ,  A61K31/496 ,  A61K31/5377 ,  A61K31/541 ,  A61K45/06 ,  C07D213/82 ,  C07D401/06 ,  C07D401/14 ,  C07D405/06 ,  C07D405/14 ,  C07D409/06 ,  C07D413/06 ,  C07D413/14 ,  C07D417/06

摘要： The present invention relates to drug delivery systems comprising ocular implant, which include organic molecules, capable of modulating tyrosine kinase signal transduction in order to regulate, modulate and/or inhibit abnormal cell proliferation, in combination with a polymer, which polymer serves to control, modify, modulate and/or slow the release of the therapeutic component into the environment of the eye in which said composite is placed.

摘要翻译： 本发明涉及药物递送系统，其包括眼部植入物，其包括能够调节酪氨酸激酶信号转导以调节，调节和/或抑制异常细胞增殖的有机分子，所述聚合物用于控制聚合物， 改变，调节和/或缓慢释放治疗组分到其中放置所述复合物的眼睛的环境中。

公开(公告)号：US08455656B2

公开(公告)日：2013-06-04

申请号：US12380493

申请日：2009-02-26

申请人： Lon T. Spada ,  Jane Guo Shiah ,  Patrick Hughes ,  Thomas C. Malone ,  Gerald W. Devries ,  Jeffrey L. Edelman ,  Julie A. Wurster ,  Xialing Guo ,  Sougato Boral

发明人： Lon T. Spada ,  Jane Guo Shiah ,  Patrick Hughes ,  Thomas C. Malone ,  Gerald W. Devries ,  Jeffrey L. Edelman ,  Julie A. Wurster ,  Xialing Guo ,  Sougato Boral

IPC分类号： A61K31/40 ,  A61F9/007 ,  C07D213/00

CPC分类号： C07D405/04 ,  A61K9/0051 ,  A61K9/5031 ,  A61K31/397 ,  A61K31/404 ,  A61K31/41 ,  A61K31/454 ,  A61K31/496 ,  A61K31/5377 ,  A61K31/541 ,  A61K45/06 ,  C07D213/82 ,  C07D401/06 ,  C07D401/14 ,  C07D405/06 ,  C07D405/14 ,  C07D409/06 ,  C07D413/06 ,  C07D413/14 ,  C07D417/06

摘要： The present invention relates to drug delivery systems comprising ocular implant, which include organic molecules, capable of modulating tyrosine kinase signal transduction in order to regulate, modulate and/or inhibit abnormal cell proliferation, in combination with a polymer, which polymer serves to control, modify, modulate and/or slow the release of the therapeutic component into the environment of the eye in which said composite is placed.

公开(公告)号：US20120238558A9

公开(公告)日：2012-09-20

申请号：US12380493

申请日：2009-02-26

申请人： Lon T. Spada ,  Jane Guo Shiah ,  Patrick Hughes ,  Thomas C. Malone ,  Gerald W. DeVries ,  Jeffrey L. Edelman ,  Julie A. Wurster ,  Xialing Guo ,  Sougato Boral

发明人： Lon T. Spada ,  Jane Guo Shiah ,  Patrick Hughes ,  Thomas C. Malone ,  Gerald W. DeVries ,  Jeffrey L. Edelman ,  Julie A. Wurster ,  Xialing Guo ,  Sougato Boral

IPC分类号： A61K31/404 ,  A61P27/00 ,  A61K31/496 ,  A61K31/541 ,  A61K31/454 ,  A61K31/5377

CPC分类号： C07D405/04 ,  A61K9/0051 ,  A61K9/5031 ,  A61K31/397 ,  A61K31/404 ,  A61K31/41 ,  A61K31/454 ,  A61K31/496 ,  A61K31/5377 ,  A61K31/541 ,  A61K45/06 ,  C07D213/82 ,  C07D401/06 ,  C07D401/14 ,  C07D405/06 ,  C07D405/14 ,  C07D409/06 ,  C07D413/06 ,  C07D413/14 ,  C07D417/06

摘要： The present invention relates to drug delivery systems comprising ocular implant, which include organic molecules, capable of modulating tyrosine kinase signal transduction in order to regulate, modulate and/or inhibit abnormal cell proliferation, in combination with a polymer, which polymer serves to control, modify, modulate and/or slow the release of the therapeutic component into the environment of the eye in which said composite is placed.

公开(公告)号：US20110263611A1

公开(公告)日：2011-10-27

申请号：US13178277

申请日：2011-07-07

申请人： Lon T. Spada ,  Jane Guo Shiah ,  Patrick Hughes ,  Thomas C. Malone ,  Gerald W. Devries ,  Jeffrey L. Edelman ,  Julie A. Wurster

发明人： Lon T. Spada ,  Jane Guo Shiah ,  Patrick Hughes ,  Thomas C. Malone ,  Gerald W. Devries ,  Jeffrey L. Edelman ,  Julie A. Wurster

IPC分类号： A61K31/496 ,  A61P27/06 ,  A61K31/5377 ,  A61P27/02

CPC分类号： C07D213/82 ,  A61K9/0051 ,  A61K31/44 ,  A61K31/4436 ,  A61K31/4439 ,  A61K31/444 ,  A61K31/4545 ,  A61K31/496 ,  A61K31/5377 ,  A61K31/541 ,  A61K47/34 ,  C07D401/06 ,  C07D401/14 ,  C07D405/06 ,  C07D405/14 ,  C07D409/06 ,  C07D413/06 ,  C07D417/06 ,  Y02A50/401

摘要： The present invention relates to drug delivery systems comprising ocular implant, which include organic molecules, capable of modulating tyrosine kinase signal transduction in order to regulate, modulate and/or inhibit abnormal cell proliferation, in combination with a polymer, which polymer serves to control, modify, modulate and/or slow the release of the therapeutic component into the environment of the eye in which said composite is placed.

摘要翻译： 本发明涉及药物递送系统，其包括眼部植入物，其包括能够调节酪氨酸激酶信号转导以调节，调节和/或抑制异常细胞增殖的有机分子，所述聚合物用于控制聚合物， 改变，调节和/或缓慢释放治疗组分到其中放置所述复合物的眼睛的环境中。

公开(公告)号：US08143410B2

公开(公告)日：2012-03-27

申请号：US12319356

申请日：2009-01-05

申请人： Lon T. Spada ,  Jane Guo Shiah ,  Patrick Hughes ,  Thomas C. Malone ,  Gerald W. Devries ,  Jeffrey L. Edelman ,  Julie A. Wurster

发明人： Lon T. Spada ,  Jane Guo Shiah ,  Patrick Hughes ,  Thomas C. Malone ,  Gerald W. Devries ,  Jeffrey L. Edelman ,  Julie A. Wurster

IPC分类号： C07D211/72 ,  C07D241/00 ,  A61K31/50 ,  A61K31/44

CPC分类号： C07D213/82 ,  A61K9/0051 ,  A61K31/44 ,  A61K31/4436 ,  A61K31/4439 ,  A61K31/444 ,  A61K31/4545 ,  A61K31/496 ,  A61K31/5377 ,  A61K31/541 ,  A61K47/34 ,  C07D401/06 ,  C07D401/14 ,  C07D405/06 ,  C07D405/14 ,  C07D409/06 ,  C07D413/06 ,  C07D417/06 ,  Y02A50/401

摘要： The present invention relates to drug delivery systems comprising ocular implant, which include organic molecules, capable of modulating tyrosine kinase signal transduction in order to regulate, modulate and/or inhibit abnormal cell proliferation, in combination with a polymer, which polymer serves to control, modify, modulate and/or slow the release of the therapeutic component into the environment of the eye in which said composite is placed.

摘要翻译： 本发明涉及药物递送系统，其包括眼部植入物，其包括能够调节酪氨酸激酶信号转导以调节，调节和/或抑制异常细胞增殖的有机分子，所述聚合物用于控制聚合物， 改变，调节和/或缓慢释放治疗组分到其中放置所述复合物的眼睛的环境中。

公开(公告)号：US20090196906A1

公开(公告)日：2009-08-06

申请号：US12319356

申请日：2009-01-05

申请人： Lon T. Spada ,  Jane Guo Shiah ,  Patrick Hughes ,  Thomas C. Malone ,  Gerald W. DeVries ,  Jeffrey L. Edelman ,  Julie A. Wurster

发明人： Lon T. Spada ,  Jane Guo Shiah ,  Patrick Hughes ,  Thomas C. Malone ,  Gerald W. DeVries ,  Jeffrey L. Edelman ,  Julie A. Wurster

IPC分类号： A61F2/14 ,  A61K31/44 ,  A61K31/444 ,  A61K31/4439 ,  A61K31/4436 ,  A61K31/5377 ,  A61K31/496 ,  A61K31/541 ,  A61K31/4545

CPC分类号： C07D213/82 ,  A61K9/0051 ,  A61K31/44 ,  A61K31/4436 ,  A61K31/4439 ,  A61K31/444 ,  A61K31/4545 ,  A61K31/496 ,  A61K31/5377 ,  A61K31/541 ,  A61K47/34 ,  C07D401/06 ,  C07D401/14 ,  C07D405/06 ,  C07D405/14 ,  C07D409/06 ,  C07D413/06 ,  C07D417/06 ,  Y02A50/401

摘要： The present invention relates to drug delivery systems comprising ocular implant, which include organic molecules, capable of modulating tyrosine kinase signal transduction in order to regulate, modulate and/or inhibit abnormal cell proliferation, in combination with a polymer, which polymer serves to control, modify, modulate and/or slow the release of the therapeutic component into the environment of the eye in which said composite is placed.

公开(公告)号：US08383825B2

公开(公告)日：2013-02-26

申请号：US13178277

申请日：2011-07-07

申请人： Lon T. Spada ,  Jane Guo Shiah ,  Patrick Hughes ,  Thomas C. Malone ,  Gerald W. Devries ,  Jeffrey L. Edelman ,  Julie A. Wurster

发明人： Lon T. Spada ,  Jane Guo Shiah ,  Patrick Hughes ,  Thomas C. Malone ,  Gerald W. Devries ,  Jeffrey L. Edelman ,  Julie A. Wurster

IPC分类号： C07D211/72 ,  A61K31/44 ,  A61K31/50

CPC分类号： C07D213/82 ,  A61K9/0051 ,  A61K31/44 ,  A61K31/4436 ,  A61K31/4439 ,  A61K31/444 ,  A61K31/4545 ,  A61K31/496 ,  A61K31/5377 ,  A61K31/541 ,  A61K47/34 ,  C07D401/06 ,  C07D401/14 ,  C07D405/06 ,  C07D405/14 ,  C07D409/06 ,  C07D413/06 ,  C07D417/06 ,  Y02A50/401

摘要： The present invention relates to drug delivery systems comprising ocular implant, which include organic molecules, capable of modulating tyrosine kinase signal transduction in order to regulate, modulate and/or inhibit abnormal cell proliferation, in combination with a polymer, which polymer serves to control, modify, modulate and/or slow the release of the therapeutic component into the environment of the eye in which said composite is placed.

公开(公告)号：US07749530B2

公开(公告)日：2010-07-06

申请号：US12317469

申请日：2008-12-23

申请人： Lon T. Spada ,  Jane Guo Shiah ,  Patrick Hughes ,  Thomas C. Malone ,  Gerald W. DeVries ,  Jeffrey L. Edelman ,  Julie A. Wurster ,  Wendy M. Blanda

发明人： Lon T. Spada ,  Jane Guo Shiah ,  Patrick Hughes ,  Thomas C. Malone ,  Gerald W. DeVries ,  Jeffrey L. Edelman ,  Julie A. Wurster ,  Wendy M. Blanda

IPC分类号： A61K31/404

CPC分类号： A61K9/204 ,  A61K9/0051 ,  A61K31/404 ,  C07D209/34 ,  C07D401/12 ,  C07D403/12 ,  C07D405/12 ,  C07D409/12 ,  C07D413/12 ,  C07D417/12 ,  C07D495/04 ,  C07D513/04 ,  C40B40/04 ,  Y10S514/954

摘要： The present invention relates to drug delivery systems comprising ocular implant, which include organic molecules, capable of modulating tyrosine kinase signal transduction in order to regulate, modulate and/or inhibit abnormal cell proliferation, in combination with a polymer, which polymer serves to control, modify, modulate and/or slow the release of the therapeutic component into the environment of the eye in which said composite is placed.

摘要翻译： 本发明涉及药物递送系统，其包括眼部植入物，其包括能够调节酪氨酸激酶信号转导以调节，调节和/或抑制异常细胞增殖的有机分子，所述聚合物用于控制聚合物， 改变，调节和/或缓慢释放治疗组分到其中放置所述复合物的眼睛的环境中。

公开(公告)号：US20090208557A1

公开(公告)日：2009-08-20

申请号：US12317469

申请日：2008-12-23

申请人： Lon T. Spada ,  Jane Guo Shiah ,  Patrick Hughes ,  Thomas C. Malone ,  Gerald W. DeVries ,  Jeffrey L. Edelman ,  Julie A. Wurster ,  Wendy M. Blanda

发明人： Lon T. Spada ,  Jane Guo Shiah ,  Patrick Hughes ,  Thomas C. Malone ,  Gerald W. DeVries ,  Jeffrey L. Edelman ,  Julie A. Wurster ,  Wendy M. Blanda

IPC分类号： A61F2/00 ,  A61K31/403 ,  A61K31/4965 ,  A61K31/4427 ,  A61K31/53

CPC分类号： A61K9/204 ,  A61K9/0051 ,  A61K31/404 ,  C07D209/34 ,  C07D401/12 ,  C07D403/12 ,  C07D405/12 ,  C07D409/12 ,  C07D413/12 ,  C07D417/12 ,  C07D495/04 ,  C07D513/04 ,  C40B40/04 ,  Y10S514/954

摘要： The present invention relates to drug delivery systems comprising ocular implant, which include organic molecules, capable of modulating tyrosine kinase signal transduction in order to regulate, modulate and/or inhibit abnormal cell proliferation, in combination with a polymer, which polymer serves to control, modify, modulate and/or slow the release of the therapeutic component into the environment of the eye in which said composite is placed.

公开(公告)号：US20050244470A1

公开(公告)日：2005-11-03

申请号：US10837361

申请日：2004-04-30

申请人： Patrick Hughes ,  Thomas Malone ,  Gerald De Vries ,  Jeffrey Edelman ,  Joan-En Chang-Lin ,  Jane Shiah ,  Thierry Nivaggioli

发明人： Patrick Hughes ,  Thomas Malone ,  Gerald De Vries ,  Jeffrey Edelman ,  Joan-En Chang-Lin ,  Jane Shiah ,  Thierry Nivaggioli

IPC分类号： A61K9/00 ,  A61K9/20 ,  A61K31/00 ,  A61K31/404 ,  A61F2/00

CPC分类号： A61K9/0051 ,  A61K9/1647 ,  Y10T428/2985

摘要： Biocompatible intraocular implants include a tyrosine kinase inhibitor and a biodegradable polymer that is effective to facilitate release of the tyrosine kinase inhibitor into an eye for an extended period of time. The therapeutic agents of the implants may be associated with a biodegradable polymer matrix, such as a matrix that is substantially free of a polyvinyl alcohol. The implants may be placed in an eye to treat or reduce the occurrence of one or more ocular conditions.

摘要翻译： 生物相容性眼内植入物包括酪氨酸激酶抑制剂和生物可降解聚合物，其有效促进酪氨酸激酶抑制剂长时间释放到眼睛中。 植入物的治疗剂可以与可生物降解的聚合物基质相关，例如基本上不含聚乙烯醇的基质。 植入物可以放置在眼睛中以治疗或减少一种或多种眼部病症的发生。