公开(公告)号：US20090286773A1

公开(公告)日：2009-11-19

申请号：US12380493

申请日：2009-02-26

申请人： Lon T. Spada ,  Jane Guo Shiah ,  Patrick Hughes ,  Thomas C. Malone ,  Gerald W. DeVries ,  Jeffrey L. Edelman ,  Julie A. Wurster ,  Xialing Guo ,  Sougato Boral

发明人： Lon T. Spada ,  Jane Guo Shiah ,  Patrick Hughes ,  Thomas C. Malone ,  Gerald W. DeVries ,  Jeffrey L. Edelman ,  Julie A. Wurster ,  Xialing Guo ,  Sougato Boral

IPC分类号： A61K31/404 ,  A61K31/454 ,  A61K31/5377 ,  A61K31/496 ,  A61K31/541 ,  A61P27/00

CPC分类号： C07D405/04 ,  A61K9/0051 ,  A61K9/5031 ,  A61K31/397 ,  A61K31/404 ,  A61K31/41 ,  A61K31/454 ,  A61K31/496 ,  A61K31/5377 ,  A61K31/541 ,  A61K45/06 ,  C07D213/82 ,  C07D401/06 ,  C07D401/14 ,  C07D405/06 ,  C07D405/14 ,  C07D409/06 ,  C07D413/06 ,  C07D413/14 ,  C07D417/06

摘要： The present invention relates to drug delivery systems comprising ocular implant, which include organic molecules, capable of modulating tyrosine kinase signal transduction in order to regulate, modulate and/or inhibit abnormal cell proliferation, in combination with a polymer, which polymer serves to control, modify, modulate and/or slow the release of the therapeutic component into the environment of the eye in which said composite is placed.

摘要翻译： 本发明涉及药物递送系统，其包括眼部植入物，其包括能够调节酪氨酸激酶信号转导以调节，调节和/或抑制异常细胞增殖的有机分子，所述聚合物用于控制聚合物， 改变，调节和/或缓慢释放治疗组分到其中放置所述复合物的眼睛的环境中。

公开(公告)号：US08455656B2

公开(公告)日：2013-06-04

申请号：US12380493

申请日：2009-02-26

申请人： Lon T. Spada ,  Jane Guo Shiah ,  Patrick Hughes ,  Thomas C. Malone ,  Gerald W. Devries ,  Jeffrey L. Edelman ,  Julie A. Wurster ,  Xialing Guo ,  Sougato Boral

发明人： Lon T. Spada ,  Jane Guo Shiah ,  Patrick Hughes ,  Thomas C. Malone ,  Gerald W. Devries ,  Jeffrey L. Edelman ,  Julie A. Wurster ,  Xialing Guo ,  Sougato Boral

IPC分类号： A61K31/40 ,  A61F9/007 ,  C07D213/00

CPC分类号： C07D405/04 ,  A61K9/0051 ,  A61K9/5031 ,  A61K31/397 ,  A61K31/404 ,  A61K31/41 ,  A61K31/454 ,  A61K31/496 ,  A61K31/5377 ,  A61K31/541 ,  A61K45/06 ,  C07D213/82 ,  C07D401/06 ,  C07D401/14 ,  C07D405/06 ,  C07D405/14 ,  C07D409/06 ,  C07D413/06 ,  C07D413/14 ,  C07D417/06

摘要： The present invention relates to drug delivery systems comprising ocular implant, which include organic molecules, capable of modulating tyrosine kinase signal transduction in order to regulate, modulate and/or inhibit abnormal cell proliferation, in combination with a polymer, which polymer serves to control, modify, modulate and/or slow the release of the therapeutic component into the environment of the eye in which said composite is placed.

公开(公告)号：US20120238558A9

公开(公告)日：2012-09-20

申请号：US12380493

申请日：2009-02-26

申请人： Lon T. Spada ,  Jane Guo Shiah ,  Patrick Hughes ,  Thomas C. Malone ,  Gerald W. DeVries ,  Jeffrey L. Edelman ,  Julie A. Wurster ,  Xialing Guo ,  Sougato Boral

发明人： Lon T. Spada ,  Jane Guo Shiah ,  Patrick Hughes ,  Thomas C. Malone ,  Gerald W. DeVries ,  Jeffrey L. Edelman ,  Julie A. Wurster ,  Xialing Guo ,  Sougato Boral

IPC分类号： A61K31/404 ,  A61P27/00 ,  A61K31/496 ,  A61K31/541 ,  A61K31/454 ,  A61K31/5377

CPC分类号： C07D405/04 ,  A61K9/0051 ,  A61K9/5031 ,  A61K31/397 ,  A61K31/404 ,  A61K31/41 ,  A61K31/454 ,  A61K31/496 ,  A61K31/5377 ,  A61K31/541 ,  A61K45/06 ,  C07D213/82 ,  C07D401/06 ,  C07D401/14 ,  C07D405/06 ,  C07D405/14 ,  C07D409/06 ,  C07D413/06 ,  C07D413/14 ,  C07D417/06

摘要： The present invention relates to drug delivery systems comprising ocular implant, which include organic molecules, capable of modulating tyrosine kinase signal transduction in order to regulate, modulate and/or inhibit abnormal cell proliferation, in combination with a polymer, which polymer serves to control, modify, modulate and/or slow the release of the therapeutic component into the environment of the eye in which said composite is placed.

公开(公告)号：US20110263611A1

公开(公告)日：2011-10-27

申请号：US13178277

申请日：2011-07-07

申请人： Lon T. Spada ,  Jane Guo Shiah ,  Patrick Hughes ,  Thomas C. Malone ,  Gerald W. Devries ,  Jeffrey L. Edelman ,  Julie A. Wurster

发明人： Lon T. Spada ,  Jane Guo Shiah ,  Patrick Hughes ,  Thomas C. Malone ,  Gerald W. Devries ,  Jeffrey L. Edelman ,  Julie A. Wurster

IPC分类号： A61K31/496 ,  A61P27/06 ,  A61K31/5377 ,  A61P27/02

CPC分类号： C07D213/82 ,  A61K9/0051 ,  A61K31/44 ,  A61K31/4436 ,  A61K31/4439 ,  A61K31/444 ,  A61K31/4545 ,  A61K31/496 ,  A61K31/5377 ,  A61K31/541 ,  A61K47/34 ,  C07D401/06 ,  C07D401/14 ,  C07D405/06 ,  C07D405/14 ,  C07D409/06 ,  C07D413/06 ,  C07D417/06 ,  Y02A50/401

摘要： The present invention relates to drug delivery systems comprising ocular implant, which include organic molecules, capable of modulating tyrosine kinase signal transduction in order to regulate, modulate and/or inhibit abnormal cell proliferation, in combination with a polymer, which polymer serves to control, modify, modulate and/or slow the release of the therapeutic component into the environment of the eye in which said composite is placed.

摘要翻译： 本发明涉及药物递送系统，其包括眼部植入物，其包括能够调节酪氨酸激酶信号转导以调节，调节和/或抑制异常细胞增殖的有机分子，所述聚合物用于控制聚合物， 改变，调节和/或缓慢释放治疗组分到其中放置所述复合物的眼睛的环境中。

公开(公告)号：US08143410B2

公开(公告)日：2012-03-27

申请号：US12319356

申请日：2009-01-05

申请人： Lon T. Spada ,  Jane Guo Shiah ,  Patrick Hughes ,  Thomas C. Malone ,  Gerald W. Devries ,  Jeffrey L. Edelman ,  Julie A. Wurster

发明人： Lon T. Spada ,  Jane Guo Shiah ,  Patrick Hughes ,  Thomas C. Malone ,  Gerald W. Devries ,  Jeffrey L. Edelman ,  Julie A. Wurster

IPC分类号： C07D211/72 ,  C07D241/00 ,  A61K31/50 ,  A61K31/44

CPC分类号： C07D213/82 ,  A61K9/0051 ,  A61K31/44 ,  A61K31/4436 ,  A61K31/4439 ,  A61K31/444 ,  A61K31/4545 ,  A61K31/496 ,  A61K31/5377 ,  A61K31/541 ,  A61K47/34 ,  C07D401/06 ,  C07D401/14 ,  C07D405/06 ,  C07D405/14 ,  C07D409/06 ,  C07D413/06 ,  C07D417/06 ,  Y02A50/401

摘要： The present invention relates to drug delivery systems comprising ocular implant, which include organic molecules, capable of modulating tyrosine kinase signal transduction in order to regulate, modulate and/or inhibit abnormal cell proliferation, in combination with a polymer, which polymer serves to control, modify, modulate and/or slow the release of the therapeutic component into the environment of the eye in which said composite is placed.

摘要翻译： 本发明涉及药物递送系统，其包括眼部植入物，其包括能够调节酪氨酸激酶信号转导以调节，调节和/或抑制异常细胞增殖的有机分子，所述聚合物用于控制聚合物， 改变，调节和/或缓慢释放治疗组分到其中放置所述复合物的眼睛的环境中。

公开(公告)号：US08383825B2

公开(公告)日：2013-02-26

申请号：US13178277

申请日：2011-07-07

申请人： Lon T. Spada ,  Jane Guo Shiah ,  Patrick Hughes ,  Thomas C. Malone ,  Gerald W. Devries ,  Jeffrey L. Edelman ,  Julie A. Wurster

发明人： Lon T. Spada ,  Jane Guo Shiah ,  Patrick Hughes ,  Thomas C. Malone ,  Gerald W. Devries ,  Jeffrey L. Edelman ,  Julie A. Wurster

IPC分类号： C07D211/72 ,  A61K31/44 ,  A61K31/50

CPC分类号： C07D213/82 ,  A61K9/0051 ,  A61K31/44 ,  A61K31/4436 ,  A61K31/4439 ,  A61K31/444 ,  A61K31/4545 ,  A61K31/496 ,  A61K31/5377 ,  A61K31/541 ,  A61K47/34 ,  C07D401/06 ,  C07D401/14 ,  C07D405/06 ,  C07D405/14 ,  C07D409/06 ,  C07D413/06 ,  C07D417/06 ,  Y02A50/401

摘要： The present invention relates to drug delivery systems comprising ocular implant, which include organic molecules, capable of modulating tyrosine kinase signal transduction in order to regulate, modulate and/or inhibit abnormal cell proliferation, in combination with a polymer, which polymer serves to control, modify, modulate and/or slow the release of the therapeutic component into the environment of the eye in which said composite is placed.

公开(公告)号：US07749530B2

公开(公告)日：2010-07-06

申请号：US12317469

申请日：2008-12-23

申请人： Lon T. Spada ,  Jane Guo Shiah ,  Patrick Hughes ,  Thomas C. Malone ,  Gerald W. DeVries ,  Jeffrey L. Edelman ,  Julie A. Wurster ,  Wendy M. Blanda

发明人： Lon T. Spada ,  Jane Guo Shiah ,  Patrick Hughes ,  Thomas C. Malone ,  Gerald W. DeVries ,  Jeffrey L. Edelman ,  Julie A. Wurster ,  Wendy M. Blanda

IPC分类号： A61K31/404

CPC分类号： A61K9/204 ,  A61K9/0051 ,  A61K31/404 ,  C07D209/34 ,  C07D401/12 ,  C07D403/12 ,  C07D405/12 ,  C07D409/12 ,  C07D413/12 ,  C07D417/12 ,  C07D495/04 ,  C07D513/04 ,  C40B40/04 ,  Y10S514/954

摘要： The present invention relates to drug delivery systems comprising ocular implant, which include organic molecules, capable of modulating tyrosine kinase signal transduction in order to regulate, modulate and/or inhibit abnormal cell proliferation, in combination with a polymer, which polymer serves to control, modify, modulate and/or slow the release of the therapeutic component into the environment of the eye in which said composite is placed.

摘要翻译： 本发明涉及药物递送系统，其包括眼部植入物，其包括能够调节酪氨酸激酶信号转导以调节，调节和/或抑制异常细胞增殖的有机分子，所述聚合物用于控制聚合物， 改变，调节和/或缓慢释放治疗组分到其中放置所述复合物的眼睛的环境中。

公开(公告)号：US20090208557A1

公开(公告)日：2009-08-20

申请号：US12317469

申请日：2008-12-23

申请人： Lon T. Spada ,  Jane Guo Shiah ,  Patrick Hughes ,  Thomas C. Malone ,  Gerald W. DeVries ,  Jeffrey L. Edelman ,  Julie A. Wurster ,  Wendy M. Blanda

发明人： Lon T. Spada ,  Jane Guo Shiah ,  Patrick Hughes ,  Thomas C. Malone ,  Gerald W. DeVries ,  Jeffrey L. Edelman ,  Julie A. Wurster ,  Wendy M. Blanda

IPC分类号： A61F2/00 ,  A61K31/403 ,  A61K31/4965 ,  A61K31/4427 ,  A61K31/53

CPC分类号： A61K9/204 ,  A61K9/0051 ,  A61K31/404 ,  C07D209/34 ,  C07D401/12 ,  C07D403/12 ,  C07D405/12 ,  C07D409/12 ,  C07D413/12 ,  C07D417/12 ,  C07D495/04 ,  C07D513/04 ,  C40B40/04 ,  Y10S514/954

摘要： The present invention relates to drug delivery systems comprising ocular implant, which include organic molecules, capable of modulating tyrosine kinase signal transduction in order to regulate, modulate and/or inhibit abnormal cell proliferation, in combination with a polymer, which polymer serves to control, modify, modulate and/or slow the release of the therapeutic component into the environment of the eye in which said composite is placed.

公开(公告)号：US20090196906A1

公开(公告)日：2009-08-06

申请号：US12319356

申请日：2009-01-05

申请人： Lon T. Spada ,  Jane Guo Shiah ,  Patrick Hughes ,  Thomas C. Malone ,  Gerald W. DeVries ,  Jeffrey L. Edelman ,  Julie A. Wurster

发明人： Lon T. Spada ,  Jane Guo Shiah ,  Patrick Hughes ,  Thomas C. Malone ,  Gerald W. DeVries ,  Jeffrey L. Edelman ,  Julie A. Wurster

IPC分类号： A61F2/14 ,  A61K31/44 ,  A61K31/444 ,  A61K31/4439 ,  A61K31/4436 ,  A61K31/5377 ,  A61K31/496 ,  A61K31/541 ,  A61K31/4545

CPC分类号： C07D213/82 ,  A61K9/0051 ,  A61K31/44 ,  A61K31/4436 ,  A61K31/4439 ,  A61K31/444 ,  A61K31/4545 ,  A61K31/496 ,  A61K31/5377 ,  A61K31/541 ,  A61K47/34 ,  C07D401/06 ,  C07D401/14 ,  C07D405/06 ,  C07D405/14 ,  C07D409/06 ,  C07D413/06 ,  C07D417/06 ,  Y02A50/401

摘要： The present invention relates to drug delivery systems comprising ocular implant, which include organic molecules, capable of modulating tyrosine kinase signal transduction in order to regulate, modulate and/or inhibit abnormal cell proliferation, in combination with a polymer, which polymer serves to control, modify, modulate and/or slow the release of the therapeutic component into the environment of the eye in which said composite is placed.

公开(公告)号：US07977351B2

公开(公告)日：2011-07-12

申请号：US11687408

申请日：2007-03-16

申请人： Sougato Boral ,  Xialing Guo ,  Shimiao Wang ,  Julie A. Wurster ,  Thomas C. Malone

发明人： Sougato Boral ,  Xialing Guo ,  Shimiao Wang ,  Julie A. Wurster ,  Thomas C. Malone

IPC分类号： A61K31/40 ,  C07D471/04

CPC分类号： C07D471/04 ,  C07D491/04 ,  C07D495/04

摘要： The present invention provides a compound represented by the formula: wherein the variables R1, b, R6, Y, Z, X, R and a are defined in the specification. Said compound may be used in a method for treating diseases related to unregulated tyrosine kinase signal transduction, wherein said disease is selected from the group consisting of cancer, blood vessel proliferative disorders, fibrotic disorders, mesangial cell proliferative disorders, and metabolic diseases.

摘要翻译： 本发明提供由下式表示的化合物：其中变量R1，b，R6，Y，Z，X，R和a在说明书中定义。 所述化合物可用于治疗与未调节的酪氨酸激酶信号转导相关的疾病的方法，其中所述疾病选自癌症，血管增生性疾病，纤维化病症，肾小球膜细胞增殖性疾病和代谢疾病。