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公开(公告)号：US09078958B2
公开(公告)日：2015-07-14
申请号：US13224515
申请日：2011-09-02
IPC分类号： A61F2/00 , A61K9/00 , A61K38/43 , A61K38/44 , C12N11/10 , C12N11/08 , C12N11/04 , A61K38/00 , A61L31/10 , A61K38/08 , A61K38/39 , A61L27/22 , A61L27/34 , A61L27/54 , A61L29/08 , A61L31/04 , A61L31/16 , C07K14/00 , C08H1/00 , B05D3/00
CPC分类号： A61L31/10 , A61K38/08 , A61K38/39 , A61L27/227 , A61L27/34 , A61L27/54 , A61L29/085 , A61L31/047 , A61L31/16 , A61L2300/25 , A61L2420/02 , B05D3/007 , C07K14/001 , C08H1/00 , Y10T428/3154 , Y10T428/31909
摘要： A copolymer comprising a block of an elastin pentapeptide and method of making and using the copolymer are provided. The copolymer may be used as a coating on a stent. Methods of using a stent coated with the copolymer are also provided.
摘要翻译： 提供了包含弹性蛋白五肽嵌段的共聚物以及制备和使用该共聚物的方法。 共聚物可以用作支架上的涂层。 还提供了使用涂覆有共聚物的支架的方法。
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公开(公告)号：US08545868B2
公开(公告)日：2013-10-01
申请号：US13453965
申请日：2012-04-23
申请人： Lothar W. Kleiner , Yiwen Tang
发明人： Lothar W. Kleiner , Yiwen Tang
CPC分类号： A61M25/0045 , A61L31/10 , A61L31/16 , A61L2300/608 , A61L2420/08 , C08L67/04
摘要： The present invention relates to implantable medical devices coated with polymer having hemocompatible and/or prohealing moieties appended thereto and to their use in the treatment of vascular diseases.
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公开(公告)号：US20120263759A1
公开(公告)日：2012-10-18
申请号：US13224515
申请日：2011-09-02
IPC分类号： C07K2/00 , C07K7/06 , C07K9/00 , A61K31/336 , A61K31/565 , A61K38/44 , A61K31/4468 , A61K31/436 , A61K31/573 , A61K38/58 , A61K31/506 , A61K31/553 , A61K38/18 , A61P35/00 , A61P29/00 , A61P9/10 , A61P7/02 , A61P9/00 , A61P7/04 , A61P1/00 , A61P13/00 , C08G73/06 , C08G69/48 , C08G63/91 , A61K9/00
CPC分类号： A61L31/10 , A61K38/08 , A61K38/39 , A61L27/227 , A61L27/34 , A61L27/54 , A61L29/085 , A61L31/047 , A61L31/16 , A61L2300/25 , A61L2420/02 , B05D3/007 , C07K14/001 , C08H1/00 , Y10T428/3154 , Y10T428/31909
摘要： A copolymer comprising a block of an elastin pentapeptide and method of making and using the copolymer are provided. The copolymer may be used as a coating on a stent. Methods of using a stent coated with the copolymer are also provided.
摘要翻译： 提供了包含弹性蛋白五肽嵌段的共聚物以及制备和使用该共聚物的方法。 共聚物可以用作支架上的涂层。 还提供了使用涂覆有共聚物的支架的方法。
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公开(公告)号：US20120209372A1
公开(公告)日：2012-08-16
申请号：US13453970
申请日：2012-04-23
申请人： Lothar W. Kleiner , Yiwen Tang
发明人： Lothar W. Kleiner , Yiwen Tang
IPC分类号： A61L27/54
CPC分类号： A61M25/0045 , A61L31/10 , A61L31/16 , A61L2300/608 , A61L2420/08 , C08L67/04
摘要： The present invention relates to implantable medical devices coated with polymer having hemocompatible and/or prohealing moieties appended thereto and to their use in the treatment of vascular diseases.
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公开(公告)号：US20120046640A1
公开(公告)日：2012-02-23
申请号：US13225165
申请日：2011-09-02
CPC分类号： A61L31/10 , A61K38/08 , A61K38/39 , A61L27/227 , A61L27/34 , A61L27/54 , A61L29/085 , A61L31/047 , A61L31/16 , A61L2300/25 , A61L2420/02 , B05D3/007 , C07K14/001 , C08H1/00 , Y10T428/3154 , Y10T428/31909
摘要： The present invention is directed to medical devices including coatings. The coatings include a topcoat which includes a copolymer comprising a block of an elastin pentapeptide. The topcoat is over a layer of poly(vinyl alcohol) on a hydrophobic coating or over a porous coating comprising pores or depots that include a bioactive agent.
摘要翻译： 本发明涉及包括涂层在内的医疗装置。 涂层包括面漆，其包括包含弹性蛋白五肽嵌段的共聚物。 面漆在疏水涂层上方的多层（聚乙烯醇）层上或包含孔或包含生物活性剂的贮槽的多孔涂层上方。
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6.发明授权Medical device coated with a coating containing elastin pentapeptide VGVPG 有权涂有含有弹性蛋白五肽VGVPG的涂层的医疗器械公开(公告)号：US08029816B2
公开(公告)日：2011-10-04
申请号：US11803031
申请日：2007-05-10
CPC分类号： A61L31/10 , A61K38/08 , A61K38/39 , A61L27/227 , A61L27/34 , A61L27/54 , A61L29/085 , A61L31/047 , A61L31/16 , A61L2300/25 , A61L2420/02 , B05D3/007 , C07K14/001 , C08H1/00 , Y10T428/3154 , Y10T428/31909
摘要： The present invention is directed to medical devices including coatings. The coatings include a topcoat which includes a copolymer comprising a block of an elastin pentapeptide. The topcoat is over a layer of poly(vinyl alcohol) on a hydrophobic coating or over a porous coating comprising pores or depots that include a bioactive agent.
摘要翻译： 本发明涉及包括涂层在内的医疗装置。 涂层包括面漆，其包括包含弹性蛋白五肽嵌段的共聚物。 面漆在疏水涂层上方的多层（聚乙烯醇）层上或包含孔或包含生物活性剂的贮槽的多孔涂层上方。
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公开(公告)号：US09056155B1
公开(公告)日：2015-06-16
申请号：US11807833
申请日：2007-05-29
CPC分类号： A61L31/10 , A61L27/34 , A61L27/54 , A61L2300/00 , A61L2300/416 , C08G63/6856 , C08L67/02 , C09D167/02 , C08L67/04
摘要： Provided herein is a coating an elastic primer layer and the method of making and using the same.
摘要翻译： 本文提供了一种弹性底漆层的涂层及其制造和使用方法。
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公开(公告)号：US08961589B2
公开(公告)日：2015-02-24
申请号：US11888807
申请日：2007-08-01
申请人： Lothar W. Kleiner , John Stankus , Nam D. Pham , Michael H. Ngo , Bozena Zofia Maslanka , Syed Faiyaz Ahmed Hossainy , Mikael Trollsas , Yiwen Tang
发明人： Lothar W. Kleiner , John Stankus , Nam D. Pham , Michael H. Ngo , Bozena Zofia Maslanka , Syed Faiyaz Ahmed Hossainy , Mikael Trollsas , Yiwen Tang
CPC分类号： A61L31/16 , A61K31/436 , A61K47/34 , A61L31/10 , A61L31/148 , A61L2300/416 , C08L67/04
摘要： The present invention relates to implantable medical devices coated with polymer having tunable hydrophobicity and their use in the treatment of vascular diseases.
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公开(公告)号：US08357390B2
公开(公告)日：2013-01-22
申请号：US13453970
申请日：2012-04-23
申请人： Lothar W. Kleiner , Yiwen Tang
发明人： Lothar W. Kleiner , Yiwen Tang
CPC分类号： A61M25/0045 , A61L31/10 , A61L31/16 , A61L2300/608 , A61L2420/08 , C08L67/04
摘要： The present invention relates to implantable medical devices coated with polymer having hemocompatible and/or prohealing moieties appended thereto and to their use in the treatment of vascular diseases.
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10.发明申请公开(公告)号：US20090240325A1
公开(公告)日：2009-09-24
申请号：US12052452
申请日：2008-03-20
申请人： Shaw Ling Hsu , Yiwen Tang , Lothar W. Kleiner , Fuh-Wei Tang , Ni Ding , Syed Faiyaz Ahmed Hossainy
发明人： Shaw Ling Hsu , Yiwen Tang , Lothar W. Kleiner , Fuh-Wei Tang , Ni Ding , Syed Faiyaz Ahmed Hossainy
CPC分类号： A61L27/34 , A61L31/10 , A61L2420/08 , C08L67/04
摘要： Implantable medical device coatings that have improved mechanical stability and medical devices coated with such coatings are disclosed.
摘要翻译： 公开了具有改善的机械稳定性的植入式医疗装置涂层和涂覆有这种涂层的医疗装置。
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