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1.发明申请ADDITIONAL HETEROPOLYCYCLIC COMPOUNDS AND THEIR USE AS METABOTROPIC GLUTAMATE RECEPTOR ANTAGONISTS 审中-公开其他杂环化合物及其作为代谢谷氨酸受体拮抗剂的使用公开(公告)号：US20080045571A1
公开(公告)日：2008-02-21
申请号：US11840953
申请日：2007-08-18
申请人： Louise Edwards , Methvin Isaac , Martin Johansson , Annika Kers , Johan Malmberg , Donald McLeod , Alexander Mindis , Karin Staaf , Abdelmalik Slassi , Tomislav Stefanac , Thomas Stormann , David Wensbo , Tao Xin , Jalaj Arora
发明人： Louise Edwards , Methvin Isaac , Martin Johansson , Annika Kers , Johan Malmberg , Donald McLeod , Alexander Mindis , Karin Staaf , Abdelmalik Slassi , Tomislav Stefanac , Thomas Stormann , David Wensbo , Tao Xin , Jalaj Arora
IPC分类号： A61K31/4439 , A61K31/4196 , A61K31/4245 , A61P19/06 , A61P25/18 , A61P25/30 , A61P29/00 , A61P9/00 , C07D413/14 , C12N5/00 , C07D271/06 , A61P35/00 , A61P27/02 , A61P25/28 , A61P25/08 , A61P19/02 , A61K31/443
CPC分类号： C07D487/04 , C07D413/06 , C07D413/12 , C07D413/14
摘要： The present invention relates to new compounds of formula I, to pharmaceutical formulations containing the compounds, and to the use of the compounds in the prevention and/or treatment of mGluR5 receptor-mediated disorders.
摘要翻译： 本发明涉及新的式I化合物，含有该化合物的药物制剂，以及该化合物在预防和/或治疗mGluR5受体介导的病症中的用途。
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2.发明申请Additional heteropolycyclic compounds and their use as metabotropic glutamate receptor antagonists 审中-公开额外的杂多环化合物及其作为代谢型谷氨酸受体拮抗剂的用途公开(公告)号：US20070179188A1
公开(公告)日：2007-08-02
申请号：US10588702
申请日：2005-02-15
申请人： Louise Edwards , Methvin Isaac , Martin Johansson , Annika Kers , Johan Malmberg , Donald Mcleod , Alexander Minidis , Karin Staaf , Abdelmalik Slassi , Tomislav Stefanac , Thomas Stormann , David Wensbo , Tao Xin , Jalaj Arora
发明人： Louise Edwards , Methvin Isaac , Martin Johansson , Annika Kers , Johan Malmberg , Donald Mcleod , Alexander Minidis , Karin Staaf , Abdelmalik Slassi , Tomislav Stefanac , Thomas Stormann , David Wensbo , Tao Xin , Jalaj Arora
IPC分类号： A61K31/4439 , A61K31/4245 , C07D413/14 , C07D413/02
CPC分类号： C07D487/04 , C07D413/06 , C07D413/12 , C07D413/14
摘要： The present invention relates to new compounds of formula (I), to pharmaceutical formulations containing the compounds, and to the use of the compounds in the prevention and/or treatment of mGluR5 receptor-mediated disorders.
摘要翻译： 本发明涉及新的式（I）化合物，含有该化合物的药物制剂，以及该化合物在预防和/或治疗mGluR5受体介导的病症中的用途。
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公开(公告)号：US20060122397A1
公开(公告)日：2006-06-08
申请号：US11274611
申请日：2005-11-14
申请人： Jalaj Arora , Louise Edwards , Methvin Isaac , Donald McLeod , Abdelmalik Slassi , Tomislav Stefanac , Thomas Stormann , David Wensbo , Tao Xin , Helena Gyback , Martin Johansson , Annika Kers , John Malmberg , Alexander Minidis , Karin Oscarsson , Mangus Waldman , Ulrika Yngve , Christoffer Osterwall
发明人： Jalaj Arora , Louise Edwards , Methvin Isaac , Donald McLeod , Abdelmalik Slassi , Tomislav Stefanac , Thomas Stormann , David Wensbo , Tao Xin , Helena Gyback , Martin Johansson , Annika Kers , John Malmberg , Alexander Minidis , Karin Oscarsson , Mangus Waldman , Ulrika Yngve , Christoffer Osterwall
IPC分类号： A61K31/4439 , A61K31/4245 , C07D417/14 , C07D413/14 , C07D409/14
CPC分类号： C07D413/14 , C07D413/12 , C07D417/14
摘要： The present invention relates to new compounds of formula I, a process for their preparation and new intermediates prepared therein, pharmaceutical formulations containing said compounds and to the use of said compounds in therapy.
摘要翻译： 本发明涉及新的式I化合物，其制备方法和其中制备的新中间体，含有所述化合物的药物制剂和所述化合物在治疗中的用途。
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4.发明授权Tetrazole compounds and their use as metabotropic glutamate receptor antagonists 失效四唑化合物及其作为代谢型谷氨酸受体拮抗剂的用途公开(公告)号：US07691892B2
公开(公告)日：2010-04-06
申请号：US11060463
申请日：2005-02-18
申请人： Martin Johansson , Alexander Minidis , Karin Staaf , David Wensbo , Donald McLeod , Louise Edwards , Methvin Isaac , Anne O'Brien , Abdelmalik Slassi , Tao Xin , Tomislav Stefanac
发明人： Martin Johansson , Alexander Minidis , Karin Staaf , David Wensbo , Donald McLeod , Louise Edwards , Methvin Isaac , Anne O'Brien , Abdelmalik Slassi , Tao Xin , Tomislav Stefanac
IPC分类号： A61K31/41 , C07D257/04
CPC分类号： C07D257/04 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/06 , C07D403/12 , C07D471/04 , C07D487/04
摘要： The present invention relates to new compounds of formula I, wherein P, Q, X1, X2, X3, X4, R1, R2, m and p, are as defined as in formula I, or, salts, solvates or solvated salts thereof, processes for their preparation and new intermediates used in the preparation thereof, pharmaceutical compositions containing said compounds and to the use of said compounds in therapy.
摘要翻译： 本发明涉及新的式I化合物，其中P，Q，X 1，X 2，X 3，X 4，R 1，R 2，m和p如式I中所定义，或其盐，溶剂合物或溶剂化盐， 其制备方法及其制备中使用的新中间体，含有所述化合物的药物组合物和所述化合物在治疗中的用途。
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5.发明申请ADDITIONAL HETEROPOLYCYCLIC COMPOUNDS AND THEIR USE AS METABOTROPIC GLUTAMATE RECEPTOR ANTAGONISTS 审中-公开其他杂环化合物及其作为代谢谷氨酸受体拮抗剂的使用公开(公告)号：US20070293545A1
公开(公告)日：2007-12-20
申请号：US11840954
申请日：2007-08-18
申请人： Louise Edwards , Methvin Isaac , Martin Johansson , Annika Kers , Johan Malmberg , Donald McLeod , Alexander Mindis , Karin Staaf , Abdelmalik Slassi , Tomislav Stefanac , Thomas Stormann , David Wensbo , Tao Xin , Jalaj Arora
发明人： Louise Edwards , Methvin Isaac , Martin Johansson , Annika Kers , Johan Malmberg , Donald McLeod , Alexander Mindis , Karin Staaf , Abdelmalik Slassi , Tomislav Stefanac , Thomas Stormann , David Wensbo , Tao Xin , Jalaj Arora
IPC分类号： A61K31/41 , A61K31/44 , A61P25/00 , C07D413/02 , C12N5/00
CPC分类号： C07D487/04 , C07D413/06 , C07D413/12 , C07D413/14
摘要： The present invention relates to new compounds of formula I, to pharmaceutical formulations containing the compounds, and to the use of the compounds in the prevention and/or treatment of mGluR5 receptor-mediated disorders.
摘要翻译： 本发明涉及新的式I化合物，含有该化合物的药物制剂，以及该化合物在预防和/或治疗mGluR5受体介导的病症中的用途。
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6.发明申请Tetrazole compounds and their use as metabotropic glutamate receptor antagonists 失效四唑化合物及其作为代谢型谷氨酸受体拮抗剂的用途公开(公告)号：US20060004021A1
公开(公告)日：2006-01-05
申请号：US11060463
申请日：2005-02-18
申请人： Martin Johansson , Alexander Minidis , Karin Staaf , David Wensbo , Donald McLeod , Louise Edwards , Methvin Isaac , Anne O'Brien , Abdelmalik Slassi , Tao Xin , Tomislav Stefanac
发明人： Martin Johansson , Alexander Minidis , Karin Staaf , David Wensbo , Donald McLeod , Louise Edwards , Methvin Isaac , Anne O'Brien , Abdelmalik Slassi , Tao Xin , Tomislav Stefanac
IPC分类号： A61K31/496 , A61K31/4439 , C07D43/02
CPC分类号： C07D257/04 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/06 , C07D403/12 , C07D471/04 , C07D487/04
摘要： The present invention relates to new compounds of formula I, wherein P, Q, X1, X2, X3, X4, R1, R2, m and p, are as defined as in formula I, or, salts, solvates or solvated salts thereof, processes for their preparation and new intermediates used in the preparation thereof, pharmaceutical compositions containing said compounds and to the use of said compounds in therapy.
摘要翻译： 本发明涉及新的式I化合物，其中P，Q，X 1，X 2，X 3，X 3， R 1，R 2，R 2，m和p如式I中所定义，或其盐，溶剂合物或溶剂化盐，方法 它们的制备方法和用于制备它们的新中间体，含有所述化合物的药物组合物和所述化合物在治疗中的用途。
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7.发明申请Tetrazole compounds and their use as metabotropic glutamate receptor antagonists 审中-公开四唑化合物及其作为代谢型谷氨酸受体拮抗剂的用途公开(公告)号：US20070197549A1
公开(公告)日：2007-08-23
申请号：US10588756
申请日：2005-02-17
申请人： Martin Johansson , Alexander Minidis , Karin Staaf , David Wensbo , Donald McLeod , Louise Edwards , Methvin Isaac , Anne O'Brien , Abdelmalik Slassi , Tao Xin , Tomislav Stefanac
发明人： Martin Johansson , Alexander Minidis , Karin Staaf , David Wensbo , Donald McLeod , Louise Edwards , Methvin Isaac , Anne O'Brien , Abdelmalik Slassi , Tao Xin , Tomislav Stefanac
IPC分类号： A61K31/445 , A61K31/41 , A61K31/519 , C07D239/02 , C07D249/08
CPC分类号： C07D257/04 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/06 , C07D403/12 , C07D471/04 , C07D487/04
摘要： The present invention relates to new compounds of formula I, wherein P, Q, X1, X2, X3, X4, R1, R2, m and p, are as defined as in formula I, or salts, solvates or solvated salts thereof, processes for their preparation and new intermediates used in the preparation thereof, pharmaceutical compositions containing said compounds, and to the use of said compounds in therapy.
摘要翻译： 本发明涉及新的式I化合物，其中P，Q，X 1，X 2，X 3，X 3， R 1，R 2，R 2，m和p如式I中所定义，或其盐，溶剂合物或溶剂化盐，用于它们的 制剂和用于制备其中的新中间体，含有所述化合物的药物组合物以及所述化合物在治疗中的用途。
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8.发明申请Fused heterocyclic compounds and their use as metabotropic glutamate receptor antagonists 审中-公开稠合杂环化合物及其作为代谢型谷氨酸受体拮抗剂的用途公开(公告)号：US20070185095A1
公开(公告)日：2007-08-09
申请号：US10588699
申请日：2005-02-17
申请人： Martin Johansson , David Wensbo , Alexander Minidis , Karin Staaf , Annika Kers , Louise Edwards , Methvin Isaac , Tomislav Stefanac , Abdelmalik Slassi , Donald McLeod , Tao Xin
发明人： Martin Johansson , David Wensbo , Alexander Minidis , Karin Staaf , Annika Kers , Louise Edwards , Methvin Isaac , Tomislav Stefanac , Abdelmalik Slassi , Donald McLeod , Tao Xin
IPC分类号： A61K31/551
CPC分类号： C07D487/04 , C07D513/04
摘要： The present invention is directed to compounds of formula: (I); wherein X1, X2, X3, X4, X5, X6, X7, X8, X9, X10, R1, R2, R3, R4, and n are as defined for formula I in the description. The invention also relates to processes for the preparation of the compounds and to new intermediates employed in the preparation, pharmaceutical compositions containing the compounds, and to the use of the compounds for treating gastrointestinal disorders.
摘要翻译： 本发明涉及式（I）的化合物： 其中X 1，X 2，X 3，X 4，X 5， ，X 6，X 7，X 8，X 9，X 10， R 1，R 2，R 3，R 4，和n如式I中所定义。 说明。 本发明还涉及制备化合物的方法和用于制备中的新中间体，含有该化合物的药物组合物，以及该化合物用于治疗胃肠道疾病的用途。
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9.发明申请公开(公告)号：US20060189661A1
公开(公告)日：2006-08-24
申请号：US11398556
申请日：2006-04-06
申请人： Bradford Wagenen , Thomas Stormann , Scott Moe , Susan Sheehan , Donald McLeod , Daryl Smith , Methvin Isaac , Abdelmalik Slassi , Ian Egle , Louise Edwards , Tomislav Stefanac , Tao Xin , Jalaj Arora , William Michne
发明人： Bradford Wagenen , Thomas Stormann , Scott Moe , Susan Sheehan , Donald McLeod , Daryl Smith , Methvin Isaac , Abdelmalik Slassi , Ian Egle , Louise Edwards , Tomislav Stefanac , Tao Xin , Jalaj Arora , William Michne
IPC分类号： C07D413/04 , A61K31/4439
CPC分类号： C07D213/75 , C07D213/55 , C07D213/78 , C07D213/79 , C07D401/04 , C07D405/04 , C07D405/14 , C07D413/04 , C07D413/14
摘要： The present invention provides compounds and pharmaceutical compositions that act as antagonists at metabotropic glutamate receptors, and that are useful for treating neurological diseases and disorders. Methods of preparing the compounds also are disclosed.
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10.发明申请公开(公告)号：US20080312246A1
公开(公告)日：2008-12-18
申请号：US11997444
申请日：2006-08-04
申请人： Louise Edwards , Abdelmalik Slassi , Methvin Isaac , Donald Mcleod , Tao Xin
发明人： Louise Edwards , Abdelmalik Slassi , Methvin Isaac , Donald Mcleod , Tao Xin
IPC分类号： A61K31/496 , A61P25/00 , A61P1/00 , C07D413/14 , A61K31/497
CPC分类号： C07D413/12 , C07D261/08 , C07D401/12 , C07D403/12
摘要： The invention relates to compounds of formula I or pharmaceutically acceptable salts or solvates thereof: where Ar1, Ar2, Hy, L, R1, m and n are as defined in the description. The invention also includes pharmaceutical compositions and uses thereof, processes for making the compounds, as well as methods for the medical treatment of mGluR5-mediated disorders.
摘要翻译： 本发明涉及式I化合物或其药学上可接受的盐或溶剂合物：其中Ar1，Ar2，Hy，L，R1，m和n如说明书中所定义。 本发明还包括药物组合物及其用途，制备该化合物的方法，以及用于治疗mGluR5介导的病症的方法。
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