公开(公告)号：US10549275B2

公开(公告)日：2020-02-04

申请号：US16185314

申请日：2018-11-09

Applicant: Lucira Health, Inc.

Inventor： Frank B. Myers, III ,  Clay D. Reber ,  Taber H. Smith ,  Faisal S. Maniar

IPC: B01L3/00 ,  C12Q1/6844 ,  G01N21/78

Abstract: This invention relates generally to devices, systems, and methods for performing biological assays by using indicators that modify one or more optical properties of the assayed biological samples. The subject methods include generating a reaction product by carrying out a biochemical reaction on the biological sample introduced into a device and reacting the reaction product with an indicator capable of generating a detectable change in an optical property of the biological sample to indicate the presence, absence, or amount of analyte suspected to be present in the sample.

公开(公告)号：US20230278030A1

公开(公告)日：2023-09-07

申请号：US17962324

申请日：2022-10-07

Applicant: Lucira Health, Inc.

Inventor： Frank B. Meyers, III ,  Clay D. Reber ,  Taber H. Smith ,  Faisal S. Maniar

IPC: B01L3/00 ,  C12Q1/6844 ,  G01N21/78 ,  G01N21/77 ,  G01N21/25 ,  G01N21/03 ,  B01L7/00 ,  G01N35/00 ,  G01N21/27

CPC classification number: B01L3/502715 ,  C12Q1/6844 ,  G01N21/78 ,  G01N21/77 ,  G01N21/253 ,  G01N21/0303 ,  B01L7/52 ,  G01N35/00 ,  G01N21/272 ,  B01L2200/027 ,  B01L2300/0864 ,  G01N2201/0626 ,  B01L2300/0654 ,  B01L2200/0689 ,  B01L2300/1805 ,  B01L2300/025 ,  B01L2200/0684 ,  B01L2300/0803 ,  G01N2035/0436

Abstract: This invention relates generally to devices, systems, and methods for performing biological assays by using indicators that modify one or more optical properties of the assayed biological samples. The subject methods include generating a reaction product by carrying out a biochemical reaction on the biological sample introduced into a device and reacting the reaction product with an indicator capable of generating a detectable change in an optical property of the biological sample to indicate the presence, absence, or amount of analyte suspected to be present in the sample.

公开(公告)号：US11465142B2

公开(公告)日：2022-10-11

申请号：US16722475

申请日：2019-12-20

Applicant: Lucira Health, Inc.

Inventor： Frank B. Myers, III ,  Clay D. Reber ,  Taber H. Smith ,  Faisal S. Maniar

IPC: B01L3/00 ,  G01N21/78 ,  C12Q1/6844 ,  G01N21/77 ,  G01N21/25 ,  G01N21/03 ,  B01L7/00 ,  G01N35/00 ,  G01N21/27 ,  G01N35/04

Abstract: This invention relates generally to devices, systems, and methods for performing biological assays by using indicators that modify one or more optical properties of the assayed biological samples. The subject methods include generating a reaction product by carrying out a biochemical reaction on the biological sample introduced into a device and reacting the reaction product with an indicator capable of generating a detectable change in an optical property of the biological sample to indicate the presence, absence, or amount of analyte suspected to be present in the sample.

公开(公告)号：US20220134327A1

公开(公告)日：2022-05-05

申请号：US17436903

申请日：2020-03-03

Applicant: Lucira Health, Inc.

Inventor： Frank B. Myers, III ,  Clay D. Reber ,  Taber H. Smith ,  Faisal S. Maniar

IPC: B01L3/00 ,  C12Q1/6844

Abstract: This invention relates generally to devices, systems, and methods for avoiding bubble formation in a fluidic chamber during filling of the fluidic chamber with a liquid. A first and second piece are operatively coupled to form the fluidic chamber. A protrusion protrudes into a volume of the fluidic chamber such that there is a distance of minimal approach between an apex of the protrusion and a surface of the fluidic chamber. The protrusion forms a channel that extends from one of an inlet and the outlet of the fluidic chamber to the protrusion apex. A maximum distance of travel through the fluidic chamber volume exists between the inlet and the outlet. A cross-sectional area of the fluidic chamber volume increases from the protrusion apex to a transverse plane of the fluidic chamber and decreases from the transverse plane to the other one of the inlet and the outlet.