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公开(公告)号：US20090068103A1
公开(公告)日：2009-03-12
申请号：US11851807
申请日：2007-09-07
申请人： Ludger Dinkelborg , Matthias Friebe , Maren Hecht , Lutz Lehmann , Bernhard Noll
发明人： Ludger Dinkelborg , Matthias Friebe , Maren Hecht , Lutz Lehmann , Bernhard Noll
IPC分类号： A61K51/08 , C07K7/06 , C07D257/00 , C07H21/02 , C07H21/04 , A61K51/04 , A61K38/14 , A61K31/711 , C07F19/00
CPC分类号： C12N15/115 , A61K51/0491 , C12N2310/16 , C12N2310/3517
摘要： This invention relates to novel nucleotide-based compounds, methods of making radiolabeled compounds and use of such compounds for diagnostic imaging. Provided are compounds according to Formula (I) A-B-L-C, wherein A stands for an aptamer, B is absent or stands for a bridging structure, L is a linker, and C is a metal ion chelator. All substituents are defined in detail in the description. Preferred embodiments of said compounds bind to Tenascin-C.
摘要翻译： 本发明涉及新的基于核苷酸的化合物，制备放射性标记的化合物的方法和用于诊断成像的这些化合物的用途。 提供根据式（I）的化合物A-B-L-C，其中A代表适体，B不存在或代表桥连结构，L是连接体，C是金属离子螯合剂。 所有取代基在说明书中详细定义。 所述化合物的优选实施方案结合腱生蛋白-C。
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![Novel [F-18]-labelled L-glutamic acid and L-glutamine derivatives (II), their use and processes for their preparation](/abs-image/US/2011/05/05/US20110104057A1/abs.jpg.150x150.jpg)
2.发明申请Novel [F-18]-labelled L-glutamic acid and L-glutamine derivatives (II), their use and processes for their preparation 审中-公开新型[F-18] - 标签L-谷氨酸和L-谷氨酰胺衍生物（II），其用途及其制备方法公开(公告)号：US20110104057A1
公开(公告)日：2011-05-05
申请号：US12993289
申请日：2009-05-13
申请人： Ludger Dinkelborg , Keith Graham , Mathias Berndt , Norman Koglin , Heribert Schmitt-Willich , Matthias Friebe , Lutz Lehmann
发明人： Ludger Dinkelborg , Keith Graham , Mathias Berndt , Norman Koglin , Heribert Schmitt-Willich , Matthias Friebe , Lutz Lehmann
IPC分类号： A61K49/08 , A61K31/4015 , A61K31/27 , A61K31/20 , A61K31/198 , C07D207/22 , C07C205/56 , C07C271/22 , C07C229/36 , C07C59/31 , C07C229/24 , A61P35/00
CPC分类号： C07D207/28 , A61K51/0402 , C07B59/00 , C07C229/24 , C07C229/28 , C07C229/36 , C07C271/22 , C07C2601/04 , Y02P20/55
摘要： What is described are the compounds and the synthesis of [F-18]-labelled L-glutamic acid, [F-18]-labelled L-glutamate, their derivatives of the formula (I) and their use.
摘要翻译： 描述了[F-18]标记的L-谷氨酸，[F-18] - 标签的L-谷氨酸，其式（I）的衍生物及其用途的化合物和合成。
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![[F-18]-LABELED L-GLUTAMIC ACID, [F-18]-LABELED L-GLUTAMINE, DERIVATIVES THEREOF AND USE THEREOF AND PROCESSES FOR THEIR PREPARATION](/abs-image/US/2010/08/26/US20100217011A1/abs.jpg.150x150.jpg)
3.发明申请[F-18]-LABELED L-GLUTAMIC ACID, [F-18]-LABELED L-GLUTAMINE, DERIVATIVES THEREOF AND USE THEREOF AND PROCESSES FOR THEIR PREPARATION 审中-公开[F-18] -L-氨基酸，[F-18] -L-谷氨酰胺，其衍生物及其用途及其制备方法公开(公告)号：US20100217011A1
公开(公告)日：2010-08-26
申请号：US12513112
申请日：2007-10-30
申请人： Ludger Dinkelborg , Matthias Friebe , Nikolaevna Raisa Krasikowa , Yuri Belokon , Fedorovna Olga Kuznetsova , Keith Graham , Lutz Lehmann , Mathias Berndt
发明人： Ludger Dinkelborg , Matthias Friebe , Nikolaevna Raisa Krasikowa , Yuri Belokon , Fedorovna Olga Kuznetsova , Keith Graham , Lutz Lehmann , Mathias Berndt
IPC分类号： C07F15/04 , C07D207/24 , C07D207/16 , C07C229/24 , C07C227/16
CPC分类号： A61K51/0402 , C07B59/001 , C07B2200/05 , C07C227/16 , C07C229/24 , C07C251/24 , C07C271/22 , C07C309/66 , C07C309/73 , C07D207/16 , C07D207/26 , C07D207/28 , C07F15/045
摘要： The compounds and the synthesis of [F-18]-labeled L-glutamic acid, [F-18]-labeled L-glutamate, their derivatives as set forth in formula (I) and their uses are described.
摘要翻译： 描述了[F-18]标记的L-谷氨酸[F-18] - 标记的L-谷氨酸酯，式（I）所示的衍生物及其用途的化合物和合成。
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![NOVEL [F-18]- LABELLED L-GLUTAMIC ACID AND L-GLUTAMINE DERIVATIVES (I), USE THEREOF AND METHOD FOR THEIR PRODUCTION](/abs-image/US/2011/07/07/US20110165076A1/abs.jpg.150x150.jpg)
4.发明申请NOVEL [F-18]- LABELLED L-GLUTAMIC ACID AND L-GLUTAMINE DERIVATIVES (I), USE THEREOF AND METHOD FOR THEIR PRODUCTION 审中-公开新型[F-18] - 标记L-谷氨酸和L-谷氨酰胺衍生物（I），其用途及其生产方法公开(公告)号：US20110165076A1
公开(公告)日：2011-07-07
申请号：US12993494
申请日：2009-05-14
申请人： Ludger Dinkelborg , Mathias Berndt , Matthias Friebe , Heribert Schmitt-Willich , Detlev Sülzle , Norman Koglin
发明人： Ludger Dinkelborg , Mathias Berndt , Matthias Friebe , Heribert Schmitt-Willich , Detlev Sülzle , Norman Koglin
IPC分类号： A61K51/04 , C07C229/24 , C07C227/16 , C07C237/06 , C07C231/12
CPC分类号： A61K49/0433 , A61K51/0402 , C07B59/001 , C07C227/16 , C07C229/24 , C07C231/12 , C07C237/06 , C07C269/06 , C07C271/22 , C07C309/66 , C07D207/16 , C07D207/28
摘要： What is described are the compounds and the synthesis of [F-18]-labelled L-glutamic acid, [F-18]-labelled L-glutamate, their derivatives of the formula (I) and their use.
摘要翻译： 描述了[F-18]标记的L-谷氨酸，[F-18] - 标签的L-谷氨酸，其式（I）的衍生物及其用途的化合物和合成。
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5.发明申请New L-Glutamic acid and L-Glutamine derivative (III), use thereof and method for obtaining them 审中-公开新的L-谷氨酸和L-谷氨酰胺衍生物（III），其用途及其获得方法公开(公告)号：US20110064673A1
公开(公告)日：2011-03-17
申请号：US12992956
申请日：2009-05-14
申请人： Ludger Dinkelborg , Heribert Schmitt-Willich , Keith Graham , Norman Koglin , Mathias Berndt , Matthias Friebe , Andre Muller
发明人： Ludger Dinkelborg , Heribert Schmitt-Willich , Keith Graham , Norman Koglin , Mathias Berndt , Matthias Friebe , Andre Muller
IPC分类号： A61K49/10 , C07C229/24 , A61K31/198 , A61P35/00 , A61P35/02 , C07C229/36
CPC分类号： C07C227/16 , A61K49/10 , C07B59/001 , C07B2200/05 , C07C229/24 , C07C229/36 , C07C237/06 , C07C2601/04
摘要： The present invention relates to fluorinated glutamic acid (glutamate) and glutamine derivatives wherein the fluorine atom is 19F. The glutamic acid (glutamate) and glutamine derivatives are compound(s) of general Formula I, which encompasses all possible diastereoisomers and/or enantiomere derivatives or mixtures thereof.
摘要翻译： 本发明涉及氟代谷氨酸（谷氨酸）和谷氨酰胺衍生物，其中氟原子是19F。 谷氨酸（谷氨酸）和谷氨酰胺衍生物是通式I的化合物，其包括所有可能的非对映异构体和/或对映体衍生物或其混合物。
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6.发明申请COMPOUNDS AS APTAMER-DIMERS AND THEIR USES IN DIAGNOSIS AND THERAPY 审中-公开化合物作为APTAMER-DIMERS及其在诊断和治疗中的用途公开(公告)号：US20080207523A1
公开(公告)日：2008-08-28
申请号：US11851789
申请日：2007-09-07
CPC分类号： C07K14/001 , A61K38/00 , A61K47/65 , A61K51/088 , C07K7/02
摘要： The object of the present invention is solved by compositions of peptide linkers and their use for synthesis and annealing of aptamer oligonucleotides in form of dimers. The present invention in particularly provides said compositions for the use as a diagnostic and/or therapeutic agent.In another preferred embodiment the present invention relates to a kit for preparing a radiopharmaceutical preparation, said kit comprising a vial comprising a quantity of the compound according to the invention.A further preferred embodiment of the present invention relates to methods of producing said compounds, comprising synthesis of said compound in an automated peptide synthesizer.In another preferred embodiment the present invention concerns the use of said compounds according to the present invention for the manufacture of a medicament, preferably for diagnosis or therapy of proliferative diseases.In a further preferred embodiment the present invention concerns methods for treating or diagnosing patients administering or utilizing the compounds according to the present invention.
摘要翻译： 本发明的目的是通过肽接头的组合物及其用于以二聚体的形式合成和退火适体寡核苷酸的用途来解决的。 本发明特别提供了用作诊断和/或治疗剂的所述组合物。 在另一个优选的实施方案中，本发明涉及一种用于制备放射性药物制剂的试剂盒，所述试剂盒包含一定量的包含本发明化合物的小瓶。 本发明的另一优选实施方案涉及生产所述化合物的方法，包括在自动肽合成仪中合成所述化合物。 在另一个优选的实施方案中，本发明涉及根据本发明的所述化合物在制备药物中的用途，优选用于诊断或治疗增殖性疾病。 在另一优选实施方案中，本发明涉及用于治疗或诊断施用或使用本发明化合物的患者的方法。
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公开(公告)号：US09017645B2
公开(公告)日：2015-04-28
申请号：US13509062
申请日：2010-11-08
申请人： Heribert Schmitt-Willich , Niels Böhnke , Norman Koglin , Andre Müller , Mathias Berndt , Matthias Friebe , Lutz Lehmann
发明人： Heribert Schmitt-Willich , Niels Böhnke , Norman Koglin , Andre Müller , Mathias Berndt , Matthias Friebe , Lutz Lehmann
IPC分类号： A61B5/055 , C07C271/22 , A61K49/10 , A61K51/04 , C07B59/00 , C07C229/24 , C07C229/30 , C07C255/58
CPC分类号： C07C271/22 , A61K49/10 , A61K51/04 , A61K51/0402 , C07B59/001 , C07B2200/05 , C07C229/24 , C07C229/30 , C07C255/58
摘要： This invention relates to homoglutamic acid derivatives suitable for labeling or already labeled with 18F or 19F, methods of preparing such compounds, compositions comprising such compounds, kits comprising such compounds or compositions and uses of such compounds, compositions or kits for diagnostic imaging.
摘要翻译： 本发明涉及适用于标记或已经用18F或19F标记的高谷氨酸衍生物，制备此类化合物的方法，包含这些化合物的组合物，包含这些化合物或组合物的试剂盒以及用于诊断成像的这些化合物，组合物或试剂盒的用途。
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公开(公告)号：US20110243846A1
公开(公告)日：2011-10-06
申请号：US13139116
申请日：2009-11-28
申请人： Jorma Hassfeld , Ulrike Roehn , Matthias Friebe , Lutz Lehmann , Tobias Heinrich , Sabine Krause , Damian Brockschnieder , Thomas Dyrks , Andrea Thiele , Ulf Boemer , Ursula Moenning , Markus Berger , Stephan Siegel
发明人： Jorma Hassfeld , Ulrike Roehn , Matthias Friebe , Lutz Lehmann , Tobias Heinrich , Sabine Krause , Damian Brockschnieder , Thomas Dyrks , Andrea Thiele , Ulf Boemer , Ursula Moenning , Markus Berger , Stephan Siegel
IPC分类号： A61K51/04 , C07D277/82 , C07F7/22 , C07F5/02 , C07D417/12 , A61P43/00
CPC分类号： C07D277/82 , C07D417/12
摘要： This invention relates to compounds (benzothiazoles) suitable for labelling or already labelled by 18F, methods of preparing such a compound, compositions comprising such compounds, kits comprising such compounds or compositions and uses of such compounds, compositions or kits for diagnostic imaging.
摘要翻译： 本发明涉及适用于标记或已经由18F标记的化合物（苯并噻唑），制备这种化合物的方法，包含这些化合物的组合物，包含这些化合物或组合物的试剂盒以及用于诊断成像的这些化合物，组合物或试剂盒的用途。
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9.发明申请Piperazine Derivatives for Binding and Imaging Amyloid Plaques and Their Use 审中-公开哌嗪衍生物用于结合和成像淀粉样斑块及其用途公开(公告)号：US20110250135A1
公开(公告)日：2011-10-13
申请号：US13063532
申请日：2009-09-04
申请人： Heribert Schmitt-Willich , Ulrike Röhn , Matthias Friebe , Lutz Lehmann , Ansgar Fitzner , Sabine Krause , Damian Brockschnieder , Thomas Dyrks , Andrea Thiele , Ulf Bömer , Ursula Mönning , Tobias Heinrich
发明人： Heribert Schmitt-Willich , Ulrike Röhn , Matthias Friebe , Lutz Lehmann , Ansgar Fitzner , Sabine Krause , Damian Brockschnieder , Thomas Dyrks , Andrea Thiele , Ulf Bömer , Ursula Mönning , Tobias Heinrich
IPC分类号： A61K51/04 , C07D403/04 , C07D241/04 , C07D403/12 , A61P25/28 , A61K31/497 , A61K49/00 , A61K49/04 , A61K49/10 , C40B30/04 , A61K31/4965
CPC分类号： C07D239/42 , C07D209/24 , C07D213/81 , C07D213/82 , C07D295/185 , C07D405/12
摘要： The invention relates to compounds of formula I, their synthesis and their use, in particular for detecting amyloid deposits in a patient.
摘要翻译： 本发明涉及式I化合物，其合成及其用途，特别是用于检测患者中的淀粉样沉积物。
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公开(公告)号：US20130071327A1
公开(公告)日：2013-03-21
申请号：US13509062
申请日：2010-11-08
申请人： Heribert Schmitt-Willich , Niels Böhnke , Norman Koglin , Andre Müller , Mathias Berndt , Matthias Friebe , Lutz Lehmann
发明人： Heribert Schmitt-Willich , Niels Böhnke , Norman Koglin , Andre Müller , Mathias Berndt , Matthias Friebe , Lutz Lehmann
IPC分类号： C07C229/24 , C07C255/59 , C07C271/22 , C07C309/73 , C07C269/06 , C07C227/00 , C07C253/00 , C07C269/00 , C07C227/20 , C07C253/30 , C07C229/30 , A61K51/04
CPC分类号： C07C271/22 , A61K49/10 , A61K51/04 , A61K51/0402 , C07B59/001 , C07B2200/05 , C07C229/24 , C07C229/30 , C07C255/58
摘要： This invention relates to homoglutamic acid derivatives suitable for labeling or already labeled with 18F or 19F, methods of preparing such compounds, compositions comprising such compounds, kits comprising such compounds or compositions and uses of such compounds, compositions or kits for diagnostic imaging.
摘要翻译： 本发明涉及适于标记或已经用18F或19F标记的高谷氨酸衍生物，制备此类化合物的方法，包含这些化合物的组合物，包含这些化合物或组合物的试剂盒以及用于诊断成像的这些化合物，组合物或试剂盒的用途。
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