公开(公告)号：US07528959B2

公开(公告)日：2009-05-05

申请号：US12041873

申请日：2008-03-04

申请人： Lukas Novotny ,  Filipp Ignatovich

发明人： Lukas Novotny ,  Filipp Ignatovich

IPC分类号： G01B11/02

CPC分类号： B82Y35/00 ,  G01N15/1459 ,  G01N2015/0038 ,  G01N2015/0088

摘要： Light from a laser source is split into a reference arm and a detection arm. The light in the detection arm is focused into a channel containing particles to be detected and is backscattered by the particles. The light in the reference arm is attenuated. The attenuated and backscattered light are caused to interfere and detected by a split detector so that the effects of background light can be subtracted out, while the backscattered light is detected to detect the particles.

摘要翻译： 来自激光源的光被分成参考臂和检测臂。 检测臂中的光聚焦成含有要检测的颗粒的通道并被颗粒反向散射。 参考臂中的光被衰减。 衰减和反向散射光被分离检测器干扰和检测，从而可以减去背景光的影响，同时检测反向散射光以检测颗粒。

公开(公告)号：US20090323061A1

公开(公告)日：2009-12-31

申请号：US11710976

申请日：2007-02-27

申请人： Lukas Novotny ,  Filipp Ignatovich

发明人： Lukas Novotny ,  Filipp Ignatovich

IPC分类号： G01N15/02 ,  G01B9/02

CPC分类号： G01N15/1456 ,  G01N15/0211 ,  G01N2015/0038 ,  G01N2015/0088 ,  G01N2015/0233 ,  G01N2015/025 ,  G01N2015/1454 ,  G01N2015/1493

摘要： A nanoparticle sensor is capable of detecting and recognizing single nanoparticles in an aqueous environment. Such sensor may find applications in broad areas of science and technology, from the analysis of diesel engine emissions to the detection of biological warfare agents. Particle detection is based on interferometric detection of multi-color light, scattered by the particle. On the fundamental level, the detected signal has a weaker dependence on particle size (ÿ R3), compared to standard detection methods (ÿ R6). This leads to a significantly larger signal-to-noise ratio for smaller particles. By using a multi-color or white excitation light, particle dielectric properties are probed at different frequencies. This scheme samples the frequency dependence of the particle's polarizability thereby making it possible to predict the composition of the particle material. The detection scheme also employs a heterodyne or pseudoheterodyne detection configuration, which allows it to reduce or eliminate noise contribution from phase variations, which appear in any interferometric measurements.

摘要翻译： 纳米颗粒传感器能够在水性环境中检测和识别单个纳米颗粒。 这种传感器可以在广泛的科学和技术领域应用，从柴油机排放分析到生物战剂的检测。 粒子检测是基于粒子散射的多色光的干涉检测。 在基本水平上，与标准检测方法（ÿR6）相比，检测到的信号对粒度（ÿR3）的依赖性较弱。 这导致较小颗粒的信噪比显着更大。 通过使用多色或白色激发光，探测不同频率的粒子介电特性。 该方案对粒子极化率的频率依赖性进行了采样，从而可以预测粒子材料的组成。 检测方案还采用外差或伪外差检测配置，其允许其减少或消除出现在任何干涉测量中的相位变化的噪声贡献。

公开(公告)号：US20080218766A1

公开(公告)日：2008-09-11

申请号：US12041873

申请日：2008-03-04

申请人： Lukas Novotny ,  Filipp Ignatovich

发明人： Lukas Novotny ,  Filipp Ignatovich

IPC分类号： G01B11/02

CPC分类号： B82Y35/00 ,  G01N15/1459 ,  G01N2015/0038 ,  G01N2015/0088

摘要： Light from a laser source is split into a reference arm and a detection arm. The light in the detection arm is focused into a channel containing particles to be detected and is backscattered by the particles. The light in the reference arm is attenuated. The attenuated and backscattered light are caused to interfere and detected by a split detector so that the effects of background light can be subtracted out, while the backscattered light is detected to detect the particles.

摘要翻译： 来自激光源的光被分成参考臂和检测臂。 检测臂中的光聚焦成含有要检测的颗粒的通道并被颗粒反向散射。 参考臂中的光被衰减。 衰减和反向散射光被分离检测器干扰和检测，从而可以减去背景光的影响，同时检测反向散射光以检测颗粒。

公开(公告)号：US20070030492A1

公开(公告)日：2007-02-08

申请号：US11417254

申请日：2006-05-04

申请人： Lukas Novotny ,  Filipp Ignatovich

发明人： Lukas Novotny ,  Filipp Ignatovich

IPC分类号： G01B11/02

CPC分类号： B82Y35/00 ,  G01N15/1459 ,  G01N2015/0038 ,  G01N2015/0088

摘要： Light from a laser source is split into a reference arm and a detection arm. The light in the detection arm is focused into a channel containing particles to be detected and is backscattered by the particles. The light in the reference arm is attenuated. The attenuated and backscattered light are caused to interfere and detected by a split detector so that the effects of background light can be subtracted out, while the backscattered light is detected to detect the particles.

摘要翻译： 来自激光源的光被分成参考臂和检测臂。 检测臂中的光聚焦成含有要检测的颗粒的通道并被颗粒反向散射。 参考臂中的光被衰减。 衰减和反向散射光被分离检测器干扰和检测，从而可以减去背景光的影响，同时检测反向散射光以检测颗粒。

公开(公告)号：US07884946B2

公开(公告)日：2011-02-08

申请号：US12150486

申请日：2008-04-28

申请人： Todd F. Blalock ,  Filipp Ignatovich

发明人： Todd F. Blalock ,  Filipp Ignatovich

IPC分类号： G01B11/02

CPC分类号： G01B9/02071 ,  A61B3/1005 ,  G01B9/02028 ,  G01B9/0209 ,  G01B2290/35 ,  G01B2290/60 ,  G01B2290/70

摘要： An apparatus for measuring the axial length of a human eye, the apparatus comprising a low coherence light source; a beam splitter; a fast displacement module for rapidly varying the path length within a reference arm of an interferometer; a laser directing a laser beam that is co-propagating with light from the low coherence light source into the displacement module.

摘要翻译： 一种用于测量人眼的轴向长度的装置，该装置包括低相干光源; 分束器; 快速位移模块，用于在干涉仪的参考臂内快速改变路径长度; 将与来自低相干光源的光共同传播的激光束引导到位移模块中。

公开(公告)号：US20090268213A1

公开(公告)日：2009-10-29

申请号：US12150486

申请日：2008-04-28

申请人： Todd F. Blalock ,  Filipp Ignatovich

发明人： Todd F. Blalock ,  Filipp Ignatovich

IPC分类号： G01B9/02

CPC分类号： G01B9/02071 ,  A61B3/1005 ,  G01B9/02028 ,  G01B9/0209 ,  G01B2290/35 ,  G01B2290/60 ,  G01B2290/70

摘要： An apparatus for measuring the axial length of a human eye, the apparatus comprising a low coherence light source; a beam splitter; a fast displacement module for rapidly varying the path length within a reference arm of an interferometer; a laser directing a laser beam that is co-propagating with light from the low coherence light source into the displacement module.

摘要翻译： 一种用于测量人眼的轴向长度的装置，该装置包括低相干光源; 分束器; 快速位移模块，用于在干涉仪的参考臂内快速改变路径长度; 将与来自低相干光源的光共同传播的激光束引导到位移模块中。