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公开(公告)号：US20180195945A1
公开(公告)日：2018-07-12
申请号：US15738227
申请日：2016-06-28
Applicant: IMEC VZW , Universiteit Gent
Inventor： Bendix Schneider , Peter Bienstman , Joni Dambre , Geert Vanmeerbeeck , Liesbet Lagae
CPC classification number: G01N15/0227 , G01N15/1434 , G01N15/147 , G01N2015/0073 , G01N2015/008 , G01N2015/0233 , G01N2015/1454 , G01N2015/149 , G01N2015/1493 , G03H1/02 , G03H1/0443 , G03H2001/0447 , G03H2226/02 , G03H2226/11
Abstract: A device for extracting at least one object characteristic of an object (106) is presented, the device comprising: a light sensor (101) for recording a hologram of an object and a processing unit (102) coupled to the light sensor and configured for extracting at least one object characteristic from the hologram; wherein the processing unit is configured for extracting the at least one object characteristic from a section of the hologram without reconstructing an image representation of the object. Further, a device (200) for sorting an object (106), a method for identifying an object and a method for sorting objects is presented.
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公开(公告)号：US20180052425A1
公开(公告)日：2018-02-22
申请号：US15542794
申请日：2016-01-22
Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
Inventor： Aydogan Ozcan , Euan McLeod , Tevfik Umut Dincer
CPC classification number: G03H1/26 , G01B9/021 , G01N15/0227 , G01N15/1429 , G01N15/1434 , G01N15/1463 , G01N2001/2826 , G01N2015/0038 , G01N2015/0046 , G01N2015/0053 , G01N2015/0233 , G01N2015/1006 , G01N2015/1454 , G01N2015/1486 , G01N2015/1493 , G02B21/0008 , G03H1/0443 , G03H1/0866 , G03H2001/0038 , G03H2001/005 , G03H2001/0447 , G03H2001/261
Abstract: A method for the label-free sizing of small, nanometer-sized objects such as particles includes a hand-held, portable holographic microscope that incorporates vapor condensation of nanolenses and time-resolved lens-free imaging. The portable device is used to generate reconstructed, time-resolved, and automatically-focused phase images of the sample field-of-view. The peak phase value for each object a function of working distance (z2) and condensation time (t) is used to measure object size. The sizing accuracy has been quantified in both monodisperse and heterogeneous particle solutions, achieving an accuracy of +/−11 nm for particles that range from 40 nm up to 500 nm. For larger particles, the technique still works while the accuracy roughly scales with particle size.
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3.发明申请公开(公告)号：US20170315041A1
公开(公告)日：2017-11-02
申请号：US15523223
申请日：2015-10-30
Inventor： Jean-Guillaume COUTARD
CPC classification number: G01N15/06 , G01N15/0211 , G01N2015/0065 , G01N2015/0233 , G01N2015/0693 , G01N2015/145
Abstract: The method enables a concentration of a species in a culture medium (12) to be estimated using an estimation system (10) comprising a light source (16), a transparent substrate (14) and a matrix photodetector (18), the substrate being located between the source and the photodetector, the medium comprising biological particles (32) and changing colour when said concentration varies. Said method comprises the following steps:—placing the medium on the substrate,—illuminating the medium via the light source,—acquisition of an image of the medium via the photodetector, each image being formed by a ray transmitted by the illuminated medium and comprising at least one diffraction pattern, each diffraction pattern corresponding to the waves diffracted by a biological particle when the medium is illuminated,—and calculating an estimate of said concentration as a function of a pixel intensity of the acquired image.
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公开(公告)号：US12000768B2
公开(公告)日：2024-06-04
申请号：US17247096
申请日：2020-11-30
Applicant: Honeywell International Inc.
Inventor： Andy Walker Brown , Adam D. McBrady , Ryadh Abdullah Zakaria , Stephan Michael Bork
CPC classification number: G01N1/2273 , G01N15/0227 , G06T7/62 , G06V10/751 , G01N15/01 , G01N2015/0233
Abstract: A flow device, method, and system are provided for determining the fluid particle composition. An example flow device includes a fluid sensor configured to monitor at least one particle characteristic of fluid flowing through the fluid sensor. The example flow device also includes at least one processor configured to, upon determining the at least one particle characteristic satisfies a particle criteria, generate a control signal for an external device. The example flow device also includes a fluid composition sensor configured to be powered based on the control signal and further configured to capture data relating to the fluid particle composition. The example flow device is also configured to generate one or more particle profiles of at least one component of the fluid based on the data captured by the fluid composition sensor.
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公开(公告)号：US11726431B2
公开(公告)日：2023-08-15
申请号：US17132657
申请日：2020-12-23
Inventor： Christophe Constancias
CPC classification number: G03H1/0866 , G01N15/0211 , G01N2015/0233 , G03H2001/0883 , G03H2222/12
Abstract: A device for detecting at least one object present in a sample, the device including a light source to emit at least one incident wave at a wavelength λ, a detection volume intended to receive the object, and to receive at least one incident wave, an image sensor positioned to receive at least one scattered light wave obtained by diffraction of the incident wave on the object and a reference wave from the source and not diffracted on the object and to generate a holographic image, and a computer data processing device to digitally reconstruct the object based at least on the holographic image and the wavelength λ. The device also comprises a support comprising patterns organized to form at least one diffraction grating, the grating being periodic and having a pitch P, such that λ/2≤P≤2λ.
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Patent Agency Ranking
6.发明申请Multi-color hetereodyne interferometric apparatus and method for sizing nanoparticles 审中-公开用于调整纳米颗粒尺寸的多色真空干涉仪和方法公开(公告)号：US20090323061A1
公开(公告)日：2009-12-31
申请号：US11710976
申请日：2007-02-27
Applicant: Lukas Novotny , Filipp Ignatovich
Inventor： Lukas Novotny , Filipp Ignatovich
CPC classification number: G01N15/1456 , G01N15/0211 , G01N2015/0038 , G01N2015/0088 , G01N2015/0233 , G01N2015/025 , G01N2015/1454 , G01N2015/1493
Abstract: A nanoparticle sensor is capable of detecting and recognizing single nanoparticles in an aqueous environment. Such sensor may find applications in broad areas of science and technology, from the analysis of diesel engine emissions to the detection of biological warfare agents. Particle detection is based on interferometric detection of multi-color light, scattered by the particle. On the fundamental level, the detected signal has a weaker dependence on particle size (ÿ R3), compared to standard detection methods (ÿ R6). This leads to a significantly larger signal-to-noise ratio for smaller particles. By using a multi-color or white excitation light, particle dielectric properties are probed at different frequencies. This scheme samples the frequency dependence of the particle's polarizability thereby making it possible to predict the composition of the particle material. The detection scheme also employs a heterodyne or pseudoheterodyne detection configuration, which allows it to reduce or eliminate noise contribution from phase variations, which appear in any interferometric measurements.
Abstract translation: 纳米颗粒传感器能够在水性环境中检测和识别单个纳米颗粒。 这种传感器可以在广泛的科学和技术领域应用，从柴油机排放分析到生物战剂的检测。 粒子检测是基于粒子散射的多色光的干涉检测。 在基本水平上，与标准检测方法（ÿR6）相比，检测到的信号对粒度（ÿR3）的依赖性较弱。 这导致较小颗粒的信噪比显着更大。 通过使用多色或白色激发光，探测不同频率的粒子介电特性。 该方案对粒子极化率的频率依赖性进行了采样，从而可以预测粒子材料的组成。 检测方案还采用外差或伪外差检测配置，其允许其减少或消除出现在任何干涉测量中的相位变化的噪声贡献。
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公开(公告)号：US11977015B2
公开(公告)日：2024-05-07
申请号：US17396980
申请日：2021-08-09
Applicant: NEW YORK UNIVERSITY
Inventor： David G. Grier , David B. Ruffner , Aaron Yevick , Mark Hannel
IPC: G01N15/02 , G01N15/0227 , G03H1/00 , G03H1/04 , G06V10/143 , G06V20/69 , G06V20/80 , B01L3/00 , G01N15/00 , G01N21/47
CPC classification number: G01N15/0227 , G03H1/0005 , G03H1/0443 , G06V10/143 , G06V20/69 , G06V20/80 , B01L3/5027 , G01N2015/0053 , G01N2015/0233 , G01N2015/03 , G01N2021/4707 , G03H2001/0033 , G03H2001/005 , G03H2001/0447
Abstract: Systems and methods for uniquely identifying fluid-phase products by endowing them with fingerprints composed of dispersed colloidal particles, and by reading out those fingerprints on demand using Total Holographic Characterization. A library of chemically inert colloidal particles is developed that can be dispersed into soft materials, the stoichiometry of the mixture encoding user-specified information, including information about the host material. Encoded information then can be recovered by high-speed analysis of holographic microscopy images of the dispersed particles. Specifically, holograms of individual colloidal spheres are analyzed with predictions of the theory of light scattering to measure each sphere's radius and refractive index, thereby building up the distribution of particle properties one particle at a time. A complete analysis of a colloidal fingerprint requires several thousand single-particle holograms and can be completed in ten minutes.
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公开(公告)号：US11747258B2
公开(公告)日：2023-09-05
申请号：US17826848
申请日：2022-05-27
Applicant: NEW YORK UNIVERSITY
Inventor： David G. Grier , Michael D. Ward , Xiao Zhong , Chen Wang , Laura A. Philips , David B. Ruffner , Fook Chiong Cheong
CPC classification number: G01N15/0227 , G01N15/0211 , G01N15/147 , G01N2015/0038 , G01N2015/0053 , G01N2015/0222 , G01N2015/0233 , G01N2015/1454
Abstract: Systems and methods for holographic characterization of protein aggregates. Size and refractive index of individual aggregates in a solution can be determined. Information regarding morphology and porosity can be extracted from holographic data.
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9.发明申请公开(公告)号：US20180252628A1
公开(公告)日：2018-09-06
申请号：US15759502
申请日：2016-09-15
Applicant: NEW YORK UNIVERSITY
Inventor： David B. RUFFNER , David G. GRIER , Laura PHILIPS
CPC classification number: G01N15/0227 , G01N15/1434 , G01N15/1459 , G01N15/1463 , G01N21/453 , G01N2015/0053 , G01N2015/0233 , G01N2015/1454 , G01N2015/1493 , G03H1/0005 , G03H1/0443 , G03H2001/0033 , G03H2001/005 , G03H2001/0447
Abstract: Impurities within a sample are detected by use of holographic video microscopy. The sample flows through the microscope and holographic images are generated. The holographic image is analyzed to identify regions associated with large impurities in the sample. The contribution of the particles of the sample to the holographic images is determined and the impurities are characterized.
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公开(公告)号：US3871769A
公开(公告)日：1975-03-18
申请号：US36162573
申请日：1973-05-18
Applicant: TURLABOR AG
Inventor： ENGEL ANDREAS HERMANN , HERZIGER GERD BERND , TSCHUDI THEODOR HEINRICH
CPC classification number: G01N15/0211 , G01N2015/0233 , G02B5/32 , G02B27/46
Abstract: Apparatus for determining the diameters of small particles by means of coherent light being scattered thereby, including holographic filters for converting the scattered light waves received from the particles exactly into spherical light waves only when said particles are of a predetermined diameter, said light waves then being passed through a lens and apertured diaphragm into separate light-measuring devices, each of which is associated with respectively one of said filters and which emits an electrical signal proportional to the intensity of the received light such as said signal becomes maximum when the diameter of the illuminated particle equals the predetermined particle diameter.
Abstract translation: 用于通过由此散射的相干光来确定小颗粒的直径的装置，包括全息滤光器，用于仅当所述颗粒具有预定直径时将从颗粒接收的散射光完全转换成球面光波，则所述光波然后是 通过透镜和孔径光阑到分离的光测量装置中，每个光测量装置分别与所述滤光器中的一个相关联，并且发射与所接收的光的强度成比例的电信号，例如当所述信号的直径为 照明粒子等于预定粒径。
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