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公开(公告)号：US09737534B2
公开(公告)日：2017-08-22
申请号：US14840118
申请日：2015-08-31
申请人： LUPIN LIMITED
发明人： Nageswara Rao Irlapati , Gokul Keruji Deshmukh , Vijay Pandurang Karche , Santosh Madhukar Jachak , Neelima Sinha , Venkata P. Palle , Rajender Kumar Kamboj
IPC分类号： C07D271/113 , A61K31/4245 , A61P19/02 , A61K31/497 , C07D261/12 , C07D413/10 , C07D413/14 , C07D417/14 , A61K31/42 , A61K31/421 , A61K31/422 , A61K31/423 , A61K31/433 , A61K31/4439 , A61K31/496
CPC分类号： A61K31/497 , A61K31/42 , A61K31/421 , A61K31/422 , A61K31/423 , A61K31/4245 , A61K31/433 , A61K31/4439 , A61K31/496 , C07D261/12 , C07D413/10 , C07D413/14 , C07D417/14
摘要： The present invention relates to compounds of Formula (I), along with processes for their preparation that are useful for treating, preventing and/or managing the diseases, disorders, syndromes or conditions associated with the modulation of CRAC. The invention further relates to methods of treating, preventing managing and/or lessening the diseases, disorders, syndromes or conditions associated with the modulation of CRAC of Formula (I).
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公开(公告)号：US10292981B2
公开(公告)日：2019-05-21
申请号：US15642899
申请日：2017-07-06
申请人： LUPIN LIMITED
发明人： Nageswara Rao Irlapati , Gokul Keruji Deshmukh , Vijay Pandurang Karche , Santosh Madhukar Jachak , Neelima Sinha , Venkata P. Palle , Rajender Kumar Kamboj
IPC分类号： C07D271/113 , A61K31/4245 , A61P11/06 , A61K31/497 , C07D261/12 , C07D413/10 , C07D413/14 , C07D417/14 , A61K31/42 , A61K31/421 , A61K31/422 , A61K31/423 , A61K31/433 , A61K31/4439 , A61K31/496
摘要： The present invention relates to compounds of Formula (I), along with processes for their preparation that are useful for treating, preventing and/or managing the diseases, disorders, syndromes or conditions associated with the modulation of CRAC. The invention further relates to methods of treating, preventing managing and/or lessening the diseases, disorders, syndromes or conditions associated with the modulation of CRAC of Formula (I).
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公开(公告)号：US20190275012A9
公开(公告)日：2019-09-12
申请号：US16320902
申请日：2017-07-28
申请人： Lupin Limited
发明人： Gagan Kukreja , Nageswara Rao Irlapati , Arun Rangnath Jagdale , Gokul Keruji Deshmukh , Vinod Popatrao Vyavahare , Kiran Chandrashekhar Kulkarni , Neelima Sinha , Venkata P. Palle , Rajender Kumar Kamboj
IPC分类号： A61K31/429 , A61P35/02 , A61P37/00 , A61P11/00
摘要： Disclosed are compounds of the general formula (I), wherein R1-R3 are as defined herein, for use as MALT1 inhibitors in the treatment of autoimmune and inflammatory diseases or disorders. Methods of synthesizing the compounds are also disclosed. Also disclosed are pharmaceutical compositions containing a compound of the invention and a method of treating a patient for an autoimmune or an inflammatory disease or disorder, for example, a cancer, by administering a compound of the invention.
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公开(公告)号：US09399638B2
公开(公告)日：2016-07-26
申请号：US14398154
申请日：2013-05-01
申请人： LUPIN LIMITED
发明人： Nageswara Rao Irlapati , Zubair Abdul Wajid Shaikh , Vijay Pandurang Karche , Gokul Keruji Deshmukh , Neelima Sinha , Venkata P. Palle , Rajender Kumar Kamboj
IPC分类号： C07D413/04 , C07D417/14 , C07D413/14
CPC分类号： C07D413/14 , C07D413/04 , C07D417/14
摘要： The present invention relates to compounds described herein Formula (I) and pharmaceutical acceptable salts thereof, which modulate the activity of calcium release-activated calcium (CRAC) channel. The invention also describes the compounds of Formula (I) and pharmaceutical compositions containing such compounds thereof for treating, managing, and/or lessening the severity of diseases, disorders, syndromes or conditions associated with the modulation of calcium release-activated calcium (CRAC) channel.
摘要翻译： 本发明涉及调节钙释放活化的钙（CRAC）通道的活性的式（I）化合物及其药学上可接受的盐。 本发明还描述了式（I）的化合物和含有其化合物的药物组合物，用于治疗，治疗和/或降低与调节钙释放激活的钙（CRAC）相关的疾病，病症，综合征或病症的严重性， 渠道。
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公开(公告)号：US20150111925A1
公开(公告)日：2015-04-23
申请号：US14398161
申请日：2013-05-01
申请人： LUPIN LIMITED
发明人： Nageswara Rao Irlapati , Gokul Keruji Deshmukh , Nilesh Raghunath Khedkar , Kiran Chandrashekhar Kulkarni , Zubair Abdul Wajid Shaikh , Neelima Sinha , Venkata P. Palle , Rajender Kumar Kamboj
IPC分类号： C07D413/14 , C07D401/14
CPC分类号： C07D413/14 , C07D401/14
摘要： The present invention relates to compounds described herein Formula (I) and pharmaceutical acceptable salts thereof, which modulate the activity of calcium release-activated calcium (CRAC) channel. The invention also describes the compounds of Formula (I) and pharmaceutical compositions containing such compounds thereof for treating, managing, and/or lessening the severity of diseases, disorders, syndromes or conditions associated with the modulation of calcium release-activated calcium (CRAC) channel.
摘要翻译： 本发明涉及调节钙释放活化的钙（CRAC）通道的活性的式（I）化合物及其药学上可接受的盐。 本发明还描述了式（I）化合物和含有其化合物的药物组合物，用于治疗，控制和/或降低与调节钙释放激活的钙（CRAC）相关的疾病，病症，综合征或病症的严重性， 渠道。
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公开(公告)号：US20210052556A1
公开(公告)日：2021-02-25
申请号：US16831301
申请日：2020-03-26
申请人： Lupin Limited
发明人： Gagan Kukreja , Nageswara Rao Irlapati , Arun Rangnath Jagdale , Gokul Keruji Deshmukh , Vinod Popatrao Vyavahare , Kiran Chandrashekhar Kulkarni , Neelima Sinha , Venkata P. Palle , Rajender Kumar Kamboj
IPC分类号： A61K31/429 , C07D513/04 , A61P37/00 , A61P35/02 , A61P11/00
摘要： Disclosed are compounds of the general formula (I), wherein R1-R3 are as defined herein, for use as MALT1 inhibitors in the treatment of autoimmune and inflammatory diseases or disorders. Methods of synthesizing the compounds are also disclosed. Also disclosed are pharmaceutical compositions containing a compound of the invention and a method of treating a patient for an autoimmune or an inflammatory disease or disorder, for example, a cancer, by administering a compound of the invention.
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公开(公告)号：US20150111900A1
公开(公告)日：2015-04-23
申请号：US14398154
申请日：2013-05-01
申请人： LUPIN LIMITED
发明人： Nageswara Rao Irlapati , Zubair Abdul Wajid Shaikh , Vijay Pandurang Karche , Gokul Keruji Deshmukh , Neelima Sinha , Venkata P. Palle , Rajender Kumar Kamboj
IPC分类号： C07D417/14 , C07D413/14 , C07D413/04
CPC分类号： C07D413/14 , C07D413/04 , C07D417/14
摘要： The present invention relates to compounds described herein Formula (I) and pharmaceutical acceptable salts thereof, which modulate the activity of calcium release-activated calcium (CRAC) channel. The invention also describes the compounds of Formula (I) and pharmaceutical compositions containing such compounds thereof for treating, managing, and/or lessening the severity of diseases, disorders, syndromes or conditions associated with the modulation of calcium release-activated calcium (CRAC) channel.
摘要翻译： 本发明涉及调节钙释放活化的钙（CRAC）通道的活性的式（I）化合物及其药学上可接受的盐。 本发明还描述了式（I）化合物和含有其化合物的药物组合物，用于治疗，控制和/或降低与调节钙释放激活的钙（CRAC）相关的疾病，病症，综合征或病症的严重性， 渠道。
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公开(公告)号：US20190160045A1
公开(公告)日：2019-05-30
申请号：US16320902
申请日：2017-07-28
申请人： Lupin Limited
发明人： Gagan Kukreja , Nageswara Rao Irlapati , Arun Rangnath Jagdale , Gokul Keruji Deshmukh , Vinod Popatrao Vyavahare , Kiran Chandrashekhar Kulkarni , Neelima Sinha , Venkata P. Palle , Rajender Kumar Kamboj
IPC分类号： A61K31/429 , A61P35/02 , A61P37/00 , A61P11/00
CPC分类号： A61K31/429 , A61P11/00 , A61P35/02 , A61P37/00 , C07D513/04
摘要： Disclosed are compounds of the general formula (I), wherein R1-R3 are as defined herein, for use as MALT1 inhibitors in the treatment of autoimmune and inflammatory diseases or disorders. Methods of synthesizing the compounds are also disclosed. Also disclosed are pharmaceutical compositions containing a compound of the invention and a method of treating a patient for an autoimmune or an inflammatory disease or disorder, for example, a cancer, by administering a compound of the invention.
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公开(公告)号：US09790231B2
公开(公告)日：2017-10-17
申请号：US14900425
申请日：2014-06-23
申请人： LUPIN LIMITED
发明人： Nageswara Rao Irlapati , Kiran Chandrashekhar Kulkarni , Vijay Pandurang Karche , Gokul Keruji Deshmukh , Neelima Sinha , Venkata P. Palle , Rajender Kumar Kamboj
IPC分类号： A61K31/352 , C07D311/04 , C07D311/96 , C07D405/04 , C07D405/12 , C07D491/107 , C07D311/22 , C07D311/58 , C07D491/10 , C07D493/10
CPC分类号： C07D491/107 , C07D311/04 , C07D311/22 , C07D311/58 , C07D311/96 , C07D405/04 , C07D405/12 , C07D491/10 , C07D493/10
摘要： The invention relates to compounds of Formula (I) and their pharmaceutically acceptable salts, wherein the substituents are as described herein, and their use in medicine for the treatment of diseases, disorders associated with the modulation of calcium release-activated calcium (CRAC) channel. The invention also relates to pharmaceutical compositions containing such compounds in treating diseases disorders associated with calcium release-activated calcium (CRAC) channel modulators.
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公开(公告)号：US09725463B2
公开(公告)日：2017-08-08
申请号：US14899719
申请日：2014-06-20
申请人： LUPIN LIMITED
发明人： Nageswara Rao Irlapati , Nilesh Raghunath Khedkar , Ravindra Babanrao Jape , Rahul Shripad Nandurdikar , Zubair Abdul Wajid Shaikh , Neelima Sinha , Venkata P. Palle , Rajender Kumar Kamboj
IPC分类号： C07D498/04 , C07D263/58 , C07D265/36 , C07D413/04 , C07D413/12 , C07D413/14 , C07D417/04 , A61K31/5377
CPC分类号： C07D498/04 , A61K31/5377 , C07D263/58 , C07D265/36 , C07D413/04 , C07D413/12 , C07D413/14 , C07D417/04
摘要： The invention relates to compounds of Formula (I) and their pharmaceutically acceptable salts, wherein the substituents are as described herein, and their use in medicine for the treatment of diseases, disorders associated with the modulation of calcium release-activated calcium (CRAC) channel. The invention also relates to pharmaceutical compositions containing such compounds in treating diseases disorders associated with calcium release-activated calcium (CRAC) channel modulators. wherein, ring D is Formula (a) or Formula (b): A and B, which may be same or different, are independently CR3 or N; Y is CR3 or N; L is selected from —NR2C(O)—, —C(O)NR2— and —NR2CRaRb—; Ra and Rb are independently hydrogen, halogen or substituted or unsubstituted alkyl; ring E is selected from the Formula (i) to (vii).
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