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19 条记录 (耗时 0.057 秒)

    23-O-substituted 5-O-mycaminosyltylonide derivatives
    1.
    发明授权
    23-O-substituted 5-O-mycaminosyltylonide derivatives 失效
    23-O-取代的5-O-碳霉糖基海藻衍生物

    公开(公告)号：US06753415B2

    公开(公告)日：2004-06-22

    申请号：US10126076

    申请日：2002-04-19

    申请人： Ly Tam Phan ,  Yao-Ling Qiu ,  Yat Sun Or ,  Nha Vo ,  Tianying Jian ,  Ying Hou ,  Marina Busuyek

    发明人： Ly Tam Phan ,  Yao-Ling Qiu ,  Yat Sun Or ,  Nha Vo ,  Tianying Jian ,  Ying Hou ,  Marina Busuyek

    IPC分类号： A61K317048

    CPC分类号： C07H17/08

    摘要： There are described novel 5-O-mycaminosyltylonide (OMT) analogs possessing increased antibacterial activity toward Gram positive and Gram negative bacteria as well as macrolide resistant Gram positives and pharmaceutically acceptable compositions comprising a therapeutically effective amount of a compound of the invention in combination with a pharmaceutically acceptable carrier. Also described are a method for treating bacterial infections by administering to a patient a pharmaceutical composition containing a therapeutically-effective amount of a compound of the invention, and processes for the preparation of such compounds

    摘要翻译： 描述了具有对革兰氏阳性和革兰氏阴性细菌以及大环内酯抗性革兰氏阳性和药学上可接受的组合物具有增加的抗细菌活性的新型5-O-碳霉糖基托伦（OMT）类似物，其包含治疗有效量的本发明化合物与 药学上可接受的载体。 还描述了通过向患者施用含有治疗有效量的本发明化合物的药物组合物和用于制备这些化合物的方法来治疗细菌感染的方法

    23-O-substituted 5-O-mycaminosyltylonide derivatives
    2.
    发明申请
    23-O-substituted 5-O-mycaminosyltylonide derivatives 审中-公开
    23-O-取代的5-O-碳霉糖基海藻衍生物

    公开(公告)号：US20050020823A1

    公开(公告)日：2005-01-27

    申请号：US10840948

    申请日：2004-05-07

    申请人： Ly Phan ,  Yao-Ling Qiu ,  Yat Or ,  Nha Vo ,  Tianying Jian ,  Ying Hou ,  Marina BusuyeK

    发明人： Ly Phan ,  Yao-Ling Qiu ,  Yat Or ,  Nha Vo ,  Tianying Jian ,  Ying Hou ,  Marina BusuyeK

    IPC分类号： A61P31/04 ,  C07H17/08

    CPC分类号： C07H17/08

    摘要： There are described novel 5-O-mycaminosyltylonide (OMT) analogs possessing increased antibacterial activity toward Gram positive and Gram negative bacteria as well as macrolide resistant Gram positives and pharmaceutically acceptable compositions comprising a therapeutically effective amount of a compound of the invention in combination with a pharmaceutically acceptable carrier. Also described are a method for treating bacterial infections by administering to a patient a pharmaceutical composition containing a therapeutically-effective amount of a compound of the invention, and processes for the preparation of such compounds

    摘要翻译： 描述了具有对革兰氏阳性和革兰氏阴性细菌以及大环内酯抗性革兰氏阳性和药学上可接受的组合物具有增加的抗细菌活性的新型5-O-碳霉糖基托伦（OMT）类似物，其包含治疗有效量的本发明化合物与 药学上可接受的载体。 还描述了通过向患者施用含有治疗有效量的本发明化合物的药物组合物和用于制备这些化合物的方法来治疗细菌感染的方法

    4′-O-substituted tylosin analogs
    3.
    发明授权
    4′-O-substituted tylosin analogs 失效
    4'-O-取代的泰乐菌素类似物

    公开(公告)号：US06576615B2

    公开(公告)日：2003-06-10

    申请号：US10007744

    申请日：2001-11-08

    申请人： Ly Tam Phan ,  Tianying Jian ,  Yao-Ling Qiu ,  Yat Sun Or

    发明人： Ly Tam Phan ,  Tianying Jian ,  Yao-Ling Qiu ,  Yat Sun Or

    IPC分类号： A61K3170

    CPC分类号： C07H17/08

    摘要： There are described novel 4′ substituted tylosin analogs and pharmaceutically acceptable compositions comprising a therapeutically effective amount of a compound of the invention in combination with a pharmaceutically acceptable carrier. Also described is a method for treating bacterial infections by administering to a mammal a pharmaceutical composition containing a therapeutically-effective amount of a compound of the invention, and processes for the preparation of such compounds.

    摘要翻译： 描述了新颖的4'取代的泰乐菌素类似物和药学上可接受的组合物，其包含治疗有效量的本发明化合物与药学上可接受的载体的组合。 还描述了一种通过向哺乳动物施用含有治疗有效量的本发明化合物的药物组合物及其制备方法来治疗细菌感染的方法。

    4'-substituted leucomycins
    4.
    发明授权
    4'-substituted leucomycins 失效
    4'-取代的莱可霉素

    公开(公告)号：US06680299B2

    公开(公告)日：2004-01-20

    申请号：US09917107

    申请日：2001-07-27

    申请人： Yat Sun Or ,  Ly Tam Phan ,  Zhaolin Wang ,  Tianying Jian

    发明人： Yat Sun Or ,  Ly Tam Phan ,  Zhaolin Wang ,  Tianying Jian

    IPC分类号： A61K3170

    CPC分类号： C07H17/08

    摘要： There are described novel 4′ substituted 16-membered macrolides and pharmaceutically acceptable compositions comprising a therapeutically effective amount of a compound of the invention in combination with a pharmaceutically acceptable carrier. Also described are a method for treating bacterial infections by administering to a mammal a pharmaceutical composition containing a therapeutically-effective amount of a compound of the invention, and processes for the preparation of such compounds.

    摘要翻译： 描述了新颖的4'取代的16元大环内酯和药学上可接受的组合物，其包含治疗有效量的本发明化合物与药学上可接受的载体的组合。 还描述了通过向哺乳动物施用含有治疗有效量的本发明化合物的药物组合物以及制备这些化合物的方法来治疗细菌感染的方法。

    Acylated Spiropiperidine Derivatives as Melanocortin-4 Receptor Modulators
    6.
    发明申请
    Acylated Spiropiperidine Derivatives as Melanocortin-4 Receptor Modulators 有权
    酰基化Spiropiperidine衍生物作为黑皮质素-4受体调节剂

    公开(公告)号：US20090170863A1

    公开(公告)日：2009-07-02

    申请号：US11992262

    申请日：2006-09-25

    申请人： Tianying Jian ,  Jian Liu ,  Ravi P. Nargund

    发明人： Tianying Jian ,  Jian Liu ,  Ravi P. Nargund

    IPC分类号： A61K31/438 ,  A61K31/501 ,  A61K31/497 ,  A61K31/506 ,  C07D491/147 ,  C07D471/10

    CPC分类号： C07D471/10

    摘要： Certain novel N-acylated spiropiperidine derivatives are ligands of the human melanocortin receptor(s) and, in particular, are selective ligands of the human melanocortin-4 receptor (MC-4R). They are therefore useful for the treatment, control, or prevention of diseases and disorders responsive to the modulation of MC-4R, such as obesity, diabetes, nicotine addiction, alcoholism, sexual dysfunction, including erectile dysfunction and female sexual dysfunction.

    摘要翻译： 某些新型N-酰化螺哌啶衍生物是人类黑皮质素受体的配体，特别是人黑素皮质素-4受体（MC-4R）的选择性配体。 因此，它们可用于治疗，控制或预防对调节MC-4R的疾病和病症，例如肥胖，糖尿病，尼古丁成瘾，酒精中毒，性功能障碍，包括勃起功能障碍和女性性功能障碍。