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    Pharmaceutical preparations comprising an ALK1-Fc fusion protein
    7.
    发明授权
    Pharmaceutical preparations comprising an ALK1-Fc fusion protein 有权
    包含ALK1-Fc融合蛋白的药物制剂

    公开(公告)号：US08158584B2

    公开(公告)日：2012-04-17

    申请号：US12434598

    申请日：2009-05-01

    申请人： Asya Grinberg ,  John Knopf ,  Ravindra Kumar ,  Robert S. Pearsall ,  Jasbir Seehra ,  Kristian Pietras

    发明人： Asya Grinberg ,  John Knopf ,  Ravindra Kumar ,  Robert S. Pearsall ,  Jasbir Seehra ,  Kristian Pietras

    IPC分类号： A61K38/00 ,  A61K38/16

    CPC分类号： C07K16/2896 ,  A61K2039/505 ,  C07K14/71 ,  C07K16/40 ,  C07K2317/76 ,  C07K2319/32

    摘要： In certain aspects, the present disclosure relates to the insight that a polypeptide comprising a ligand-binding portion of the extracellular domain of activin-like kinase I (ALK1) polypeptide may be used to inhibit angiogenesis in vivo, particularly in mammals suffering angiogenesis-related disorders. Additionally, the disclosure demonstrates that inhibitors of ALK1 may be used to increase pericyte coverage in vascularized tissues, including tumors and the retina. The disclosure also identifies ligands for ALK1 and demonstrates that such ligands have pro-angiogenic activity, and describes antibodies that inhibit receptor-ligand interaction.

    摘要翻译： 在某些方面，本公开涉及以下认识：包含活化素样激酶I（ALK1）多肽的细胞外结构域的配体结合部分的多肽可用于抑制体内血管发生，特别是在血管生成相关的哺乳动物中 疾病 此外，本公开表明ALK1的抑制剂可用于增加血管化组织（包括肿瘤和视网膜）中的周细胞覆盖。 本公开还鉴定了ALK1的配体，并证明这些配体具有促血管生成活性，并且描述了抑制受体 - 配体相互作用的抗体。

    Method and system for managing data in storage systems
    8.
    发明授权
    Method and system for managing data in storage systems 有权
    用于管理存储系统中的数据的方法和系统

    公开(公告)号：US08135676B1

    公开(公告)日：2012-03-13

    申请号：US12111053

    申请日：2008-04-28

    申请人： Sathisha Poojary ,  Ravindra Kumar

    发明人： Sathisha Poojary ,  Ravindra Kumar

    IPC分类号： G06F17/30

    CPC分类号： G06F11/1451

    摘要： Method and system for incremental backup of data containers with fixed length records is provided. Initially, a backup application copies all stored data containers to create an initial backup container. A data structure corresponding to the first backup operation is also created. The data structure maintains unique file identifiers for each data container and information regarding when a record was added. The data structure is created and maintained by an application that also creates, updates, and modifies the fixed length records. The application updates the base data structure when records are added to a data container, after the initial backup. For a next backup operation, the initial data structure is compared to an updated data structure that is current at the next backup time. The comparison identifies the new records that were added (or updated) since the initial backup operation. The backup application then incrementally copies the new records.

    摘要翻译： 提供了具有固定长度记录的数据容器的增量备份方法和系统。 最初，备份应用程序复制所有存储的数据容器以创建初始备份容器。 还创建与第一备份操作相对应的数据结构。 数据结构为每个数据容器提供唯一的文件标识符，以及关于何时添加记录的信息。 数据结构由也创建，更新和修改固定长度记录的应用程序创建和维护。 在初始备份之后，当将记录添加到数据容器时，应用程序会更新基础数据结构。 对于下一个备份操作，将初始数据结构与在下一个备份时间当前的更新数据结构进行比较。 比较确定自初始备份操作以来添加（或更新）的新记录。 备份应用程序然后递增地复制新记录。