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公开(公告)号：US07501525B2
公开(公告)日：2009-03-10
申请号：US12012184
申请日：2008-01-31
申请人： Lydie Poitout , Valerie Brault , Carole Sackur , Pierre Roubert , Pascale Plas
发明人： Lydie Poitout , Valerie Brault , Carole Sackur , Pierre Roubert , Pascale Plas
IPC分类号： C07D235/00 , A61K31/44
CPC分类号： C07D401/04 , C07D235/30 , C07D401/06 , C07D401/12 , C07D403/06 , C07D403/12 , C07D405/12 , C07D409/12 , C07D413/12 , C07D491/10
摘要： A subject of the present Application is novel derivatives of benzimidazole and imidazo-pyridine which have a good affinity for certain sub-types of melanocortin receptors, in particular the MC4 receptors. They are particularly useful for treating pathological conditions and diseases in which one or more melanocortin receptors are involved. The invention also relates to pharmaceutical compositions containing said products.
摘要翻译： 本申请的主题是对某些亚型黑皮质素受体，特别是MC4受体具有良好亲和力的苯并咪唑和咪唑并 - 吡啶的新衍生物。 它们对于治疗涉及一种或多种黑皮质素受体的病理状况和疾病特别有用。 本发明还涉及含有所述产品的药物组合物。
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2.发明申请Pyrimido-Benzimidazole Derivatives and the Use Thereof in the Form of Agonists and Antagonists of Melanocortin Receptors 失效嘧菌胺 - 苯并咪唑衍生物及其用途以激动剂和黑皮质素受体拮抗剂的形式公开(公告)号：US20090209531A1
公开(公告)日：2009-08-20
申请号：US11571230
申请日：2005-06-22
申请人： Lydie Poitout , Carole Sackur , Valerie Brault , Pierre Roubert , Pascale Plas
发明人： Lydie Poitout , Carole Sackur , Valerie Brault , Pierre Roubert , Pascale Plas
IPC分类号： A61K31/5377 , A61K31/497 , A61K31/519 , C07D495/14
CPC分类号： C07D495/14 , C07D471/14 , C07D487/04
摘要： The invention relates to novel pyrimido-benzimidazole derivatives. Said products exhibit a good affinity for certain melanocortin receptor sub-types, in particular MC4 receptors. Said products represent a particular interest for treating pathological disorders and diseases associated with one or several melanocortin receptors. Pharmaceutical compositions containing said products and the use thereof for a drug preparation are also disclosed.
摘要翻译： 本发明涉及新颖的嘧啶并苯并咪唑衍生物。 所述产物对某些黑皮质素受体亚型，特别是MC4受体表现出良好的亲和力。 所述产品对于治疗与一种或几种黑皮质素受体相关的病理性疾病和疾病具有特别的兴趣。 还公开了含有所述产物的药物组合物及其用于药物制剂的用途。
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3.发明授权Derivatives of benzimidazole and imidazo-pyridine and their use as medicaments 失效苯并咪唑和咪唑并吡啶的衍生物及其用作药物公开(公告)号：US07501524B2
公开(公告)日：2009-03-10
申请号：US10915920
申请日：2004-08-11
申请人： Lydie Poitout , Valerie Brault , Carole Sackur , Pierre Roubert , Pascale Plas
发明人： Lydie Poitout , Valerie Brault , Carole Sackur , Pierre Roubert , Pascale Plas
IPC分类号： C07D235/00 , A61K31/44
CPC分类号： C07D401/04 , C07D235/30 , C07D401/06 , C07D401/12 , C07D403/06 , C07D403/12 , C07D405/12 , C07D409/12 , C07D413/12 , C07D491/10
摘要： A compound of the formula wherein the substituents are as defined in the specification and pharmaceutical salts thereof having a good affinity for sub-types of melanocortin receptors making them useful for treating diseases in which such receptors are included such as pain, inflammatory conditions, etc.
摘要翻译： 下式的化合物，其中取代基如本说明书中所定义，及其对于亚型黑皮质素受体具有良好亲和力的药用盐，使得它们可用于治疗其中包括此类受体的疾病，例如疼痛，炎症状况等。
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4.发明申请Novel benzimidazole and imidazopyridine derivatives and use thereof as a medicament 失效新型苯并咪唑和咪唑并吡啶衍生物及其作为药物的用途公开(公告)号：US20060281784A1
公开(公告)日：2006-12-14
申请号：US11441116
申请日：2006-05-26
申请人： Lydie Poitout , Valerie Brault , Carole Sackur , Pierre Roubert , Pascale Plas
发明人： Lydie Poitout , Valerie Brault , Carole Sackur , Pierre Roubert , Pascale Plas
IPC分类号： A61K31/4745 , A61K31/4184 , C07D471/02 , C07D235/04 , C07D405/02 , C07D403/02
CPC分类号： C07D401/04 , C07D235/12 , C07D235/18 , C07D401/06 , C07D403/06 , C07D403/10 , C07D405/04 , C07D405/06 , C07D409/04 , C07D409/06 , C07D409/12 , C07D413/04 , C07D417/04
摘要： The invention relates to novel benzimidazole and imidazopyridine derivatives having general formula (I), which have a good affinity with certain sub-types of melanocortin receptors, particularly MC4 receptors. Said derivatives are particularly suitable for the treatment of pathological states and diseases involving one or more melanocortin receptors. The invention also relates to pharmaceutical compositions containing said products.
摘要翻译： 本发明涉及具有通式（I）的新颖的苯并咪唑和咪唑并吡啶衍生物，它们与某些亚型的黑皮质素受体，特别是MC4受体具有良好的亲合力。 所述衍生物特别适用于治疗涉及一种或多种黑皮质素受体的病理状态和疾病。 本发明还涉及含有所述产品的药物组合物。
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5.发明申请Novel derivatives of benzimidazole and imidazo-pyridine and their use as medicaments 失效苯并咪唑和咪唑并吡啶的新型衍生物及其用作药物公开(公告)号：US20050065179A1
公开(公告)日：2005-03-24
申请号：US10915920
申请日：2004-08-11
申请人： Lydie Poitout , Valerie Brault , Carole Sackur , Pierre Roubert , Pascale Plas
发明人： Lydie Poitout , Valerie Brault , Carole Sackur , Pierre Roubert , Pascale Plas
IPC分类号： A61P3/04 , A61P15/10 , A61P25/22 , A61P25/24 , C07D235/30 , C07D401/04 , C07D401/06 , C07D401/12 , C07D403/06 , C07D405/12 , C07D491/10 , C07D471/02 , A61K31/4184 , A61K31/4745
CPC分类号： C07D401/04 , C07D235/30 , C07D401/06 , C07D401/12 , C07D403/06 , C07D403/12 , C07D405/12 , C07D409/12 , C07D413/12 , C07D491/10
摘要： A compound of the formula wherein the substituents are as defined in the specification and pharmaceutical salts thereof having a good affinity for sub-types of melanocortin receptors making them useful for treating diseases in which such receptors are included such as pain, inflammatory conditions, etc.
摘要翻译： 下式的化合物，其中取代基如本说明书中所定义，及其对于亚型黑皮质素受体具有良好亲和力的药用盐，使得它们可用于治疗其中包括此类受体的疾病，例如疼痛，炎症状况等。
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6.发明授权Benzimidazole and imidazopyridine derivatives and use thereof as a medicament 失效苯并咪唑和咪唑并吡啶衍生物及其作为药物的用途公开(公告)号：US07355052B2
公开(公告)日：2008-04-08
申请号：US10504033
申请日：2004-02-25
申请人： Lydie Poitout , Valerie Brault , Carole Sackur , Pierre Roubert , Pascale Plas
发明人： Lydie Poitout , Valerie Brault , Carole Sackur , Pierre Roubert , Pascale Plas
IPC分类号： C07D235/00
CPC分类号： C07D401/04 , C07D235/30 , C07D401/06 , C07D401/12 , C07D403/06 , C07D403/12 , C07D405/12 , C07D409/12 , C07D413/12 , C07D491/10
摘要： A compound of the formula wherein the substituents are as defined in the specification and pharmaceutical salts thereof having a good affinity for sub-types of melanocortin receptors making them useful for treating diseases in which such receptors are included such as pain, inflammatory conditions, etc.
摘要翻译： 下式的化合物，其中取代基如本说明书中所定义，及其对于亚型黑皮质素受体具有良好亲和力的药用盐，使得它们可用于治疗其中包括此类受体的疾病，例如疼痛，炎症状况等。
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7.发明授权Pyrimido-benzimidzole derivatives and the use thereof in the form of agonists or antagonists of melanocortin receptors 失效嘧啶亚肼基咪唑衍生物及其作为黑皮质素受体激动剂或拮抗剂形式的用途公开(公告)号：US08288395B2
公开(公告)日：2012-10-16
申请号：US12817929
申请日：2010-06-17
申请人： Lydie Poitout , Carole Sackur , Valerie Brault , Pierre Roubert , Pascale Plas
发明人： Lydie Poitout , Carole Sackur , Valerie Brault , Pierre Roubert , Pascale Plas
IPC分类号： C07D471/04 , C07D471/22 , C07D487/04 , C07D491/00 , C07D413/00
CPC分类号： C07D495/14 , C07D471/14 , C07D487/04
摘要： The invention relates to novel pyrimido-benzimidazole derivatives. Said products exhibit a good affinity for certain melanocortin receptor sub-types, in particular MC4 receptors. Said products represent a particular interest for treating pathological disorders and diseases associated with one or several melanocortin receptors. Pharmaceutical compositions containing said products and the use thereof for a drug preparation are also disclosed.
摘要翻译： 本发明涉及新颖的嘧啶并苯并咪唑衍生物。 所述产物对某些黑皮质素受体亚型，特别是MC4受体表现出良好的亲和力。 所述产品对于治疗与一种或几种黑皮质素受体相关的病理性疾病和疾病具有特别的兴趣。 还公开了含有所述产物的药物组合物及其用于药物制剂的用途。
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8.发明申请Novel derivatives of benzimidazale and imidazo-pyridine and their use as medicaments 失效苯并咪唑和咪唑并吡啶的新型衍生物及其用作药物公开(公告)号：US20080139619A1
公开(公告)日：2008-06-12
申请号：US12012184
申请日：2008-01-31
申请人： Lydie Poitout , Valerie Brault , Carole Sackur , Pierre Roubert , Pascale Plas
发明人： Lydie Poitout , Valerie Brault , Carole Sackur , Pierre Roubert , Pascale Plas
IPC分类号： A61K31/445 , A61P3/04 , C07D403/02 , A61K31/4164 , C07D235/00 , C07D401/02
CPC分类号： C07D401/04 , C07D235/30 , C07D401/06 , C07D401/12 , C07D403/06 , C07D403/12 , C07D405/12 , C07D409/12 , C07D413/12 , C07D491/10
摘要： A subject of the present application is novel derivatives of benzimidazole and imidazo-pyridine which have a good affinity for certain sub-types of melanocortin receptors, in particular the MC4 receptors. They are particularly useful for treating pathological conditions and diseases in which one or more melanocortin receptors are involved. The invention also relates to pharmaceutical compositions containing said products.
摘要翻译： 本申请的主题是对某些亚型的黑皮质素受体，特别是MC4受体具有良好亲和力的苯并咪唑和咪唑并 - 吡啶的新衍生物。 它们对于治疗涉及一种或多种黑皮质素受体的病理状况和疾病特别有用。 本发明还涉及含有所述产品的药物组合物。
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9.发明授权Benzimidazole and imidazopyridine derivatives and use thereof as a medicament 失效苯并咪唑和咪唑并吡啶衍生物及其作为药物的用途公开(公告)号：US08227485B2
公开(公告)日：2012-07-24
申请号：US11441116
申请日：2006-05-26
申请人： Lydie Poitout , Valerie Brault , Carole Sackur , Pierre Roubert , Pascale Plas
发明人： Lydie Poitout , Valerie Brault , Carole Sackur , Pierre Roubert , Pascale Plas
IPC分类号： A61K31/4745 , C07D403/02
CPC分类号： C07D401/04 , C07D235/12 , C07D235/18 , C07D401/06 , C07D403/06 , C07D403/10 , C07D405/04 , C07D405/06 , C07D409/04 , C07D409/06 , C07D409/12 , C07D413/04 , C07D417/04
摘要： The invention relates to novel benzimidazole and imidazopyridine derivatives having general formula (I), which have a good affinity with certain sub-types of melanocortin receptors, particularly MC4 receptors. Said derivatives are particularly suitable for the treatment of pathological states and diseases involving one or more melanocortin receptors. The invention also relates to pharmaceutical compositions containing said products.
摘要翻译： 本发明涉及具有通式（I）的新颖的苯并咪唑和咪唑并吡啶衍生物，它们与某些亚型的黑皮质素受体，特别是MC4受体具有良好的亲合力。 所述衍生物特别适用于治疗涉及一种或多种黑皮质素受体的病理状态和疾病。 本发明还涉及含有所述产品的药物组合物。
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10.发明授权Derivatives of benzimidazole and imidazo-pyridine and their use as medicaments 有权苯并咪唑和咪唑并吡啶的衍生物及其用作药物公开(公告)号：US07816539B2
公开(公告)日：2010-10-19
申请号：US12356964
申请日：2009-01-21
申请人： Lydie Poitout , Valerie Brault , Carole Sackur , Pierre Roubert , Pascale Plas
发明人： Lydie Poitout , Valerie Brault , Carole Sackur , Pierre Roubert , Pascale Plas
IPC分类号： C07D235/00 , A61K31/445
CPC分类号： C07D401/04 , C07D235/30 , C07D401/06 , C07D401/12 , C07D403/06 , C07D403/12 , C07D405/12 , C07D409/12 , C07D413/12 , C07D491/10
摘要： A subject of the present Application is novel derivatives of benzimidazole and imidazopyridine which have a good affinity for certain sub-types of melanocortin receptors, in particular the MC4 receptors. They are particularly useful for treating pathological conditions and diseases in which one or more melanocortin receptors are involved. The invention also relates to pharmaceutical compositions containing said products.
摘要翻译： 本申请的主题是苯并咪唑和咪唑并吡啶的新型衍生物，其对某些亚型的黑皮质素受体，特别是MC4受体具有良好的亲和力。 它们对于治疗涉及一种或多种黑皮质素受体的病理状况和疾病特别有用。 本发明还涉及含有所述产品的药物组合物。
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