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公开(公告)号：US20230028039A1
公开(公告)日：2023-01-26
申请号：US17837832
申请日：2022-06-10
申请人： Lygos, Inc.
摘要： Methods and materials related to producing D-lactic acid are disclosed. Specifically, isolated synthetic or natural nucleic acids, synthetic or natural polypeptides, host cells, and methods and materials for producing D-lactic acid by direct fermentation from carbon sources are disclosed, along with methods of preparing D-lactic acid polymers.
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公开(公告)号：US11248215B2
公开(公告)日：2022-02-15
申请号：US16595253
申请日：2019-10-07
申请人： Lygos, Inc.
摘要： Systems and methods for the production of malonate in recombinant host cells.
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公开(公告)号：US10472653B2
公开(公告)日：2019-11-12
申请号：US15627191
申请日：2017-06-19
申请人： Lygos, Inc.
摘要： Systems and methods for the production of malonate in recombinant host cells.
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公开(公告)号：US10385368B2
公开(公告)日：2019-08-20
申请号：US15321662
申请日：2015-06-24
申请人： Lygos, Inc.
发明人： Jeffrey A. Dietrich
摘要： Compositions and methods for producing malonate in recombinant host cells in order to increase malonate titer, yield, and/or productivity are provided. Recombinant host cells comprising nucleic acids encoding MAE1 transport proteins that increase production of malonate by the host cell and vectors for expressing MAE1 transport proteins that increase production of malonate by the host cell are also disclosed.
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公开(公告)号：US20160177345A1
公开(公告)日：2016-06-23
申请号：US14386272
申请日：2013-03-06
申请人： Lygos, Inc.
CPC分类号： C12P7/46 , C07C51/38 , C07C67/08 , C07C67/31 , C12N9/16 , C12Y301/02004 , C07C69/675 , C07C69/38 , C07C57/04
摘要： Systems and methods for the production of malonate in recombinant host cells.
摘要翻译： 用于在重组宿主细胞中生产丙二酸的系统和方法。
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公开(公告)号：US11597951B2
公开(公告)日：2023-03-07
申请号：US16969517
申请日：2019-02-12
申请人： Lygos, Inc.
摘要： Methods for the preparation of bio-based malonic acid and diester derivatives of malonic acid are provided. For example, a dialkyl malonate may be prepared by the steps of (i) separating calcium malonate crystals from a fermentation broth; (ii) obtaining dissolved malonic acid; (iii) crystallizing the dissolved malonic acid; and (iv) performing esterification to obtain the dialkyl malonate. The disclosed methods produce diester derivatives of malonic acid with fewer impurities, which is useful for many industrial processes. The diester derivatives of malonic acid can be purified from existing sources of malonic acid, or from malonic acid made from a renewable carbon source.
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公开(公告)号：US20220315956A1
公开(公告)日：2022-10-06
申请号：US17651720
申请日：2022-02-18
申请人： Lygos, Inc.
摘要： Provided herein are recombinant cells comprising a heterologous L-lactate dehydrogenase, and processes of preparing L-lactic acid employing such cells.
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公开(公告)号：US20220119821A1
公开(公告)日：2022-04-21
申请号：US16973270
申请日：2019-06-24
申请人： Lygos, Inc.
发明人： Jeffrey A. Dietrich , Mario Ouellet , Ee-Been Goh , Chi Le , Kelvin Shing , Drew Ross , Daniel Blackburn
IPC分类号： C12N15/52 , C12N9/06 , C12N9/10 , C12N9/88 , C12N9/00 , C12P13/06 , C12P13/20 , C12N1/02 , C12N1/20 , C12N9/02
摘要： Methods and materials related to producing aspartic acid, β-alanine and salts of each thereof are disclosed. Specifically, isolated nucleic acids, polypeptides, host cells, methods and materials for producing aspartic acid by direct fermentation from sugars are disclosed.
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9.发明申请公开(公告)号：US20210061748A1
公开(公告)日：2021-03-04
申请号：US16969866
申请日：2019-02-18
申请人： Lygos, Inc.
IPC分类号： C07C67/08 , C12P7/42 , C12N1/16 , C12N1/20 , C12N9/02 , C12N9/16 , C12N9/88 , C12N9/90 , C12N9/12
摘要： Methods and materials related to producing glyceric acid and downstream products are disclosed. Specifically, isolated nucleic acids, polypeptides, host cells, methods and materials for producing glycolic acid by direct fermentation from sugars are disclosed.
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公开(公告)号：US20240191216A1
公开(公告)日：2024-06-13
申请号：US18123840
申请日：2023-03-20
申请人： LYGOS, INC.
摘要： Systems and methods for the production of malonate in recombinant host cells.
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