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公开(公告)号：US09804295B2
公开(公告)日：2017-10-31
申请号：US11416260
申请日：2006-05-02
CPC分类号： G02B1/043 , A61K9/0051 , B29D11/00038 , B29D11/00865 , C08L29/04
摘要： The invention relates to an ophthalmic product which has a capability of delivering a guest material (e.g., a lubricant or a drug) in a time-controlled-releasing manner. The invention also provides a process for making an ophthalmic product of the invention. In addition, the invention provides a method for time-controlled delivery of a drug or a lubricant.
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公开(公告)号：US08647658B2
公开(公告)日：2014-02-11
申请号：US12229769
申请日：2008-08-27
CPC分类号： G02B1/043 , A61K9/0048 , A61L12/04 , B29D11/00067
摘要： The present invention relates to improved contact lens products which not only have initial insertion comfort but also are comfortable to wear for more than about 6 hours. The invention is achieved by packaging and storing a hydrogel lens with two or more leachable polymeric lubricants incorporated therein in a relatively viscous packaging solution including a relatively low molecular weight polyethylene glycol (PEG) and a viscosity-enhancing hydrophilic polymer. The present invention also provides methods for making contact lens products of the invention.
摘要翻译： 本发明涉及改进的隐形眼镜产品，其不仅具有初始插入舒适性，而且佩戴舒适时间超过约6小时。 本发明通过将包含两种或更多种可浸出的聚合润滑剂的水凝胶透镜包装并储存在包含相对低分子量聚乙二醇（PEG）和增粘亲水性聚合物的相对粘稠的包装溶液中来实现。 本发明还提供了制造本发明隐形眼镜产品的方法。
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公开(公告)号：US08440735B2
公开(公告)日：2013-05-14
申请号：US12834998
申请日：2010-07-13
IPC分类号： C08F2/46 , C08F290/06 , C08J3/28 , G02B1/06 , G02B1/04
摘要： The instant invention pertains to a method and a fluid composition for producing contact lenses with improved lens quality and with increased product yield. The method of the invention involves adding a phospholipid into a fluid composition including a lens-forming material in an amount sufficient to reduce an averaged mold separation force by at least about 40% in comparison with that without the phospholipids.
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公开(公告)号：US08415404B2
公开(公告)日：2013-04-09
申请号：US12794333
申请日：2010-06-04
申请人： Paul Clement Nicolson , Richard Carlton Baron , Peter Chabrecek , John Court , Angelika Domschke , Hans Jorg Griesser , Arthur Ho , Jens Hopken , Bronwyn Glenice Laycock , Qin Liu , Dieter Lohmann , Gordon Francis Meijs , Eric Papaspiliotopoulos , Judy Smith Riffle , Klaus Schindhelm , Deborah Sweeney , Wilson Leonard Terry, Jr. , Jurgen Vogt , Lynn Cook Winterton
发明人： Paul Clement Nicolson , Richard Carlton Baron , Peter Chabrecek , John Court , Angelika Domschke , Hans Jorg Griesser , Arthur Ho , Jens Hopken , Bronwyn Glenice Laycock , Qin Liu , Dieter Lohmann , Gordon Francis Meijs , Eric Papaspiliotopoulos , Judy Smith Riffle , Klaus Schindhelm , Deborah Sweeney , Wilson Leonard Terry, Jr. , Jurgen Vogt , Lynn Cook Winterton
IPC分类号： G02B1/04
CPC分类号： G02B1/043 , A61L27/26 , B29C39/42 , B29C71/00 , B29L2011/0041 , C08G18/10 , C08G18/4833 , C08G18/5015 , C08G18/61 , C08G18/672 , C08G18/8116 , C08G18/8175 , C08L43/04 , C08L75/04 , C08L51/085 , C08L2666/20 , C08L51/08 , C08L83/04 , C08L33/00 , C08G18/63 , C08G18/48
摘要： An ophthalmic lens suited for extended-wear periods of at least one day on the eye without a clinically significant amount of corneal swelling and without substantial wearer discomfort. In one embodiment, an ophthalmic lens is a copolymerization product of at least one oxyperm, at least one ionoperm, and a crosslinker. In one embodiment, a lens has a tensile modulus of less than about 3.0 MPa, yet in another embodiment, the tensile modulus is between about 0.5 to about 1.5 MPa.
摘要翻译： 一种适用于眼睛延长磨损期至少一天的眼科镜片，没有临床显着量的角膜肿胀，并且没有实质的佩戴者不适。 在一个实施方案中，眼用透镜是至少一种氧精，至少一种离子交换剂和交联剂的共聚产物。 在一个实施方案中，透镜的拉伸模量小于约3.0MPa，而在另一个实施方案中，拉伸模量为约0.5至约1.5MPa。
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公开(公告)号：US20100276823A1
公开(公告)日：2010-11-04
申请号：US12834979
申请日：2010-07-13
IPC分类号： B29D11/00
摘要： The instant invention pertains to a method and a fluid composition for producing contact lenses with improved lens quality and with increased product yield. The method of the invention involves adding a phospholipid into a fluid composition including a lens-forming material in an amount sufficient to reduce an averaged mold separation force by at least about 40% in comparison with that without the phospholipids.
摘要翻译： 本发明涉及一种用于制造具有改善的镜片质量和增加的产品产量的隐形眼镜的方法和流体组合物。 本发明的方法包括将磷脂添加到包含透镜形成材料的流体组合物中，其量足以将平均的模具分离力与没有磷脂的模具分离力相比降低至少约40％。
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公开(公告)号：US20100238398A1
公开(公告)日：2010-09-23
申请号：US12794333
申请日：2010-06-04
申请人： Paul Clement Nicolson , Richard Carlton Baron , Peter Chabrecek , John Court , Angelika Domschke , Hans Jörg Griesser , Arthur Ho , Jens Hõpken , Bronwyn Glenice Laycock , Qin Liu , Dieter Lohmann , Gordon Francis Meijs , Eric Papaspiliotopoulos , Judy Smith Riffle , Klaus Schindhelm , Deborah Sweeney , Wilson Leonard Terry, JR. , Jürgen Vogt , Lynn Cook Winterton
发明人： Paul Clement Nicolson , Richard Carlton Baron , Peter Chabrecek , John Court , Angelika Domschke , Hans Jörg Griesser , Arthur Ho , Jens Hõpken , Bronwyn Glenice Laycock , Qin Liu , Dieter Lohmann , Gordon Francis Meijs , Eric Papaspiliotopoulos , Judy Smith Riffle , Klaus Schindhelm , Deborah Sweeney , Wilson Leonard Terry, JR. , Jürgen Vogt , Lynn Cook Winterton
IPC分类号： G02C7/04
CPC分类号： G02B1/043 , A61L27/26 , B29C39/42 , B29C71/00 , B29L2011/0041 , C08G18/10 , C08G18/4833 , C08G18/5015 , C08G18/61 , C08G18/672 , C08G18/8116 , C08G18/8175 , C08L43/04 , C08L75/04 , C08L51/085 , C08L2666/20 , C08L51/08 , C08L83/04 , C08L33/00 , C08G18/63 , C08G18/48
摘要： An ophthalmic lens suited for extended-wear periods of at least one day on the eye without a clinically significant amount of corneal swelling and without substantial wearer discomfort. In one embodiment, an opthalmic lens is a copolymerization product of at least one oxyperm, at least one ionoperm, and a crosslinker. In one embodiment, a lens has a tensile modulus of less than about 3.0 MPa, yet in another embodiment, the tensile modulus is between about 0.5 to about 1.5 MPa.
摘要翻译： 一种适用于眼睛延长磨损期至少一天的眼科镜片，没有临床显着量的角膜肿胀，并且没有实质的佩戴者不适。 在一个实施方案中，眼用透镜是至少一种氧精，至少一种离子交换剂和交联剂的共聚产物。 在一个实施方案中，透镜的拉伸模量小于约3.0MPa，而在另一个实施方案中，拉伸模量为约0.5至约1.5MPa。
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公开(公告)号：US20090288369A1
公开(公告)日：2009-11-26
申请号：US12454122
申请日：2009-05-13
摘要： Biomedical devices, such as ophthalmic lenses, and methods of making such devices having a surface coating including at least one polyionic layer. A preferred method involves spray coating a polycationic material onto a core lens, rinsing and drying the lens, followed by spray coating a polyanionic material, rinsing and drying. The coating process may be applied a plurality of times to achieve a multi-layer coating on the lens surface. A particularly preferred embodiment is a contact lens comprising a highly oxygen permeable hydrophobic core coated with a 5 to 20 bilayers of hydrophilic polyionic materials.
摘要翻译： 生物医学装置，如眼科镜片，以及制造具有包括至少一个聚离子层的表面涂层的装置的方法。 优选的方法包括将聚阳离子材料喷涂到芯晶片上，漂洗和干燥晶状体，然后喷涂聚阴离子材料，冲洗和干燥。 涂覆过程可以多次施加以在透镜表面上实现多层涂层。 特别优选的实施方案是包含涂覆有5至20双亲水性聚离子材料的高透氧性疏水核心的隐形眼镜。
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公开(公告)号：US20090059165A1
公开(公告)日：2009-03-05
申请号：US12229769
申请日：2008-08-27
CPC分类号： G02B1/043 , A61K9/0048 , A61L12/04 , B29D11/00067
摘要： The present invention relates to improved contact lens products which not only have initial insertion comfort but also are comfortable to wear for more than about 6 hours. The invention is achieved by packaging and storing a hydrogel lens with two or more leachable polymeric lubricants incorporated therein in a relatively viscous packaging solution including a relatively low molecular weight polyethylene glycol (PEG) and a viscosity-enhancing hydrophilic polymer. The present invention also provides methods for making contact lens products of the invention.
摘要翻译： 本发明涉及改进的隐形眼镜产品，其不仅具有初始插入舒适性，而且佩戴舒适时间超过约6小时。 本发明通过将包含两种或更多种可浸出的聚合润滑剂的水凝胶透镜包装并储存在包含相对低分子量聚乙二醇（PEG）和增粘亲水性聚合物的相对粘稠的包装溶液中来实现。 本发明还提供了制造本发明隐形眼镜产品的方法。
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公开(公告)号：US06926965B2
公开(公告)日：2005-08-09
申请号：US10654566
申请日：2003-09-03
IPC分类号： G02C7/04 , A61F9/00 , A61L27/00 , A61L27/34 , A61L31/10 , G02B1/04 , B32B25/20 , B32B27/08 , B32B27/30
CPC分类号： A61L31/10 , A61L27/34 , G02B1/043 , Y10T428/31504 , Y10T428/31663 , Y10T428/31855 , C08L39/00
摘要： The present invention provides a medical device, preferably an ophthalmic device, more preferably a contact lens, which comprises a core material and a biocompatible LbL coating non-covalently attached to said core material. The biocompatible LbL coating comprises at least one charge/non-charge bilayer, wherein said charge/non-charge bilayer is composed of, in no particular order, one layer of a charged polymeric material and one layer of a non-charged polymeric material which is capable of being non-covalently bond to the charged polymeric material.
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公开(公告)号：US06896926B2
公开(公告)日：2005-05-24
申请号：US10654340
申请日：2003-09-03
IPC分类号： G02C7/04 , A61L27/00 , A61L27/34 , A61L29/00 , A61L31/00 , B05D1/18 , G02B1/04 , G02C13/00 , B05D1/36 , B05D1/38
摘要： The present invention provides an improved LbL-coating process for modifying the surface of a medical device, preferably an ophthalmic device, more preferably a contact lens. An LbL coating on a contact lens, which is prepared according to the process of the invention, can have increased hydrophilicity characterized by an averaged contact angle of about 80 degree or less, preferably about 50 degrees or less, while maintaining the desired bulk properties such as oxygen permeability and ion permeability of lens material.
摘要翻译： 本发明提供改进的LbL涂覆方法，用于改变医疗装置的表面，优选眼科装置，更优选隐形眼镜。 根据本发明的方法制备的隐形眼镜上的LbL涂层可以具有增强的亲水性，其特征在于约80度或更小，优选约50度或更小的平均接触角，同时保持所需的松散性 作为透镜材料的透氧性和离子透过性。
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