公开(公告)号：US11185626B2

公开(公告)日：2021-11-30

申请号：US15727015

申请日：2017-10-06

Applicant: MASSACHUSETTS INSTITUTE OF TECHNOLOGY

Inventor： Carl Magnus Schoellhammer ,  Carlo Giovanni Traverso ,  Avraham Schroeder ,  Baris Polat ,  Daniel Blankschtein ,  Robert S. Langer ,  William Brugge

IPC: A61M3/02 ,  A61M37/00 ,  A61M31/00

Abstract: Apparatus, kits, and methods for administering a substance are presented. A device for administering a substance includes an elongated body having a proximal end and a distal end, the elongated body defining an internal chamber extending between the proximal end and the distal end to direct the substance to the distal end, the distal end to connect with a tip, the tip to be at least partially inserted into an orifice of a body lumen of a subject, the tip having a shape configured to reduce leakage of the substance from the orifice upon the at least partial insertion. The tip includes an opening to pass the substance from the internal chamber into the body lumen; and a transducer to emit an ultrasound wave from the tip into the body lumen, thereby administering the substance to tissue in the body lumen.

公开(公告)号：US20190111130A1

公开(公告)日：2019-04-18

申请号：US16162060

申请日：2018-10-16

Applicant: Massachusetts Institute of Technology ,  The Brigham and Women's Hospital, Inc.

Inventor： Robert S. Langer ,  Carlo Giovanni Traverso ,  Dan Minahan ,  Taylor A. Bensel ,  Thomas von Erlach ,  Carl Magnus Schoellhammer

IPC: A61K41/00 ,  A61K9/00 ,  A61P1/00 ,  G01N1/28 ,  A61M37/00

Abstract: Disclosed herein are compositions comprising a pharmaceutical agent and an ultrasound enhancing agent. The compositions are useful in combination with ultrasound to enhance delivery of a pharmaceutical agent to, for example, tissue of a subject in need thereof. Accordingly, also provided herein are methods involving ultrasound for delivering a pharmaceutical agent to a subject, e.g., a subject that has inflammatory bowel disease or proctitis.

公开(公告)号：US20140228715A1

公开(公告)日：2014-08-14

申请号：US14116628

申请日：2012-05-14

Applicant: The General Hospital Corporation ,  Massachusetts Institute of Technology

Inventor： Avraham D. Schroeder ,  Carlo Giovanni Traverso ,  Baris E. Polat ,  Kathryn A. Whitehead ,  Daniel G. Anderson ,  Robert S. Langer, Jr. ,  Carl Magnus Schoellhammer ,  Daniel Blankschtein

IPC: A61N7/00

CPC classification number: A61N7/00 ,  A61B5/01 ,  A61B5/073 ,  A61B5/14539 ,  A61B5/14546 ,  A61B5/4839 ,  A61M31/002 ,  A61M37/0092

Abstract: A method of delivering a substance includes providing a substance at a location in a gastrointestinal (GI) tract, excluding a buccal membrane, of a biological body; and applying ultrasonic waves, having a frequency between about 20 kHz and about 10 MHz, at the location. The method can include storing the substance in at least one reservoir and exposing a medium within or of the GI tract to the substance. The method can further include delivering a device into the GI tract, the device including at least one ultrasound transducer and circuitry; powering the at least one ultrasound transducer and circuitry from within the device; and driving the at least one ultrasound transducer, using the circuitry, in a manner causing the at least one ultrasound transducer to emit ultrasonic waves to a medium within or of the GI tract.

Abstract translation: 递送物质的方法包括在生物体的胃肠（GI）道（不包括颊膜）的位置处提供物质; 并且在该位置施加具有约20kHz至约10MHz之间的频率的超声波。 该方法可以包括将物质储存在至少一个储存器中并将GI道内或介质中的介质暴露于物质。 该方法还可以包括将装置递送到胃肠道，该装置包括至少一个超声换能器和电路; 为设备内的至少一个超声换能器和电路供电; 以及使得所述至少一个超声换能器以使得所述至少一个超声换能器向胃肠道内或胃肠道内的介质发射超声波的方式来驱动所述至少一个超声换能器。

公开(公告)号：US10814115B2

公开(公告)日：2020-10-27

申请号：US13728300

申请日：2012-12-27

Applicant: MASSACHUSETTS INSTITUTE OF TECHNOLOGY ,  THE GENERAL HOSPITAL CORPORATION

Inventor： Carlo Giovanni Traverso ,  Avraham D. Schroeder ,  Baris Erinc Polat ,  Carl Magnus Schoellhammer ,  Daniel Blankschtein ,  Daniel G. Anderson ,  Robert S. Langer

IPC: A61M37/00 ,  A61M31/00 ,  A61M5/00

Abstract: The present disclosure provides devices and uses thereof. A devices disclosed herein comprises a plurality of microneedles adapted to protrude from the device. In some embodiments, a device is dimensioned and constructed to carry a payload, so that the payload can be delivered to an internal tissue of a subject or through a wall of a vessel after interaction with microneedles. In some embodiments, devices can be used for oral or intravenous administration. In some embodiments, devices can be used for implantation such as vaginal, rectal, urethral or bladder suppository or pessary.

公开(公告)号：US20130165772A1

公开(公告)日：2013-06-27

申请号：US13728300

申请日：2012-12-27

Applicant: MASSACHUSETTS INSTITUTE OF TECHNOLOGY ,  THE GENERAL HOSPITAL CORPORATION

Inventor： Carlo Giovanni Traverso ,  Avraham D. Schroeder ,  Baris Erinc Polat ,  Carl Magnus Schoellhammer ,  Daniel Blankschtein ,  Daniel G. Anderson ,  Robert S. Langer

IPC: A61M37/00 ,  A61M5/00

Abstract: The present disclosure provides devices and uses thereof A devices disclosed herein comprises a plurality of microneedles adapted to protrude from the device. In some embodiments, a device is dimensioned and constructed to carry a payload, so that the payload can be delivered to an internal tissue of a subject or through a wall of a vessel after interaction with microneedles. In some embodiments, devices can be used for oral or intravenous administration. In some embodiments, devices can be used for implantation such as vaginal, rectal, urethral or bladder suppository or pessary.

Abstract translation: 本公开提供了装置及其用途。本文公开的装置包括适于从装置突出的多个微针。 在一些实施例中，将装置的尺寸设计和构造为承载有效载荷，使得有效载荷可以在与微针相互作用之后被递送到受试者的内部组织或通过血管的壁。 在一些实施方案中，装置可用于口服或静脉内施用。 在一些实施例中，装置可用于植入，例如阴道，直肠，尿道或膀胱栓剂或子宫托。