公开(公告)号：US11833255B2

公开(公告)日：2023-12-05

申请号：US15766706

申请日：2016-10-07

Applicant: The Brigham and Women's Hospital, Inc. ,  MASSACHUSETTS INSTITUTE OF TECHNOLOGY

Inventor： Sunandini Chopra ,  Rohit Karnik ,  Amy Wang ,  Omid C. Farokhzad ,  Xue-Qing Zhang

IPC: A61K9/51 ,  A61K9/00 ,  A61K47/69 ,  A61K47/68 ,  A61P3/10 ,  A61P35/00 ,  A61K38/28

CPC classification number: A61K9/5153 ,  A61K9/0019 ,  A61K9/5138 ,  A61K9/5146 ,  A61K38/28 ,  A61K47/6803 ,  A61K47/6933 ,  A61K47/6937 ,  A61P3/10 ,  A61P35/00 ,  Y02A50/30

Abstract: Provided is a nanoparticle comprising a pH-responsive polymer, a pH-insensitive polymer and a payload molecule. The nanoparticle can act as a system for delivery of the payload that releases the payload in a pH sensitive manner.

公开(公告)号：US11726015B2

公开(公告)日：2023-08-15

申请号：US17392326

申请日：2021-08-03

Applicant: MASSACHUSETTS INSTITUTE OF TECHNOLOGY

Inventor： Emily Hanhauser ,  Michael Bono ,  Anastasios John Hart ,  Rohit Karnik ,  Xiaoyuan Ren ,  Chintan Vaishnav

IPC: G01N1/40 ,  G01N1/10 ,  B01L3/00 ,  G01N1/12 ,  G01N1/20 ,  B01D15/18 ,  B01J20/28 ,  B01J20/26 ,  B01J20/34 ,  C02F1/28 ,  C02F1/42 ,  C12Q1/6806 ,  G01N1/00 ,  C02F101/10 ,  C02F101/20

CPC classification number: G01N1/405 ,  B01D15/1892 ,  B01J20/264 ,  B01J20/2805 ,  B01J20/3425 ,  B01L3/5023 ,  C02F1/281 ,  C02F1/285 ,  C02F1/42 ,  C12Q1/6806 ,  G01N1/10 ,  G01N1/12 ,  G01N1/20 ,  G01N1/4055 ,  B01J2220/00 ,  B01L2200/028 ,  B01L2200/0631 ,  B01L2200/185 ,  B01L2300/069 ,  B01L2300/0627 ,  B01L2300/12 ,  C02F2101/103 ,  C02F2101/20 ,  C02F2303/16 ,  G01N2001/005 ,  G01N2001/4061

Abstract: A device for collecting contaminants from water samples is provided. The device includes a solid sorbent that collects and stores the contaminants from water samples. The solid sorbent is configured to allow for the preservation of the stored contaminants. The concentrations of the contaminants in the water samples are determined via analysis of the solid sorbent or via elution of the stored contaminants from the sorbent and analysis of the eluate solution.

公开(公告)号：US20210364398A1

公开(公告)日：2021-11-25

申请号：US17392326

申请日：2021-08-03

Applicant: MASSACHUSETTS INSTITUTE OF TECHNOLOGY

Inventor： Emily Hanhauser ,  Michael Bono ,  Anastasios John Hart ,  Rohit Karnik ,  Xiaoyuan Ren ,  Chintan Vaishnav

IPC: G01N1/40 ,  G01N1/10 ,  G01N1/12 ,  G01N1/20 ,  B01D15/18 ,  B01J20/28 ,  B01J20/26 ,  B01J20/34 ,  B01L3/00 ,  C02F1/28 ,  C02F1/42 ,  C12Q1/6806

Abstract: A device for collecting contaminants from water samples is provided. The device includes a solid sorbent that collects and stores the contaminants from water samples. The solid sorbent is configured to allow for the preservation of the stored contaminants. The concentrations of the contaminants in the water samples are determined via analysis of the solid sorbent or via elution of the stored contaminants from the sorbent and analysis of the eluate solution.

公开(公告)号：US09873092B2

公开(公告)日：2018-01-23

申请号：US14401799

申请日：2013-05-20

Applicant: Singapore University of Technology and Design ,  Massachusetts Institute of Technology

Inventor： Hui Ying Yang ,  Rohit Karnik

IPC: B01D71/12 ,  C02F1/44 ,  B01D61/18 ,  B01D69/14 ,  B01D71/02 ,  B82Y30/00 ,  B01D69/02 ,  B01D69/10

CPC classification number: B01D71/12 ,  B01D61/18 ,  B01D69/02 ,  B01D69/10 ,  B01D69/148 ,  B01D71/021 ,  B82Y30/00 ,  C02F1/441

Abstract: The present invention relates to a material. In particular, it relates to a membrane for filtering water. More particularly, it relates to a membrane comprising carbon nanotubes and mixed cellulose ester porous membranes for water desalination and purification. Still more particular, the membrane comprising a fibrous substrate and carbon nanotubes formed on a fibrous substrate, wherein the surface of the carbon nanotubes is functionally modified. A microfluidic device comprising such a membrane and a method for filtering water are also disclosed.

公开(公告)号：US20150265716A1

公开(公告)日：2015-09-24

申请号：US14434300

申请日：2013-10-09

Applicant: The Brigham and Women's Hospital, Inc. ,  Massachusetts Institute of Technology

Inventor： Pedro M. Valencia ,  Eric M. Pridgen ,  Suresh Gadde ,  Rohit Karnik ,  Robert S. Langer ,  Stephen J. Lippard ,  Omid C. Farokhzad

IPC: A61K47/48 ,  A61K31/4745 ,  A61K47/34 ,  A61K9/14 ,  A61K45/06 ,  A61K33/24 ,  A61K9/51

CPC classification number: A61K47/6937 ,  A61K9/14 ,  A61K9/51 ,  A61K9/5146 ,  A61K9/5153 ,  A61K31/4745 ,  A61K31/555 ,  A61K33/24 ,  A61K45/06 ,  A61K47/34 ,  A61K47/593 ,  A61K47/6869 ,  B82Y5/00 ,  A61K2300/00

Abstract: Provided herein are compositions that contain a nanoparticle containing a plurality of polymers, wherein at least a fraction of the polymers comprise a hydrophobic polymer, a topoisomerase inhibitor, and a Pt-containing chemotherapeutic agent, where the polymers self-assemble in an aqueous liquid to form the nanoparticle, and where the Pt-containing chemotherapeutic agent and the topoisomerase inhibitor are present within the hydrophobic core of the nanoparticle in a ratio of between about 24:1 to about 1:24. Also provided are methods of reducing the proliferation of a cancer cell and methods of treating cancer in a subject that include the use of these compositions. Also provided are methods of making these nanoparticles.

Abstract translation: 本文提供了含有含有多种聚合物的纳米颗粒的组合物，其中至少一部分聚合物包含疏水性聚合物，拓扑异构酶抑制剂和含Pt化学治疗剂，其中聚合物在水性液体中自组装成 形成纳米颗粒，并且其中含Pt化学治疗剂和拓扑异构酶抑制剂以约24:1至约1:24的比例存在于纳米颗粒的疏水核心内。 还提供了减少癌细胞增殖的方法和在包括使用这些组合物的受试者中治疗癌症的方法。 还提供了制备这些纳米颗粒的方法。

公开(公告)号：US11131609B2

公开(公告)日：2021-09-28

申请号：US15497761

申请日：2017-04-26

Applicant: MASSACHUSETTS INSTITUTE OF TECHNOLOGY

Inventor： Emily Hanhauser ,  Michael Bono ,  Anastasios John Hart ,  Rohit Karnik ,  Xiaoyuan Ren ,  Chintan Vaishnav

IPC: G01N1/40 ,  G01N1/10 ,  B01L3/00 ,  G01N1/12 ,  G01N1/20 ,  B01D15/18 ,  B01J20/28 ,  B01J20/26 ,  B01J20/34 ,  C02F1/28 ,  C02F1/42 ,  C12Q1/6806 ,  G01N1/00 ,  C02F101/10 ,  C02F101/20

Abstract: A device for collecting contaminants from water samples is provided. The device includes a solid sorbent that collects and stores the contaminants from water samples. The solid sorbent is configured to allow for the preservation of the stored contaminants. The concentrations of the contaminants in the water samples are determined via analysis of the solid sorbent or via elution of the stored contaminants from the sorbent and analysis of the eluate solution.

公开(公告)号：US20180318230A1

公开(公告)日：2018-11-08

申请号：US15766706

申请日：2016-10-07

Applicant: MASSACHUSETTS INSTITUTE OF TECHNOLOGY ,  The Brigham and Women's Hospital, Inc.

Inventor： Sunandini Chopra ,  Rohit Karnik ,  Amy Wang ,  Omid C. Farokhzad ,  Xue-Qing Zhang

IPC: A61K9/51 ,  A61K47/68 ,  A61K47/69 ,  A61K38/28 ,  A61P3/10 ,  A61P35/00

CPC classification number: A61K9/5153 ,  A61K9/0019 ,  A61K9/5138 ,  A61K9/5146 ,  A61K38/28 ,  A61K47/6803 ,  A61K47/6933 ,  A61K47/6937 ,  A61P3/10 ,  A61P35/00 ,  Y02A50/401 ,  Y02A50/475 ,  Y02A50/481

Abstract: Provided is a nanoparticle comprising a pH-responsive polymer, a pH-insensitive polymer and a payload molecule. The nanoparticle can act as a system for delivery of the payload that releases the payload in a pH sensitive manner.

公开(公告)号：US09931410B2

公开(公告)日：2018-04-03

申请号：US14434300

申请日：2013-10-09

Applicant: The Brigham and Women's Hospital, Inc. ,  Massachusetts Institute of Technology

Inventor： Pedro M. Valencia ,  Eric M. Pridgen ,  Suresh Gadde ,  Rohit Karnik ,  Robert S. Langer ,  Stephen J. Lippard ,  Omid C. Farokhzad

IPC: A61K47/48 ,  A61K45/06 ,  A61K31/555 ,  A61K33/24 ,  A61K9/14 ,  A61K9/51 ,  A61K31/4745 ,  A61K47/34 ,  A61K47/59 ,  A61K47/68 ,  A61K47/69 ,  B82Y5/00

CPC classification number: A61K47/6937 ,  A61K9/14 ,  A61K9/51 ,  A61K9/5146 ,  A61K9/5153 ,  A61K31/4745 ,  A61K31/555 ,  A61K33/24 ,  A61K45/06 ,  A61K47/34 ,  A61K47/593 ,  A61K47/6869 ,  B82Y5/00 ,  A61K2300/00

Abstract: Provided herein are compositions that contain a nanoparticle containing a plurality of polymers, wherein at least a fraction of the polymers comprise a hydrophobic polymer, a topoisomerase inhibitor, and a Pt-containing chemotherapeutic agent, where the polymers self-assemble in an aqueous liquid to form the nanoparticle, and where the Pt-containing chemotherapeutic agent and the topoisomerase inhibitor are present within the hydrophobic core of the nanoparticle in a ratio of between about 24:1 to about 1:24. Also provided are methods of reducing the proliferation of a cancer cell and methods of treating cancer in a subject that include the use of these compositions. Also provided are methods of making these nanoparticles.

公开(公告)号：US20170322127A1

公开(公告)日：2017-11-09

申请号：US15497761

申请日：2017-04-26

Applicant: MASSACHUSETTS INSTITUTE OF TECHNOLOGY

Inventor： Emily Hanhauser ,  Michael Bono ,  Anastasios John Hart ,  Rohit Karnik ,  Xiaoyuan Ren ,  Chintan Vaishnav

IPC: G01N1/40 ,  B01J20/34 ,  B01L3/00 ,  C02F1/28 ,  C02F1/42 ,  C12Q1/68 ,  B01J20/26 ,  G01N1/10 ,  C02F101/10 ,  G01N1/00 ,  C02F101/20

CPC classification number: G01N1/405 ,  B01J20/264 ,  B01J20/3425 ,  B01J2220/00 ,  B01L3/5023 ,  B01L2200/028 ,  B01L2200/0631 ,  B01L2200/185 ,  B01L2300/0627 ,  B01L2300/069 ,  B01L2300/12 ,  C02F1/281 ,  C02F1/285 ,  C02F1/42 ,  C02F2101/103 ,  C02F2101/20 ,  C02F2303/16 ,  C12Q1/6806 ,  G01N1/10 ,  G01N1/12 ,  G01N1/20 ,  G01N1/4055 ,  G01N2001/005 ,  G01N2001/4061

Abstract: A device for collecting contaminants from water samples is provided. The device includes a solid sorbent that collects and stores the contaminants from water samples. The solid sorbent is configured to allow for the preservation of the stored contaminants. The concentrations of the contaminants in the water samples are determined via analysis of the solid sorbent or via elution of the stored contaminants from the sorbent and analysis of the eluate solution.

公开(公告)号：US20150122735A1

公开(公告)日：2015-05-07

申请号：US14401799

申请日：2013-05-20

Applicant: Singapore University of Technology and Design ,  Massachusetts Institute of Technology

Inventor： Hui Ying Yang ,  Rohit Karnik

IPC: B01D71/12 ,  C02F1/44 ,  B01D71/02

CPC classification number: B01D71/12 ,  B01D61/18 ,  B01D69/02 ,  B01D69/10 ,  B01D69/148 ,  B01D71/021 ,  B82Y30/00 ,  C02F1/441

Abstract: The present invention relates to a material. In particular, it relates to a membrane for filtering water. More particularly, it relates to a membrane comprising carbon nanotubes and mixed cellulose ester porous membranes for water desalination and purification. Still more particular, the membrane comprising a fibrous substrate and carbon nanotubes formed on a fibrous substrate, wherein the surface of the carbon nanotubes is functionally modified. A microfluidic device comprising such a membrane and a method for filtering water are also disclosed.

Abstract translation: 本发明涉及材料。 特别涉及用于过滤水的膜。 更具体地说，本发明涉及包含碳纳米管和用于水脱盐和净化的混合纤维素酯多孔膜的膜。 更具体地，膜包含纤维基材和形成在纤维基材上的碳纳米管，其中碳纳米管的表面在功能上被改变。 还公开了包含这种膜的微流体装置和用于过滤水的方法。