公开(公告)号：US20180067102A1

公开(公告)日：2018-03-08

申请号：US15632497

申请日：2017-06-26

Applicant: MCMASTER UNIVERSITY

Inventor： Warren Foster ,  Jocelyn Wessels ,  Sanjay Agarwal ,  Leyla Soleymani

IPC: G01N33/50 ,  G01N33/53 ,  B01L3/00

CPC classification number: G01N33/5023 ,  B01L3/5023 ,  B01L2300/0819 ,  C07K16/22 ,  C12Q1/6883 ,  C12Q2600/118 ,  C12Q2600/158 ,  G01N33/53 ,  G01N33/689 ,  G01N33/74 ,  G01N2333/475 ,  G01N2800/364 ,  G01N2800/52

Abstract: Methods for diagnosing or monitoring endometriosis in a mammal are provided. The methods include the steps of determining the expression levels of BDNF, glycodelin and optionally ZAG, in a biological sample from the mammal, and determining that the mammal has endometriosis when the biomarker expression levels in the sample are elevated.

公开(公告)号：US11221327B2

公开(公告)日：2022-01-11

申请号：US15632497

申请日：2017-06-26

Applicant: MCMASTER UNIVERSITY

Inventor： Warren Foster ,  Jocelyn Wessels ,  Sanjay Agarwal ,  Leyla Soleymani

IPC: G01N33/50 ,  B01L3/00 ,  G01N33/53 ,  C07K16/22 ,  G01N33/74 ,  C12Q1/6883 ,  G01N33/68

Abstract: Methods for diagnosing or monitoring endometriosis in a mammal are provided. The methods include the steps of determining the expression levels of BDNF, glycodelin and optionally ZAG, in a biological sample from the mammal, and determining that the mammal has endometriosis when the biomarker expression levels in the sample are elevated.

公开(公告)号：US20220326222A1

公开(公告)日：2022-10-13

申请号：US17545041

申请日：2021-12-08

Applicant: MCMASTER UNIVERSITY ,  The Regents of the University of California

Inventor： Warren Foster ,  Jocelyn Wessels ,  Sanjay Agarwal ,  Leyla Soleymani

IPC: G01N33/50 ,  B01L3/00 ,  G01N33/53 ,  C07K16/22 ,  G01N33/74 ,  C12Q1/6883 ,  G01N33/68

Abstract: Methods for diagnosing or monitoring endometriosis in a mammal are provided. The methods include the steps of determining the expression levels of BDNF, glycodelin and optionally ZAG, in a biological sample from the mammal, and determining that the mammal has endometriosis when the biomarker expression levels in the sample are elevated.

公开(公告)号：US10415093B2

公开(公告)日：2019-09-17

申请号：US15094086

申请日：2016-04-08

Applicant: MCMASTER UNIVERSITY

Inventor： Warren Foster ,  Nicholas Leyland ,  Jocelyne Wessels ,  Sanjay Agarwal

IPC: G01N33/74 ,  G01N33/53 ,  C12Q1/6883 ,  C07K16/22 ,  G01N33/68

Abstract: Methods for diagnosing or monitoring endometriosis in a mammal are provided. The methods include the steps of determining the expression levels of BDNF and its receptor, Ntrk2, in a biological sample from the mammal, and determining that the mammal has endometriosis when the BDNF and Ntrk2 expression levels in the sample are elevated.

公开(公告)号：US20160281167A1

公开(公告)日：2016-09-29

申请号：US15094086

申请日：2016-04-08

Applicant: MCMASTER UNIVERSITY

Inventor： Warren Foster ,  Nicholas Leyland ,  Jocelyne Wessels ,  Sanjay Agarwal

IPC: C12Q1/68 ,  G01N33/68 ,  C07K16/22

CPC classification number: C12Q1/6883 ,  C07K16/22 ,  C12Q2600/106 ,  C12Q2600/118 ,  C12Q2600/158 ,  G01N33/6893 ,  G01N33/74 ,  G01N2333/475 ,  G01N2333/71 ,  G01N2800/364 ,  G01N2800/52 ,  G01N2800/7095

Abstract: Methods for diagnosing or monitoring endometriosis in a mammal are provided. The methods include the steps of determining the expression levels of BDNF and its receptor, Ntrk2, in a biological sample from the mammal, and determining that the mammal has endometriosis when the BDNF and Ntrk2 expression levels in the sample are elevated.

Abstract translation: 提供了用于诊断或监测哺乳动物子宫内膜异位症的方法。 所述方法包括确定来自哺乳动物的生物样品中BDNF及其受体Ntrk2的表达水平的步骤，并且当样品中的BDNF和Ntrk2表达水平升高时，确定哺乳动物具有子宫内膜异位症。