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    DIFFERENTIAL PHOTOELECTROCHEMICAL BIOSENSOR AND METHODS OF USE THEREOF
    4.
    发明申请
    DIFFERENTIAL PHOTOELECTROCHEMICAL BIOSENSOR AND METHODS OF USE THEREOF 有权

    公开(公告)号：US20220221418A1

    公开(公告)日：2022-07-14

    申请号：US17572376

    申请日：2022-01-10

    Applicant: McMaster University

    Inventor： Leyla Soleymani ,  Sudip Saha ,  Amanda Victorious

    IPC: G01N27/30 ,  G01N27/12 ,  G01N27/327 ,  G01N27/02 ,  H01G9/20

    Abstract: This disclosure relates to a biosensor, and methods of use thereof, for detecting a target in a sample comprising a photoelectrode comprising a conductive substrate and a photoactive material; a population of capture probes functionalized on the photoelectrode wherein the capture probes are capable of binding to the target and a reporter moiety; and the reporter moiety comprising a detectable label and a capture probe binding portion; wherein exposure of the target to the population of the capture probes results in binding of the target to a fraction of the population which results in a decrease in detection signal intensity compared to the intensity in the absence of the target, and subsequent binding of the reporter moiety to the remaining unbound capture probes results in an increase in detection signal intensity that is less than an increase from the reporter moiety binding to capture probes not exposed to the target.

    ELECTROCHEMICAL BIOSENSOR FOR TARGET ANALYTE DETECTION
    5.
    发明公开
    ELECTROCHEMICAL BIOSENSOR FOR TARGET ANALYTE DETECTION 审中-公开

    公开(公告)号：US20240044833A1

    公开(公告)日：2024-02-08

    申请号：US18026043

    申请日：2021-09-14

    Applicant: McMaster University

    Inventor： Leyla Soleymani ,  Sarah Traynor ,  Feng Li

    IPC: G01N27/327 ,  G01N33/53 ,  G01N33/543

    CPC classification number: G01N27/3276 ,  G01N33/5308 ,  G01N33/5438 ,  G01N27/3277

    Abstract: This disclosure relates to a biosensor for detecting a target analyte in a sample comprising: a double-stranded oligonucleotide comprising an overhang on a first strand of the oligonucleotide, and a second strand of the oligonucleotide that is a reporter moiety comprising a detectable label; a first detection probe comprising a recognition moiety and a junction forming moiety, wherein the junction forming moiety comprises a first portion capable of binding by complementarity to the overhang of the first strand of the double-stranded oligonucleotide; a second detection probe comprising a recognition moiety and a junction forming moiety, wherein the junction forming moiety comprises a first portion capable of binding by complementarity to an internal segment of the first strand of the double-stranded oligonucleotide; and a capture probe functionalized on an electrode, wherein the capture probe comprises an immobilized strand attached to the electrode. Methods and uses thereof are also disclosed herein.

    Photoelectrochemical biosensor and methods of use thereof
    6.
    发明授权
    Photoelectrochemical biosensor and methods of use thereof 有权

    公开(公告)号：US11874247B2

    公开(公告)日：2024-01-16

    申请号：US17466354

    申请日：2021-09-03

    Applicant: McMaster University

    Inventor： Leyla Soleymani ,  Sudip Saha ,  Amanda Victorious

    IPC: G01N27/30 ,  G01N27/327

    CPC classification number: G01N27/305 ,  G01N27/3276

    Abstract: Provided herein is a biosensor for detecting a target analyte in a sample comprising a first and second photoelectrode each comprising conductive substrate and photoactive material, a first and second capture probe functionalized on the first and second photoelectrode, respectively, and optionally one or more reporter moieties comprising a detectable label, wherein the first and second capture probe each, independently, provides a distance between the detectable label and the photoactive material in the presence of the target analyte, wherein intensity of detection signal dictated by the distance is generated from the first and second photoelectrode by transfer of electrons between the detectable label and the photoactive material, wherein a higher, or higher increase than in absence of sample, in the intensity of the detection signal from the first as compared to the second photoelectrode in the presence of the sample, is indicative of the presence of the target analyte.

    DEVICES FOR MANIPULATING MAGNETIC PARTICLES, AND METHODS OF FABRICATING THE DEVICES AND THE USE THEREOF
    9.
    发明申请
    DEVICES FOR MANIPULATING MAGNETIC PARTICLES, AND METHODS OF FABRICATING THE DEVICES AND THE USE THEREOF 审中-公开
    用于操作磁性颗粒的装置，以及制造装置的方法及其用途

    公开(公告)号：US20160260534A1

    公开(公告)日：2016-09-08

    申请号：US15060835

    申请日：2016-03-04

    Applicant: McMaster University

    Inventor： Leyla Soleymani ,  Seyed Mohammadamin Hosseini

    IPC: H01F7/20 ,  H01F1/01

    CPC classification number: B03C1/288 ,  B03C1/0335 ,  B03C1/286 ,  B03C2201/18 ,  B03C2201/26 ,  H01F41/308 ,  H01F2007/068

    Abstract: A device for manipulating magnetic particles, and the method of fabricating and use thereof. The device includes a substrate; a conductive element formed onto the substrate in a pattern shaped to enhance a magnetic field generated in response to an applied current; an insulating layer to isolate the conductive element from a magnetic element; and a magnetic element formed onto the insulating layer to enhance a magnetic force resulting from the magnetic field generated by the conductive element. The magnetic element can be shaped similarly to the conductive element, and edges of the magnetic element are substantially aligned with edges of the conductive element. During fabrication, the substrate and the conductive element can be heated to cause the substrate to shrink thereby resulting in a wrinkled structure at the conductive element. The device can be used to manipulate the magnetic particles within a biological sample, such as cells and/or biomolecules.

    Abstract translation: 一种用于操纵磁性颗粒的装置及其制造和使用方法。 该装置包括基板; 以形成为增强响应于所施加电流而产生的磁场的图案形成在所述基板上的导电元件; 绝缘层，用于将导电元件与磁性元件隔离; 以及形成在绝缘层上的磁性元件，以增强由导电元件产生的磁场产生的磁力。 磁性元件可以与导电元件类似地成形，并且磁性元件的边缘基本上与导电元件的边缘对准。 在制造期间，可以加热衬底和导电元件以使衬底收缩，从而在导电元件处产生起皱结构。 该装置可用于操纵生物样品（如细胞和/或生物分子）内的磁性颗粒。

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