公开(公告)号：US11918349B2

公开(公告)日：2024-03-05

申请号：US17084474

申请日：2020-10-29

Applicant: MEDTRONIC MINIMED, INC.

Inventor： Garry M. Steil ,  Sami S. Kanderian, Jr. ,  Martin T. Cantwell ,  Udo Hoss

IPC: A61B5/145 ,  A61B5/00 ,  A61B5/1486 ,  A61B5/1495 ,  A61K38/28 ,  A61M5/142 ,  A61M5/158 ,  A61M5/172 ,  G16H20/10 ,  G16H20/17 ,  G16Z99/00

CPC classification number: A61B5/14532 ,  A61B5/14865 ,  A61B5/4839 ,  A61B5/6849 ,  A61B5/7275 ,  A61K38/28 ,  A61M5/14244 ,  A61M5/1723 ,  C12Y301/01003 ,  G16H20/17 ,  G16Z99/00 ,  A61B5/1495 ,  A61M2005/14208 ,  A61M5/158 ,  A61M2005/1581 ,  A61M5/1582 ,  A61M2205/3523 ,  A61M2205/3561 ,  A61M2205/3569 ,  G16H20/10

Abstract: Disclosed herein are techniques related to model predictive control. The techniques may involve generating a desired glucose trajectory that approaches a desired steady state setpoint from a current glucose value over a prediction horizon. The techniques may involve generating a plurality of insulin delivery patterns. Each insulin delivery pattern may correspond to an amount of insulin to be delivered over a control horizon. The techniques may involve generating a plurality of predicted glucose trajectories over the control horizon. Each predicted glucose may be generated based on the current glucose value and a respective insulin delivery pattern. The techniques may involve comparing the desired glucose trajectory against each predicted glucose trajectory and selecting a predicted glucose trajectory that is more similar to the desired glucose trajectory than any other predicted glucose trajectory. The techniques may involve determining an insulin delivery pattern used to generate the selected predicted glucose trajectory.

公开(公告)号：US09440025B2

公开(公告)日：2016-09-13

申请号：US14276986

申请日：2014-05-13

Applicant: MEDTRONIC MINIMED, INC.

Inventor： Sami S. Kanderian, Jr. ,  Garry M. Steil

IPC: A61M5/172 ,  A61B5/145 ,  A61B5/1486 ,  A61M5/142 ,  A61M5/158 ,  A61B5/00

CPC classification number: A61M5/1723 ,  A61B5/14532 ,  A61B5/14539 ,  A61B5/14865 ,  A61B5/6849 ,  A61M5/14244 ,  A61M5/158 ,  A61M5/1582 ,  A61M2005/14296 ,  A61M2005/1581 ,  A61M2005/1726 ,  A61M2230/201 ,  G06F19/00

Abstract: An infusion system, which may be a closed loop infusion system or “semi-closed-loop” system, uses state variable feedback to control the rate that fluid is infused into the body of a user. The closed loop infusion system includes a sensor system, a controller, and a delivery system. The “semi-closed-loop” system further includes prompts that are displayed or sounded or otherwise provide indications to the user prior to fluid delivery. The sensor system includes a sensor for monitoring a condition of the user. The sensor produces a sensor signal, which is representative of the condition of the user. The delivery system infuses a fluid into the user at a rate dictated by the commands from the controller. The system may use three state variables, subcutaneous insulin concentration, plasma insulin concentration, and insulin effect, and corresponding gains, to calculate an additional amount of fluid to be infused as a bolus and to be removed from the basal delivery of the fluid.

Abstract translation: 可以是闭环输注系统或“半闭环”系统的输注系统使用状态变量反馈来控制流体输入到使用者体内的速率。 闭环输注系统包括传感器系统，控制器和输送系统。 “半闭环”系统还包括显示或听到的提示，或者在流体输送之前向使用者提供指示。 传感器系统包括用于监测用户状况的传感器。 传感器产生一个传感器信号，代表用户的状态。 输送系统以由控制器的命令指示的速率将流体输入到用户中。 该系统可以使用三种状态变量，皮下胰岛素浓度，血浆胰岛素浓度和胰岛素效应以及相应的增益，以计算要作为大剂量输注并从基础输送中移出的额外量的流体。

公开(公告)号：US08777924B2

公开(公告)日：2014-07-15

申请号：US13692510

申请日：2012-12-03

Applicant: Medtronic Minimed, Inc.

Inventor： Sami S. Kanderian, Jr. ,  Garry M. Steil

IPC: A61M5/172

CPC classification number: A61M5/1723 ,  A61B5/14532 ,  A61B5/14539 ,  A61B5/14865 ,  A61B5/6849 ,  A61M5/14244 ,  A61M5/158 ,  A61M5/1582 ,  A61M2005/14296 ,  A61M2005/1581 ,  A61M2005/1726 ,  A61M2230/201 ,  G06F19/00

Abstract: An infusion system, which may be a closed loop, or “semi-closed-loop”, infusion system, uses state variable feedback to control the rate at which fluid is infused into a user's body. The closed loop system includes a sensor system, a controller, and a delivery system. The “semi-closed-loop” system further includes prompts that provide indications to the user prior to fluid delivery. The sensor system includes a sensor for monitoring a condition of the user and produces a sensor signal which is representative of the user's condition. The delivery system infuses a fluid into the user at a rate dictated by the commands from the controller. The system may use three state variables, e.g., subcutaneous insulin concentration, plasma insulin concentration, and insulin effect, and corresponding gains, to calculate an additional amount of fluid to be infused with a bolus and to be removed from the basal delivery of the fluid.

Abstract translation: 可以是闭环的输注系统或“半闭环”输注系统使用状态变量反馈来控制流体注入使用者身体的速率。 闭环系统包括传感器系统，控制器和传送系统。 “半闭环”系统还包括在流体输送之前向使用者提供指示的提示。 传感器系统包括用于监视用户状况的传感器，并产生代表用户状况的传感器信号。 输送系统以由控制器的命令指示的速率将流体输入到用户中。 该系统可以使用三个状态变量，例如皮下胰岛素浓度，血浆胰岛素浓度和胰岛素效应以及相应的增益，以计算要用大剂量输注的另外量的流体，并从流体的基础输送中移除 。

公开(公告)号：US08771222B2

公开(公告)日：2014-07-08

申请号：US13688894

申请日：2012-11-29

Applicant: Medtronic Minimed, Inc.

Inventor： Sami S. Kanderian, Jr. ,  Garry M. Steil

IPC: A61M31/00

CPC classification number: A61M5/1723 ,  A61B5/14532 ,  A61B5/14539 ,  A61B5/14865 ,  A61B5/6849 ,  A61M5/14244 ,  A61M5/158 ,  A61M5/1582 ,  A61M2005/14296 ,  A61M2005/1581 ,  A61M2005/1726 ,  A61M2230/201 ,  G06F19/00

Abstract: An infusion system, which may be a closed loop infusion system or “semi-closed-loop” system, uses state variable feedback to control the rate that fluid is infused into the body of a user. The closed loop infusion system includes a sensor system, a controller, and a delivery system. The “semi-closed-loop” system further includes prompts that are displayed or sounded or otherwise provide indications to the user prior to fluid delivery. The sensor system includes a sensor for monitoring a condition of the user. The sensor produces a sensor signal, which is representative of the condition of the user. The delivery system infuses a fluid into the user at a rate dictated by the commands from the controller. The system may use three state variables, subcutaneous insulin concentration, plasma insulin concentration, and insulin effect, and corresponding gains, to calculate an additional amount of fluid to be infused as a bolus and to be removed from the basal delivery of the fluid.

Abstract translation: 可以是闭环输注系统或“半闭环”系统的输注系统使用状态变量反馈来控制流体输入到使用者体内的速率。 闭环输注系统包括传感器系统，控制器和输送系统。 “半闭环”系统还包括显示或听到的提示，或者在流体输送之前向使用者提供指示。 传感器系统包括用于监测用户状况的传感器。 传感器产生一个传感器信号，代表用户的状态。 输送系统以由控制器的命令指示的速率将流体输入到用户中。 该系统可以使用三种状态变量，皮下胰岛素浓度，血浆胰岛素浓度和胰岛素效应以及相应的增益，以计算要作为大剂量输注并从基础输送中移出的额外量的流体。

公开(公告)号：US10856786B2

公开(公告)日：2020-12-08

申请号：US16154997

申请日：2018-10-09

Applicant: MEDTRONIC MINIMED, INC.

Inventor： Garry M. Steil ,  Sami S. Kanderian, Jr. ,  Martin T. Cantwell ,  Udo Hoss

IPC: A61B5/145 ,  A61B5/1486 ,  A61B5/00 ,  A61M5/142 ,  A61M5/172 ,  A61K38/28 ,  G16H20/17 ,  A61B5/1495 ,  A61M5/158 ,  G16H20/10 ,  G06F19/00

Abstract: A system and method for controlling and monitoring a diabetes-management system through the use of a model that predicts or estimates future dynamic states of glucose and insulin from variables such as insulin delivery or exogenous glucose appearance as well as inherent physiological parameters. The model predictive estimator can be used as an insulin bolus advisor to give an apriori estimate of postprandial glucose for a given insulin delivery profile administered with a known meal to optimize insulin delivery; as a supervisor to monitor the operation of the diabetes-management system; and as a model predictive controller to optimize the automated delivery of insulin into a user's body to achieve a desired blood glucose profile or concentration. Open loop, closed-loop, and semi-closed loop embodiments of the invention utilize a mathematical metabolic model that includes a Minimal Model, a Pump Delivery to Plasma Insulin Model, and a Meal Appearance Rate Model.