公开(公告)号：US11918349B2

公开(公告)日：2024-03-05

申请号：US17084474

申请日：2020-10-29

Applicant: MEDTRONIC MINIMED, INC.

Inventor： Garry M. Steil ,  Sami S. Kanderian, Jr. ,  Martin T. Cantwell ,  Udo Hoss

IPC: A61B5/145 ,  A61B5/00 ,  A61B5/1486 ,  A61B5/1495 ,  A61K38/28 ,  A61M5/142 ,  A61M5/158 ,  A61M5/172 ,  G16H20/10 ,  G16H20/17 ,  G16Z99/00

CPC classification number: A61B5/14532 ,  A61B5/14865 ,  A61B5/4839 ,  A61B5/6849 ,  A61B5/7275 ,  A61K38/28 ,  A61M5/14244 ,  A61M5/1723 ,  C12Y301/01003 ,  G16H20/17 ,  G16Z99/00 ,  A61B5/1495 ,  A61M2005/14208 ,  A61M5/158 ,  A61M2005/1581 ,  A61M5/1582 ,  A61M2205/3523 ,  A61M2205/3561 ,  A61M2205/3569 ,  G16H20/10

Abstract: Disclosed herein are techniques related to model predictive control. The techniques may involve generating a desired glucose trajectory that approaches a desired steady state setpoint from a current glucose value over a prediction horizon. The techniques may involve generating a plurality of insulin delivery patterns. Each insulin delivery pattern may correspond to an amount of insulin to be delivered over a control horizon. The techniques may involve generating a plurality of predicted glucose trajectories over the control horizon. Each predicted glucose may be generated based on the current glucose value and a respective insulin delivery pattern. The techniques may involve comparing the desired glucose trajectory against each predicted glucose trajectory and selecting a predicted glucose trajectory that is more similar to the desired glucose trajectory than any other predicted glucose trajectory. The techniques may involve determining an insulin delivery pattern used to generate the selected predicted glucose trajectory.

公开(公告)号：US10288578B2

公开(公告)日：2019-05-14

申请号：US15851359

申请日：2017-12-21

Applicant: MEDTRONIC MINIMED, INC.

Inventor： Rajiv Shah ,  Wayne A. Morgan ,  David Y. Choy ,  James L. Henke ,  Bahar Reghabi ,  Gopikrishnan Soundararajan ,  Peter Schultz ,  Udo Hoss

IPC: G01N27/403 ,  A61B5/145 ,  G01N27/327 ,  G01N27/416 ,  A61B5/1473 ,  C12Q1/00

Abstract: A sensor system includes a sensor and a sensor electronics device. The sensor includes a plurality of electrodes. The sensor electronics device includes a connection detection device, a power source, and a delay circuit. The connection detection device determines if the sensor electronics device is connected to the sensor and transmits a connection signal. The delay circuit receives the connection signal, waits a preset hydration time, and couples the regulated voltage from the power source to an electrode in the sensor after the preset hydration time has elapsed. Alternatively, the sensor electronics device may include an electrical detection circuit and a microcontroller. The electrical detection circuit determines if the plurality of electrodes are hydrated and generates an interrupt if the electrodes are hydrated. A microcontroller receives the interrupt and transmits a signal representative of a voltage to an electrode of the plurality of electrodes.

公开(公告)号：US10420496B2

公开(公告)日：2019-09-24

申请号：US15366247

申请日：2016-12-01

Applicant: MEDTRONIC MINIMED, INC.

Inventor： Rajiv Shah ,  Bahar Reghabi ,  James L. Henke ,  Wayne A. Morgan ,  Gopikrishnan Soundararajan ,  David Y. Choy ,  Peter Schultz ,  Udo Hoss

IPC: A61B5/00 ,  A61B5/1495 ,  G01N27/327 ,  A61B5/145 ,  A61B5/1486 ,  A61M5/172

Abstract: A blood glucose sensing system includes a sensor and a sensor electronics device. The sensor includes a plurality of electrodes. The sensor electronics device includes stabilization circuitry. The stabilization circuitry causes a first voltage to be applied to one of the electrodes for a first timeframe and causes a second voltage to be applied to one of the electrodes for a second timeframe. The stabilization circuitry repeats the application of the first voltage and the second voltage to continue the anodic-cathodic cycle. The sensor electronics device may include a power supply, a regulator, and a voltage application device, where the voltage application device receives a regulated voltage from the regulator, applies a first voltage to an electrode for the first timeframe, and applies a second voltage to an electrode for the second timeframe.

公开(公告)号：US20140046154A1

公开(公告)日：2014-02-13

申请号：US14055155

申请日：2013-10-16

Applicant: MEDTRONIC MINIMED, INC.

Inventor： Rajiv Shah ,  Wayne A. Morgan ,  David Y. Choy ,  James L. Henke ,  Bahar Reghabi ,  Gopikrishnan Soundararajan ,  Peter Schultz ,  Udo Hoss

IPC: G01N27/403 ,  A61B5/1473

CPC classification number: G01N27/403 ,  A61B5/14532 ,  A61B5/1473 ,  A61B2560/0223 ,  A61B2562/02 ,  C12Q1/006 ,  G01N27/327 ,  G01N27/416

Abstract: A sensor system includes a sensor and a sensor electronics device. The sensor includes a plurality of electrodes. The sensor electronics device includes a connection detection device, a power source, and a delay circuit. The connection detection device determines if the sensor electronics device is connected to the sensor and transmits a connection signal. The delay circuit receives the connection signal, waits a preset hydration time, and couples the regulated voltage from the power source to an electrode in the sensor after the preset hydration time has elapsed. Alternatively, the sensor electronics device may include an electrical detection circuit and a microcontroller. The electrical detection circuit determines if the plurality of electrodes are hydrated and generates an interrupt if the electrodes are hydrated. A microcontroller receives the interrupt and transmits a signal representative of a voltage to an electrode of the plurality of electrodes.

公开(公告)号：US11980463B2

公开(公告)日：2024-05-14

申请号：US16534131

申请日：2019-08-07

Applicant: MEDTRONIC MINIMED, INC.

Inventor： Rajiv Shah ,  Bahar Reghabi ,  James L. Henke ,  Wayne A. Morgan ,  Gopikrishnan Soundararajan ,  David Y. Choy ,  Peter Schultz ,  Udo Hoss

IPC: A61B5/1495 ,  A61B5/00 ,  A61B5/145 ,  A61B5/1486 ,  A61M5/172 ,  G01N27/327

CPC classification number: A61B5/1495 ,  A61B5/14532 ,  A61B5/14865 ,  A61B5/4839 ,  G01N27/327 ,  G01N27/3274 ,  A61B2560/0223 ,  A61M5/1723 ,  A61M2230/201

Abstract: A blood glucose sensing system includes a sensor and a sensor electronics device. The sensor includes a plurality of electrodes. The sensor electronics device includes stabilization circuitry. The stabilization circuitry causes a first voltage to be applied to one of the electrodes for a first timeframe and causes a second voltage to be applied to one of the electrodes for a second timeframe. The stabilization circuitry repeats the application of the first voltage and the second voltage to continue the anodic—cathodic cycle. The sensor electronics device may include a power supply, a regulator, and a voltage application device, where the voltage application device receives a regulated voltage from the regulator, applies a first voltage to an electrode for the first timeframe, and applies a second voltage to an electrode for the second timeframe.

公开(公告)号：US09976978B2

公开(公告)日：2018-05-22

申请号：US15640888

申请日：2017-07-03

Applicant: MEDTRONIC MINIMED, INC.

Inventor： Rajiv Shah ,  Wayne A. Morgan ,  David Y. Choy ,  James L. Henke ,  Bahar Reghabi ,  Gopikrishnan Soundararajan ,  Peter Schultz ,  Udo Hoss

IPC: A61B5/00 ,  G01N27/403 ,  A61B5/145 ,  G01N27/327 ,  G01N27/416 ,  A61B5/1473 ,  C12Q1/00

CPC classification number: G01N27/403 ,  A61B5/14532 ,  A61B5/1473 ,  A61B2560/0223 ,  A61B2562/02 ,  C12Q1/006 ,  G01N27/327 ,  G01N27/416

Abstract: A sensor system includes a sensor and a sensor electronics device. The sensor includes a plurality of electrodes. The sensor electronics device includes a connection detection device, a power source, and a delay circuit. The connection detection device determines if the sensor electronics device is connected to the sensor and transmits a connection signal. The delay circuit receives the connection signal, waits a preset hydration time, and couples the regulated voltage from the power source to an electrode in the sensor after the preset hydration time has elapsed. Alternatively, the sensor electronics device may include an electrical detection circuit and a microcontroller. The electrical detection circuit determines if the plurality of electrodes are hydrated and generates an interrupt if the electrodes are hydrated. A microcontroller receives the interrupt and transmits a signal representative of a voltage to an electrode of the plurality of electrodes.

公开(公告)号：US09360447B2

公开(公告)日：2016-06-07

申请号：US13964591

申请日：2013-08-12

Applicant: MEDTRONIC MINIMED, INC.

Inventor： Rajiv Shah ,  Wayne A. Morgan ,  David Y. Choy ,  James L. Henke ,  Bahar Reghabi ,  Gopikrishnan Soundararajan ,  Peter Schultz ,  Udo Hoss

IPC: A61B5/00 ,  G01N27/403 ,  A61B5/145 ,  G01N27/327 ,  G01N27/416 ,  A61B5/1473

CPC classification number: G01N27/403 ,  A61B5/14532 ,  A61B5/1473 ,  A61B2560/0223 ,  A61B2562/02 ,  C12Q1/006 ,  G01N27/327 ,  G01N27/416

Abstract: A sensor system includes a sensor and a sensor electronics device. The sensor includes a plurality of electrodes. The sensor electronics device includes a connection detection device, a power source, and a delay circuit. The connection detection device determines if the sensor electronics device is connected to the sensor and transmits a connection signal. The delay circuit receives the connection signal, waits a preset hydration time, and couples the regulated voltage from the power source to an electrode in the sensor after the preset hydration time has elapsed. Alternatively, the sensor electronics device may include an electrical detection circuit and a microcontroller. The electrical detection circuit determines if the plurality of electrodes are hydrated and generates an interrupt if the electrodes are hydrated. A microcontroller receives the interrupt and transmits a signal representative of a voltage to an electrode of the plurality of electrodes.

公开(公告)号：US10856786B2

公开(公告)日：2020-12-08

申请号：US16154997

申请日：2018-10-09

Applicant: MEDTRONIC MINIMED, INC.

Inventor： Garry M. Steil ,  Sami S. Kanderian, Jr. ,  Martin T. Cantwell ,  Udo Hoss

IPC: A61B5/145 ,  A61B5/1486 ,  A61B5/00 ,  A61M5/142 ,  A61M5/172 ,  A61K38/28 ,  G16H20/17 ,  A61B5/1495 ,  A61M5/158 ,  G16H20/10 ,  G06F19/00

Abstract: A system and method for controlling and monitoring a diabetes-management system through the use of a model that predicts or estimates future dynamic states of glucose and insulin from variables such as insulin delivery or exogenous glucose appearance as well as inherent physiological parameters. The model predictive estimator can be used as an insulin bolus advisor to give an apriori estimate of postprandial glucose for a given insulin delivery profile administered with a known meal to optimize insulin delivery; as a supervisor to monitor the operation of the diabetes-management system; and as a model predictive controller to optimize the automated delivery of insulin into a user's body to achieve a desired blood glucose profile or concentration. Open loop, closed-loop, and semi-closed loop embodiments of the invention utilize a mathematical metabolic model that includes a Minimal Model, a Pump Delivery to Plasma Insulin Model, and a Meal Appearance Rate Model.

公开(公告)号：US09885684B2

公开(公告)日：2018-02-06

申请号：US14055155

申请日：2013-10-16

Applicant: MEDTRONIC MINIMED, INC.

Inventor： Rajiv Shah ,  Wayne A. Morgan ,  David Y. Choy ,  James L. Henke ,  Bahar Reghabi ,  Gopikrishnan Soundararajan ,  Peter Schultz ,  Udo Hoss

IPC: A61B5/00 ,  G01N27/403 ,  A61B5/145 ,  G01N27/327 ,  G01N27/416 ,  A61B5/1473 ,  C12Q1/00

CPC classification number: G01N27/403 ,  A61B5/14532 ,  A61B5/1473 ,  A61B2560/0223 ,  A61B2562/02 ,  C12Q1/006 ,  G01N27/327 ,  G01N27/416

Abstract: A sensor system includes a sensor and a sensor electronics device. The sensor includes a plurality of electrodes. The sensor electronics device includes a connection detection device, a power source, and a delay circuit. The connection detection device determines if the sensor electronics device is connected to the sensor and transmits a connection signal. The delay circuit receives the connection signal, waits a preset hydration time, and couples the regulated voltage from the power source to an electrode in the sensor after the preset hydration time has elapsed. Alternatively, the sensor electronics device may include an electrical detection circuit and a microcontroller. The electrical detection circuit determines if the plurality of electrodes are hydrated and generates an interrupt if the electrodes are hydrated. A microcontroller receives the interrupt and transmits a signal representative of a voltage to an electrode of the plurality of electrodes.

公开(公告)号：US09835580B2

公开(公告)日：2017-12-05

申请号：US14050231

申请日：2013-10-09

Applicant: MEDTRONIC MINIMED, INC.

Inventor： Rajiv Shah ,  Wayne A. Morgan ,  David Y. Choy ,  James L. Henke ,  Bahar Reghabi ,  Gopikrishnan Soundararajan ,  Peter Schultz ,  Udo Hoss

IPC: A61B5/00 ,  G01N27/403 ,  A61B5/145 ,  G01N27/327 ,  G01N27/416 ,  A61B5/1473 ,  C12Q1/00

CPC classification number: G01N27/403 ,  A61B5/14532 ,  A61B5/1473 ,  A61B2560/0223 ,  A61B2562/02 ,  C12Q1/006 ,  G01N27/327 ,  G01N27/416

Abstract: A sensor system includes a sensor and a sensor electronics device. The sensor includes a plurality of electrodes. The sensor electronics device includes a connection detection device, a power source, and a delay circuit. The connection detection device determines if the sensor electronics device is connected to the sensor and transmits a connection signal. The delay circuit receives the connection signal, waits a preset hydration time, and couples the regulated voltage from the power source to an electrode in the sensor after the preset hydration time has elapsed. Alternatively, the sensor electronics device may include an electrical detection circuit and a microcontroller. The electrical detection circuit determines if the plurality of electrodes are hydrated and generates an interrupt if the electrodes are hydrated. A microcontroller receives the interrupt and transmits a signal representative of a voltage to an electrode of the plurality of electrodes.