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公开(公告)号：US20170008906A1
公开(公告)日：2017-01-12
申请号：US15272669
申请日：2016-09-22
发明人： Craig A. Coburn , Steven W. Ludmerer , Kun Liu , Hao Wu , Richard Soll , Bin Zhong , Jian Zhu
IPC分类号： C07D498/04 , A61K31/4178 , A61K31/553 , A61K45/06 , A61K31/5365
CPC分类号： C07D498/04 , A61K31/4025 , A61K31/404 , A61K31/4178 , A61K31/4184 , A61K31/423 , A61K31/437 , A61K31/4439 , A61K31/4985 , A61K31/506 , A61K31/5365 , A61K31/5377 , A61K31/5383 , A61K31/553 , A61K38/05 , A61K38/06 , A61K45/06 , C07D401/14 , C07D403/12 , C07D403/14 , C07D405/12 , C07D405/14 , C07D409/14 , C07D413/14 , C07D471/04 , C07D487/04 , C07D498/10 , C07K5/06 , C07K5/08
摘要： The present invention relates to compounds of formula (I) that are useful as hepatitis C virus (HCV) NS5A inhibitors, the synthesis of such compounds, and the use of such compounds for inhibiting HCV NS5A activity, for treating or preventing HCV infections and for inhibiting HCV viral replication and/or viral production in a cell-based system.
摘要翻译： 本发明涉及可用作丙型肝炎病毒（HCV）NS5A抑制剂，这种化合物的合成以及这些化合物用于抑制HCV NS5A活性用于治疗或预防HCV感染的用途的式（I）化合物和 抑制基于细胞的系统中的HCV病毒复制和/或病毒生产。
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公开(公告)号：US09446130B2
公开(公告)日：2016-09-20
申请号：US14762929
申请日：2014-01-17
发明人： Ronald M. Kim , Jian Liu , Hao Wu , Shilan Liu , Chundao Yang , Shuling Zheng
IPC分类号： C07D487/04 , C07D473/34 , A61K31/519 , A61K31/4985 , A61P19/02 , A61K45/06 , C07D519/00
CPC分类号： A61K45/06 , A61K31/4985 , A61K31/519 , C07D473/34 , C07D487/04 , C07D519/00
摘要： The present invention provides Bruton's Tyrosine Kinase (Btk) inhibitor compounds according to Formula I or pharmaceutically acceptable salts thereof. Formula I or a pharmaceutically acceptable salt thereof or to pharmaceutical compositions comprising these compounds and to their use in therapy. In particular, the present invention relates to the use of Btk inhibitor compounds in the treatment of Btk mediated disorders.
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公开(公告)号：US20140371138A1
公开(公告)日：2014-12-18
申请号：US14473117
申请日：2014-08-29
发明人： Craig A. Coburn , John A. McCauley , Steven W. Ludmerer , Kun Liu , Joseph P. Vacca , Hao Wu , Bin Hu , Richard Soll , Fei Sun , Xinghai Wang , Man Yan , Chengren Zhang , Mingwei Zheng , Bin Zhong , Jian Zhu
IPC分类号： C07K5/08 , A61K38/05 , A61K38/06 , C07D471/04 , A61K31/437 , C07K5/06 , A61K45/06
CPC分类号： C07D498/04 , A61K31/4025 , A61K31/404 , A61K31/4178 , A61K31/4184 , A61K31/423 , A61K31/437 , A61K31/4439 , A61K31/4985 , A61K31/506 , A61K31/5365 , A61K31/5377 , A61K31/5383 , A61K31/553 , A61K38/05 , A61K38/06 , A61K45/06 , C07D401/14 , C07D403/12 , C07D403/14 , C07D405/12 , C07D405/14 , C07D409/14 , C07D413/14 , C07D471/04 , C07D487/04 , C07D498/10 , C07K5/06 , C07K5/08
摘要： The present invention relates to compounds of formula (I) that are useful as hepatitis C virus (HCV) NS5A inhibitors, the synthesis of such compounds, and the use of such compounds for inhibiting HCV NS5A activity, for treating or preventing HCV infections and for inhibiting HCV viral replication and/or viral production in a cell-based system.
摘要翻译： 本发明涉及可用作丙型肝炎病毒（HCV）NS5A抑制剂，这种化合物的合成以及这些化合物用于抑制HCV NS5A活性用于治疗或预防HCV感染的用途的式（I）化合物和 抑制基于细胞的系统中的HCV病毒复制和/或病毒生产。
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公开(公告)号：US20220356182A1
公开(公告)日：2022-11-10
申请号：US17324799
申请日：2021-05-19
发明人： Craig A. Coburn , Steven W. Ludmerer , Kun Liu , Hao Wu , Richard Soll , Bin Zhong , Jian Zhu
IPC分类号： C07D471/04 , C07D407/14 , A61K31/4985 , A61K31/4439 , A61K31/4184 , A61K31/423 , A61K31/4025 , A61K31/519 , A61K31/404 , A61K31/506 , A61K31/5377 , A61K31/427 , A61K31/4245 , A61K31/475 , A61K31/536 , A61K31/4178 , A61K31/517 , A61K31/5386 , A61K31/553 , C07D487/04 , C07D401/14 , C07D403/14 , C07D403/12 , C07D413/14 , C07D405/14 , C07D405/12 , C07D417/14 , C07D409/14 , A61K31/437
摘要： The present invention relates to compounds of formula (I) that are useful as hepatitis C virus (HCV) NS5A inhibitors, the synthesis of such compounds, and the use of such compounds for inhibiting HCV NS5A activity, for treating or preventing HCV infections and for inhibiting HCV viral replication and/or viral production in a cell-based system.
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公开(公告)号：US20200262836A1
公开(公告)日：2020-08-20
申请号：US16829878
申请日：2020-03-25
发明人： CRAIG A. COBURN , STEVEN W. LUDMERER , KUN LIU , Hao Wu , Richard Soll , Bin Zhong , Jian Zhu
IPC分类号： C07D471/04 , A61K31/437 , C07D409/14 , C07D417/14 , C07D405/12 , C07D405/14 , C07D413/14 , C07D403/12 , C07D403/14 , C07D401/14 , C07D487/04 , A61K31/553 , A61K31/5386 , A61K31/517 , A61K31/4178 , A61K31/536 , A61K31/475 , A61K31/4245 , A61K31/427 , A61K31/5377 , A61K31/506 , A61K31/404 , A61K31/519 , A61K31/4025 , A61K31/423 , A61K31/4184 , A61K31/4439 , A61K31/4985 , C07D407/14
摘要： The present invention relates to compounds of formula (I) that are useful as hepatitis C virus (HCV) NS5A inhibitors, the synthesis of such compounds, and the use of such compounds for inhibiting HCV NS5A activity, for treating or preventing HCV infections and for inhibiting HCV viral replication and/or viral production in a cell-based system.
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公开(公告)号：US10214546B2
公开(公告)日：2019-02-26
申请号：US15538971
申请日：2015-12-17
发明人： Jian Liu , Joseph A. Kozlowski , Sobhana Babu Boga , Xiaolei Gao , Deodial Guy Guiadeen , Jiaqiang Cai , Shilan Liu , Dahai Wang , Hao Wu , Chundao Yang
IPC分类号： C07D519/00 , A61K45/06 , A61K31/4985 , A61P19/02
摘要： The present invention provides Bruton's Tyrosine Kinase (Btk) inhibitor compounds according to Formula (I), or pharmaceutically acceptable salts thereof, or to pharmaceutical compositions comprising these compounds and to their use in therapy. In particular, the present invention relates to the use of Btk inhibitor compounds of Formula (I) in the treatment of Btk mediated disorders.
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7.发明授权Spiropyrrolidine beta-secretase inhibitors for the treatment of alzheimer's disease 有权用于治疗阿尔茨海默氏病的Spiropyrrolidineβ-分泌酶抑制剂公开(公告)号：US09505739B2
公开(公告)日：2016-11-29
申请号：US14518825
申请日：2014-10-20
发明人： Shawn J. Stachel , Craig A. Coburn , Thomas G. Steele , Hao Wu
IPC分类号： A61K31/55 , C07D513/20 , A61K31/438 , A61K31/445 , A61P25/28 , C07D405/14 , C07D413/14 , C07D401/06 , C07D209/96 , C07D471/10 , C07D471/20 , C07D491/10 , C07D491/20 , C07D495/10 , C07D513/10 , C07D491/107
CPC分类号： C07D401/06 , C07D209/96 , C07D471/10 , C07D471/20 , C07D491/10 , C07D491/107 , C07D491/20 , C07D495/10 , C07D513/10 , C07D513/20
摘要： The present invention is directed to spiropyrrolidine compounds of formula (I) which are inhibitors of the beta-secretase enzyme and that are useful in the treatment of diseases in which the beta-secretase enzyme is involved, such as Alzheimer's disease. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the treatment of such diseases in which the beta-secretase enzyme is involved.
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公开(公告)号：US09090661B2
公开(公告)日：2015-07-28
申请号：US14473117
申请日：2014-08-29
发明人： Craig A. Coburn , John A. McCauley , Steven W. Ludmerer , Kun Liu , Joseph P. Vacca , Hao Wu , Bin Hu , Richard Soll , Fei Sun , Xinghai Wang , Man Yan , Chengren Zhang , Mingwei Zheng , Bin Zhong , Jian Zhu
IPC分类号： A61K31/4178 , C07D405/14 , C07K5/08 , C07D401/14 , C07D403/12 , C07D403/14 , C07D405/12 , C07D409/14 , C07D413/14 , C07D471/04 , C07D487/04 , C07D498/04 , C07D498/10 , A61K31/437 , A61K38/05 , A61K38/06 , A61K45/06 , C07K5/06
CPC分类号： C07D498/04 , A61K31/4025 , A61K31/404 , A61K31/4178 , A61K31/4184 , A61K31/423 , A61K31/437 , A61K31/4439 , A61K31/4985 , A61K31/506 , A61K31/5365 , A61K31/5377 , A61K31/5383 , A61K31/553 , A61K38/05 , A61K38/06 , A61K45/06 , C07D401/14 , C07D403/12 , C07D403/14 , C07D405/12 , C07D405/14 , C07D409/14 , C07D413/14 , C07D471/04 , C07D487/04 , C07D498/10 , C07K5/06 , C07K5/08
摘要： The present invention relates to compounds of formula (I) that are useful as hepatitis C virus (HCV) NS5A inhibitors, the synthesis of such compounds, and the use of such compounds for inhibiting HCV NS5A activity, for treating or preventing HCV infections and for inhibiting HCV viral replication and/or viral production in a cell-based system.
摘要翻译： 本发明涉及可用作丙型肝炎病毒（HCV）NS5A抑制剂，这种化合物的合成以及这些化合物用于抑制HCV NS5A活性用于治疗或预防HCV感染的用途的式（I）化合物和 抑制基于细胞的系统中的HCV病毒复制和/或病毒生产。
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公开(公告)号：US11053243B2
公开(公告)日：2021-07-06
申请号：US16829878
申请日：2020-03-25
发明人： Craig A. Coburn , Steven W. Ludmerer , Kun Liu , Hao Wu , Richard Soil , Bin Zhong , Jian Zhu
IPC分类号： C07D471/04 , C07D407/14 , C07D487/04 , C07D401/14 , C07D403/14 , C07D403/12 , C07D413/14 , C07D405/14 , C07D405/12 , C07D417/14 , C07D409/14 , A61K31/4985 , A61K31/4439 , A61K31/4184 , A61K31/423 , A61K31/4025 , A61K31/519 , A61K31/404 , A61K31/506 , A61K31/5377 , A61K31/427 , A61K31/4245 , A61K31/475 , A61K31/536 , A61K31/4178 , A61K31/517 , A61K31/5386 , A61K31/553 , A61K31/437
摘要： The present invention relates to compounds of formula (I) that are useful as hepatitis C virus (HCV) NS5A inhibitors, the synthesis of such compounds, and the use of such compounds for inhibiting HCV NS5A activity, for treating or preventing HCV infections and for inhibiting HCV viral replication and/or viral production in a cell-based system.
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公开(公告)号：US09718828B2
公开(公告)日：2017-08-01
申请号：US15250978
申请日：2016-08-30
发明人： Adrianus Petrus Antonius De Man , Jan-Gerard Sterrenburg , Hans C. A. Raaijmakers , Allard Kaptein , Arthur A. Oubrie , Johannes Bernardus Maria Rewinkel , Christiaan Gerardus Johannes Maria Jans , Jacobus C. H. M. Wijkmans , Tjeerd A. Barf , Alan B. Cooper , Ronald M. Kim , Sobhana Babu Boga , Hugh Y. Zhu , Xiaolei Gao , Xin Yao , Rajan Anand , Hao Wu , Shilan Liu , Chundao Yang , Abdul-Basit Alhassan , James Wang , Younong Yu , Jian Liu , Henry M. Vaccaro
IPC分类号： C07D487/04 , C07D497/02 , C07D401/04 , C07D401/14 , C07D403/04 , C07D403/14 , A61K31/437 , A61K31/4985 , A61K31/519 , A61K31/52 , A61K31/53 , A61P19/02 , C07D519/00 , A61K45/06 , A61K31/5377 , A61K31/541 , A61K31/55 , C07D513/04 , C07D471/04
CPC分类号： C07D487/04 , A61K31/4985 , A61K31/53 , A61K31/5377 , A61K31/541 , A61K31/55 , A61K45/06 , C07D471/04 , C07D513/04 , C07D519/00
摘要： Provided are 6-5 membered fused pyridine ring compounds according to Formula (I) or pharmaceutically acceptable salts thereof, pharmaceutical compositions comprising these compounds and their use in therapy. In particular, provided is the use of 6-5 membered fused pyridine ring compounds in the treatment of Bruton's Tyrosine Kinase (Btk) mediated disorders.
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