公开(公告)号：US20220144837A1

公开(公告)日：2022-05-12

申请号：US17438479

申请日：2020-03-16

Applicant: Merck Sharp & Dohme Corp.

Inventor： Wensheng Yu ,  Joseph A. Kozlowski ,  Dane James Clausen ,  Jian Liu ,  James Fells

IPC: C07D471/22 ,  A61P31/18 ,  A61K31/4748 ,  C07D491/18 ,  C07D498/22 ,  C07D487/08 ,  A61K31/438 ,  A61K31/426 ,  A61K31/635 ,  A61K31/4418 ,  A61K31/506 ,  A61K31/685 ,  A61K31/505 ,  A61K31/4439 ,  A61K31/52 ,  A61K31/513

Abstract: The present invention relates to Compounds of Formula I and Ia and pharmaceutically acceptable salts or prodrug thereof, wherein R1, R2, X, A and B are as defined herein. The present invention also relates to compositions comprising at least one compound of Formula I or Ia, and methods of using the compounds of Formula I or Ia for treating or preventing HIV infection in a subject.

公开(公告)号：US20220089585A1

公开(公告)日：2022-03-24

申请号：US17422642

申请日：2020-01-10

Applicant: Dane James CLAUSEN ,  Joseph A. KOZLOWSKI ,  Jian LIU ,  Scott E. WOLKENBERG ,  Wensheng YU ,  Merck Sharp & Dohme Corp.

Inventor： Dane James Clausen ,  Joseph A. Kozlowski ,  Jian Liu ,  Scott E. Wolkenberg ,  Wengsheng Yu

IPC: C07D413/14 ,  C07D413/12 ,  A61K45/06 ,  A61K31/422 ,  A61K31/4709 ,  C07D417/14 ,  A61P31/18

Abstract: The present invention relates to Compounds of Formula I and pharmaceutically acceptable salts or prodrug thereof, wherein R1, R2, R3, R4, X and A are as defined herein. The present invention also relates to compositions comprising at least one compound of Formula I, and methods of using the compounds of Formula I for treating or preventing HIV infection in a subject.

公开(公告)号：US10787441B2

公开(公告)日：2020-09-29

申请号：US16094621

申请日：2017-04-17

Applicant: Merck Sharp & Dohme Corp.

Inventor： Joseph A. Kozlowski ,  Wensheng Yu ,  Bin Hu ,  Bin Zhong ,  Jinglai Hao ,  Dahai Wang ,  Zhixin Lei

IPC: A61K31/4178 ,  C07D405/14 ,  A61K38/21 ,  A61K38/19 ,  A61K45/06

Abstract: A compound of Formula (I) or (II), for treating or preventing an HCV infection in a subject.

公开(公告)号：US10738062B2

公开(公告)日：2020-08-11

申请号：US16326043

申请日：2017-08-14

Applicant: Merck Sharp & Dohme Corp.

Inventor： Wensheng Yu ,  Joseph A. Kozlowski ,  Ling Tong ,  Craig A. Coburn ,  Bin Hu ,  Bin Zhong ,  Jinglai Hao ,  Dahai Wang

IPC: C07D498/04 ,  A61K45/06 ,  A61K31/496 ,  A61K31/5365 ,  A61P31/14

Abstract: The present invention relates to novel Chromane-Substituted Tetracyclic Compounds of Formula (I) and pharmaceutically acceptable salts thereof, wherein A, A′, R2 R3, R4 and R5 are as defined herein. The present invention also relates to compositions comprising a Chromane-Substituted Tetracyclic Compound, and methods of using the Chromane-Substituted Tetracyclic Compounds for treating or preventing HCV infection in a patient.

公开(公告)号：US20180319804A1

公开(公告)日：2018-11-08

申请号：US16032715

申请日：2018-07-11

Applicant: Merck Sharp & Dohme Corp.

Inventor： Jongwon Lim ,  Xianhai Huang ,  Ronald D. Ferguson ,  Wei Zhou ,  Christopher W. Boyce ,  Phieng Siliphaivanh ,  David J. Witter ,  Milana M. Maletic ,  Joseph A. Kozlowski ,  Kevin J. Wilson

IPC: C07D487/04 ,  C07D519/00 ,  C07D471/04 ,  C07D471/14

CPC classification number: C07D487/04 ,  C07D471/04 ,  C07D471/14 ,  C07D519/00

Abstract: Disclosed are the ERK inhibitors of formula (1): and the pharmaceutically acceptable salts thereof. Also disclosed are methods of treating cancer using the compounds of formula (I).

公开(公告)号：US10759805B2

公开(公告)日：2020-09-01

申请号：US16032715

申请日：2018-07-11

Applicant: Merck Sharp & Dohme Corp.

Inventor： Jongwon Lim ,  Xianhai Huang ,  Ronald D. Ferguson ,  Wei Zhou ,  Christopher W. Boyce ,  Phieng Siliphaivanh ,  David J. Witter ,  Milana M. Maletic ,  Joseph A. Kozlowski ,  Kevin J. Wilson

IPC: C07D471/04 ,  C07D471/14 ,  C07D519/00 ,  C07D487/04

Abstract: Disclosed are the ERK inhibitors of formula (1): and the pharmaceutically acceptable salts thereof. Also disclosed are methods of treating cancer using the compounds of formula (I).

公开(公告)号：US10646494B2

公开(公告)日：2020-05-12

申请号：US16326039

申请日：2017-08-14

Applicant: Merck Sharp & Dohme Corp.

Inventor： Wensheng Yu ,  Ling Tong ,  Joseph A. Kozlowski ,  Craig A. Coburn ,  De-Yi Yang ,  Deyou Sha ,  Jae-Hun Kim ,  Michael Dwyer ,  Kartik M Keertikar ,  Bin Hu ,  Bin Zhong ,  Jinglai Hao ,  Dahai Wang

IPC: C07D498/04 ,  A61K31/5365 ,  C07D519/00 ,  C07D513/04 ,  A61K45/06 ,  A61P31/12 ,  A61P31/22 ,  A61P31/14 ,  A61K31/4995

Abstract: The present invention relates to novel Heterocycle-Substituted Tetracyclic Compounds of Formula (I): (I) and pharmaceutically acceptable salts thereof, wherein A, A′, R2 R3 and R5 are as defined herein. The present invention also relates to compositions comprising at least one Heterocycle-Substituted Tetracyclic Compound, and methods of using the Heterocycle-Substituted Tetracyclic Compounds for treating or preventing HCV infection in a patient.

公开(公告)号：US20190127355A1

公开(公告)日：2019-05-02

申请号：US16094621

申请日：2017-04-17

Applicant: Merck Sharp & Dohme Corp.

Inventor： Joseph A. Kozlowski ,  Wensheng Yu ,  Bin Hu ,  Bin Zhong ,  Jinglai Hao ,  Dahai Wang ,  Zhixin Lei

IPC: C07D405/14 ,  A61K31/4178 ,  A61K45/06

Abstract: A compound of Formula (I) or (II), for treating or preventing an HCV infection in a subject.

公开(公告)号：US10087188B2

公开(公告)日：2018-10-02

申请号：US15538902

申请日：2015-12-17

Applicant: MERCK SHARP & DOHME CORP.

Inventor： Jian Liu ,  Joseph A. Kozlowski ,  Abdul-Basit Alhassan ,  Sobhana Babu Boga ,  Xiaolei Gao ,  Deodial Guy Guiadeen ,  Jyhshing Wang ,  Wensheng Yu ,  Jiaqiang Cai ,  Shilan Liu ,  Dahai Wang ,  Hao Wu ,  Chundao Yang

IPC: C07D487/04 ,  C07D519/00 ,  A61K31/4985 ,  A61K31/5377

Abstract: The present invention provides Bruton's Tyrosine Kinase (Btk) inhibitor compounds according to Formula (I), or pharmaceutically acceptable salts thereof, or to pharmaceutical compositions comprising these compounds and to their use in therapy. In particular, the present invention relates to the use of Btk inhibitor compounds of Formula (I) in the treatment of Btk mediated disorders.

公开(公告)号：US10040805B2

公开(公告)日：2018-08-07

申请号：US15538957

申请日：2015-12-17

Applicant: MERCK SHARP & DOHME CORP.

Inventor： Jian Liu ,  Joseph A. Kozlowski ,  Xiaolei Gao ,  Deodial Guy Guiadeen ,  Shilan Liu ,  Dahai Wang

IPC: A61K31/4985 ,  C07D487/04 ,  C07D519/00

Abstract: The present invention provides Bruton's Tyrosine Kinase (Btk) inhibitor compounds according to Formula (I), or pharmaceutically acceptable salts thereof, Formula (I) or to pharmaceutical compositions comprising these compounds and to their use in therapy. In particular, the present invention relates to the use of Btk inhibitor compounds of Formula I in the treatment of Btk mediated disorders.