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1.发明申请公开(公告)号：US20180163230A1
公开(公告)日：2018-06-14
申请号：US15840764
申请日：2017-12-13
申请人： MERIAL, INC.
发明人： Michel Bublot , Teshome Mebatsion , Joyce Pritchard , Perry Linz , Aemro Kassa
IPC分类号： C12N15/869
CPC分类号： C12N15/869 , A61K39/12 , A61K39/155 , A61K39/245 , A61K39/295 , C07K14/03 , C07K14/08 , C12N7/00 , C12N2710/16311 , C12N2710/16334 , C12N2710/16343 , C12N2710/16363 , C12N2720/10034 , C12N2760/16163 , C12N2760/18134 , C12N2760/18163 , C12N2830/20 , C12N2830/50 , C12N2840/203
摘要： The present invention provides recombinant herpesvirus of turkeys (HVT) vectors that contain and express antigens of avian pathogens, compositions comprising the recombinant HVT vectors and polyvalent vaccines comprising the recombinant HVT vectors. The present invention further provides methods of vaccination against a variety of avian pathogens and method of producing the recombinant HVT vectors.
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2.发明申请公开(公告)号：US20180243398A1
公开(公告)日：2018-08-30
申请号：US15961635
申请日：2018-04-24
申请人： MERIAL INC.
发明人： Teshome Mebatsion , Aemro Kassa , Taejoong Kim
摘要： The present invention encompasses recombinant porcine reproductive and respiratory syndrome virus (PRRSV) vaccines or compositions. In particular, the invention encompasses recombinant adenovirus vectors encoding and expressing PRRSV gp2, gp3, gp4, gp5a, gp5 and/or E antigens, proteins, epitopes or immunogens. Such vaccines or compositions can be used to protect animals from PRRSV.
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公开(公告)号：US09770502B2
公开(公告)日：2017-09-26
申请号：US14682798
申请日：2015-04-09
申请人： Merial, Inc.
发明人： Michel Bublot , Teshome Mebatsion , Joyce Pritchard , Perry Linz
IPC分类号： A61K39/17 , C12N7/00 , A61K39/12 , A61K39/245 , A61K39/00 , A61K39/295
CPC分类号： A61K39/17 , A61K39/12 , A61K39/295 , A61K2039/5256 , A61K2039/53 , A61K2039/545 , A61K2039/55 , A61K2039/552 , A61K2039/70 , C12N7/00 , C12N2710/16043 , C12N2710/16334 , C12N2710/16343 , C12N2710/20034 , C12N2720/10034 , C12N2720/10071 , C12N2760/18134 , C12N2760/18171
摘要： The present invention provides recombinant Gallid herpesvirus 3 (MDV-2) vectors that contain and express antigens of avian pathogens, recombinant Gallid herpesvirus 3 (MDV-2) vectors that contain a mutated gC gene, compositions comprising the recombinant Gallid herpesvirus 3 (MDV-2) vectors, polyvalent vaccines comprising the recombinant Gallid herpesvirus 3 (MDV-2) vectors and one or more wild type viruses or recombinant vectors. The present invention further provides methods of vaccination against a variety of avian pathogens and method of producing the recombinant Gallid herpesvirus 3 (MDV-2) vectors.
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公开(公告)号：US20170087242A1
公开(公告)日：2017-03-30
申请号：US15233013
申请日：2016-08-10
申请人： MERIAL, INC.
IPC分类号： A61K39/155 , C12N7/00
CPC分类号： A61K39/155 , A61K39/12 , A61K2039/505 , A61K2039/5254 , A61K2039/5256 , A61K2039/53 , A61K2039/545 , A61K2039/70 , C07K14/005 , C12N7/00 , C12N2710/24043 , C12N2760/18222 , C12N2760/18234 , C12N2799/023
摘要： The present invention provides vectors that contain and express in vivo or in vitro one or more Hendra virus polypeptides or antigens that elicit an immune response in animal or human against Hendra virus and Nipah virus, compositions comprising said vectors and/or Hendra virus polypeptides, methods of vaccination against Hendra virus and Nipah virus, and kits for use with such methods and compositions.
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5.发明申请PRRSV minor protein-containing recombinant viral vectors and methods of making and use thereof 有权含PRRSV的次要蛋白质重组病毒载体及其制备和使用方法公开(公告)号：US20160375122A1
公开(公告)日：2016-12-29
申请号：US15190740
申请日：2016-06-23
申请人： MERIAL INC.
发明人： Teshome Mebatsion , Aemro Kassa , Taejoong Kim
CPC分类号： A61K39/12 , A61K2039/5256 , A61K2039/552 , C07K14/082 , C07K2319/03 , C12N7/00 , C12N15/86 , C12N2710/10043 , C12N2770/10034 , C12N2770/10051 , C12N2840/203
摘要： The present invention encompasses recombinant porcine reproductive and respiratory syndrome virus (PRRSV) vaccines or compositions. In particular, the invention encompasses recombinant adenovirus vectors encoding and expressing PRRSV gp2, gp3, gp4, gp5a, gp5 and/or E antigens, proteins, epitopes or immunogens. Such vaccines or compositions can be used to protect animals from PRRSV.
摘要翻译： 本发明包括重组猪繁殖与呼吸综合征病毒（PRRSV）疫苗或组合物。 特别地，本发明包括编码和表达PRRSV gp2，gp3，gp4，gp5a，gp5和/或E抗原，蛋白质，表位或免疫原的重组腺病毒载体。 这样的疫苗或组合物可用于保护动物免于PRRSV。
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6.发明申请RECOMBINANT HVT VECTORS EXPRESSING ANTIGENS OF AVIAN PATHOGENS AND USES THEREOF 有权表达AVIAN病原体抗原的重组HVT载体及其用途公开(公告)号：US20150283225A1
公开(公告)日：2015-10-08
申请号：US14747419
申请日：2015-06-23
申请人： MERIAL INC.
发明人： Michel Bublot , Teshome Mebatsion , Joyce Pritchard , Perry Linz
CPC分类号： A61K39/17 , A61K39/12 , A61K2039/5256 , A61K2039/552 , A61K2039/70 , C12N7/00 , C12N15/86 , C12N2710/16334 , C12N2710/16343 , C12N2720/10034 , C12N2720/10071 , C12N2760/18134 , C12N2760/18171 , C12N2800/22
摘要： The present invention provides recombinant herpesvirus of turkeys (HVT) vectors that contain and express antigens of avian pathogens, compositions comprising the recombinant HVT vectors, polyvalent vaccines comprising the recombinant HVT vectors and one or more wild type viruses or recombinant vectors. The present invention further provides methods of vaccination against a variety of avian pathogens and method of producing the recombinant HVT vectors.
摘要翻译： 本发明提供含有和表达禽类病原体抗原的火鸡（HVT）载体的重组疱疹病毒，包含重组HVT载体的组合物，包含重组HVT载体和一种或多种野生型病毒或重组载体的多价疫苗。 本发明进一步提供针对各种禽类病原体的疫苗接种方法和生产重组HVT载体的方法。
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公开(公告)号：US11058761B2
公开(公告)日：2021-07-13
申请号：US15789936
申请日：2017-10-20
发明人： Teshome Mebatsion , Joyce Pritchard , David Swayne
IPC分类号： A61K39/145 , C12N7/00 , A61K39/00
摘要： The present invention provides recombinant viral vectors that contain and express antigens of avian pathogens, compositions comprising the recombinant viral vectors, polyvalent vaccines comprising the recombinant viral vectors. The present invention further provides methods of vaccination against a variety of avian pathogens and method of producing the recombinant viral vectors.
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8.发明授权公开(公告)号：US10006050B2
公开(公告)日：2018-06-26
申请号：US15410588
申请日：2017-01-19
申请人： MERIAL, INC.
IPC分类号： C12N15/63 , C12N15/86 , C12N15/863 , A61K39/008 , A61K39/12 , A61K39/39 , A61K39/205 , A61K39/00
CPC分类号： C12N15/86 , A61K39/008 , A61K39/12 , A61K39/205 , A61K39/39 , A61K2039/5256 , A61K2039/53 , A61K2039/552 , A61K2039/55516 , C12N15/8633 , C12N2710/24043 , C12N2760/20134
摘要： The present invention provides vectors that contain and co-express in vivo or in vitro immunogenic polypeptides or antigens together with an OX40L polypeptide, which functions as a genetic adjuvant. Together, the immunogenic polypeptide and the OX40L polypeptide elicit an immune response in animal or human, which is greater than the immune response elicited by the immunogenic polypeptide alone. In a particular example, the invention provides vectors encoding a Rabies G immunogenic polypeptide and a canine OX40L genetic adjuvant, which vectors elicit strong immune responses in canine against rabies virus.
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公开(公告)号：US20180110852A1
公开(公告)日：2018-04-26
申请号：US15789936
申请日：2017-10-20
发明人： Teshome Mebatsion , Joyce Pritchard , David Swayne
IPC分类号： A61K39/145 , C12N7/00
CPC分类号： A61K39/145 , A61K2039/5256 , A61K2039/552 , C12N7/00 , C12N2710/16343 , C12N2760/16122 , C12N2760/16134
摘要： The present invention provides recombinant viral vectors that contain and express antigens of avian pathogens, compositions comprising the recombinant viral vectors, polyvalent vaccines comprising the recombinant viral vectors. The present invention further provides methods of vaccination against a variety of avian pathogens and method of producing the recombinant viral vectors.
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公开(公告)号：US20160220659A1
公开(公告)日：2016-08-04
申请号：US14863181
申请日：2015-09-23
申请人： MERIAL, INC.
发明人： Jean-Christophe Audonnet , Zahia Hannas-Djebbara , Teshome Mebatsion , Yu-Wei Chiang , Justin Widener , Frédéric Reynard
IPC分类号： A61K39/135 , C07K14/005 , C12N7/00
CPC分类号： A61K39/135 , A61K39/12 , A61K2039/5258 , A61K2039/545 , A61K2039/55577 , C07K14/005 , C12N7/00 , C12N2710/10043 , C12N2710/14043 , C12N2770/32123 , C12N2770/32134
摘要： The present invention encompasses FMDV vaccines or compositions. The vaccine or composition may be a vaccine or composition containing FMDV antigens. The invention also encompasses recombinant vectors encoding and expressing FMDV antigens, epitopes or immunogens which can be used to protect animals, in particular ovines, bovines, caprines, or swines, against FMDV.
摘要翻译： 本发明包括FMDV疫苗或组合物。 疫苗或组合物可以是含有FMDV抗原的疫苗或组合物。 本发明还包括编码和表达FMDV抗原，表位或免疫原的重组载体，其可用于保护动物，特别是针对FMDV的动物，特别是羊，牛，cap或猪。
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