公开(公告)号：US20190328868A1

公开(公告)日：2019-10-31

申请号：US16473393

申请日：2017-12-20

申请人： MOGAM INSTITUTE FOR BIOMEDICAL RESEARCH ,  INFECTIOUS DISEASE RESEARCH INSTITUTE

发明人： Hyo Jung NAM ,  Eun Mi KIM ,  Duck Hyang SHIN ,  Steven G. REED ,  Kang Il YOO ,  Sung Jun HONG

IPC分类号： A61K39/25 ,  A61K39/39 ,  A61P31/22 ,  G01N33/569

摘要： The present invention relates to a herpes zoster vaccine composition, which comprises glycoprotein E of Varicella zoster virus, a glucopyranosyl lipid adjuvant, and a metabolic oil, and selectively increases a cell-mediated immune reaction without having disadvantages of attenuated live vaccines, thereby exhibit high safety and a high preventive effect against herpes zoster.

公开(公告)号：US20200338180A1

公开(公告)日：2020-10-29

申请号：US16333596

申请日：2017-09-15

申请人： Infectious Disease Research Institute

发明人： Steven G. REED ,  Malcolm S. Duthie

IPC分类号： A61K39/04 ,  A61K39/39

摘要： Compositions and methods for preventing, treating and detecting leprosy are disclosed. The compositions generally comprise polypeptides comprising one or more Mycobacterium leprae antigens as well as polynucleotides encoding such polypeptides.

公开(公告)号：US20150017200A1

公开(公告)日：2015-01-15

申请号：US14286647

申请日：2014-05-23

申请人： INFECTIOUS DISEASE RESEARCH INSTITUTE

发明人： Ajay BHATIA ,  Steven G. REED

IPC分类号： C07K14/44 ,  G01N33/569 ,  C07K16/20

CPC分类号： C07K14/44 ,  A61K38/00 ,  A61K39/00 ,  C07K16/20 ,  G01N33/56905 ,  G01N33/6893 ,  Y10S435/81 ,  Y10S435/975

摘要： The present invention relates generally to a fusion protein made from a synthetic gene construct comprising of elements derived from the Leishmania antigens K26, K39, and K9. The fusion protein is particularly useful in the diagnosis of leishmaniasis, particularly visceral leishmaniasis in animals such as humans and dogs.

摘要翻译： 本发明一般涉及由包含源自利什曼原虫抗原K26，K39和K9的元件的合成基因构建体制成的融合蛋白。 融合蛋白特别可用于诊断利什曼病，特别是动物如人和狗中的内脏利什曼病。

公开(公告)号：US20170182155A1

公开(公告)日：2017-06-29

申请号：US15285378

申请日：2016-10-04

申请人： Infectious Disease Research Institute

发明人： Steven G. REED ,  Darrick CARTER

IPC分类号： A61K39/39 ,  A61K31/665 ,  A61K39/04 ,  A61K9/107

CPC分类号： A61K39/39 ,  A61K9/107 ,  A61K31/665 ,  A61K31/7016 ,  A61K39/00 ,  A61K39/04 ,  A61K39/21 ,  A61K39/235 ,  A61K39/245 ,  A61K39/275 ,  A61K2039/525 ,  A61K2039/55572 ,  A61K2039/57 ,  A61K2039/575 ,  C07H15/04 ,  C07H15/12 ,  C07H15/20

摘要： Compounds, particularly, glucopyranosyl lipid adjuvant (GLA) compounds, having the following structure (I) are provided: or a pharmaceutically acceptable salt thereof, wherein L1, L2, L3, L4, L5, L6, L7, L8, L9, L10, Y1, Y2, Y3, Y4, R1, R2, R3, R4, R5, R6, are as defined herein. Pharmaceutical compositions, vaccine compositions, and related methods for inducing or enhancing immune responses, are also provided.

公开(公告)号：US20160186158A1

公开(公告)日：2016-06-30

申请号：US14780504

申请日：2014-03-28

申请人： INFECTIOUS DISEASE RESEARCH INSTITUTE

发明人： Malcolm DUTHIE ,  Jeff GUDERIAN ,  Steven G. REED

IPC分类号： C12N9/24 ,  G01N33/569 ,  C12N9/10 ,  A61K39/008

CPC分类号： C12N9/2497 ,  A61K39/008 ,  C12N9/1007 ,  C12Y201/01041 ,  C12Y302/02001 ,  G01N33/56905 ,  G01N2333/44 ,  G01N2469/20 ,  Y02A50/41

摘要： Compositions and methods for preventing, treating and detecting leishmaniasis are disclosed. The compositions generally comprise polypeptides comprising Leishmania antigens as well as polynucleotides encoding such polypeptides.

摘要翻译： 公开了用于预防，治疗和检测利什曼病的组合物和方法。 组合物通常包含包含利什曼原虫抗原的多肽以及编码这种多肽的多核苷酸。

公开(公告)号：US20150087615A1

公开(公告)日：2015-03-26

申请号：US14256881

申请日：2014-04-18

申请人： Infectious Disease Research Institute

发明人： Shamgar BEN-ELIYAHU ,  Pini MATZNER ,  Steven G. REED

IPC分类号： A61K31/7024 ,  A61K31/138 ,  A61K31/407 ,  A61K45/06

CPC分类号： A61K31/7024 ,  A61K31/138 ,  A61K31/407 ,  A61K31/7008 ,  A61K31/7012 ,  A61K31/7016 ,  A61K45/06

摘要： Compositions comprising glucopyranosyl lipid adjuvant (GLA) and methods for reducing or preventing the formation of cancer metastasis utilizing same are provided. The compositions may be formulated for local-regional delivery. The compositions may be substantially devoid of a cancer antigen. The treatment with GLA may be combined with treatment with a COX2 inhibitor and a beta-adrenergic blocker.

摘要翻译： 提供了包含吡喃葡萄糖基脂质佐剂（GLA）的组合物和利用其减少或预防癌症转移形成的方法。 组合物可以配制用于局部 - 区域递送。 组合物可以基本上没有癌抗原。 用GLA治疗可以与COX2抑制剂和β-肾上腺素能阻滞剂联合治疗。

公开(公告)号：US20130209500A1

公开(公告)日：2013-08-15

申请号：US13791511

申请日：2013-03-08

申请人： Infectious Disease Research Institute

发明人： Steven G. REED ,  Rhea N. Coler ,  Gregory C. Ireton

IPC分类号： C07K14/35 ,  G01N33/68

CPC分类号： C07K14/35 ,  A61K39/04 ,  A61K2039/55561 ,  C07K14/285 ,  C07K2319/00 ,  G01N33/5695 ,  G01N33/68 ,  G01N2469/20 ,  Y02A50/41 ,  Y02A50/55

摘要： The present invention relates to compositions and fusion proteins containing at least two Mycobacterium sp. antigens, and polynucleotides encoding such compositions and fusion proteins. The invention also relates to methods for their use in the treatment, prevention and/or diagnosis of tuberculosis infections.

摘要翻译： 本发明涉及含有至少两种分枝杆菌属的组合物和融合蛋白。 抗原和编码这种组合物的多核苷酸和融合蛋白。 本发明还涉及其用于治疗，预防和/或诊断结核病感染的方法。

公开(公告)号：US20220396797A1

公开(公告)日：2022-12-15

申请号：US17777255

申请日：2020-11-13

申请人： INFECTIOUS DISEASE RESEARCH INSTITUTE

发明人： Malcolm S. DUTHIE ,  Steven G. REED

IPC分类号： C12N15/117 ,  A61P35/00 ,  A61K9/107

摘要： Cancer immunotherapies effective for treating tumors are disclosed. A cytosolic receptor that detects viral ribonucleic acid (RNA), retinoic-acid-inducible protein 1 (RIG-I), is activated by a synthetic double-stranded oligonucleotide pUUC Auk. In one implementation, RIG-I is activated by a single-stranded oligonucleotide agonist formulated with a squalene emulsion (SE) adjuvant. Activation of RIG-I with pUUC Auk results in slower tumor growth. Formulation with a SE adjuvant increases the ability of RIG-I agonists to slow tumor growth. The novel agonist and formulations provided herein are effective for slowing the growth of new tumors and reducing further growth of established tumors. RIG-I agonist/adjuvant formulations may be administered to a subject by any of multiple routes including intratumoral injection.

公开(公告)号：US20220017578A1

公开(公告)日：2022-01-20

申请号：US17367812

申请日：2021-07-06

申请人： Infectious Disease Research Institute

发明人： Steven G. REED ,  Rhea N. COLER ,  Gregory C. IRETON ,  Sylvie BERTHOLET

IPC分类号： C07K14/35 ,  A61K39/04 ,  C07K14/285 ,  G01N33/569 ,  G01N33/68

摘要： The present invention relates to compositions and fusion proteins containing at least two Mycobacterium sr) antigens, and polynucleotides encoding such compositions and fusion proteins, The invention also relates to methods for their use in the treatment, prevention and/or diagnosis of tuberculosis infections.

公开(公告)号：US20160324783A1

公开(公告)日：2016-11-10

申请号：US15108773

申请日：2014-12-29

申请人： INFECTIOUS DISEASE RESEARCH INSTITUTE

发明人： Christopher B. FOX ,  Thomas S. VEDVICK ,  Lucien BARNES V. ,  Ryan M. KRAMER ,  Steven G. REED

IPC分类号： A61K9/19 ,  A61K47/22 ,  A61K47/26 ,  A61K47/10 ,  A61K39/04 ,  A61K39/39

CPC分类号： A61K9/19 ,  A61K39/00 ,  A61K39/04 ,  A61K39/39 ,  A61K47/10 ,  A61K47/22 ,  A61K47/26 ,  A61K2039/552 ,  A61K2039/55511 ,  A61K2039/55572

摘要： The invention provides for thermostable lyophilized formulations, including vaccines and pharmaceutical compositions for inducing or enhancing an immune response, and methods of use thereof. The lyophilized formulations generally comprise an antigen and/or an adjuvant, a metabolizable oil, and a cake-forming excipient.

摘要翻译： 本发明提供了耐热冻干制剂，包括用于诱导或增强免疫应答的疫苗和药物组合物及其使用方法。 冻干制剂通常包含抗原和/或佐剂，可代谢的油和成饼赋形剂。