公开(公告)号：US10001478B2

公开(公告)日：2018-06-19

申请号：US14904764

申请日：2014-08-14

Applicant: MYCARTIS NV

Inventor： Raphael Tornay ,  Patrick Van Den Bogaard ,  Nicolas Demierre ,  Didier Falconnet

IPC: G01N21/75 ,  G01N33/543 ,  B01L3/00

CPC classification number: G01N33/54386 ,  B01J2219/00536 ,  B01J2219/00556 ,  B01J2219/0056 ,  B01J2219/00612 ,  B01J2219/00637 ,  B01J2219/00693 ,  B01J2219/00725 ,  B01J2219/0074 ,  B01L3/502761 ,  B01L2200/0647 ,  B01L2300/021 ,  B01L2300/0636 ,  B01L2300/0819 ,  B01L2300/0832

Abstract: The present invention relates to a microcarrier comprising at least a detection surface for performing an assay, said detection surface comprising a first area being functionalized with a first functional group for detecting at least a chemical and/or biological interaction, said first area being designed for providing a first signal. The microcarrier is characterized in that the detection surface further comprises a second area being designed for providing a second signal different from the first signal, said second signal being emitted during the assay. Thus, information about the presence of the at least a chemical and/or biological interaction is provided by a comparison of the first signal and the second signal.

公开(公告)号：US20150141281A1

公开(公告)日：2015-05-21

申请号：US14413314

申请日：2013-07-10

Applicant: MYCARTIS NV

Inventor： Raphael Tornay ,  Nicolas Demierre ,  Jose De Gil ,  Robin Muller ,  Didier Falconnet

IPC: G01N33/543

CPC classification number: G01N33/54313 ,  B01L3/502761 ,  B01L2200/0668 ,  B01L2400/086 ,  G01N33/54366 ,  G01N33/54373 ,  Y10T436/2575

Abstract: The present invention relates to a method for performing a chemical and/or a biological assay comprising the following successive steps of: a) providing an assay device with a microchannel having an inlet and an outlet and further comprising restricting means designed to restrict the movement toward the outlet of microparticles introduced in the microchannel while letting a fluid to flow through the restricting means, b) introducing microparticles in the microchannel via the inlet, c) restricting the movement of said microparticles in the microchannel toward the outlet using restricting means, d) flowing a fluid sample through the microchannel, e) performing a biological and/or chemical read-out on each microparticle, the method further comprising the steps of: f) moving the microparticles in the microchannel, and g) repeating successively the steps d) and e).

Abstract translation: 本发明涉及一种用于进行化学和/或生物测定的方法，包括以下连续步骤：a）提供具有入口和出口的微通道的测定装置，并且还包括限制装置， 在使流体流过所述限制装置的同时引入微通道的出口，b）通过所述入口将微粒引入所述微通道中，c）使用限制装置限制所述微通道中所述微粒向所述出口的移动; d） 流体样品通过微通道，e）对每个微粒进行生物和/或化学读出，所述方法还包括以下步骤：f）移动微通道中的微粒，并且g）连续重复步骤d） 和e）。

公开(公告)号：US09625455B2

公开(公告)日：2017-04-18

申请号：US14413314

申请日：2013-07-10

Applicant: MYCARTIS NV

Inventor： Raphael Tornay ,  Nicolas Demierre ,  Jose De Gil ,  Robin Muller ,  Didier Falconnet

IPC: G01N33/543 ,  B01L3/00

CPC classification number: G01N33/54313 ,  B01L3/502761 ,  B01L2200/0668 ,  B01L2400/086 ,  G01N33/54366 ,  G01N33/54373 ,  Y10T436/2575

Abstract: A method for performing a chemical and/or a biological assay including the following successive steps of: a) providing an assay device with a microchannel having an inlet and an outlet and restricting means for restricting movement toward the outlet of microparticles introduced in the microchannel while letting a fluid to flow through the restricting means, b) introducing microparticles in the microchannel via the inlet, c) restricting the movement of said microparticles in the microchannel toward the outlet using the restricting means, d) flowing a fluid sample through the microchannel, and e) performing a biological and/or chemical read-out on each microparticle. The method also includes the steps of: f) moving the microparticles in the microchannel, and g) repeating successively the steps d) and e).