公开(公告)号：US11732298B2

公开(公告)日：2023-08-22

申请号：US16416856

申请日：2019-05-20

Applicant: Ultima Genomics, Inc.

Inventor： Gilad Almogy ,  Kristopher Barbee ,  Nathan Beckett

IPC: C12Q1/6874 ,  C12Q1/6809 ,  C12Q1/6825 ,  B01J19/00 ,  B01L3/00 ,  G01N33/543 ,  C12Q1/6834

CPC classification number: C12Q1/6874 ,  B01J19/0046 ,  B01L3/50273 ,  B01L3/502715 ,  C12Q1/6809 ,  C12Q1/6825 ,  B01J2219/00536 ,  B01J2219/00596 ,  B01J2219/00605 ,  B01J2219/00689 ,  B01J2219/00702 ,  B01J2219/00722 ,  B01L3/5023 ,  B01L2200/026 ,  B01L2200/0647 ,  B01L2300/0654 ,  B01L2400/0409 ,  C12Q1/6834 ,  G01N33/54366 ,  C12Q1/6874 ,  C12Q2565/629 ,  C12Q1/6834 ,  C12Q2565/629

Abstract: Provided are methods for biological sample processing and analysis. A method can comprise providing a substrate configured to rotate. The substrate can comprise an array having immobilized thereto a biological analyte. A solution comprising a plurality of probes may be directed, via centrifugal force, across the substrate during rotation of the substrate, to couple at least one of the plurality of probes with the biological analyte. A detector can be configured to detect a signal from the at least one probe coupled to the biological analyte, thereby analyzing the biological analyte.

公开(公告)号：US20150298089A1

公开(公告)日：2015-10-22

申请号：US14582122

申请日：2014-12-23

Applicant: Ian Hunter ,  Colin J.H. Brenan ,  Tanya S. Kanigan

Inventor： Ian Hunter ,  Colin J.H. Brenan ,  Tanya S. Kanigan

IPC: B01J19/00 ,  C12Q1/34 ,  G01N21/75

CPC classification number: B01J19/0046 ,  B01F13/0071 ,  B01F13/0084 ,  B01J2219/00313 ,  B01J2219/00317 ,  B01J2219/00351 ,  B01J2219/00533 ,  B01J2219/00536 ,  B01J2219/00549 ,  B01J2219/00585 ,  B01J2219/00599 ,  B01L3/5025 ,  B01L3/5085 ,  B01L3/50857 ,  B01L2200/0642 ,  C12Q1/34 ,  C40B60/14 ,  C40B70/00 ,  G01N21/75 ,  G01N35/00069 ,  G01N35/1002 ,  G01N2035/00237 ,  Y10T436/11 ,  Y10T436/112499 ,  Y10T436/25

Abstract: A method and an array filling system for loading a plurality of disparate sample containers, the sample containers comprising an integral structure. Each receptacle is characterized by a hydrophilic surface,, and the receptacles are separated by a hydrophobic surface. The system has a liquid transfer device capable of holding liquid and adapted for motion to cause sequential communication of liquid held in the liquid transfer device with successive receptacles of the array by dragging the liquid across the hydrophobic surface.

Abstract translation: 一种用于装载多个不同样本容器的方法和阵列填充系统，所述样本容器包括整体结构。 每个容器的特征在于亲水表面，并且容器由疏水表面分开。 该系统具有能够保持液体并适于运动的液体转移装置，以通过将液体拖过疏水表面而使保持在液体转移装置中的液体与阵列的连续容器顺序连通。

公开(公告)号：US09040762B2

公开(公告)日：2015-05-26

申请号：US14517524

申请日：2014-10-17

Applicant: Siluria Technologies, Inc.

Inventor： Joel M. Cizeron ,  Erik C. Scher ,  Fabio R. Zurcher ,  Wayne P. Schammel ,  Greg Nyce ,  Anja Rumplecker ,  Jarod McCormick ,  Marian Alcid ,  Joel Gamoras ,  Daniel Rosenberg ,  Erik-Jan Ras

IPC: C07C1/00 ,  C07C2/00 ,  C07C4/00 ,  C07C5/00 ,  C07C6/00 ,  C07C5/327 ,  C07C5/373 ,  B01J23/00 ,  B01J23/10 ,  C07C2/84

CPC classification number: C07C2/84 ,  B01J19/0046 ,  B01J21/066 ,  B01J21/08 ,  B01J23/002 ,  B01J23/10 ,  B01J23/34 ,  B01J23/54 ,  B01J23/63 ,  B01J23/76 ,  B01J23/83 ,  B01J23/8892 ,  B01J27/16 ,  B01J35/0006 ,  B01J37/031 ,  B01J37/035 ,  B01J2219/00527 ,  B01J2219/00536 ,  B01J2219/00702 ,  B01J2219/00747 ,  B01J2523/00 ,  C07C2521/10 ,  C07C2521/14 ,  C07C2523/10 ,  C07C2523/18 ,  C07C2523/34 ,  C07C2529/072 ,  C07C2529/076 ,  C07C2529/89 ,  Y02P20/52 ,  B01J2523/24 ,  B01J2523/3706 ,  B01J2523/3725 ,  B01J2523/3712 ,  B01J2523/54 ,  B01J2523/23 ,  B01J2523/11 ,  B01J2523/22 ,  B01J2523/305 ,  B01J2523/72 ,  B01J2523/845 ,  B01J2523/12 ,  B01J2523/69 ,  C07C11/04

Abstract: Metal oxide catalysts comprising various dopants are provided. The catalysts are useful as heterogenous catalysts in a variety of catalytic reactions, for example, the oxidative coupling of methane to C2 hydrocarbons such as ethane and ethylene. Related methods for use and manufacture of the same are also disclosed.

Abstract translation: 提供了包含各种掺杂剂的金属氧化物催化剂。 催化剂可用作各种催化反应中的异质催化剂，例如甲烷与C 2烃如乙烷和乙烯的氧化偶联。 还公开了相关的使用和制造方法。

公开(公告)号：US20130171832A1

公开(公告)日：2013-07-04

申请号：US13338507

申请日：2011-12-28

Applicant: Wayne French

Inventor： Wayne French

IPC: H01L21/18 ,  B05B1/00

CPC classification number: C23C16/45574 ,  B01J2219/00443 ,  B01J2219/00536 ,  B01J2219/00756 ,  C23C16/04 ,  C23C16/45519 ,  C23C16/45544 ,  C23C16/45565

Abstract: An apparatus and method for delivering fluids to a semiconductor chamber for combinatorial processing is provided. In some embodiments the apparatus is comprised of a showerhead assembly having a plurality of processing sectors separated by a purge member. The processing sectors are configured to receive one or more processing fluids for combinatorial processing on a substrate. The processing sectors are isolated by a purge fluid conveyed through the purge member. The purge member is configured to selectively control the profile of the purge fluid to enhance isolation of the processing fluids within each sector. The profile of the purge fluid is manipulated by selectively controlling the shape and/or density of the purge curtain, independently between each processing sector.

Abstract translation: 提供了用于将流体输送到半导体室用于组合处理的装置和方法。 在一些实施例中，装置包括具有由吹扫构件隔开的多个处理扇区的喷头组件。 处理扇区被配置为在衬底上接收用于组合处理的一个或多个处理流体。 处理扇区由通过吹扫构件输送的吹扫流体隔离。 吹扫构件构造成选择性地控制吹扫流体的轮廓以增强每个扇区内的处理流体的隔离。 通过在每个处理扇区之间独立地选择性地控制吹扫帘的形状和/或密度来操纵吹扫流体的轮廓。

公开(公告)号：US08387563B2

公开(公告)日：2013-03-05

申请号：US13372729

申请日：2012-02-14

Applicant: Rick Endo ,  Jeremy Cheng ,  Indranil De ,  James Tsung ,  Kurt Weiner ,  Maosheng Zhao

Inventor： Rick Endo ,  Jeremy Cheng ,  Indranil De ,  James Tsung ,  Kurt Weiner ,  Maosheng Zhao

IPC: H01L21/31 ,  C23C16/458 ,  C23C16/50 ,  B65H1/00

CPC classification number: H01L21/32051 ,  B01J19/0046 ,  B01J2219/0043 ,  B01J2219/00536 ,  B01J2219/00596 ,  B01J2219/00659 ,  B01J2219/00745 ,  B01J2219/00756 ,  C23C14/042 ,  C23C14/50 ,  C23C14/548 ,  C23C16/45544 ,  H01L21/67005 ,  H01L21/6719

Abstract: A combinatorial processing chamber is provided. The combinatorial processing chamber is configured to isolate a radial portion of a rotatable substrate support, which in turn is configured to support a substrate. The chamber includes a plurality of clusters process heads in one embodiment. An insert having a base plate disposed between the substrate support and the process heads defines a confinement region for a deposition process in one embodiment. The base plate has an opening to enable access of the deposition material to the substrate. Through rotation of the substrate and movement of the opening, multiple regions of the substrate are accessible for performing combinatorial processing on a single substrate.

公开(公告)号：US08277888B2

公开(公告)日：2012-10-02

申请号：US13332104

申请日：2011-12-20

Applicant: Jay Brian Dedontney

Inventor： Jay Brian Dedontney

IPC: C23C16/455 ,  C23C16/44 ,  C23F1/00 ,  H01L21/306 ,  C23C16/06 ,  C23C16/22

CPC classification number: C23C16/45565 ,  B01J19/0046 ,  B01J2219/0036 ,  B01J2219/00376 ,  B01J2219/00418 ,  B01J2219/00443 ,  B01J2219/00495 ,  B01J2219/00536 ,  B01J2219/00603 ,  B01J2219/00698 ,  C23C16/45574 ,  C23C16/45578 ,  Y10T29/49764 ,  Y10T137/0318

Abstract: An apparatus for deploying two fluids separately into a reaction chamber is provided. The apparatus includes a first distribution network that is formed on a plate having a distribution face and a dispensing face. The first distribution network is defined by a plurality of recessed channels on the distribution face. The plurality of recessed channels includes a plurality of thru-ports that extend from the plurality of recessed channels to the dispensing face. The apparatus further includes a second distribution network that has passages formed below the plurality of recessed channels and above the dispensing face. A first set of ports extends from the passages to the distribution face and a second set of ports extends from a top surface of the distribution face to the dispensing face.

公开(公告)号：US08012765B2

公开(公告)日：2011-09-06

申请号：US12753777

申请日：2010-04-02

Applicant: Carol T. Schembri

Inventor： Carol T. Schembri

IPC: G01N1/38

CPC classification number: B01L3/502707 ,  B01F13/0059 ,  B01F13/02 ,  B01F2215/0431 ,  B01F2215/0472 ,  B01J19/0046 ,  B01J2219/00479 ,  B01J2219/00495 ,  B01J2219/00536 ,  B01J2219/0059 ,  B01J2219/00596 ,  B01J2219/00605 ,  B01J2219/0061 ,  B01J2219/00612 ,  B01J2219/00626 ,  B01J2219/00653 ,  B01J2219/00659 ,  B01J2219/00722 ,  B01J2219/00725 ,  B01J2219/1941 ,  B01L3/50273 ,  B01L2300/0636 ,  B01L2300/0803 ,  B01L2300/0887 ,  B01L2300/1827 ,  B01L2400/0406 ,  B01L2400/0409 ,  B01L2400/0442 ,  B01L2400/0448 ,  B01L2400/0487 ,  C40B40/06 ,  C40B40/10 ,  C40B40/14 ,  C40B60/14 ,  Y10S366/03 ,  Y10T436/25

Abstract: A method and apparatus is provided for mixing a film of fluid, particularly a film of chemical, biochemical, or biological fluids undergoing a reaction. The apparatus comprises a means for nucleating a bubble using a discrete heat source, such as a resistor, and moving the bubble in the fluid by creating a temperature gradient, thereby mixing the fluid.

Abstract translation: 提供了一种用于混合流体薄膜，特别是经历反应的化学，生物化学或生物流体的薄膜的方法和装置。 该装置包括用于使用诸如电阻器的离散热源使气泡成核的装置，并且通过产生温度梯度来移动流体中的气泡，由此混合流体。

公开(公告)号：US20110065590A1

公开(公告)日：2011-03-17

申请号：US12794353

申请日：2010-06-04

Applicant: Ian W. Hunter

Inventor： Ian W. Hunter

IPC: C40B30/00 ,  C40B60/12

CPC classification number: B01J19/0046 ,  B01F13/0071 ,  B01F13/0084 ,  B01J2219/00313 ,  B01J2219/00317 ,  B01J2219/00351 ,  B01J2219/00533 ,  B01J2219/00536 ,  B01J2219/00549 ,  B01J2219/00585 ,  B01J2219/00599 ,  B01L3/5025 ,  B01L3/5085 ,  B01L3/50857 ,  B01L2200/0642 ,  C12Q1/34 ,  C40B60/14 ,  C40B70/00 ,  G01N21/75 ,  G01N35/00069 ,  G01N35/1002 ,  G01N2035/00237 ,  Y10T436/11 ,  Y10T436/112499 ,  Y10T436/25

Abstract: A method and apparatus for analyzing a plurality of substances. A platen is provided having two substantially parallel planar surfaces and a plurality of through-holes. An optical arrangement analyzes light emanating from the through-holes. The through-holes may be individually addressable, and may have volumes less than 100 nanoliters. Samples may be accurately dispensed, diluted and mixed in accordance with embodiments of the invention, and may be plated onto walls of the through-holes, and then subsequently resuspended prior to characterization, or, alternatively, retained in the through-holes by surface tension.

Abstract translation: 一种用于分析多种物质的方法和装置。 提供具有两个基本上平行的平坦表面和多个通孔的压板。 光学装置分析从通孔发出的光。 通孔可以单独寻址，并且可以具有小于100纳升的体积。 可以根据本发明的实施方案将样品精确地分配，稀释和混合，并且可以涂覆在通孔的壁上，然后在表征之前重新悬浮，或者替代地，通过表面张力保留在通孔中 。

公开(公告)号：US07888009B2

公开(公告)日：2011-02-15

申请号：US10854482

申请日：2004-05-25

Applicant: Francis Barany ,  George Barany ,  Robert P. Hammer ,  Maria Kempe ,  Herman Blok ,  Monib Zirvi

Inventor： Francis Barany ,  George Barany ,  Robert P. Hammer ,  Maria Kempe ,  Herman Blok ,  Monib Zirvi

IPC: C12Q1/68 ,  C12P19/34

CPC classification number: C12Q1/6827 ,  B01J19/0046 ,  B01J2219/00432 ,  B01J2219/00527 ,  B01J2219/00529 ,  B01J2219/00536 ,  B01J2219/00585 ,  B01J2219/0059 ,  B01J2219/00596 ,  B01J2219/00605 ,  B01J2219/00608 ,  B01J2219/0061 ,  B01J2219/00612 ,  B01J2219/00621 ,  B01J2219/00626 ,  B01J2219/00637 ,  B01J2219/00659 ,  B01J2219/00711 ,  B01J2219/00722 ,  B01J2219/00729 ,  B82Y30/00 ,  C12Q1/6816 ,  C12Q1/6837 ,  C12Q1/6876 ,  C12Q2600/156 ,  C40B40/06 ,  C40B60/14 ,  Y02A50/58 ,  C12Q2565/501 ,  C12Q2561/125 ,  C12Q2537/143 ,  C12Q2565/514

Abstract: The present invention describes a method for identifying one or more of a plurality of sequences differing by one or more single base changes, insertions, deletions, or translocations in a plurality of target nucleotide sequences. The method includes a ligation phase, a capture phase, and a detection phase. The ligation phase utilizes a ligation detection reaction between one oligonucleotide probe, which has a target sequence-specific portion and an addressable array-specific portion, and a second oligonucleotide probe, having a target sequence-specific portion and a detectable label. After the ligation phase, the capture phase is carried out by hybridizing the ligated oligonucleotide probes to a solid support with an array of immobilized capture oligonucleotides at least some of which are complementary to the addressable array-specific portion. Following completion of the capture phase, a detection phase is carried out to detect the labels of ligated oligonucleotide probes hybridized to the solid support.

公开(公告)号：US07846747B2

公开(公告)日：2010-12-07

申请号：US11598306

申请日：2006-11-13

Applicant: Jonathan S. Dordick ,  Douglas S. Clark

Inventor： Jonathan S. Dordick ,  Douglas S. Clark

IPC: G01N33/543

CPC classification number: B01J19/0093 ,  B01J19/0046 ,  B01J2219/00317 ,  B01J2219/00364 ,  B01J2219/00497 ,  B01J2219/00527 ,  B01J2219/00533 ,  B01J2219/00536 ,  B01J2219/00585 ,  B01J2219/00596 ,  B01J2219/00644 ,  B01J2219/00691 ,  B01J2219/0072 ,  B01J2219/00722 ,  B01J2219/00725 ,  B01J2219/00743 ,  B01J2219/00835 ,  B01J2219/00837 ,  B01J2219/0086 ,  B01L3/5027 ,  B01L3/5085 ,  B01L2300/069 ,  B01L2300/0819 ,  B01L2300/0829

Abstract: A system and method for conducting high-throughput interactions between test compositions and analytes, comprising one or more test compositions, and a plurality of independent micromatrices, wherein each said micromatrix encapsulates at least one said test composition; and said micromatrices are made of a material that is permeable to an analyte.

Abstract translation: 一种用于在测试组合物和分析物之间进行高通量相互作用的系统和方法，包括一种或多种测试组合物和多种独立的微阵列，其中每个所述微阵列封装至少一种所述测试组合物; 并且所述微阵列由对分析物可渗透的材料制成。