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    Carbocyanines for G-Quadruplex DNA Stabilization and Telomerase Inhibition
    2.
    发明申请
    Carbocyanines for G-Quadruplex DNA Stabilization and Telomerase Inhibition 审中-公开
    用于G-Quadruplex DNA稳定化和端粒酶抑制的花青素

    公开(公告)号：US20140142147A1

    公开(公告)日：2014-05-22

    申请号：US14233044

    申请日：2012-07-18

    申请人： Maged Henary ,  W. David Wilson

    发明人： Maged Henary ,  W. David Wilson

    IPC分类号： C09B23/06

    CPC分类号： C09B23/06 ,  C07D209/14 ,  C07D209/18 ,  C07D209/49 ,  C07D213/64 ,  C07D213/73 ,  C07D231/14 ,  C07D231/20 ,  C07D235/24 ,  C07D239/34 ,  C07D249/10 ,  C07D401/04 ,  C07D401/14 ,  C07D403/06 ,  C07D403/10 ,  C07D403/12 ,  C07D407/12 ,  C07D413/14 ,  C07D417/12

    摘要： Cyanines which selectively bind to G-quadruplex DNA complexes, particularly quadruplexes expressed in cancer cells, and methods of making and using thereof are described herein. The cyanine can be a symmetrical or unsymmetrical streptocyanine, hemicyanine, closed chain cyanine, or combinations thereof. The cyanine is preferably substituted with one or more groups that minimize or prevent aggregation of the cyanine and/or inhibit binding of the cyanine to duplex DNA. One or more of the cyanines can be formulated with one or more pharmaceutical excipients and/or carrier to prepare pharmaceutical compositions suitable for administration to a patient, particular a human patient. The compounds and compositions described herein can be used to treat diseases or disorders characterized by the expression of G-quadruplex DNA, such as cancer.

    摘要翻译： 在本文中描述了选择性结合G-四链体DNA复合物，特别是在癌细胞中表达的四链体的花青苷及其制备和使用方法。 花青可以是对称或不对称的链花青，半花青，闭链花青或其组合。 花青优选被一个或多个使花青聚集和/或抑制花青与双链DNA结合的聚合作用的基团取代。 一种或多种花青可以与一种或多种药物赋形剂和/或载体一起配制，以制备适于给予患者，特别是人类患者的药物组合物。 本文所述的化合物和组合物可用于治疗特征在于表达G-四链体DNA例如癌症的疾病或病症。

    Method and dyes for detecting and destroying cancer cells
    3.
    发明授权
    Method and dyes for detecting and destroying cancer cells 有权

    公开(公告)号：US10030036B2

    公开(公告)日：2018-07-24

    申请号：US12778569

    申请日：2010-05-12

    申请人： James J. Krutak ,  Lyle Small ,  Maged Henary ,  Gabor Patonay

    发明人： James J. Krutak ,  Lyle Small ,  Maged Henary ,  Gabor Patonay

    IPC分类号： A61N1/40 ,  C07F1/00 ,  A61K49/00 ,  A61K41/00 ,  C09B23/01 ,  C09B23/08

    摘要： This invention relates to new carbocyanine dye compositions, pharmaceutical compositions comprising such compositions, methods of detecting via near infrared fluorescent imaging incipient cancer cells and selective destruction of cancer cells identified by administration of such pharmaceutical compositions. A method of detecting and destroying cancer cells includes introducing a gold dye into an organism suspected of having a cancer cell. The gold dye is a carbocyanine dye covalently attached to a gold nanoparticle. A near infrared light is shined on a region suspected of having the cancer cell. Fluorescence from the gold dye is detected. A beam of radio frequency energy is directed at the region to induce hyperthermia in the cancer cell. The carbocyanine dye has the most basic structure of MHI-148 and structures 6 and 22 with a Aun—[CH2(CH2)9CH2—(OCH2CH2)4O]COCH2CH2-phenyl-O group on a cyclohexene ring that imparts activity to the cancer cell binding and destruction processes.

    METHOD AND DYES FOR DETECTING AND DESTROYING CANCER CELLS
    5.
    发明申请
    METHOD AND DYES FOR DETECTING AND DESTROYING CANCER CELLS 审中-公开
    用于检测和破坏癌细胞的方法和方法

    公开(公告)号：US20150376209A1

    公开(公告)日：2015-12-31

    申请号：US12778569

    申请日：2010-05-12

    申请人： JAMES J. KRUTAK ,  Lyle Small ,  Maged Henary ,  Gabor Patonay

    发明人： JAMES J. KRUTAK ,  Lyle Small ,  Maged Henary ,  Gabor Patonay

    IPC分类号： C07F1/00 ,  A61N1/40 ,  C09B23/01 ,  A61K49/00 ,  A61K41/00

    CPC分类号： C07F1/00 ,  A61K41/0052 ,  A61K41/0057 ,  A61K49/0032 ,  A61K49/0093 ,  A61N1/406 ,  C09B23/0016 ,  C09B23/0025 ,  C09B23/0066 ,  C09B23/086

    摘要： This invention relates to new carbocyanine dye compositions, pharmaceutical compositions comprising such compositions, methods of detecting via near infrared fluorescent imaging incipient cancer cells and selective destruction of cancer cells identified by administration of such pharmaceutical compositions. A method of detecting and destroying cancer cells includes introducing a gold dye into an organism suspected of having a cancer cell. The gold dye is a carbocyanine dye covalently attached to a gold nanoparticle. A near infrared light is shined on a region suspected of having the cancer cell. Fluorescence from the gold dye is detected. A beam of radio frequency energy is directed at the region to induce hyperthermia in the cancer cell. The carbocyanine dye has the most basic structure of MHI-148 and structures 6 and 22 with a Aun—[CH2(CH2)9CH2—(OCH2CH2)4O]COCH2CH2-phenyl-O group on a cyclohexene ring that imparts activity to the cancer cell binding and destruction processes.

    摘要翻译： 本发明涉及新的碳菁染料组合物，包含这种组合物的药物组合物，通过近红外荧光成像检测初始癌细胞的方法和通过施用这种药物组合物鉴定的癌细胞的选择性破坏。 一种检测和破坏癌细胞的方法包括将金染料引入怀疑具有癌细胞的生物体中。 金染料是共价连接到金纳米颗粒上的碳菁染料。 近红外光照射在怀疑患有癌细胞的区域。 检测到来自金色染料的荧光。 射频能量束被引导到该区域以诱导癌细胞中的高热。 碳菁染料具有MHI-148和结构6和22的最基本结构，在赋予癌细胞活性的环己烯环上具有Aun- [CH 2（CH 2）9 CH 2 - （OCH 2 CH 2）4 O] COCH 2 CH 2 - 苯基-O基团 绑定和销毁过程。