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1.发明授权Human T cell reactive feline protein (TRFP) isolated from house dust and uses therefor 失效人类T细胞反应性猫科动物蛋白（TRFP）从室内灰尘中分离出来，并用于其中公开(公告)号：US07482008B1
公开(公告)日：2009-01-27
申请号：US09662784
申请日：2000-09-15
申请人： Malcolm L. Gefter , Richard D. Garman , Julia L. Greenstein , Mei-chang Kuo , Bruce L. Rogers , Irwin J. Griffith , Jay P. Morgenstern , Julian F. Bond , Andrew W. Brauer , Malcolm Morville , Thomas J. Briner , Ze'ev Shaked
发明人： Malcolm L. Gefter , Richard D. Garman , Julia L. Greenstein , Mei-chang Kuo , Bruce L. Rogers , Irwin J. Griffith , Jay P. Morgenstern , Julian F. Bond , Andrew W. Brauer , Malcolm Morville , Thomas J. Briner , Ze'ev Shaked
CPC分类号： G01N33/5091 , A61K38/00 , C07K14/415 , C07K14/47 , C07K14/4705 , C07K16/18 , C07K2319/00 , C07K2319/02 , C07K2319/21 , C07K2319/40 , C12N15/62
摘要： A substantially pure, covalently linked human T cell reactive feline protein (TRFP) has been isolated from vacuum bag extract obtained by affinity purification of house dust collected from several homes with cats; DNA encoding all or a portion of the TRFP or peptide; compositions containing such a protein or peptide or portions thereof; and antibodies reactive with the TRFP or peptide are disclosed. Also disclosed are recombinant TRFP or peptide; modified or mutated TRFP peptides; their use for diagnostic or therapeutic purposes.
摘要翻译： 从真空袋提取物中分离得到的基本上纯的共价连接的人T细胞反应性猫科蛋白（TRFP），通过亲和纯化从几个家庭用猫收集的房屋灰尘获得; 编码全部或部分TRFP或肽的DNA; 含有这种蛋白质或肽或其部分的组合物; 并且公开了与TRFP或肽反应的抗体。 还公开了重组TRFP或肽; 修饰或突变的TRFP肽; 它们用于诊断或治疗目的。
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公开(公告)号：US6048962A
公开(公告)日：2000-04-11
申请号：US430014
申请日：1995-04-27
申请人： Malcolm L. Gefter , Richard D. Garman , Julia L. Greenstein , Mei-chang Kuo , Bruce L. Rogers , Irwin J. Griffith , Jay P. Morgenstern , Andrew W. Brauer
发明人： Malcolm L. Gefter , Richard D. Garman , Julia L. Greenstein , Mei-chang Kuo , Bruce L. Rogers , Irwin J. Griffith , Jay P. Morgenstern , Andrew W. Brauer
IPC分类号： A61K38/00 , A61P37/08 , C07K14/415 , C07K14/47 , C07K14/725 , C07K16/18 , C12N15/62 , G01N33/50 , C07K1/00
CPC分类号： G01N33/5091 , C07K14/415 , C07K14/47 , C07K14/4705 , C07K16/18 , C12N15/62 , A61K38/00 , C07K2319/00 , C07K2319/02 , C07K2319/21 , C07K2319/40
摘要： A substantially pure, covalently linked human T cell reactive feline protein (TRFP) has been isolated from vacuum bag extract obtained by affinity purification of house dust collected from several homes with cats; DNA encoding all or a portion of the TRFP or peptide; compositions containing such a protein or peptide or portions thereof; and antibodies reactive with the TRFP or peptide are disclosed. Also disclosed are recombinant TRFP or peptide; modified or mutated TRFP peptides; their use for diagnostic or therapeutic purposes.
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公开(公告)号：US06489118B2
公开(公告)日：2002-12-03
申请号：US09374671
申请日：1999-08-16
IPC分类号： G01N3353
CPC分类号： G01N33/6893 , A61K38/00 , A61K39/00 , C07K14/46 , C07K14/47 , G01N2800/24
摘要： Isolated nucleic acids encoding allergens of Canis familiaris, Canf I or Can f II, are disclosed. A cDNA encoding a peptide having a Can f I activity and a predicted molecular weight of about 19,200 daltons is also described. A cDNA encoding a peptide having Can f II activity and a predicted molecular weight of about 18,200 daltons is also disclosed. The nucleic acids can be used as probes to detect the presence of Can f I or Can f II nucleic acid in a sample or for the recombinant production of petides having a Can f I or Can f II activity. Peptides having a Can f I or Can f II activity can be used in compositions suitable for pharmaceutical administration or methods of diagnosing sensitivity to dog dander.
摘要翻译： 公开了编码Canis familiaris，Canf I或Can f II的过敏原的分离的核酸。 还描述了编码具有Can f I活性和约19,200道尔顿的预测分子量的肽的cDNA。 还公开了编码具有Can f II活性和预测分子量约18,200道尔顿的肽的cDNA。 核酸可以用作探针以检测样品中Can f I或Can f II核酸的存在，或用于重组生产具有Can f I或Can f II活性的化合物。 具有Can f I或Can f II活性的肽可用于适用于药物施用的组合物或诊断对狗皮的敏感性的方法。
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公开(公告)号：US5843672A
公开(公告)日：1998-12-01
申请号：US467603
申请日：1995-06-06
IPC分类号： G01N33/53 , A61K38/00 , A61K39/35 , A61K39/395 , A61P37/08 , C07K14/47 , C12N1/21 , C12N15/09 , C12N15/12 , C12P21/02 , C12P21/08 , C12R1/19 , C07K7/00
CPC分类号： G01N33/6893 , C07K14/46 , C07K14/47 , A61K38/00 , A61K39/00 , G01N2800/24
摘要： Isolated nucleic acids encoding allergens of Canis familiaris, Can f I or Can f II, are disclosed. A cDNA encoding a peptide having a Can f I activity and a predicted molecular weight of about 19,200 daltons is also described. A cDNA encoding a peptide having Can f II activity and a predicted molecular weight of about 18,200 daltons is also disclosed. The nucleic acids can be used as probes to detect the presence of Can f I or Can f II nucleic acid in a sample or for the recombinant production of peptides having a Can f I or Can f II activity. Peptides having a Can f I or Can f II activity can be used in compositions suitable for pharmaceutical administration or methods of diagnosing sensitivity to dog dander.
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公开(公告)号：US07166291B2
公开(公告)日：2007-01-23
申请号：US11202960
申请日：2005-08-12
CPC分类号： G01N33/6893 , A61K38/00 , A61K39/00 , C07K14/46 , C07K14/47 , G01N2800/24
摘要： Isolated nucleic acids encoding allergens of Canis familiaris, Can fI or Can fII. are disclosed. A cDNA encoding a peptide having a Can fI activity and a predicted molecular weight of about 19,200 daltons is also described. A cDNA encoding a peptide having Can fII activity and a predicted molecular weight of about 18,200 daltons is also disclosed. The nucleic acids can be used as probes to detect the presence of Can fI or Can fII nucleic acid in a sample or for the recombinant production of petides having a Can fI or Can fII activity. Peptides having a Can fI or Can fII activity can be used in compositions suitable for pharmaceutical administration or methods of diagnosing sensitivity to dog dander.
摘要翻译： 编码Canis familiaris，Can fI或Can fII的过敏原的分离核酸。 被披露。 还描述了编码具有Can fI活性和约19,200道尔顿的预测分子量的肽的cDNA。 还公开了编码具有Can fII活性和预测分子量约18,200道尔顿的肽的cDNA。 核酸可以用作探针，以检测样品中Can fI或Can fII核酸的存在，或用于重组生产具有Can fI或Can fII活性的化合物。 具有Can fI或Can fII活性的肽可用于适合于药物施用的组合物或诊断对狗皮的敏感性的方法。
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公开(公告)号：US07026128B2
公开(公告)日：2006-04-11
申请号：US10196107
申请日：2002-07-16
CPC分类号： G01N33/6893 , A61K38/00 , A61K39/00 , C07K14/46 , C07K14/47 , G01N2800/24
摘要： Isolated nucleic acids encoding allergens of Canis familiaris, Can f I or Can f II, are disclosed. A cDNA encoding a peptide having a Can f I activity and a predicted molecular weight of about 19,200 daltons is also described. A cDNA encoding a peptide having Can f II activity and a predicted molecular weight of about 18,200 daltons is also disclosed. The nucleic acids can be used as probes to detect the presence of Can f I or Can f II nucleic acid in a sample or for the recombinant production of peptides having a Can f I or Can f II activity. Peptides having a Can f I or Can f II activity can be used in compositions suitable for pharmaceutical administration or methods of diagnosing sensitivity to dog dander.
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公开(公告)号：US07666441B2
公开(公告)日：2010-02-23
申请号：US11637637
申请日：2006-12-12
CPC分类号： G01N33/6893 , A61K38/00 , A61K39/00 , C07K14/46 , C07K14/47 , G01N2800/24
摘要： Isolated nucleic acids encoding allergens of Canis familiaris, Can f I or Can f II, are disclosed. A cDNA encoding a peptide having a Can f I activity and a predicted molecular weight of about 19,200 daltons is also described. A cDNA encoding a peptide having Can f II activity and a predicted molecular weight of about 18,200 daltons is also disclosed. The nucleic acids can be used as probes to detect the presence of Can f I or Can f II nucleic acid in a sample or for the recombinant production of petides having a Can f I or Can f II activity. Peptides having a Can f I or Can f II activity can be used in compositions suitable for pharmaceutical administration or methods of diagnosing sensitivity to dog dander.
摘要翻译： 编码Canis familiaris，Can f I或Can f II的过敏原的分离的核酸被公开。 还描述了编码具有Can f I活性和约19,200道尔顿的预测分子量的肽的cDNA。 还公开了编码具有Can f II活性和预测分子量约18,200道尔顿的肽的cDNA。 核酸可以用作探针以检测样品中Can f I或Can f II核酸的存在，或用于重组生产具有Can f I或Can f II活性的化合物。 具有Can f I或Can f II活性的肽可用于适用于药物施用的组合物或诊断对狗皮的敏感性的方法。
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公开(公告)号：US5939283A
公开(公告)日：1999-08-17
申请号：US491861
申请日：1995-10-27
IPC分类号： G01N33/53 , A61K38/00 , A61K39/35 , A61K39/395 , A61P37/08 , C07K14/47 , C12N1/21 , C12N15/09 , C12N15/12 , C12P21/02 , C12P21/08 , C12R1/19 , C12N5/10 , C12N15/63
CPC分类号： G01N33/6893 , C07K14/46 , C07K14/47 , A61K38/00 , A61K39/00 , G01N2800/24
摘要： Isolated nucleic acids encoding allergens of Canis familiaris, Can f I or Can f II, are disclosed. A cDNA encoding a peptide having a Can f I activity and a predicted molecular weight of about 19,200 daltons is also described. A cDNA encoding a peptide having Can f II activity and a predicted molecular weight of about 18,200 daltons is also disclosed. The nucleic acids can be used as probes to detect the presence of Can f I or Can f II nucleic acid in a sample or for the recombinant production of peptides having a Can f I or Can f II activity. Peptides having a Can f I or Can f II activity can be used in compositions suitable for pharmaceutical administration or methods of diagnosing sensitivity to dog dander.
摘要翻译： PCT No.PCT / US93 / 12468 Sec。 371 1995年10月27日第 102（e）日期1995年10月27日PCT 1993年12月30日PCT公布。 WO94 / 16068 PCT公开号 日期1994年7月21日公开了编码Canis familiaris，Can f I或Can f II的过敏原的分离的核酸。 还描述了编码具有Can f I活性和约19,200道尔顿的预测分子量的肽的cDNA。 还公开了编码具有Can f II活性和预测分子量约18,200道尔顿的肽的cDNA。 核酸可以用作探针，以检测样品中Can f I或Can f II核酸的存在，或用于重组产生具有Can f I或Can f II活性的肽。 具有Can f I或Can f II活性的肽可用于适用于药物施用的组合物或诊断对狗皮的敏感性的方法。
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公开(公告)号：US5891716A
公开(公告)日：1999-04-06
申请号：US466793
申请日：1995-06-06
IPC分类号： G01N33/53 , A61K38/00 , A61K39/35 , A61K39/395 , A61P37/08 , C07K14/47 , C12N1/21 , C12N15/09 , C12N15/12 , C12P21/02 , C12P21/08 , C12R1/19 , C12N5/10 , C12N15/63
CPC分类号： G01N33/6893 , C07K14/46 , C07K14/47 , A61K38/00 , A61K39/00 , G01N2800/24
摘要： Isolated nucleic acids encoding allergens of Canis familiaris, Can f I or Can f II, are disclosed. A cDNA encoding a peptide having a Can f I activity and a predicted molecular weight of about 19,200 daltons is also described. A cDNA encoding a peptide having Can f II activity and a predicted molecular weight of about 18,200 daltons is also disclosed. The nucleic acids can be used as probes to detect the presence of Can f I or Can f II nucleic acid in a sample or for the recombinant production of petides having a Can f I or Can f II activity. Peptides having a Can f I or Can f II activity can be used in compositions suitable for pharmaceutical administration or methods of diagnosing sensitivity to dog dander.
摘要翻译： 编码Canis familiaris，Can f I或Can f II的过敏原的分离的核酸被公开。 还描述了编码具有Can f I活性和约19,200道尔顿的预测分子量的肽的cDNA。 还公开了编码具有Can f II活性和预测分子量约18,200道尔顿的肽的cDNA。 核酸可以用作探针以检测样品中Can f I或Can f II核酸的存在，或用于重组生产具有Can f I或Can f II活性的化合物。 具有Can f I或Can f II活性的肽可用于适用于药物施用的组合物或诊断对狗皮的敏感性的方法。
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