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    T cell peptides of the CRX JII allergen
    3.
    发明授权
    T cell peptides of the CRX JII allergen 失效
    CRX JII变应原的T细胞肽

    公开(公告)号：US6090386A

    公开(公告)日：2000-07-18

    申请号：US467023

    申请日：1995-06-06

    申请人： Irwin J. Griffith ,  Joanne Pollock ,  Julian F. Bond ,  Richard D. Garman ,  Mei-chang Kuo ,  Stephen P. Powers ,  Mark A. Exley ,  Xian Chen ,  Ze'ev Shaked

    发明人： Irwin J. Griffith ,  Joanne Pollock ,  Julian F. Bond ,  Richard D. Garman ,  Mei-chang Kuo ,  Stephen P. Powers ,  Mark A. Exley ,  Xian Chen ,  Ze'ev Shaked

    IPC分类号： A61K39/00 ,  C07K14/415 ,  C07K14/725 ,  A61K38/10 ,  A61K39/36 ,  C07K7/08

    CPC分类号： C07K14/415 ,  A61K39/00

    摘要： The present invention provides nucleic acid sequences coding for the Cryptomeria japonica major pollen allergen Cry j I, Cry j II, Jun s I and Jun v I and fragments or peptides thereof. The present invention also provides purified Cry j I, Cry j II, Jun s I and Jun v I and at least one fragment thereof produced in a host cell transformed with a nucleic acid sequence coding for Cry j I, Cry j II, Jun s I and Jun v I or at least one fragment thereof, and fragments of Cry j I, Cry j II, Jun s I or Jun v I or at least one fragment thereof, and fragments of Cry j I, Cry j II, Jun s I or Jun v I prepared synthetically. Cry j I, Cry j II, Jun s I and Jun v I and fragments thereof are useful for diagnosing, treating, and preventing Japanese cedar pollinosis. The present invention also provides isolated peptides of Cry j I and Cry j II. Peptides within the scope of the invention comprise at least one T cell epitope, or preferably at least two T cell epitopes of Cry j I or Cry j II. The invention also pertains to modified peptides having similar or enhanced therapeutic properties as the corresponding naturally-occurring allergen or portion thereof but having reduced side effects. Methods of treatment or of diagnosis of sensitivity to Japanese cedar pollens in an individual and therapeutic compositions, and multipeptide formulations comprising one or more peptides of the invention are also provided.

    摘要翻译： 本发明提供了编码粳稻主要花粉过敏原Cryj I，Cryj II，Jun s I和Jun v I的核酸序列及其片段或肽。 本发明还提供纯化的Cry j I，Cryj II，Jun s I和Jun v I，以及在用编码Cryj I，Cryj II，Jun的核酸序列转化的宿主细胞中产生的至少一个片段 I和Jun v I或其至少一个片段，以及Cry j I，Cry j II，Jun s I或Jun v I或其至少一个片段的片段，以及Cryj I，Cryj II，Jun 我或Jun v我合成了。 Cry j I，Cry j II，Jun s I和Jun v I及其片段可用于诊断，治疗和预防日本雪松花粉病。 本发明还提供了Cryj I和Cryj II的分离的肽。 本发明范围内的肽包含至少一个T细胞表位，或优选至少两个Cryj I或Cryj II的T细胞表位。 本发明还涉及与相应的天然存在的变应原或其部分具有相似或增强的治疗性质但具有减少的副作用的改性肽。 还提供了治疗或诊断个体对日本雪松花粉和治疗组合物的方法，以及包含一种或多种本发明的肽的多肽制剂。

    Allergenic proteins and peptides from Japanese cedar pollen
    5.
    发明授权
    Allergenic proteins and peptides from Japanese cedar pollen 有权
    来自日本雪松花粉的过敏蛋白和肽

    公开(公告)号：US08540999B2

    公开(公告)日：2013-09-24

    申请号：US10931260

    申请日：2004-08-30

    申请人： Irwin J. Griffith ,  Joanne Pollock ,  Julian F. Bond ,  Richard D. Garman ,  Mei-Chang Kuo ,  Stephen P. Powers ,  Mark A. Exley ,  Xian Chen ,  Ze'ev Shaked

    发明人： Irwin J. Griffith ,  Joanne Pollock ,  Julian F. Bond ,  Richard D. Garman ,  Mei-Chang Kuo ,  Stephen P. Powers ,  Mark A. Exley ,  Xian Chen ,  Ze'ev Shaked

    IPC分类号： A61K39/00 ,  A61K39/35 ,  A61K39/36 ,  A61K39/38 ,  C07K1/00 ,  C07K14/00 ,  C07K17/00

    CPC分类号： C07K14/415 ,  A61K38/00 ,  A61K39/00 ,  C07K16/16

    摘要： The present invention provides nucleic acid sequences coding for the Cryptomeria japonica major pollen allergen Cry j I, Cry j II, Jun s I and Jun v I and fragments or peptides thereof. The present invention also provides purified Cry j I, Cry j II, Jun s I and Jun v I and at least one fragment thereof produced in a host cell transformed with a nucleic acid sequence coding for Cry j I, Cry j II, Jun s I and Jun v I or at least one fragment thereof, and fragments of Cry j I, Cry j II, Jun s I or Jun v I or at least one fragment thereof, and fragments of Cry j I, Cry j II, Jun s I or Jun v I prepared synthetically. Cry j I, Cry j II, Jun s I and Jun v I and fragments thereof are useful for diagnosing, treating, and preventing Japanese cedar pollinosis. The present invention also provides isolated peptides of Cry j I and Cry j II. Peptides within the scope of the invention comprise at least one T cell epitope, or preferably at least two T cell epitopes of Cry j I or Cry j II. The invention also pertains to modified peptides having similar or enhanced therapeutic properties as the corresponding naturally-occurring allergen or portion thereof but having reduced side effects. Methods of treatment or of diagnosis of sensitivity to Japanese cedar pollens in an individual and therapeutic compositions, and multipeptide formulations comprising one or more peptides of the invention are also provided.

    摘要翻译： 本发明提供了编码粳稻主要花粉过敏原Cryj I，Cryj II，Jun s I和Jun v I的核酸序列及其片段或肽。 本发明还提供纯化的Cry j I，Cryj II，Jun s I和Jun v I，以及在用编码Cryj I，Cryj II，Jun的核酸序列转化的宿主细胞中产生的至少一个片段 I和Jun v I或其至少一个片段，以及Cry j I，Cry j II，Jun s I或Jun v I或其至少一个片段的片段，以及Cryj I，Cryj II，Jun 我或Jun v我合成了。 Cry j I，Cry j II，Jun s I和Jun v I及其片段可用于诊断，治疗和预防日本雪松花粉病。 本发明还提供了Cryj I和Cryj II的分离的肽。 本发明范围内的肽包含至少一个T细胞表位，或优选至少两个Cryj I或Cryj II的T细胞表位。 本发明还涉及与相应的天然存在的变应原或其部分具有相似或增强的治疗性质但具有减少的副作用的改性肽。 还提供了治疗或诊断个体对日本雪松花粉和治疗组合物的方法，以及包含一种或多种本发明的肽的多肽制剂。

    Allergenic proteins and peptides from Japanese cedar pollen
    6.
    发明授权
    Allergenic proteins and peptides from Japanese cedar pollen 失效

    公开(公告)号：US06982326B1

    公开(公告)日：2006-01-03

    申请号：US09240203

    申请日：1999-01-29

    申请人： Irwin J. Griffith ,  Joanne Pollock ,  Julian F. Bond ,  Richard D. Garman ,  Mei-chang Kuo ,  Stephen P. Powers ,  Mark A. Exley ,  Xian Chen ,  Ze'ev Shaked

    发明人： Irwin J. Griffith ,  Joanne Pollock ,  Julian F. Bond ,  Richard D. Garman ,  Mei-chang Kuo ,  Stephen P. Powers ,  Mark A. Exley ,  Xian Chen ,  Ze'ev Shaked

    IPC分类号： C07H21/04

    CPC分类号： C07K14/415 ,  A61K38/00 ,  A61K39/00 ,  C07K16/16

    摘要： The present invention provides nucleic acid sequences coding for the Cryptomeria japonica major pollen allergen Cry j I, Cry j II, Jun s I and Jun v I and fragments or peptides thereof. The present invention also provides purified Cry j I, Cry j II, Jun s I and Jun v I and at least one fragment thereof produced in a host cell transformed with a nucleic acid sequence coding for Cry j I, Cry j II, Jun s I and Jun v I or at least one fragment thereof, and fragments of Cry j I, Cry j II, Jun s I or Jun v I or at least one fragment thereof, and fragments of Cry j I, Cry j II, Jun s I or Jun v I prepared synthetically. Cry j I, Cry j II, Jun s I and Jun v I and fragments thereof are useful for diagnosing, treating, and preventing Japanese cedar pollinosis. The present invention also provides isolated peptides of Cry j I and Cry j II. Peptides within the scope of the invention comprise at least one T cell epitope, or preferably at least two T cell epitopes of Cry j I or Cry j II. The invention also pertains to modified peptides having similar or enhanced therapeutic properties as the corresponding naturally-occurring allergen or portion thereof but having reduced side effects. Methods of treatment or of diagnosis of sensitivity to Japanese cedar pollens in an individual and therapeutic compositions, and multipeptide formulations comprising one or more peptides of the invention are also provided.

    T cell epitopes of ryegrass pollen allergen
    7.
    发明授权
    T cell epitopes of ryegrass pollen allergen 失效
    黑麦草花粉过敏原的T细胞表位

    公开(公告)号：US5710126A

    公开(公告)日：1998-01-20

    申请号：US440861

    申请日：1995-05-15

    申请人： Irwin J. Griffith ,  Mei-chang Kuo ,  Mohammad Luqman

    发明人： Irwin J. Griffith ,  Mei-chang Kuo ,  Mohammad Luqman

    IPC分类号： A61K38/00 ,  C07K14/415 ,  C07K16/16 ,  A61K38/10 ,  A61K38/16 ,  A61K39/36

    CPC分类号： C07K14/415 ,  C07K16/16 ,  A61K38/00

    摘要： The present invention provides isolated peptides of Lol p V, a major protein allergen of the species Lolium perenne. Therapeutic peptides within the scope of the invention comprise at least one T cell epitope, or preferably at least two T cell epitopes of a protein allergen of Lol p V. Diagnostic peptides within the scope of the invention bind IgE. The invention also provides modified peptides having similar or enhanced therapeutic properties as the corresponding, naturally-occurring allergen or portion thereof, but having reduced side effects. The invention further provides nucleic acid sequences coding for peptides of the invention. Methods of treatment or diagnosis of sensitivity to Lol p V or an allergen immunologically related to Lol p V in an individual. Therapeutic compositions comprising one or more peptides of the invention are also provided.

    摘要翻译： 本发明提供了Lol p V的孤立肽，Lol p V是白僵菌物种的主要蛋白质过敏原。 本发明范围内的治疗肽包含至少一个T细胞表位，或优选至少两个Lol p V蛋白变应原的T细胞表位。本发明范围内的诊断肽结合IgE。 本发明还提供了与相应的天然存在的变应原或其部分具有相似或增强的治疗性质但具有减少的副作用的修饰肽。 本发明还提供了编码本发明的肽的核酸序列。 治疗或诊断对Lol p V的敏感性或与个体中Lol p V免疫相关的变应原的方法。 还提供了包含本发明的一种或多种肽的治疗组合物。

    T cell epitopes of ryegrass pollen allergen
    8.
    发明授权
    T cell epitopes of ryegrass pollen allergen 失效
    黑麦草花粉过敏原的T细胞表位

    公开(公告)号：US07112333B1

    公开(公告)日：2006-09-26

    申请号：US08737904

    申请日：1994-08-05

    申请人： Irwin J. Griffith ,  Mei-Chang Kuo ,  Mohammad Luqman

    发明人： Irwin J. Griffith ,  Mei-Chang Kuo ,  Mohammad Luqman

    IPC分类号： A61K38/04 ,  A61K38/10 ,  C07K7/00 ,  C07K7/06

    CPC分类号： C07K7/08 ,  A61K38/00 ,  Y10S514/885 ,  Y10S530/868

    摘要： The present invention provides isolated peptides of Lol p V, a major protein allergen of the species Lolium perenne. Therapeutic peptides within the scope of the invention comprise at least one T cell epitope, or preferably at least two T cell epitopes of a protein allergen of Lol p V. Diagnostic peptides within the scope of the invention bind IgE. The invention also provides modified peptides having similar or enhanced therapeutic properties or other desirable properties as the corresponding, naturally-occurring allergen or portion thereof. The invention further provides nucleic acid sequences coding for peptides of the invention. Use of the therapeutic compositions comprising one or more peptides of the invention in the manufacture of medicaments for treating sensitivity to Lol p V or an allergen immunologically related to Lol p V, or for general ryegrass sensitivity in an individual, is also provided. The invention also provides nucleic acid sequence coding for Dac g V protein allergen as well as the amino acid sequence of Dac g V protein allergen.

    摘要翻译： 本发明提供了Lol p V的孤立肽，Lol p V是白僵菌物种的主要蛋白质过敏原。 本发明范围内的治疗肽包含至少一个T细胞表位，或优选至少两个Lol p V蛋白变应原的T细胞表位。本发明范围内的诊断肽结合IgE。 本发明还提供具有与相应的天然存在的变应原或其部分相似或增强的治疗性质或其它所需性质的修饰肽。 本发明还提供了编码本发明的肽的核酸序列。 还提供了包含本发明的一种或多种肽的治疗组合物在制备用于治疗对Lol p V的敏感性的药物或与Lol p V免疫相关的变应原的治疗组合物或在个体中的一般黑麦草敏感性的用途。 本发明还提供编码Dac g V蛋白变应原的核酸序列以及Dac g V蛋白变应原的氨基酸序列。