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    Compositions and methods for administering to humans, peptides capable of down regulating an antigen specific immune response
    9.
    发明授权
    Compositions and methods for administering to humans, peptides capable of down regulating an antigen specific immune response 失效
    用于对人施用能够下调抗原特异性免疫应答的肽的组合物和方法

    公开(公告)号：US06759234B1

    公开(公告)日：2004-07-06

    申请号：US08300510

    申请日：1994-09-02

    申请人： Malcolm L. Gefter ,  Ze′ev Shaked ,  Malcolm Morville

    发明人： Malcolm L. Gefter ,  Ze′ev Shaked ,  Malcolm Morville

    IPC分类号： A61K3816

    CPC分类号： A61K38/16 ,  A61K39/35 ,  A61K2039/545

    摘要： The present invention provides therapeutic compositions and methods for treating disease conditions in humans associated with an antigen specific immune response by the human to an antigen such as a protein antigen (i.e. allergy and autoimmune diseases). Therapeutic compositions of the invention are reproducible preparations which are suitable for human therapy. Compositions of the invention comprise at least one isolated peptide having a defined sequence of amino acid residues and the composition is capable of down regulating an antigen specific immune response to an offending antigen in a population of humans subject to the antigen specific immune response. Compositions and methods of the invention may be used to treat sensitivity to protein allergens in humans and may also be used to treat autoimmune disease such as rheumatoid arthritis, diabetes, myasthenia gravis, Grave's disease, Good Pasture's syndrome, thyroiditis and multiple sclerosis.

    摘要翻译： 本发明提供用于治疗人类与人类对抗原（例如过敏和自身免疫性疾病）的抗原特异性免疫应答相关的疾病状况的治疗组合物和方法。 本发明的治疗组合物是适用于人类治疗的可重复制剂。 本发明的组合物包含具有确定的氨基酸残基序列的至少一种分离的肽，并且该组合物能够下调受抗原特异性免疫应答的人群中的违规抗原的抗原特异性免疫应答。 本发明的组合物和方法可用于治疗人类对蛋白质过敏原的敏感性，并且还可用于治疗自身免疫疾病，例如类风湿性关节炎，糖尿病，重症肌无力，格雷夫斯病，良好牧场综合征，甲状腺炎和多发性硬化。

    Structural Support Scheme for the Replacement of Trailing Portions of Sails
    10.
    发明申请
    Structural Support Scheme for the Replacement of Trailing Portions of Sails 审中-公开
    结构支援计划，用于替代尾部的帆

    公开(公告)号：US20140102346A1

    公开(公告)日：2014-04-17

    申请号：US13748254

    申请日：2013-01-23

    申请人： Malcolm L. Gefter

    发明人： Malcolm L. Gefter

    IPC分类号： B63H9/06

    CPC分类号： B63H9/0657 ,  B63B2231/40 ,  B64D17/12

    摘要： A sail for a wind-powered craft includes a web which forms a flying shape upon engagement with the wind, flying shape extending from leading to trailing edges. The web includes a combination of wind-impermeable and wind-permeable portions disposed between the leading and trailing edges, with a permeability ratio of wind-permeable area to wind-impermeable area within a range of about 5 to 80 percent.

    摘要翻译： 用于风力工艺的帆帆包括在与风接合时形成飞行形状的腹板，从前缘到后缘延伸的飞行形状。 纤维网包括设置在前缘和后缘之间的防风透气部分和风渗透部分的组合，风渗透面积与不透风区域的渗透率比在约5-80％的范围内。