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公开(公告)号：US08658133B2
公开(公告)日：2014-02-25
申请号：US11574367
申请日：2005-08-26
申请人： Malcolm Ward , Vaksha Patel , Emma McGregor , Nicola Leeds , Helen Byers , James Campbell , Kit-Yi Leung , Jules Westbrook
发明人： Malcolm Ward , Vaksha Patel , Emma McGregor , Nicola Leeds , Helen Byers , James Campbell , Kit-Yi Leung , Jules Westbrook
CPC分类号： G01N33/6896 , G01N2500/00 , G01N2800/2821
摘要： Methods and compositions relating to Alzheimer's disease are provided, including proteins that are differentially expressed in Alzheimer's disease as compared to the normal state. Further provided are methods, particularly experimental paradigms, for the identification of differential expressed proteins that are potential molecular targets for compounds to treat or prevent Alzheimer's disease. Also provided are methods for the identification and therapeutic use of compounds for the prevention and treatment of Alzheimer's disease.
摘要翻译： 提供了与阿尔茨海默病相关的方法和组合物，包括与正常状态相比在阿尔茨海默氏病中差异表达的蛋白质。 还提供了用于鉴定作为治疗或预防阿尔茨海默病的化合物的潜在分子靶标的差异表达蛋白质的方法，特别是实验范例。 还提供了用于鉴定和治疗用于预防和治疗阿尔茨海默病的化合物的方法。
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公开(公告)号：US20090275495A1
公开(公告)日：2009-11-05
申请号：US11574367
申请日：2005-08-26
申请人： Malcolm Ward , Vaksha Patel , Emma McGregor , Nicola Leeds , Helen Byers , James Campbell , Kit-Yi Leung , Jules Westbrook
发明人： Malcolm Ward , Vaksha Patel , Emma McGregor , Nicola Leeds , Helen Byers , James Campbell , Kit-Yi Leung , Jules Westbrook
IPC分类号： A61K38/00
CPC分类号： G01N33/6896 , G01N2500/00 , G01N2800/2821
摘要： Methods and compositions relating to Alzheimer's disease are provided, including proteins that are differentially expressed in Alzheimer's disease as compared to the normal state. Further provided are methods, particularly experimental paradigms, for the identification of differential expressed proteins that are potential molecular targets for compounds to treat or prevent Alzheimer's disease. Also provided are methods for the identification and therapeutic use of compounds for the prevention and treatment of Alzheimer's disease.
摘要翻译： 提供了与阿尔茨海默病相关的方法和组合物，包括与正常状态相比在阿尔茨海默氏病中差异表达的蛋白质。 还提供了用于鉴定作为治疗或预防阿尔茨海默病的化合物的潜在分子靶标的差异表达蛋白质的方法，特别是实验范例。 还提供了用于鉴定和治疗用于预防和治疗阿尔茨海默病的化合物的方法。
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公开(公告)号：US07897361B2
公开(公告)日：2011-03-01
申请号：US11664076
申请日：2005-09-29
申请人： Jules Westbrook , Helen Byers , Malcolm Ward , Simon Lovestone , Abdul Hye , Stephen Lynham , Richard Joubert , Petra Prefot , Karsten Kuhn , Christian Baumann , Juergen Schaefer , Thorsten Prinz , Stefan Kienle
发明人： Jules Westbrook , Helen Byers , Malcolm Ward , Simon Lovestone , Abdul Hye , Stephen Lynham , Richard Joubert , Petra Prefot , Karsten Kuhn , Christian Baumann , Juergen Schaefer , Thorsten Prinz , Stefan Kienle
IPC分类号： C12Q1/68 , G01N33/53 , G01N33/566 , G01N33/567
CPC分类号： G01N33/6896 , G01N2800/2821 , G01N2800/52
摘要： Methods and compositions relating to Alzheimer's disease are provided. Specifically, proteins that are differentially expressed in the Alzheimer's disease state relative to their expression in the normal state are provided. Proteins associated with Alzheimer's disease are identified and described. Methods of diagnosis of Alzheimer's disease using the differentially expressed proteins are also provided, as are methods for the identification and therapeutic use of compounds for the prevention and treatment of Alzheimer's disease.
摘要翻译： 提供了与阿尔茨海默病相关的方法和组合物。 具体地，提供了在阿尔茨海默病状态下相对于其在正常状态下的表达差异表达的蛋白质。 鉴定和描述与阿尔茨海默氏病相关的蛋白质。 还提供了使用差异表达的蛋白质来诊断阿尔茨海默氏病的方法，以及化合物的鉴定和治疗用途的预防和治疗阿尔茨海默病的方法。
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公开(公告)号：US20080070995A1
公开(公告)日：2008-03-20
申请号：US11664076
申请日：2005-09-29
申请人： Jules Westbrook , Helen Byers , Malcolm Ward , Simon Lovestone , Abdul Hye , Stephen Lynham , Richard Joubert , Petra Prefot , Karsten Kuhn , Christian Baumann , Juergen Schaefer , Thorsten Prinz , Stefan Kienle
发明人： Jules Westbrook , Helen Byers , Malcolm Ward , Simon Lovestone , Abdul Hye , Stephen Lynham , Richard Joubert , Petra Prefot , Karsten Kuhn , Christian Baumann , Juergen Schaefer , Thorsten Prinz , Stefan Kienle
CPC分类号： G01N33/6896 , G01N2800/2821 , G01N2800/52
摘要： Methods and compositions relating to Alzheimer's disease are provided. Specifically, proteins that are differentially expressed in the Alzheimer's disease state relative to their expression in the normal state are provided. Proteins associated with Alzheimer's disease are identified and described. Methods of diagnosis of Alzheimer's disease using the differentially expressed proteins are also provided, as are methods for the identification and therapeutic use of compounds for the prevention and treatment of Alzheimer's disease.
摘要翻译： 提供了与阿尔茨海默病相关的方法和组合物。 具体地，提供了在阿尔茨海默病状态下相对于其在正常状态下的表达差异表达的蛋白质。 鉴定和描述与阿尔茨海默氏病相关的蛋白质。 还提供了使用差异表达的蛋白质来诊断阿尔茨海默氏病的方法，以及化合物的鉴定和治疗用途的预防和治疗阿尔茨海默病的方法。
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公开(公告)号：US20110165146A1
公开(公告)日：2011-07-07
申请号：US13005121
申请日：2011-01-12
申请人： Jules Westbrook , Helen Byers , Malcolm Ward , Simon Lovestone , Abdul Hye , Stephen Lynham , Richard Joubert , Petra Prefot , Karsten Kuhn , Christian Baumann , Juergen Schaefer , Thorsten Prinz , Stefan Kienle
发明人： Jules Westbrook , Helen Byers , Malcolm Ward , Simon Lovestone , Abdul Hye , Stephen Lynham , Richard Joubert , Petra Prefot , Karsten Kuhn , Christian Baumann , Juergen Schaefer , Thorsten Prinz , Stefan Kienle
IPC分类号： A61K39/395 , G01N33/53 , G01N33/00 , A61P25/28
CPC分类号： G01N33/6896 , G01N2800/2821 , G01N2800/52
摘要： Methods and compositions relating to Alzheimer's disease are provided. Specifically, proteins that are differentially expressed in the Alzheimer's disease state relative to their expression in the normal state are provided. Proteins associated with Alzheimer's disease are identified and described. Methods of diagnosis of Alzheimer's disease using the differentially expressed proteins are also provided, as are methods for the identification and therapeutic use of compounds for the prevention and treatment of Alzheimer's disease.
摘要翻译： 提供了与阿尔茨海默病相关的方法和组合物。 具体地，提供了在阿尔茨海默病状态下相对于其在正常状态下的表达差异表达的蛋白质。 鉴定和描述与阿尔茨海默氏病相关的蛋白质。 还提供了使用差异表达的蛋白质来诊断阿尔茨海默氏病的方法，以及化合物的鉴定和治疗用途的预防和治疗阿尔茨海默病的方法。
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