公开(公告)号：US08658133B2

公开(公告)日：2014-02-25

申请号：US11574367

申请日：2005-08-26

申请人： Malcolm Ward ,  Vaksha Patel ,  Emma McGregor ,  Nicola Leeds ,  Helen Byers ,  James Campbell ,  Kit-Yi Leung ,  Jules Westbrook

发明人： Malcolm Ward ,  Vaksha Patel ,  Emma McGregor ,  Nicola Leeds ,  Helen Byers ,  James Campbell ,  Kit-Yi Leung ,  Jules Westbrook

IPC分类号： A61K49/00 ,  G01N33/15

CPC分类号： G01N33/6896 ,  G01N2500/00 ,  G01N2800/2821

摘要： Methods and compositions relating to Alzheimer's disease are provided, including proteins that are differentially expressed in Alzheimer's disease as compared to the normal state. Further provided are methods, particularly experimental paradigms, for the identification of differential expressed proteins that are potential molecular targets for compounds to treat or prevent Alzheimer's disease. Also provided are methods for the identification and therapeutic use of compounds for the prevention and treatment of Alzheimer's disease.

摘要翻译： 提供了与阿尔茨海默病相关的方法和组合物，包括与正常状态相比在阿尔茨海默氏病中差异表达的蛋白质。 还提供了用于鉴定作为治疗或预防阿尔茨海默病的化合物的潜在分子靶标的差异表达蛋白质的方法，特别是实验范例。 还提供了用于鉴定和治疗用于预防和治疗阿尔茨海默病的化合物的方法。

公开(公告)号：US20090275495A1

公开(公告)日：2009-11-05

申请号：US11574367

申请日：2005-08-26

申请人： Malcolm Ward ,  Vaksha Patel ,  Emma McGregor ,  Nicola Leeds ,  Helen Byers ,  James Campbell ,  Kit-Yi Leung ,  Jules Westbrook

发明人： Malcolm Ward ,  Vaksha Patel ,  Emma McGregor ,  Nicola Leeds ,  Helen Byers ,  James Campbell ,  Kit-Yi Leung ,  Jules Westbrook

IPC分类号： A61K38/00

CPC分类号： G01N33/6896 ,  G01N2500/00 ,  G01N2800/2821

摘要： Methods and compositions relating to Alzheimer's disease are provided, including proteins that are differentially expressed in Alzheimer's disease as compared to the normal state. Further provided are methods, particularly experimental paradigms, for the identification of differential expressed proteins that are potential molecular targets for compounds to treat or prevent Alzheimer's disease. Also provided are methods for the identification and therapeutic use of compounds for the prevention and treatment of Alzheimer's disease.

摘要翻译： 提供了与阿尔茨海默病相关的方法和组合物，包括与正常状态相比在阿尔茨海默氏病中差异表达的蛋白质。 还提供了用于鉴定作为治疗或预防阿尔茨海默病的化合物的潜在分子靶标的差异表达蛋白质的方法，特别是实验范例。 还提供了用于鉴定和治疗用于预防和治疗阿尔茨海默病的化合物的方法。

公开(公告)号：US09028801B2

公开(公告)日：2015-05-12

申请号：US11792686

申请日：2005-12-07

申请人： Malcolm Andrew Ward ,  John Collinge ,  Graham Stuart Jackson ,  Emma McGregor ,  Nicola Louise Leeds ,  James Campbell ,  Jules Arthur Westbrook ,  Helen Louise Byers

发明人： Malcolm Andrew Ward ,  John Collinge ,  Graham Stuart Jackson ,  Emma McGregor ,  Nicola Louise Leeds ,  James Campbell ,  Jules Arthur Westbrook ,  Helen Louise Byers

IPC分类号： A61B5/145 ,  G01N33/48 ,  C07K14/805 ,  C07K14/75 ,  C07K14/705 ,  G01N33/68

CPC分类号： G01N33/6896 ,  G01N2800/2828 ,  G01N2800/56 ,  G01N2800/60

摘要： The invention relates to a method of diagnosis of vCJD in a diagnostic sample of a valid body tissue taken from a human subject, which comprises detecting an increased concentration of a protein in the diagnostic sample, compared with a sample of a control human subject, the protein being: beta-actin (SwissProt Acc. No. P60709), apolipoprotein A-IV precursor (SwissProt Acc. No. P06727); haptoglobin beta-chain consisting of residues 162-406 (SwissProt Acc. No. P00738); haemoglobin beta chain (SwissProt Acc. No. P02023); or alpha-1-antitrypsin (SwissProt Acc. No. P01009); or a decreased concentration of a protein in the diagnostic sample, compared with a sample of a control, normal human subject, the protein being plasma protease (C1) inhibitor precursor (SwissProt Acc. No. P05155); complement component 1, s sub-component (SwissProt Acc. No. P09871); butyrylcholinesterase precursor (SwissProt Acc. No. P06276); complement component C4B (SwissProt Acc. No. P01028); lumican (SwissProt Acc. No. P51884); alpha-fibrinogen precursor (SwissProt Acc. No. P02671); IGHG4 protein (Swiss Prot Acc. No. Q8TC63) or immunoglobulin lambda heavy chain. Other marker proteins are also disclosed.

摘要翻译： 本发明涉及一种诊断样品中vCJD的方法，该方法是从人体受试者获取的有效身体组织的诊断样本中，其与检测样本中的蛋白质的浓度相比较，与对照人受试者相比， 蛋白质是：β-肌动蛋白（SwissProt Acc.P60709），载脂蛋白A-IV前体（SwissProt Acc.Po6727）; 由残基162-406组成的触珠蛋白β链（SwissProt Acc.P00738）; 血红蛋白β链（SwissProt Acc。编号P02023）; 或α-1-抗胰蛋白酶（SwissProt Acc。编号P01009）; 或与对照组，正常人受试者的样品，蛋白质是血浆蛋白酶（C1）抑制剂前体（SwissProt Acc.No.P05155））相比，诊断样品中蛋白质的浓度降低。 补充成分1的子成分（SwissProt Acc。No.P09871）; 丁酰胆碱酯酶前体（SwissProt Acc.Po6276）; 补体成分C4B（SwissProt Acc。No.P01028）; lumican（SwissProt Acc。No. P51884）; α-纤维蛋白原前体（SwissProt Acc。编号P02671）; IGHG4蛋白（Swiss Prot Acc。No.Q8TC63）或免疫球蛋白λ重链。 还公开了其它标记蛋白。

公开(公告)号：US20080213802A1

公开(公告)日：2008-09-04

申请号：US11792686

申请日：2005-12-07

申请人： Malcolm Andrew Ward ,  John Collinge ,  Graham Stuart Jackson ,  Emma McGregor ,  Nicola Louise Leeds ,  James Campbell ,  Jules Arthur Westbrook ,  Helen Louise Byers

发明人： Malcolm Andrew Ward ,  John Collinge ,  Graham Stuart Jackson ,  Emma McGregor ,  Nicola Louise Leeds ,  James Campbell ,  Jules Arthur Westbrook ,  Helen Louise Byers

IPC分类号： G01N33/53 ,  C12Q1/02 ,  C12Q1/46

CPC分类号： G01N33/6896 ,  G01N2800/2828 ,  G01N2800/56 ,  G01N2800/60

摘要： The invention relates to a method of diagnosis of vCJD in a diagnostic sample of a valid body tissue taken from a human subject, which comprises detecting an increased concentration of a protein in the diagnostic sample, compared with a sample of a control human subject, the protein being: beta-actin (SwissProt Ace. No. P60709), apolipoprotein A-IV precursor (SwissProt Acc. No. P06727); haptoglobin beta-chain consisting of residues 162-406 (SwissProt Acc. No. P00738); haemoglobin beta chain (SwissProt Ace. No. P02023); or alpha-1-antitrypsin (SwissProt Ace. No. P01009); or a decreased concentration of a protein in the diagnostic sample, compared with a sample of a control, normal human subject, the protein being plasma protease (C1) inhibitor precursor (SwissProt Acc. No. P05155); complement component 1, s sub-component (SwissProt Acc. No. P09871); butyrylcholinesterase precursor (SwissProt Acc. No. P06276); complement component C4B (SwissProt Acc. No. P01028); lumican (SwissProt Ace. No. P51884); alpha-fibrinogen precursor (SwissProt Ace. No. P02671); IGHG4 protein (Swiss Prot Ace. No. Q8TC63) or immunoglobulin lambda heavy chain. Other marker proteins are also disclosed.

摘要翻译： 本发明涉及一种诊断样品中vCJD的方法，该方法是从人体受试者获取的有效身体组织的诊断样本中，其与检测样本中的蛋白质的浓度相比较，与对照人受试者相比， 蛋白质是：β-肌动蛋白（SwissProt Ace.No.P60709），载脂蛋白A-IV前体（SwissProt Acc.Po6727）; 由残基162-406组成的触珠蛋白β链（SwissProt Acc.P00738）; 血红蛋白β链（SwissProt Ace。编号P02023）; 或α-1-抗胰蛋白酶（SwissProt Ace.Po1009）; 或与对照组，正常人受试者的样品，蛋白质是血浆蛋白酶（C1）抑制剂前体（SwissProt Acc.No.P05155））相比，诊断样品中蛋白质的浓度降低。 补充成分1的子成分（SwissProt Acc。No.P09871）; 丁酰胆碱酯酶前体（SwissProt Acc.Po6276）; 补体成分C4B（SwissProt Acc。No.P01028）; lumican（SwissProt Ace。No. P51884）; α-纤维蛋白原前体（SwissProt Ace。编号P02671）; IGHG4蛋白（Swiss Prot Ace。No.Q8TC63）或免疫球蛋白λ重链。 还公开了其它标记蛋白。

公开(公告)号：US20080286263A1

公开(公告)日：2008-11-20

申请号：US11792758

申请日：2005-12-07

申请人： Nicola Louise Leeds ,  Malcolm Andrew Ward ,  Sarah Joanna Tabrizi ,  Annette Dalrymple ,  Emma McGregor ,  James Campbell ,  Jules Arthur Westbrook ,  Helen Louise Dyers

发明人： Nicola Louise Leeds ,  Malcolm Andrew Ward ,  Sarah Joanna Tabrizi ,  Annette Dalrymple ,  Emma McGregor ,  James Campbell ,  Jules Arthur Westbrook ,  Helen Louise Dyers

IPC分类号： A61K39/395 ,  C12Q1/02 ,  A61P25/00 ,  C07K1/26 ,  G01N33/53

CPC分类号： G01N33/6896 ,  G01N2800/2828 ,  G01N2800/56 ,  G01N2800/60

摘要： The invention relates to a method of diagnosis of Huntington's Disease in a diagnostic sample of a valid body tissue taken from a human subject, which comprises detecting an altered concentration of a protein in the diagnostic sample, compared with a sample of a control human subject, the protein being selected from: Swiss Prot accession number: Protein name; P10909: Clusterin precursor; P00738: Haptoglobin precursor; P01009: Alpha-1-antitrypsin precursor; P01024: Complement C3 precursor; P01620: 1 g kappa chain V-III region; P01834: 1 g kappa chain C region P01842: 1 g lambda chain C regions; P01857: 1 g gamma-1 chain C region; P01859: Ig gamma-2 chain C region; P01876: 1 g alpha-1 chain C region P02647: Apolipoprotein A-I precursor; P02649: Apolipoprotein E precursor; P02652: Apolipoprotein A-II precursor; P02655: Apolipoprotein C-II precursor; P02656: Apolipoprotein C-II precursor P02671: Fibrinogen alpha/alpha-E chain precursor; P02763: Alpha-1-acid glycoprotein 1 precursor; P02766: Transthyretin precursor; P02768: Serum albumin precursor; P02787: Serotransferrin precursor; P04196: Histidine-rich glycoprotein precursor; P06727: Apolipoprotein A-IV precursor; P19652: Alpha-1-acid glycoprotein 2 precursor; P68871/P02042: Hemoglobin beta chain/Hemoglobin delta chain; P60709: Beta actin.

摘要翻译： 本发明涉及一种在人受试者的有效身体组织的诊断样本中诊断亨廷顿病的方法，其包括检测诊断样品中蛋白质的浓度变化，与对照人受试者的样品相比， 该蛋白质选自：瑞士抗原登录号：蛋白质名称; P10909：Clusterin前体; P00738：近红球蛋白前体; P01009：α-1-抗胰蛋白酶前体; P01024：补体C3前体; P01620：1g卡巴链V-III区; P01834：1g卡巴链C区P01842：1个λ链C区; P01857：1gγ-1链C区; P01859：Igγ-2链C区; P01876：1gα-1链C区P02647：载脂蛋白A-1前体; P02649：载脂蛋白E前体; P02652：载脂蛋白A-II前体; P02655：载脂蛋白C-II前体; P02656：载脂蛋白C-II前体P02671：纤维蛋白原α/α-E链前体; P02763：α-1-酸性糖蛋白1前体; P02766：曲氨酸蛋白前体; P02768：血清白蛋白前体; P02787：血清转铁蛋白前体; P04196：富含组氨酸糖蛋白前体; P06727：载脂蛋白A-IV前体; P19652：α-1酸性糖蛋白2前体; P68871 / P02042：血红蛋白β链/血红蛋白三角链; P60709：β肌动蛋白

公开(公告)号：US08506957B2

公开(公告)日：2013-08-13

申请号：US11792758

申请日：2005-12-07

申请人： Nicola Louise Leeds ,  Malcolm Andrew Ward ,  Sarah Joanna Tabrizi ,  Annette Dalrymple ,  Emma McGregor ,  James Campbell ,  Jules Arthur Westbrook ,  Helen Louise Byers

发明人： Nicola Louise Leeds ,  Malcolm Andrew Ward ,  Sarah Joanna Tabrizi ,  Annette Dalrymple ,  Emma McGregor ,  James Campbell ,  Jules Arthur Westbrook ,  Helen Louise Byers

IPC分类号： A61K39/395 ,  G01N33/68

CPC分类号： G01N33/6896 ,  G01N2800/2828 ,  G01N2800/56 ,  G01N2800/60

摘要： The invention relates to a method of diagnosis of Huntington's Disease in a diagnostic sample of a valid body tissue taken from a human subject, which comprises detecting an altered concentration of a protein in the diagnostic sample, compared with a sample of a control human subject, the protein being selected from: Swiss Prot accession number: Protein name; P10909: Clusterin precursor; P00738: Haptoglobin precursor; P01009: Alpha-1-antitrypsin precursor; P01024: Complement C3 precursor; P01620: 1g kappa chain V-III region; P01834: 1 g kappa chain C region P01842: 1g lambda chain C regions; P01857: 1g gamma-1 chain C region; P01859: Ig gamma-2 chain C region; P01876: 1g alpha-1 chain C region P02647: Apolipoprotein A-I precursor; P02649: Apolipoprotein E precursor; P02652: Apolipoprotein A-II precursor; P02655: Apolipoprotein C-II precursor; P02656: Apolipoprotein C-II precursor P02671: Fibrinogen alpha/alpha-E chain precursor; P02763: Alpha-1-acid glycoprotein 1 precursor; P02766: Transthyretin precursor; P02768: Serum albumin precursor; P02787: Serotransferrin precursor; P04196: Histidine-rich glycoprotein precursor; P06727: Apolipoprotein A-IV precursor; P19652: Alpha-1-acid glycoprotein 2 precursor; P68871/P02042: Hemoglobin beta chain/Hemoglobin delta chain; P60709: Beta actin.

摘要翻译： 本发明涉及一种在人受试者的有效身体组织的诊断样本中诊断亨廷顿病的方法，其包括检测诊断样品中蛋白质的浓度变化，与对照人受试者的样品相比， 该蛋白质选自：瑞士抗原登录号：蛋白质名称; P10909：Clusterin前体; P00738：近红球蛋白前体; P01009：α-1-抗胰蛋白酶前体; P01024：补体C3前体; P01620：1gκ链V-III区; P01834：1g卡巴链C区P01842：1gλ链C区; P01857：1gγ-1链C区; P01859：Igγ-2链C区; P01876：1gα-1链C区P02647：载脂蛋白A-1前体; P02649：载脂蛋白E前体; P02652：载脂蛋白A-II前体; P02655：载脂蛋白C-II前体; P02656：载脂蛋白C-II前体P02671：纤维蛋白原α/α-E链前体; P02763：α-1-酸性糖蛋白1前体; P02766：曲氨酸蛋白前体; P02768：血清白蛋白前体; P02787：血清转铁蛋白前体; P04196：富含组氨酸糖蛋白前体; P06727：载脂蛋白A-IV前体; P19652：α-1酸性糖蛋白2前体; P68871 / P02042：血红蛋白β链/血红蛋白三角链; P60709：β肌动蛋白

公开(公告)号：US09956475B1

公开(公告)日：2018-05-01

申请号：US14998913

申请日：2016-03-03

申请人： James Campbell ,  Benjamin Cichoski ,  Daniel Mandel

发明人： James Campbell ,  Benjamin Cichoski ,  Daniel Mandel

IPC分类号： A63F1/04 ,  A63H3/00

CPC分类号： A63F1/04 ,  A63F9/0495 ,  A63F2250/1036 ,  A63H3/005

摘要： A game action figure for use in a tabletop combat game with other game action figures is disclosed. The game action figure includes a body having arms and legs; a lower housing, the lower housing including a first storage location for a pair of dice, a second storage location for a set of cards, a hexagonal spacer, and a weapon held by one of the arms during game play, and a third storage location for a measuring string; and an upper housing, the upper housing configured to attach to the lower housing and enclose a space between the lower and upper housing in which the set of cards, hexagonal spacer and measuring string are stored.

公开(公告)号：US08807958B2

公开(公告)日：2014-08-19

申请号：US12442782

申请日：2007-09-25

申请人： Timothy Sidlyarevich ,  James Campbell ,  John A. Metza

发明人： Timothy Sidlyarevich ,  James Campbell ,  John A. Metza

IPC分类号： F04B43/12 ,  F04B11/00

CPC分类号： F04B11/005 ,  F04B11/0058 ,  F04B15/02 ,  F04B17/03 ,  F04B49/06 ,  F04B2201/00 ,  F04B2201/12 ,  F04B2201/1201 ,  F04B2203/02 ,  F04B2203/0209 ,  F04B2205/00 ,  F04B2205/05

摘要： A two (or more) piston pump system (10) is provided with both pumps (12) being crank (14) driven. The system does not have a mechanical camshaft, but a software algorithm, which acts like one in controller (20). The algorithm will LEARN and create a unique speed profile, which will mimic the mechanical camshaft. For practical purposes the speed profile of output gear is called Cam profile with software acting as an imaginary camshaft. The algorithm utilizes Crank Angle Estimation, Learn Curve Generation, Smoothing and Advance Timing Calculation.

摘要翻译： 两个（或多个）活塞泵系统（10）设置有驱动曲柄（14）的两个泵（12）。 该系统没有机械凸轮轴，而是一个软件算法，它像控制器（20）中一样。 该算法将学习并创建一个独特的速度曲线，这将模拟机械凸轮轴。 出于实际目的，输出齿轮的速度曲线称为凸轮轮廓，软件用作假想凸轮轴。 该算法利用曲柄角估计，学习曲线生成，平滑和提前计时。

公开(公告)号：US20120259921A1

公开(公告)日：2012-10-11

申请号：US13528152

申请日：2012-06-20

申请人： Brian Reistad ,  William D. Snapper ,  Andrew C. Payne ,  James Campbell

发明人： Brian Reistad ,  William D. Snapper ,  Andrew C. Payne ,  James Campbell

IPC分类号： G06F15/16

CPC分类号： H04L51/32 ,  G06F3/04847 ,  G06Q10/06316 ,  G06Q30/02 ,  G06Q30/0201 ,  G06Q30/0235 ,  G06Q30/0239 ,  G06Q30/0241 ,  G06Q30/0255 ,  G06Q30/0271 ,  H04L51/04 ,  H04L51/22

摘要： Systems and methods for personalizing marketing dialogues are disclosed. Specifically, embodiments of the systems and methods presented may associate a variable to each event in a script. A variable may be associated with each event. A first instruction in the script may be operable to send a first communication to a user from a server via the network. A second instruction may be operable to according to the script based on the stored set of user information and the variable associated with the first event

摘要翻译： 披露了个性化营销对话的系统和方法。 具体地，所呈现的系统和方法的实施例可以将变量与脚本中的每个事件相关联。 变量可能与每个事件相关联。 脚本中的第一指令可以用于经由网络从服务器向用户发送第一通信。 第二指令可以可操作以根据所存储的用户信息集合和与第一事件相关联的变量的脚本

公开(公告)号：US20120060298A1

公开(公告)日：2012-03-15

申请号：US12878033

申请日：2010-09-09

申请人： James Campbell

发明人： James Campbell

IPC分类号： A01K97/00

CPC分类号： A01K97/00 ,  B24D15/02 ,  B24D15/06

摘要： A fish hook cleaning tool comprising a tapered body including a blunt end and a pointed end, a hole within the blunt end, a tip along the pointed end, and a textured material within the hole and on the pointed end wherein the textured material enables a user to clean and file a fish hook to remove a particulate from the fish hook and to sharpen the fish hook between uses. The tip of the pointed end is sharp enough to fit within an eyelet of the fish hook to clean the particulate within the eyelet to more easily thread a fishing line.

摘要翻译： 一种鱼钩清洁工具，其包括锥形体，其包括钝端和尖端，钝端内的孔，沿着尖端的尖端，以及在孔内和尖端上的纹理材料，其中纹理材料使得 用户清洁并提起鱼钩以从鱼钩中除去颗粒物，并在使用之间锐化鱼钩。 尖端的尖端足够锐利，以适合鱼钩的孔眼以清洁孔眼内的颗粒，以更容易地钓鱼线。