公开(公告)号：US20090177145A1

公开(公告)日：2009-07-09

申请号：US12373356

申请日：2007-02-22

申请人： Malin Ohlander ,  Kjell Noren ,  Johan Eckerdal ,  Mika Hietanen ,  Kenth Nilsson ,  Urban Lonn

发明人： Malin Ohlander ,  Kjell Noren ,  Johan Eckerdal ,  Mika Hietanen ,  Kenth Nilsson ,  Urban Lonn

IPC分类号： A61M37/00 ,  G06Q50/00 ,  A61B5/1459 ,  A61B5/02

CPC分类号： A61B5/02055 ,  A61B5/0086 ,  A61B5/053 ,  A61B5/0538 ,  A61B5/14535 ,  A61N1/36521 ,  G06Q50/22

摘要： A method, an implantable medical device, and a computer-readable medium encoded with programming instructions allow monitoring of a hematocrit value and an SvO2 level of a patient, making use of at least one medical lead connected to an implantable medical device that carries an optical sensor module that measures at least one hematocrit value and at least one SvO2 value using at least first, second and third light radiation wavelengths, by determining a present hematocrit value from at least one of the measured hematocrit values and determining a present SvO2 value from at least one of the measured SvO2 values, and determining a patient status by evaluating the present hematocrit value and the present SvO2 value, to allow a change in the patient status to be identified.

摘要翻译： 一种方法，可植入医疗装置和用程序指令编码的计算机可读介质允许监测患者的血细胞比容值和SvO2水平，利用连接到可植入医疗装置的至少一个医疗引线，该医用引线携带光学 传感器模块，其通过使用至少第一，第二和第三光辐射波长测量至少一个血细胞比容值和至少一个SvO2值，通过从所测量的血细胞比容值中的至少一个确定目前的血细胞比容值，并从 测量的SvO2值中的至少一个，以及通过评估当前血细胞比容值和当前SvO2值来确定患者状态，以允许识别患者状态的改变。

公开(公告)号：US20080091239A1

公开(公告)日：2008-04-17

申请号：US11582211

申请日：2006-10-16

申请人： Anna-Karin Johansson ,  Kenth Nilsson ,  Cecilia Tuvstedt ,  Kjell Noren ,  Anders Bjorling ,  Andreas Blomqvist ,  Berit Larsson ,  Sven-Erik Hedberg ,  Karin Jarverud ,  Nils Holmstrom

发明人： Anna-Karin Johansson ,  Kenth Nilsson ,  Cecilia Tuvstedt ,  Kjell Noren ,  Anders Bjorling ,  Andreas Blomqvist ,  Berit Larsson ,  Sven-Erik Hedberg ,  Karin Jarverud ,  Nils Holmstrom

IPC分类号： A61N1/36 ,  A61N1/362 ,  A61N1/39

CPC分类号： A61N1/36514 ,  A61N1/3956

摘要： In a cardiac assist device and method, a microphone is placed in contact with the epicardium of the heart of a patient, and heart and lung sounds are simultaneously detected at the placement location of the microphone. The heart and lung sounds are automatically analyzed to set an appropriate cardiac therapy for the patient.

摘要翻译： 在心脏辅助装置和方法中，将麦克风放置成与患者心脏的心外膜接触，并且在麦克风的放置位置同时检测心脏和肺部的声音。 自动分析心脏和肺部声音，为患者设定适当的心脏治疗。

公开(公告)号：US06915162B2

公开(公告)日：2005-07-05

申请号：US10002496

申请日：2001-11-15

申请人： Kjell Noren ,  Charlotte Kjellmann ,  Kenth Nilsson ,  Sven-Erik Hedberg

发明人： Kjell Noren ,  Charlotte Kjellmann ,  Kenth Nilsson ,  Sven-Erik Hedberg

IPC分类号： A61B5/0215 ,  A61N1/365 ,  A61B5/04

CPC分类号： A61N1/36564 ,  A61B5/0215 ,  A61B5/7239

摘要： An implantable medical device has a pressure sensing arrangement to measure right ventricular pressure of a heart including a pressure sensor adapted to be positioned in the right ventricle of the heart, to measure the pressure and to generate a pressure signal in response to the measured pressure. The pressure sensing arrangement also has a pressure signal processor and a timing unit. The processor determines from the pressure signal, using diastolic timing signals from the timing unit based on the pressure signal identifying the diastolic phase, a diastolic pressure signal representing the ventricular pressure only during the diastolic phase of the heart cycle.

摘要翻译： 可植入医疗装置具有用于测量心脏的右心室压力的压力感测装置，包括适于定位在心脏右心室的压力传感器，以测量压力并响应于测量的压力产生压力信号。 压力感测装置还具有压力信号处理器和定时单元。 处理器根据压力信号，基于识别舒张期的压力信号使用来自定时单元的舒张定时信号，仅在心脏周期舒张期期间表示心室压力的舒张压信号。

公开(公告)号：US20090210023A1

公开(公告)日：2009-08-20

申请号：US12305552

申请日：2006-06-21

申请人： Kjell Noren ,  Kenth Nilsson

发明人： Kjell Noren ,  Kenth Nilsson

IPC分类号： A61N1/365

CPC分类号： A61N1/36585 ,  A61N1/36521 ,  A61N1/36564 ,  A61N1/36578

摘要： An implantable heart stimulating device has a stimulation pulse generator that emits stimulation pulses at an adjustable stimulation rate, an activity sensor that emits an activity signal in response to detected activity of the patient, and a physiological parameter sensor that generates a physiological sensor signal in response to a detected physiological parameter. The activity and physiological sensor signals are supplied to a control arrangement that sets the stimulation rate for the stimulation pulse generator by executing a stimulation rate algorithm dependent on those signals. In the stimulation rate algorithm, if the physiological signal indicates an emotional stress on the part of the patient, the stimulation rate is increased to an adjustable emotional stress rate level, and if no increase in the activity signal occurs during a predetermined time period following the stimulation rate increase, the stimulation rate is decreased.

摘要翻译： 可植入心脏刺激装置具有以可调节刺激速率发出刺激脉冲的刺激脉冲发生器，响应于患者的检测到的活动而发出活动信号的活动传感器，以及响应于生成生理传感器信号的生理参数传感器 到检测到的生理参数。 活动和生理传感器信号被提供给控制装置，其通过执行依赖于那些信号的刺激速率算法来设定刺激脉冲发生器的刺激速率。 在刺激速率算法中，如果生理信号表示患者的情绪应激，则刺激率增加到可调节的情绪应激率水平，并且如果活动信号的增加在后面的预定时间段内不发生 刺激率增加，刺激率降低。

公开(公告)号：US08812109B2

公开(公告)日：2014-08-19

申请号：US13593334

申请日：2012-08-23

申请人： Andreas Blomqvist ,  Kjell Noren

发明人： Andreas Blomqvist ,  Kjell Noren

IPC分类号： A61N1/00

CPC分类号： A61N1/00 ,  A61N1/3627 ,  A61N1/36514 ,  A61N1/36564 ,  A61N1/3682 ,  A61N1/3684

摘要： In an implantable medical device and a method for stimulating a heart of a patient, at least one left atrial pressure (LAP) signal over a cardiac cycle is obtained. The A-wave is identified using the LAP signal and a maximum positive rate of change of the A-wave of the LAP signal is determined. The maximum positive rate of change of the A-wave corresponds to the rate which the pressure in the atrium raises as the atria contraction forces more blood into the ventricle during the very last stage of diastole. Further, AV and/or VV delay is adjusted in response to the maximum positive rate of change of the A-wave, wherein a reduction of the maximum positive rate of change of the A-wave indicates an AV and/or VV delay providing an enhanced hemodynamic performance.

摘要翻译： 在可植入医疗装置和刺激患者心脏的方法中，获得心动周期上的至少一个左心房压力（LAP）信号。 使用LAP信号识别A波，并确定LAP信号的A波的最大正比率。 A波的最大阳性变化率对应于心房收缩期间压力升高的速率，因为心房收缩在舒张期的最后阶段迫使更多的血液进入心室。 此外，AV和/或VV延迟响应于A波的最大正的变化速率而被调整，其中A波的最大正的变化率的减小表示AV和/或VV延迟提供 增强血液动力学性能。

公开(公告)号：US08798765B2

公开(公告)日：2014-08-05

申请号：US13471167

申请日：2012-05-14

申请人： Kjell Noren ,  Anders Bjorling ,  Tomas Svensson ,  Sven-Erik Hedberg ,  Allen Keel ,  Stuart Rosenberg ,  Kyungmoo Ryu

发明人： Kjell Noren ,  Anders Bjorling ,  Tomas Svensson ,  Sven-Erik Hedberg ,  Allen Keel ,  Stuart Rosenberg ,  Kyungmoo Ryu

IPC分类号： A61N1/365 ,  A61N1/372 ,  A61N1/368

CPC分类号： A61N1/36507 ,  A61N1/3682 ,  A61N1/3684 ,  A61N1/37252

摘要： CRT settings for an implantable medical device are determined by applying pacing pulses to heart chambers of a scheme of different combinations of interchamber delays. A respective width parameter value representing an R or P wave width is determined for each such delay combination based on an ECG representing signal and the width parameter values are employed to estimate a parametric model defining the width parameter as a function of interchamber delays. Candidate interchamber delays that minimize the width parameter are determined from the parametric model and employed to determine optimal CRT settings. The technique provides an efficient way of finding optimal CRT settings when multiple pacing sites are available in a heart chamber.

摘要翻译： 用于可植入医疗装置的CRT设置通过将不同组合的车间延迟的方案应用于心室来进行起搏脉冲来确定。 基于ECG表示信号为每个这样的延迟组合确定表示R或P波宽的相应宽度参数值，并且使用宽度参数值来估计定义作为间歇延迟的函数的宽度参数的参数模型。 从参数模型中确定最小化宽度参数的候选车间延迟，并用于确定最佳CRT设置。 该技术提供了一种在心室中可用多个起搏部位时可以找到最佳CRT设置的有效方式。

公开(公告)号：US08211032B2

公开(公告)日：2012-07-03

申请号：US13191253

申请日：2011-07-26

申请人： Stuart O. Schecter ,  Kjell Noren

发明人： Stuart O. Schecter ,  Kjell Noren

IPC分类号： A61B5/0452

CPC分类号： A61N1/36514 ,  A61N1/36578

摘要： A first lead provides therapeutic stimulation to the heart and includes a first mechanical sensor that measures physical contraction and relaxation of the heart. A controller induces delivery of therapeutic stimulation via the first lead. The controller receives signals from the first mechanical sensor indicative of the contraction and relaxation; develops a template signal that corresponds to the contraction and relaxation; and uses the template signal to modify the delivery of therapeutic stimulations. In another arrangement, a second lead, with a second mechanical sensor also provides signals to the controller indicative of contraction and relaxation. The first mechanical sensor is adapted to be positioned at the interventricular septal region of the heart, and the second mechanical sensor is adapted to be positioned in the lateral region of the left ventricle. The controller processes the signals from the first mechanical sensor and the second mechanical sensor to develop a dysynchrony index.

摘要翻译： 第一个引线提供对心脏的治疗刺激，并且包括测量心脏的身体收缩和松弛的第一机械传感器。 控制器通过第一引线诱导治疗性刺激。 控制器从第一机械传感器接收指示收缩和松弛的信号; 开发对应于收缩和放松的模板信号; 并使用模板信号修改治疗刺激的递送。 在另一种布置中，具有第二机械传感器的第二引线还向控制器提供指示收缩和松弛的信号。 第一机械传感器适于定位在心脏的室间隔区域，并且第二机械传感器适于定位在左心室的侧向区域中。 控制器处理来自第一机械传感器和第二机械传感器的信号以产生异步指数。

公开(公告)号：US20110245701A1

公开(公告)日：2011-10-06

申请号：US13076627

申请日：2011-03-31

申请人： Anders Bjorling ,  Malin Hollmark ,  Tomas Svensson ,  Stefan Hjelm ,  Kjell Noren ,  Karin Jarverud

发明人： Anders Bjorling ,  Malin Hollmark ,  Tomas Svensson ,  Stefan Hjelm ,  Kjell Noren ,  Karin Jarverud

IPC分类号： A61B5/0456 ,  A61N1/39

CPC分类号： A61B5/0456 ,  A61B5/0031 ,  A61B5/053 ,  A61B5/7264 ,  A61N1/3621 ,  A61N1/36521 ,  A61N1/3702 ,  A61N1/3925 ,  A61N1/3962

摘要： An implantable medical device, is designed to collect a signal representative of the electric activity of the heart and determine a cardiogenic impedance signal for at least a portion of the heart. An R-wave detector of the IMD detects the timing of an R-wave during a cardiac cycle based on the signal representative of the electric activity. A minimum detector detects the timing of a cardiogenic impedance minimum in the cardiogenic impedance signal and within a systolic time window of the cardiac cycle. A detected arrhythmia is then classified by the IMD based on the timing of the R-wave detected by the R-wave detector and the timing of the cardiogenic impedance minimum detected by the minimum detector.

摘要翻译： 可植入医疗装置被设计成收集表示心脏的电活动的信号，并确定至少一部分心脏的心源性阻抗信号。 基于代表电活动的信号，IMD的R波检测器在心动周期中检测R波的定时。 最小检测器检测心源性阻抗信号中心源性阻抗最小值的定时，并在心动周期的收缩时间窗内检测。 然后，基于由R波检测器检测到的R波的定时和由最小检测器检测的心源阻抗最小值的定时，通过IMD对检测到的心律失常进行分类。

公开(公告)号：US07970473B2

公开(公告)日：2011-06-28

申请号：US12244607

申请日：2008-10-02

申请人： Yelena Nabutovsky ,  Taraneh Ghaffari Farazi ,  Anders Bjorling ,  Kjell Noren ,  Gene A. Bornzin

发明人： Yelena Nabutovsky ,  Taraneh Ghaffari Farazi ,  Anders Bjorling ,  Kjell Noren ,  Gene A. Bornzin

IPC分类号： A61N1/00

CPC分类号： A61B5/046 ,  A61B5/04011 ,  A61B5/0464 ,  A61N1/3702 ,  A61N1/3956

摘要： Methods and systems are provided for performing ventricular arrhythmia monitoring using at least two sensing channels that are each associated with different sensing vectors, for example by different pairs of extracardiac remote sensing electrodes. Myopotential associated with each of the sensing channels in monitored, and a ventricular arrhythmia monitoring mode is selected based thereon (e.g., based on determined myopotential levels). Ventricular arrhythmia monitoring is then performed using the selected monitoring mode.

摘要翻译： 提供的方法和系统用于使用至少两个感测通道进行心室心律失常监测，每个感测通道各自与不同的感测向量相关联，例如通过不同的心外感测电极对。 与监测的每个感测通道相关联的神经电位和基于（例如，基于确定的电位电平）来选择心室心律失常监测模式。 然后使用所选择的监测模式进行室性心律失常监测。

公开(公告)号：US20100249864A1

公开(公告)日：2010-09-30

申请号：US12438397

申请日：2006-08-28

申请人： Karin Järverud ,  Kjell Noren

发明人： Karin Järverud ,  Kjell Noren

IPC分类号： A61N1/362 ,  A61B5/103

CPC分类号： A61B5/0205 ,  A61B5/0031 ,  A61B5/02028 ,  A61B5/0215 ,  A61B5/1116 ,  A61B5/686 ,  A61B5/7239 ,  A61N1/36564 ,  A61N1/3702

摘要： An apparatus for determining variation over time of a medical parameter of a human being obtained from a sensed signal has a sensor implantable in the human being for sensing the signal. A comparator compares at least one characteristic property, derived from the sensed signal obtained for at least one predetermined first level of activity of the human being, with corresponding reference property of a sensed reference signal, obtained for a predetermined reference level of activity of the human being, for determining a relation between the characteristic property of the sensed signal and the reference property. A trend determining unit determines trends in the medical parameter by analyzing the relation between the characteristic property of the sensed signal obtained at different times and the reference property. A corresponding method also function an implant for heart failure diagnostics also function as described. A sensor is then arranged to pick up dynamic mechanical information from the heart of the human being and generate a corresponding signal. A heart stimulator includes such an implant and a control unit arranged to control stimulation of the heart depending on determined trends in the medical parameter.

摘要翻译： 用于确定从感测信号获得的人的医学参数随时间变化的装置具有可植入人体的用于感测信号的传感器。 比较器比较从针对人的至少一个预定的第一活动水平获得的感测信号导出的至少一个特征属性与针对人的预定参考活动水平获得的感测参考信号的相应参考特性 用于确定感测信号的特性与参考属性之间的关系。 趋势确定单元通过分析在不同时间获得的感测信号的特性与参考属性之间的关系来确定医疗参数的趋势。 相应的方法也可以用于心力衰竭诊断的植入物也起到所述的作用。 然后设置传感器以从人的心脏拾取动态机械信息并产生相应的信号。 心脏刺激器包括这样的植入物和控制单元，其被布置成根据医学参数中确定的趋势来控制心脏的刺激。