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公开(公告)号：US06331324B1
公开(公告)日：2001-12-18
申请号：US09581554
申请日：2000-07-14
申请人： Mamoru Tomita , Kazuyoshi Sotoyama , Ryozo Watanabe , Kenji Mizuguchi , Hideo Shidara , Shoji Wakao , Masanori Hattori , Nobuyuki Motoyoshi
发明人： Mamoru Tomita , Kazuyoshi Sotoyama , Ryozo Watanabe , Kenji Mizuguchi , Hideo Shidara , Shoji Wakao , Masanori Hattori , Nobuyuki Motoyoshi
IPC分类号： A23L120
CPC分类号： A23C20/025 , A23L11/07
摘要： A soybean curd puree which can be applied to various foods and are useful for expansion of applications of soybean milk, and a process and apparatus for preparing the same, and the apparatus includes a system in which a raw material tank, heating apparatus, a holding pipe, first emulsifying dispersion apparatus, cooling apparatus and second emulsifying dispersion apparatus are arranged in that order, and coagulant supply apparatus connected between the heating apparatus and the holding pipe, and the process includes adding the coagulant to the soy milk, holding the temperature thereof at 40 to 90° C. to form a coagulated product, pre-crushing the product by the first emulsifying dispersion apparatus, followed by cooling to 10 to 35° C., and crushing the product by the second emulsifying dispersion apparatus into particles having the average particle diameter of 2 to 15 &mgr;m and 90% particles diameter of not more than 35 &mgr;m.
摘要翻译： 可应用于各种食品并可用于膨胀豆浆的应用的大豆凝乳泥以及其制备方法和装置，该装置包括：原料罐，加热装置，保持 管，第一乳化分散装置，冷却装置和第二乳化分散装置，并且凝结剂供给装置连接在加热装置和保持管之间，该方法包括将凝结剂加入到豆浆中，保持其温度 在40〜90℃下形成凝固物，通过第一乳化分散装置对产物进行预破碎，然后冷却至10〜35℃，通过第二乳化分散装置将产物粉碎成具有 平均粒径为2〜15μm，粒径90μm以下为90μm以下。
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公开(公告)号：US4361653A
公开(公告)日：1982-11-30
申请号：US225532
申请日：1981-01-16
申请人： Ryozo Watanabe , Mitsuomi Ohgaki
发明人： Ryozo Watanabe , Mitsuomi Ohgaki
CPC分类号： C12N9/6435 , C12Y304/21007
摘要： A plasminogen preparation comprising a plasminogen-containing aqueous solution or of plasminogen dry powder each admixed with at least one of lysine, phenylmethanesulfonyl fluoride, aprotinin, and soybean trypsin inhibitor in an effective amount for stabilizing plasminogen.
摘要翻译： 一种纤维蛋白溶酶原制剂，其含有纤维蛋白溶酶原的水溶液或纤维蛋白溶酶原干燥粉末，其与赖氨酸，苯基甲磺酰氟，抑肽酶和大豆胰蛋白酶抑制剂中的至少一种以有效量混合，用于稳定纤溶酶原。
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公开(公告)号：US3993581A
公开(公告)日：1976-11-23
申请号：US485318
申请日：1974-07-02
CPC分类号： A61K9/0026 , A61K31/02 , Y10S516/06
摘要： Oxygen-transferable perfluorocarbon compounds having 9 to 11 carbon atoms such as perfluorodecalin, perfluoro(C.sub.3.sub.-5 -alkylcyclohexanes), perfluoro(C.sub.4.sub.-6 -alkyl tetrahydropyrans), perfluoro(C.sub.5.sub.-7 -alkyltetrahydrofurans), perfluoro(C.sub.5.sub.-7 -alkylmorpholins) and perfluoro(C.sub.9.sub.-11 -trialkylamines) are emulsified in a physiologically acceptable aqueous solution such as Ringer's solution by the aid of a phospholipid as emulsifier and a fatty acid of 8 to 22 carbon atoms, alkali metal salt or monoglyceride thereof as emulsifying adjuvant. The emulsion is stable for a considerable period of time and contains particles having a particle size ranging from 0.05 to 0.3 .mu.. It is usable as a blood substitute or a perfurate for preservation of the internal organs.
摘要翻译： 可全氟（C 5-8 - 烷基环己烷），全氟（C 5-6 - 烷基四氢吡喃），全氟（C 5-7 - 烷基四氢呋喃），全氟（C 5-7 - 烷基四氢呋喃），全氟 ）和全氟（C9-11-三烷基胺）在生理学上可接受的水溶液如林格氏溶液中借助于磷脂作为乳化剂和8-22个碳原子的脂肪酸，其碱金属盐或其单甘油酯作为乳化助剂乳化 。 该乳液在相当长的一段时间内是稳定的并且含有粒度范围为0.05-0.3μm的颗粒。 它可用作血液替代物或用于保存内脏的胃酸。
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4.发明授权Process for preparing injection-purpose fluorocarbon emulsion capable of carrying oxygen 失效制备能承载氧气的注射用碳氟化合物乳液的方法
公开(公告)号：US3958014A
公开(公告)日：1976-05-18
申请号：US343148
申请日：1973-03-20
CPC分类号： A61K9/0026 , A61K31/02 , B01F17/0028 , B01F17/0042 , Y10S514/937
摘要： An injectable fluorocarbon emulsion capable of carrying oxygen, which can be used as artificial blood and organ perfusate, is prepared by emulsifying a fluorocarbon, having an ability to dissolve at least 30 V/V % of oxygen under a 100% oxygen atmosphere at an atmospheric pressure, in an aqueous salt solution with a surfactant, centrifuging the resulting aqueous emulsion thereby to reduce the fluorocarbon particles in the emulsion in size to particle sizes of the order of about 0.05 to 0.25 .mu., and then sterilizing the thus obtained emulsion under rotation. The resulting fluorocarbon emulsion can be used as an emergency blood substitute for transfusion.
摘要翻译： 通过在大气压下在100％氧气气氛下乳化具有溶解至少30V / V％的氧的能力的碳氟化合物来制备能够携带氧气的可注射的氟化碳乳液，其可以用作人造血液和器官灌注液 压力，在含有表面活性剂的盐水溶液中离心所得水乳液，从而将乳液中的碳氟化合物颗粒尺寸减小到约0.05至0.25μm量级的粒度，然后在旋转下对由此获得的乳液进行灭菌。 所得氟碳乳液可用作输血的紧急血液替代品。
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公开(公告)号：US4476093A
公开(公告)日：1984-10-09
申请号：US489387
申请日：1983-04-28
申请人： Ryozo Watanabe , Keiichi Kawasumi , Shoichi Maeda , Takashi Shoji
发明人： Ryozo Watanabe , Keiichi Kawasumi , Shoichi Maeda , Takashi Shoji
IPC分类号： G01N33/50 , G01N33/531 , G01N33/579 , G01N33/96 , G01N33/48 , G01N33/54
CPC分类号： G01N33/96 , G01N33/50 , G01N33/531 , G01N33/579 , G01N2333/81 , Y10S436/808 , Y10S436/825
摘要： A method for preparing a sample for use in endotoxin test which comprises subjecting a sample of plasma or blood preparation to a contact with water-insoluble anti human .alpha..sub.2 -macroglobulin antibody and to a gel filtration by means of a gel of allyl dextran crosslinked with N,N'-methylenebis acrylamide or a gel of polyvinyl alcohol having many hydrophilic hydroxyl groups, and recovering the maximum molecular weight fraction.A kit for preparing a sample for use in the endotoxin test consisting of a set of a sample-developing column prepared by packing a water-insoluble anti-human .alpha..sub.2 -macroglobulin antibody and a gel of allyl dextran crosslinked with N,N'-methylenebis acrylamide or a gel of polyvinyl alcohol having many hydrophilic hydroxyl groups, both equilibrated with a buffer solution of pH 7.0-7.4, into a column and tightly sealing the column, an aqueous solution of a high molecular weight colored substance to be added to the sample and a buffer solution for use in developing the sample.
摘要翻译： 一种制备用于内毒素试验的样品的方法，其包括使血浆或血液制剂的样品与水不溶性抗人α2-巨球蛋白抗体接触，并通过与 N，N'-亚甲基双丙烯酰胺或具有许多亲水性羟基的聚乙烯醇的凝胶，并回收最大分子量分数。 一种用于制备用于内毒素试验的样品的试剂盒，其由一组通过包装不溶于水的抗人α2-巨球蛋白抗体和用N，N'-二乙酰交联的交联的烯丙基葡聚糖凝胶制备的样品显影柱组成， 亚甲基双丙烯酰胺或具有许多亲水性羟基的聚乙烯醇凝胶，两者都用pH 7.0-7.4的缓冲溶液平衡，并将柱紧密地密封，加入高分子量有色物质的水溶液 样品和用于开发样品的缓冲溶液。
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公开(公告)号：US4414336A
公开(公告)日：1983-11-08
申请号：US306647
申请日：1981-09-29
申请人： Ryozo Watanabe , Keiichi Kawasumi , Shoichi Maeda , Takashi Shoji
发明人： Ryozo Watanabe , Keiichi Kawasumi , Shoichi Maeda , Takashi Shoji
IPC分类号： G01N33/50 , G01N33/579 , G01N33/96 , G01N33/48 , G01N33/54
CPC分类号： G01N33/96 , G01N33/50 , G01N33/579 , G01N2333/81 , Y10S436/825 , Y10T436/255
摘要： (1) A method for preparing a sample for use in the endotoxin test which comprises subjecting a sample of plasma or blood preparation to a contact with water-insoluble anti-human .alpha..sub.2 -macroglobulin antibody and to a gel filtration by means of a gel of allyl dextran crosslinked with N,N'-methylenebis acrylamide or a gel of polyvinyl alcohol having many hydrophilic hydroxyl groups, and recovering the maximum molecular weight fraction.(2) A kit for preparing a sample for use in the endotoxin test consisting of a set of a sample-developing column prepared by packing a water-insoluble anti-human .alpha..sub.2 -macroglobulin antibody and a gel of allyl dextran crosslinked with N,N'-methylenebis acrylamide or a gel of polyvinyl alcohol having many hydrophilic hydroxyl groups, both equilibrated with a buffer solution of pH 7.0-7.4, into a column and tightly sealing the column, an aqueous solution of a high molecular colored substance to be added to the sample and a buffer solution for use in developing the sample.
摘要翻译： （1）一种制备用于内毒素试验的样品的方法，其包括使血浆或血液制剂的样品与不溶于水的抗人α2-巨球蛋白抗体接触并通过凝胶进行凝胶过滤 的与N，N'-亚甲基双丙烯酰胺交联的烯丙基葡聚糖或具有许多亲水性羟基的聚乙烯醇凝胶，并回收最大分子量分数。 （2）一种用于制备用于内毒素测试的样品的试剂盒，其由一组通过包装不溶于水的抗人α2-巨球蛋白抗体和与N交联的烯丙基葡聚糖凝胶制备的样品显影柱组成， N'-亚甲基双丙烯酰胺或具有许多亲水性羟基的聚乙烯醇凝胶，两者都用pH 7.0-7.4的缓冲溶液平衡，并将柱紧密密封，加入高分子色素物质的水溶液 到样品和用于开发样品的缓冲溶液。
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公开(公告)号：US4265888A
公开(公告)日：1981-05-05
申请号：US110753
申请日：1980-01-08
CPC分类号： A61K31/621 , A61K31/60 , A61K47/02 , A61K9/0019
摘要： Acetylsalicylates with basic amino acids such as DL-lysine is stabilized in the form of solid preparation by admixing anhydrous calcium chloride therewith. The preparation containing calcium chloride is prevented from hydrolysis and can be stored for a long period of time even at a relatively high room temperature. The preparation is further prevented from discarolation when glycine is added thereto.
摘要翻译： 具有碱性氨基酸如DL-赖氨酸的乙酰水杨酸酯通过将无水氯化钙与其混合而稳定化为固体制剂的形式。 含有氯化钙的制剂被防止水解，并且即使在相对较高的室温下也可以长期储存。 当加入甘氨酸时，进一步防止了该制备。
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公开(公告)号：US3962439A
公开(公告)日：1976-06-08
申请号：US439638
申请日：1974-02-04
IPC分类号： A61K9/107 , A61K9/00 , A61K31/02 , B01F17/14 , A61K31/535 , A61K31/335 , A61K31/35 , A61K31/445
CPC分类号： A61K9/0026 , A61K31/02 , Y10S514/832
摘要： Oxygen-transferable perfluorocarbon compounds having 9 to 11 carbon atoms such as perfluorodecalin, perfluoro(C.sub.3-5 -alkylcyclohexanes), perfluoro(C.sub.4-6 -alkyl tetrahydropyrans), perfluoro(C.sub.5-7 -alkyltetrahydrofurans), perfluoro(C.sub.5-7 -alkylmorpholins) and perfluoro(C.sub.9-11 -trialkylamines) are emulsified in a physiologically acceptable aqueons solution such as Ringer's solution by the aid of a phospholipid as emulsifier and a fatty acid of 8 to 22 carbon atoms, alkali metal salt or monoglyceride thereof as emulsifying adjuvant. The emulsion is stable for a considerable period of time and contains particles having a particle size ranging from 0.05 to 0.3 .mu.. It is usable as a blood substitute or a perfusate for preservation of the internal organs.
摘要翻译： 可全氟（C 5-8 - 烷基环己烷），全氟（C 5-6 - 烷基四氢吡喃），全氟（C 5-7 - 烷基四氢呋喃），全氟（C 5-7 - 烷基四氢呋喃），全氟 ）和全氟（C9-11-三烷基胺）在生理学上可接受的水溶液如林格氏溶液中借助于磷脂作为乳化剂和8-22个碳原子的脂肪酸，其碱金属盐或其单甘油酯作为乳化剂乳化 。 该乳液在相当长的一段时间内是稳定的并且含有粒度范围为0.05-0.3μm的颗粒。 它可用作血液替代物或灌注液，用于保存内脏。
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