公开(公告)号：US20140065655A1

公开(公告)日：2014-03-06

申请号：US13641790

申请日：2012-09-05

申请人： Manabu Itoh ,  Kazuya Arai ,  Hiroshi Kajita ,  Satoru Tanaka

发明人： Manabu Itoh ,  Kazuya Arai ,  Hiroshi Kajita ,  Satoru Tanaka

IPC分类号： G01N33/50

CPC分类号： G01N33/5044 ,  G01N33/5011

摘要： A screening method for a substance acting on a maintenance of the epithelial properties of cells which enables obtainment of highly-reliable data quickly at low costs is provided. The screening method includes (a) a step for culturing cells on a cell culture substrate that can form a spheroid, (b) a step for causing the cells to contact a test substance, and (c) a step for evaluating an effect of the test substance acting on a maintenance of the epithelial properties of the cells with a change in a morphology of the spheroid being as an indicator. In this case, the step (c) can carry out an evaluation through a measurement of the number of spheroids in a predetermined size or a measurement of the hypoxic areas in the spheroid.

摘要翻译： 提供了一种能够维持细胞上皮性质的物质的筛选方法，其能够以低成本快速获得高可靠性数据。 筛选方法包括：（a）在能够形成球状体的细胞培养基底上培养细胞的步骤，（b）使细胞接触被检物质的步骤，（c） 作为维持细胞的上皮性质的测试物质，以球状体形态的变化为指标。 在这种情况下，步骤（c）可以通过测定球体中预定尺寸的球体数量或球体中的缺氧区域的测量来进行评价。

公开(公告)号：US08159685B2

公开(公告)日：2012-04-17

申请号：US11655845

申请日：2007-01-22

申请人： Manabu Itoh

发明人： Manabu Itoh

IPC分类号： G06K15/00

CPC分类号： H04N1/0057 ,  H04N1/00591 ,  H04N1/00631 ,  H04N1/32635 ,  H04N1/32646

摘要： In one embodiment of an image processing apparatus, when multi-feeding during transport of originals is detected, except for the multi-fed originals, which are all of the originals simultaneously multi-fed by the multi-feeding, the images written on only the other remaining originals are recorded on recording paper; and a shifted discharge position in the discharge tray of only pre-multi-feeding original recording paper is different from a standard discharge position of other recorded recording paper, the pre-multi-feeding original recording paper being recording paper on which is recorded the image written on the original transported immediately before the original initially transported among the multi-fed originals.

摘要翻译： 在图像处理装置的一个实施例中，当检测到传送原稿期间的多次进给时，除了由多次进给同时多次馈送的所有原稿的多次馈送原稿之外，仅在 其他剩余的原件记录在记录纸上; 并且只有预多份进纸的原始记录纸的排出托盘中的移动的排出位置与其他记录的记录纸的标准排出位置不同，所以预先进纸的原始记录纸是作为记录在其上的图像的记录纸 写在原始的原始运输之前，原始最初在多份原稿之间运输。

公开(公告)号：US08874199B2

公开(公告)日：2014-10-28

申请号：US11709874

申请日：2007-02-23

申请人： Hiroshi Kawada ,  Kiyoshi Inui ,  Kenji Nakai ,  Manabu Itoh

发明人： Hiroshi Kawada ,  Kiyoshi Inui ,  Kenji Nakai ,  Manabu Itoh

IPC分类号： A61B5/0468 ,  A61B5/0452 ,  A61B5/00

CPC分类号： A61B5/0452 ,  A61B5/7239

摘要： The estimated contour positions of the atrium and ventricle are obtained from multi-channel electrocardiographic waveforms. Information useful to predict the possibility of the occurrence of fatal arrhythmia, such as the position of the maximum excitation propagation point, the distribution of the late potential(LP) as an index of depolarization abnormality, and the distribution of the RT dispersion as an index of repolarization abnormality are displayed together with the estimated contour positions.

摘要翻译： 心室和心室的估计轮廓位置是从多通道心电图波形获得的。 用于预测发生致命性心律失常的可能性的信息，例如最大激发传播点的位置，作为去极化异常指数的晚期电位（LP）的分布和作为指标的RT分散的分布 的复极异常与估计的轮廓位置一起显示。

公开(公告)号：US06642257B2

公开(公告)日：2003-11-04

申请号：US09969644

申请日：2001-10-04

申请人： Ichiro Yamamoto ,  Manabu Itoh ,  Fumiaki Yamasaki ,  Yasushige Akada ,  Yutaka Miyazaki ,  Shinichi Ogawa

发明人： Ichiro Yamamoto ,  Manabu Itoh ,  Fumiaki Yamasaki ,  Yasushige Akada ,  Yutaka Miyazaki ,  Shinichi Ogawa

IPC分类号： A61K3144

CPC分类号： C07D405/06 ,  C07D211/48 ,  C07D407/06 ,  C07D409/06

摘要： The present invention relates to a compound represented by Formula (I) below: (wherein A represents, for example, phenyl group substituted by R1 and R2, or an unsubstituted furyl group or an unsubstitued thienyl group; R1 represents, for example, hydrogen atom, fluorine atom, chlorine atom, trifluoromethyl group, nitro group, cyano group or methyl group while R2 represents, for example, hydrogen atom; R3 represents, for example, hydrogen atom or methyl group; R4 represents, for example, hydrogen atom or methyl group; R5 represents ethoxy group or isopropoxy group; X represents group: —CH(OH)— or methylene group; and Z represents, for example, a single bond or methylene group unsubstituted or substituted by hydroxyl group), and its salts, and medicinal compositions containing, as their active ingredient, the above compound or its salts. The compound of this invention, which is orally applicable, is highly effective for treating neuroapthic pain while presenting with fewer side-effects than do the conventional analgesics.

摘要翻译： 本发明涉及由下式（I）表示的化合物：其中A表示例如被R 1和R 2取代的苯基或未取代的呋喃基或未取代的噻吩基; 1表示例如氢原子，氟原子，氯原子，三氟甲基，硝基，氰基或甲基，而R 2表示例如氢原子; R 3表示例如氢 原子或甲基; R 4表示例如氢原子或甲基; R 5表示乙氧基或异丙氧基; X表示基团：-CH（OH） - 或亚甲基; Z表示对于 例如，未取代或被羟基取代的单键或亚甲基）及其盐，以及含有作为其活性成分的上述化合物或其盐的药物组合物。 口服适用的本发明化合物对于治疗神经痛与非常有效，同时具有比常规止痛剂更少的副作用。

公开(公告)号：US5587392A

公开(公告)日：1996-12-24

申请号：US453054

申请日：1995-05-26

申请人： Kimihiro Murakami ,  Shuhei Ohnishi ,  Takashi Yano ,  Manabu Itoh

发明人： Kimihiro Murakami ,  Shuhei Ohnishi ,  Takashi Yano ,  Manabu Itoh

IPC分类号： C07D233/60 ,  C07D249/08 ,  C07D521/00 ,  A61K31/41 ,  C07D403/10 ,  C07D403/12 ,  C07D247/18

CPC分类号： C07D231/12 ,  C07D233/56 ,  C07D249/08

摘要： Compounds exerting excellent aromatase inhibitory activity in vivo and in vitro with higher specificity and greater safety are provided together with the salts thereof. Using the same, there are also provided, prophylactic agents and/or therapeutical agents of estrogen-dependent diseases, contraceptive agents for females, and aromatase inhibitory agents for use in the form of reagents for human or animals. The compounds are of the formula (I), wherein R.sup.2 is represented by the formula (II) or (III). ##STR1##

摘要翻译： 在其体内和体外具有优异芳香化酶抑制活性的化合物与其盐具有更高的特异性和更高的安全性。 使用同样的方法，还提供雌激素依赖性疾病的预防剂和/或治疗剂，雌性避孕剂和用于人或动物试剂形式的芳香酶抑制剂。 所述化合物具有式（I），其中R 2由式（II）或（III）表示。 （I） （II）或

公开(公告)号：US20070171438A1

公开(公告)日：2007-07-26

申请号：US11655845

申请日：2007-01-22

申请人： Manabu Itoh

发明人： Manabu Itoh

IPC分类号： H04N1/00

CPC分类号： H04N1/0057 ,  H04N1/00591 ,  H04N1/00631 ,  H04N1/32635 ,  H04N1/32646

摘要： In one embodiment of an image processing apparatus, when multi-feeding during transport of originals is detected, except for the multi-fed originals, which are all of the originals simultaneously multi-fed by the multi-feeding, the images written on only the other remaining originals are recorded on recording paper; and a shifted discharge position in the discharge tray of only pre-multi-feeding original recording paper is different from a standard discharge position of other recorded recording paper, the pre-multi-feeding original recording paper being recording paper on which is recorded the image written on the original transported immediately before the original initially transported among the multi-fed originals.

摘要翻译： 在图像处理装置的一个实施例中，当检测到传送原稿期间的多次进给时，除了由多次进给同时多次馈送的所有原稿的多次馈送原稿之外，仅在 其他剩余的原件记录在记录纸上; 并且只有预多份进纸的原始记录纸的排出托盘中的移动的排出位置与其他记录的记录纸的标准排出位置不同，所以预先进纸的原始记录纸是作为记录在其上的图像的记录纸 写在原始的原始运输之前，原始最初在多份原稿之间运输。

公开(公告)号：US06710060B2

公开(公告)日：2004-03-23

申请号：US09969639

申请日：2001-10-04

申请人： Ichiro Yamamoto ,  Manabu Itoh ,  Fumiaki Yamasaki ,  Yutaka Miyazaki ,  Shinichi Ogawa

发明人： Ichiro Yamamoto ,  Manabu Itoh ,  Fumiaki Yamasaki ,  Yutaka Miyazaki ,  Shinichi Ogawa

IPC分类号： A61K31445

CPC分类号： C07D405/06 ,  C07D211/48 ,  C07D407/06 ,  C07D409/06

摘要： The present invention relates to a compound represented by the following formula (I) or a salt thereof, or a pharmaceutical composition containing the compound as an effective ingredient: (wherein A represents, for example, phenyl group substituted with R1 and R2 or unsubstituted thienyl group; R1 and R2 each independently represent, for example, hydrogen atom, halogen atom or lower alkoxycarbonyl group; R3 represents, for example, hydrogen atom; R4 represents, for example, lower alkyl group; R5 represents, for example, lower alkoxy group; R6 represents, for example, hydrogen atom; R7 and R8 each represent, for example, hydrogen atom, respectively; X represents, for example, a single bond; Y represents, for example, methylene group or benzylidene group substituted with R1; and Z represents, for example, methylene group.) The compounds according to the present invention that do not suppress the transient sodium current of the cardiac muscle and do not manifest proarrhythimic activity is useful as a therapeutic agent for preventing and/or treating arrhythimia and for preventing sudden death.

摘要翻译： 本发明涉及由下式（I）表示的化合物或其盐或含有该化合物作为有效成分的药物组合物：（其中A表示例如被R 1和R 2取代的苯基） 2或未取代的噻吩基; R 1和R 2各自独立地表示例如氢原子，卤素原子或低级烷氧基羰基; R 3表示例如氢原子; R 4， 表示例如低级烷基; R 5表示例如低级烷氧基; R 6表示例如氢原子; R 7和R 8各自表示例如氢 原子; X表示例如单键; Y表示例如被R 1取代的亚甲基或亚苄基; Z表示例如亚甲基。）根据本发明的化合物 不抑制心肌的瞬时钠电流，并不表现出血浆 节奏活动可用作预防和/或治疗心律失常并用于预防猝死的治疗剂。

公开(公告)号：US4894344A

公开(公告)日：1990-01-16

申请号：US276785

申请日：1988-11-28

申请人： Makoto Sugiyama ,  Yoji Ezure ,  Nobutoshi Ojima ,  Kiyotaka Konno ,  Takashi Seto ,  Teruya Nakamura ,  Manabu Itoh

发明人： Makoto Sugiyama ,  Yoji Ezure ,  Nobutoshi Ojima ,  Kiyotaka Konno ,  Takashi Seto ,  Teruya Nakamura ,  Manabu Itoh

IPC分类号： C12P13/00

CPC分类号： C12P13/001 ,  Y10S435/826 ,  Y10S435/886

摘要： 2-amino-2-deoxy-D-mannitol is produced from a microorganism strain of the genus Streptomyces or a mutant strain thereof in improved yields and purity.

公开(公告)号：US07740241B2

公开(公告)日：2010-06-22

申请号：US12017082

申请日：2008-01-21

申请人： Manabu Itoh ,  Satoshi Murakami ,  Kazumasa Tonami

发明人： Manabu Itoh ,  Satoshi Murakami ,  Kazumasa Tonami

IPC分类号： B65H7/12

CPC分类号： H04N1/00628 ,  B65H5/062 ,  B65H7/12 ,  B65H2220/09 ,  B65H2301/44514 ,  B65H2301/4474 ,  B65H2404/14 ,  B65H2404/1442 ,  B65H2511/11 ,  B65H2511/414 ,  B65H2511/524 ,  B65H2513/104 ,  B65H2513/11 ,  B65H2513/222 ,  B65H2513/512 ,  B65H2801/06 ,  G03G15/235 ,  G03G15/6564 ,  G03G2215/004 ,  G03G2215/00637 ,  H04N1/0057 ,  H04N1/00602 ,  H04N1/00652 ,  B65H2220/01 ,  B65H2220/02 ,  B65H2220/11 ,  B65H2220/03

摘要： A sheet transporting device including: a sheet feeding section that feeds plural sheets to a transporting path; three or more roller pairs that are arranged along the transporting path; a double feed detecting section that detects a length of a double feed portion when sheets are fed in an overlapped manner; a selecting section that selects two of the three or more roller pairs based on the length of the double feed portion; and a transport control section that can change a transporting speed of at least one of the selected roller pairs, wherein the selecting section selects two roller pairs that have a space between which the double feed portion can be positioned, and the transport control section controls the transporting speeds of the selected roller pairs such that the speeds differ from each other to separate the delaying sheet from the preceding sheet.

摘要翻译： 一种片材传送装置，包括：片材馈送部，其将多张片材供给到传送路径; 沿着传送路径布置的三个或更多个辊对; 双重进给检测部，当重叠地进给纸张时，检测双重进给部的长度; 选择部，其基于所述双重进给部的长度选择所述三个以上的辊对中的两个; 以及输送控制部，其能够改变所选择的辊对中的至少一个的输送速度，其中所述选择部选择两个辊对，所述两对辊对具有能够定位所述双重进给部的空间，并且所述输送控制部控制所述 所选择的辊对的运送速度使得速度彼此不同以将延迟片与前一张片分开。

公开(公告)号：US20070276274A1

公开(公告)日：2007-11-29

申请号：US11709874

申请日：2007-02-23

申请人： Hiroshi Kawada ,  Kiyoshi Inui ,  Kenji Nakai ,  Manabu Itoh

发明人： Hiroshi Kawada ,  Kiyoshi Inui ,  Kenji Nakai ,  Manabu Itoh

IPC分类号： A61B5/04

CPC分类号： A61B5/0452 ,  A61B5/7239

摘要： The estimated contour positions of the atrium and ventricle are obtained from multi-channel electrocardiographic waveforms. Information useful to predict the possibility of the occurrence of fatal arrhythmia, such as the position of the maximum excitation propagation point, the distribution of the late potential(LP) as an index of depolarization abnormality, and the distribution of the RT dispersion as an index of repolarization abnormality are displayed together with the estimated contour positions.

摘要翻译： 心室和心室的估计轮廓位置是从多通道心电图波形获得的。 用于预测发生致命性心律失常的可能性的信息，例如最大激发传播点的位置，作为去极化异常指数的晚期电位（LP）的分布和作为指标的RT分散的分布 的复极异常与估计的轮廓位置一起显示。