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公开(公告)号：US08481692B2
公开(公告)日：2013-07-09
申请号：US13451631
申请日：2012-04-20
申请人： Maninder K. Sidhu , Annaliesa Sybil Anderson , Robert G. K. Donald , Kathrin Ute Jansen , Narender K. Kalyan , Justin Keith Moran , Mark E. Ruppen , Michael James Flint
发明人： Maninder K. Sidhu , Annaliesa Sybil Anderson , Robert G. K. Donald , Kathrin Ute Jansen , Narender K. Kalyan , Justin Keith Moran , Mark E. Ruppen , Michael James Flint
CPC分类号： C07K14/33 , A61K39/08 , C07K16/1282 , C07K2317/33 , C07K2317/76 , C07K2317/92 , C12N9/1051 , C12N9/99 , C12N15/74
摘要： In one aspect, the invention relates to an immunogenic composition that includes a mutant Clostridium difficile toxin A and/or a mutant Clostridium difficile toxin B. Each mutant toxin includes a glucosyltransferase domain having at least one mutation and a cysteine protease domain having at least one mutation, relative to the corresponding wild-type C. difficile toxin. The mutant toxins may further include at least one amino acid that is chemically crosslinked. In another aspect, the invention relates to antibodies or binding fragments thereof that binds to said immunogenic compositions. In further aspects, the invention relates to isolated nucleotide sequences that encode any of the foregoing, and methods of use of any of the foregoing compositions.
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2.发明申请COMPOSITIONS RELATING TO A MUTANT CLOSTRIDIUM DIFFICILE TOXIN AND METHODS THEREOF 有权关于一种突变型脱落孢子虫毒素的组合物及其方法公开(公告)号：US20120269841A1
公开(公告)日：2012-10-25
申请号：US13451631
申请日：2012-04-20
申请人： Maninder K. Sidhu , Annaliesa Sybil Anderson , Robert G. K. Donald , Kathrin Ute Jansen , Narender K. Kalyan , Terri L. Mininni , Justin Keith Moran , Mark E. Ruppen , Michael James Flint
发明人： Maninder K. Sidhu , Annaliesa Sybil Anderson , Robert G. K. Donald , Kathrin Ute Jansen , Narender K. Kalyan , Terri L. Mininni , Justin Keith Moran , Mark E. Ruppen , Michael James Flint
CPC分类号： C07K14/33 , A61K39/08 , C07K16/1282 , C07K2317/33 , C07K2317/76 , C07K2317/92 , C12N9/1051 , C12N9/99 , C12N15/74
摘要： In one aspect, the invention relates to an immunogenic composition that includes a mutant Clostridium difficile toxin A and/or a mutant Clostridium difficile toxin B. Each mutant toxin includes a glucosyltransferase domain having at least one mutation and a cysteine protease domain having at least one mutation, relative to the corresponding wild-type C. difficile toxin. The mutant toxins may further include at least one amino acid that is chemically crosslinked. In another aspect, the invention relates to antibodies or binding fragments thereof that binds to said immunogenic compositions. In further aspects, the invention relates to isolated nucleotide sequences that encode any of the foregoing, and methods of use of any of the foregoing compositions.
摘要翻译： 一方面，本发明涉及包含突变型艰难梭菌毒素A和/或突变型艰难梭菌毒素B的免疫原性组合物。每种突变毒素包括具有至少一个突变的葡糖基转移酶结构域和具有至少一个突变的半胱氨酸蛋白酶结构域 突变，相对于相应的野生型艰难梭菌毒素。 突变毒素还可以包括至少一个化学交联的氨基酸。 在另一方面，本发明涉及结合所述免疫原性组合物的抗体或其结合片段。 在另外的方面，本发明涉及编码前述任何一种的分离的核苷酸序列，以及任何上述组合物的使用方法。
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3.发明授权Polynucleotides encoding coccidian parasite casein kinase I, a chemotherapeutic target for antiprotozoal agents 失效编码球虫寄生虫酪蛋白激酶I的多核苷酸，一种抗原虫药的化疗靶公开(公告)号：US07671181B2
公开(公告)日：2010-03-02
申请号：US10586374
申请日：2005-01-12
CPC分类号： C07K14/45 , C07K14/455 , C12N9/12
摘要： Isolated nucleic acid molecules encoding coccidian casein kinase I, CKI, enzymes from the species Eimeria tenella and Toxoplasma gondii are disclosed. The isolation of these coccidian CKI cDNA sequences results in the disclosure of purified forms of E. tenella and T. gondii CKI proteins, recombinant vectors and recombinant hosts which express coccidian CKI.
摘要翻译： 公开了编码球虫酪蛋白激酶I，CKI，来自艾美球虫（Eimeria tenella）和弓形虫（弓形虫）的酶的分离的核酸分子。 这些球虫CKI cDNA序列的分离导致纯化形式的E. tenella和弓形虫CKI蛋白，重组载体和表达球虫CKI的重组宿主的公开。
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