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1.发明授权Polynucleotides encoding coccidian parasite casein kinase I, a chemotherapeutic target for antiprotozoal agents 失效编码球虫寄生虫酪蛋白激酶I的多核苷酸，一种抗原虫药的化疗靶公开(公告)号：US07671181B2
公开(公告)日：2010-03-02
申请号：US10586374
申请日：2005-01-12
CPC分类号： C07K14/45 , C07K14/455 , C12N9/12
摘要： Isolated nucleic acid molecules encoding coccidian casein kinase I, CKI, enzymes from the species Eimeria tenella and Toxoplasma gondii are disclosed. The isolation of these coccidian CKI cDNA sequences results in the disclosure of purified forms of E. tenella and T. gondii CKI proteins, recombinant vectors and recombinant hosts which express coccidian CKI.
摘要翻译： 公开了编码球虫酪蛋白激酶I，CKI，来自艾美球虫（Eimeria tenella）和弓形虫（弓形虫）的酶的分离的核酸分子。 这些球虫CKI cDNA序列的分离导致纯化形式的E. tenella和弓形虫CKI蛋白，重组载体和表达球虫CKI的重组宿主的公开。
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2.发明申请Coccidian Parasite Casein Kinase I as a Chemotherapeutic Target for Antiprotozoal Agents 失效球虫寄生虫酪蛋白激酶I作为抗原虫药的化疗靶标公开(公告)号：US20080280313A1
公开(公告)日：2008-11-13
申请号：US10586374
申请日：2005-01-12
CPC分类号： C07K14/45 , C07K14/455 , C12N9/12
摘要： Isolated nucleic acid molecules encoding coccidian casein kinase I, CKI, enzymes from the species Eimeria tenella and Toxoplasma gondii are disclosed. The isolation of these coccidian CKI cDNA sequences results in the disclosure of purified forms of E. tenella and T. gondii CKI proteins, recombinant vectors and recombinant hosts which express coccidian CKI.
摘要翻译： 公开了编码球虫酪蛋白激酶I，CKI，来自艾美球虫（Eimeria tenella）和弓形虫（弓形虫）的酶的分离的核酸分子。 这些球虫CKI cDNA序列的分离导致纯化形式的E. tenella和弓形虫CKI蛋白，重组载体和表达球虫CKI的重组宿主的公开。
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3.发明申请Dna encoding novel cyclic gmp dependent protein kinases from two protozoal sources for use as chemotherapeutic targets for antiprotozoal agents 有权Dna编码来自两个原生动物源的新型循环gmp依赖性蛋白激酶用作抗原虫药物的化疗靶公开(公告)号：US20050147628A1
公开(公告)日：2005-07-07
申请号：US10499554
申请日：2002-12-18
申请人： Paul Liberator , Dennis Schmatz , Anne Gurnett , Carmen Diaz
发明人： Paul Liberator , Dennis Schmatz , Anne Gurnett , Carmen Diaz
IPC分类号： A61K38/00 , A61K39/00 , A61K39/012 , C07H21/04 , C12N1/10 , C12N9/12 , C12Q1/68 , G01N33/53 , G01N33/569
CPC分类号： C12Y207/01037 , A61K38/00 , A61K39/00 , C12N9/1205 , Y02A50/412
摘要： The present invention relates to novel protozoal cyclic GMP dependent protein kinases and genes encoding same that have been isolated from Eimeria maxima and Plasmodium falciparum. Nucleic acid molecules having sequences that encode such proteins as well as antibodies raised against such proteins are also disclosed. These enzymes may be used in screening assays to identify potential antiprotozoal agents. As well, methods to obtain such nucleic acid molecules, proteins, antibodies and inhibitor are also provided as are therapeutic compositions comprising such nucleic acid molecules, proteins, antibodies and inhibitors as well as their use to protect animals from disease caused by parasites such as Eimeria maxima and Plasmodium falciparum.
摘要翻译： 本发明涉及从艾美球虫和恶性疟原虫分离的新型原生动物环状GMP依赖性蛋白激酶和编码相同的基因。 还公开了具有编码这种蛋白质的序列以及针对这种蛋白质产生的抗体的核酸分子。 这些酶可用于筛选测定以鉴定潜在的抗原虫药。 同样，也提供了获得这种核酸分子，蛋白质，抗体和抑制剂的方法，包括这样的核酸分子，蛋白质，抗体和抑制剂的治疗组合物以及它们用于保护动物免受寄生虫如艾美球虫 最大值和恶性疟原虫。
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4.发明授权Nucleic acids encoding novel cyclic GMP dependent protein kinases from Elmeria maxima 有权编码来自Elmeria maxima的新型循环GMP依赖性蛋白激酶的核酸公开(公告)号：US07390892B2
公开(公告)日：2008-06-24
申请号：US10499554
申请日：2002-12-18
申请人： Paul Liberator , Dennis Schmatz , Anne Gurnett , Carmen Diaz
发明人： Paul Liberator , Dennis Schmatz , Anne Gurnett , Carmen Diaz
CPC分类号： C12Y207/01037 , A61K38/00 , A61K39/00 , C12N9/1205 , Y02A50/412
摘要： The present invention relates to novel protozoal cyclic GMP dependent protein kinases and genes encoding same that have been isolated from Eimeria maxima and Plasmodium falciparum. Nucleic acid molecules having sequences that encode such proteins as well as antibodies raised against such proteins are also disclosed. These enzymes may be used in screening assays to identify potential antiprotozoal agents. As well, methods to obtain such nucleic acid molecules, proteins, antibodies and inhibitor are also provided as are therapeutic compositions comprising such nucleic acid molecules, proteins, antibodies and inhibitors as well as their use to protect animals from disease caused by parasites such as Eimeria maxima and Plasmodium falciparum.
摘要翻译： 本发明涉及从艾美球虫和恶性疟原虫分离的新型原生动物环状GMP依赖性蛋白激酶和编码其的基因。 还公开了具有编码这种蛋白质的序列以及针对这种蛋白质产生的抗体的核酸分子。 这些酶可用于筛选测定以鉴定潜在的抗原虫药。 同样，也提供了获得这种核酸分子，蛋白质，抗体和抑制剂的方法，包括这样的核酸分子，蛋白质，抗体和抑制剂的治疗组合物以及它们用于保护动物免受寄生虫如艾美球虫 最大值和恶性疟原虫。
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5.发明申请Cyclic GMP dependent protein kinase as a chemotherapeutic target for antiprotozoal agents 有权循环GMP依赖性蛋白激酶作为抗原虫剂的化疗靶标公开(公告)号：US20070009979A1
公开(公告)日：2007-01-11
申请号：US11525062
申请日：2006-09-21
申请人： Anne Gurnett , Robert Donald , Georgianna Harris , Paul Liberator , Dennis Schmatz , Sandra Rattray
发明人： Anne Gurnett , Robert Donald , Georgianna Harris , Paul Liberator , Dennis Schmatz , Sandra Rattray
CPC分类号： C12N9/1205 , C12Q1/18 , C12Q1/485 , G01N2333/45
摘要： Protozoal cyclic GMP dependent protein kinases have been isolated and cloned. These enzymes may be used in screening assays to identify potential antiprotozoal agents.
摘要翻译： 原始循环GMP依赖性蛋白激酶已被分离和克隆。 这些酶可用于筛选测定以鉴定潜在的抗原虫药。
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