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公开(公告)号:US20050008650A1
公开(公告)日:2005-01-13
申请号:US10915069
申请日:2004-08-10
申请人: Marc Whitlow , Robert Shorr , David Filpula , Lihsyng Lee
发明人: Marc Whitlow , Robert Shorr , David Filpula , Lihsyng Lee
IPC分类号: G01N33/53 , A61K39/38 , A61K47/48 , A61P35/00 , C07H21/04 , C07K14/00 , C07K14/715 , C07K16/00 , C07K16/30 , C07K16/44 , C07K19/00 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N15/09 , C12P21/02 , C12P21/08 , C12R1/84 , G01N33/68 , A61K39/395 , C07K16/46
CPC分类号: G01N33/6857 , A61K47/60 , A61K2039/505 , C07K16/30 , C07K19/00 , C07K2317/41 , C07K2317/622 , C07K2319/00
摘要: The present invention relates to the chemical modification of single chain polypeptides by means of covalent attachment of strands of poly(ethylene glycol) PEG and similar poly(alkylene oxides) to single chain polypeptide binding molecules that have the three dimensional folding and, thus, the binding ability and specificity, of the variable region of an antibody. Such preparations of modified single chain polypeptide binding molecules have reduced immugenicity and antigenicity as well as having a longer halflife in the bloodstream as compared to the parent polypeptide. These beneficial properties of the modified single chain polypeptide binding molecules make them very useful in a variety of therapeutic applications. The invention also relates to multivalent antigen-binding molecules capable of PEGylation. Compositions of, genetic constructions for, methods of use, and methods for producing PEGylated antigen-binding proteins are disclosed.
摘要翻译: 本发明涉及通过将聚(乙二醇)PEG和类似的聚(环氧烷)的链共价连接到具有三维折叠的单链多肽结合分子的单链多肽的化学修饰,因此涉及 抗体的可变区的结合能力和特异性。 与亲本多肽相比,修饰的单链多肽结合分子的这种制剂具有降低的免疫性和抗原性,并且在血流中具有更长的半衰期。 修饰的单链多肽结合分子的这些有益性质使得它们在各种治疗应用中非常有用。 本发明还涉及能够进行PEG化的多价抗原结合分子。 公开了用于生产聚乙二醇化抗原结合蛋白的遗传构建,使用方法和方法的组合物。
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公开(公告)号:US20050048064A1
公开(公告)日:2005-03-03
申请号:US10909948
申请日:2004-08-02
申请人: Marc Whitlow , Robert Shorr , David Filpula , Lihsyng Lee
发明人: Marc Whitlow , Robert Shorr , David Filpula , Lihsyng Lee
IPC分类号: G01N33/53 , A61K39/38 , A61K47/48 , A61P35/00 , C07H21/04 , C07K14/00 , C07K14/715 , C07K16/00 , C07K16/30 , C07K16/44 , C07K19/00 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N15/09 , C12P21/02 , C12P21/08 , C12R1/84 , G01N33/68 , A61K39/395
CPC分类号: G01N33/6857 , A61K47/60 , A61K2039/505 , C07K16/30 , C07K19/00 , C07K2317/41 , C07K2317/622 , C07K2319/00
摘要: The present invention relates to the chemical modification of single chain polypeptides by means of covalent attachment of strands of poly(ethylene glycol) PEG and similar poly(alkylene oxides) to single chain polypeptide binding molecules that have the three dimensional folding and, thus, the binding ability and specificity, of the variable region of an antibody. Such preparations of modified single chain polypeptide binding molecules have reduced immugenicity and antigenicity as well as having a longer halflife in the bloodstream as compared to the parent polypeptide. These beneficial properties of the modified single chain polypeptide binding molecules make them very useful in a variety of therapeutic applications. The invention also relates to multivalent antigen-binding molecules capable of PEGylation. Compositions of, genetic constructions for, methods of use, and methods for producing PEGylated antigen-binding proteins are disclosed.
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3.
公开(公告)号:US20060153839A1
公开(公告)日:2006-07-13
申请号:US10527936
申请日:2003-09-16
申请人: Nehal Mohamed , Leslie Casey , James Porter , Xiaoliang Wang , Muctarr Sesay , Lihsyng Lee
发明人: Nehal Mohamed , Leslie Casey , James Porter , Xiaoliang Wang , Muctarr Sesay , Lihsyng Lee
CPC分类号: C07K16/1278 , A61K2039/505 , C07K16/2896 , C07K2317/24 , C07K2317/31 , C07K2317/55 , C07K2317/622
摘要: The invention relates to a bispecific molecule comprising a first recognition binding moeity that binds a Cab-like receptor cross-linked using a poly-(ethylene glycol) (“PEG”) linker with one or more second recognition binding moieties that bind a molecule. The invention also relates to methods of producing such bispecific molecules and to therapeutic uses of such bispecific molecules.
摘要翻译: 本发明涉及双特异性分子,其包含结合使用聚(乙二醇)(“PEG”)连接体与结合分子的一个或多个第二识别结合部分交联的Cab样受体的第一识别结合力。 本发明还涉及产生这种双特异性分子的方法和这种双特异性分子的治疗用途。
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