公开(公告)号：US6121466A

公开(公告)日：2000-09-19

申请号：US261227

申请日：1999-03-03

Applicant: Clemens Osterholt ,  Josef Metz ,  Gunther Kohler ,  Marcel Feld

Inventor： Clemens Osterholt ,  Josef Metz ,  Gunther Kohler ,  Marcel Feld

IPC: C07D319/00 ,  B01J31/18 ,  B01J31/22 ,  C07B61/00 ,  C07D321/00

CPC classification number: C07D321/00 ,  Y02P20/582

Abstract: The invention relates to a process for the preparation of a macrocyclic ester of the general formula: in which m is an integer from 6 to 14 and n is an integer from 2 to 12.

Abstract translation: 本发明涉及制备通式如下的大环酯的方法：其中m为6至14的整数，n为2至12的整数。

公开(公告)号：US6107522A

公开(公告)日：2000-08-22

申请号：US350289

申请日：1999-07-09

Applicant: Wolfgang Kleemiss ,  Marcel Feld ,  Manfred Kaufhold

Inventor： Wolfgang Kleemiss ,  Marcel Feld ,  Manfred Kaufhold

IPC: C07C209/56 ,  C07B61/00 ,  C07C51/363 ,  C07C67/00 ,  C07C67/333 ,  C07C69/74 ,  C07C209/58 ,  C07C211/17 ,  C07C211/35 ,  C07C231/02 ,  C07C233/58 ,  C07L209/00

CPC classification number: C07C231/02 ,  C07C209/58 ,  C07C51/363 ,  C07C67/00 ,  C07C2101/02

Abstract: Cyclopropylamine is prepared from butyrolactone by a process comprising:(a) reacting butyrolactone with hydrogen chloride, thereby yielding chlorobutyric acid, (b) esterifying said chlorobutyric acid with a primary or secondary alcohol having 4-8 carbon atoms, (c) cyclizing the ester with an alkali metal alcoholate of a primary alcohol having 1-3 carbon atoms to give a mixture of cyclopropanecarboxylic acid esters, (d) converting the cyclopropanecarboxylic acid ester mixture into cyclopropanecarboxylic acid amide by reacting the ester mixture with ammonia, and (e) reacting said cyclopropanecarboxylic acid amide with hypohalite ion in a basic medium, thereby forming cyclopropylamine.

Abstract translation: 环丙胺由丁内酯制备，包括：（a）使丁内酯与氯化氢反应，从而产生氯代丁酸，（b）用具有4-8个碳原子的伯或仲醇酯化所述氯代丁酸，（c）使酯 与具有1-3个碳原子的伯醇的碱金属醇化物反应得到环丙烷羧酸酯的混合物，（d）通过使酯混合物与氨反应将环丙烷羧酸酯混合物转化为环丙烷羧酸酰胺，和（e）使 所述环丙烷羧酸酰胺与碱式介质中的次卤酸离子形成环丙胺。

公开(公告)号：US5847197A

公开(公告)日：1998-12-08

申请号：US868799

申请日：1997-06-04

Applicant: Frank Bauer ,  Marcel Feld

Inventor： Frank Bauer ,  Marcel Feld

IPC: B01J23/44 ,  C07B61/00 ,  C07C227/04 ,  C07C227/06 ,  C07C227/40 ,  C07C229/24 ,  C07C229/00

CPC classification number: C07C227/04

Abstract: The invention relates to a process for the preparation of aminomalonic acid esters and optionally their salts by the catalytic hydrogenation of a substituted malonic acid ester in an inert solvent, and optionally by the addition of an acid to the hydrogenation mixture. The process comprises carrying out the hydrogenation in the presence of a solid dehydrating agent and a solvent or solvent mixture in which the aminomalonic acid ester salt is substantially insoluble.

Abstract translation: 本发明涉及通过在惰性溶剂中的取代的丙二酸酯的催化氢化以及任选通过向氢化混合物中加入酸来制备氨基马来酸酯和任选的其盐的方法。 该方法包括在固体脱水剂和其中氨基马来酸酯盐基本上不溶的溶剂或溶剂混合物的存在下进行氢化。

公开(公告)号：US5412146A

公开(公告)日：1995-05-02

申请号：US253347

申请日：1994-06-03

Applicant: Manfred Kaufhold ,  Marcel Feld

Inventor： Manfred Kaufhold ,  Marcel Feld

IPC: B01J31/02 ,  C07B61/00 ,  C07C253/30 ,  C07C255/19

CPC classification number: C07C255/19 ,  C07C253/30

Abstract: For the preparation of 2-cyanoacetoxypropionic esters, a mixture of lactic ester and cyanoacetic ester is introduced, an alkali metal alcoholate is added as catalyst and the mixture is heated while the alcohol eliminated during the course of the reaction is distilled off. The course of the reaction is followed by means of gas chromatographic analysis and the reaction is terminated prior to eliminating the theoretical amount of alcohol by destroying the catalyst by acidification. The reaction mixture is worked up by distillation and the product easily separated from the reaction mass due to the substantial absence of high boiling components.

Abstract translation: 为了制备2-氰基乙酰氧基丙酸酯，引入乳酸酯和氰基乙酸酯的混合物，加入碱金属醇化物作为催化剂，加热混合物，同时蒸馏除去反应过程中的醇。 反应过程之后是气相色谱分析，在通过酸化破坏催化剂消除理论量的醇之前终止反应。 通过蒸馏处理反应混合物，由于实质上不存在高沸点组分，产物容易与反应物质分离。

公开(公告)号：US4603220A

公开(公告)日：1986-07-29

申请号：US632261

申请日：1984-07-18

Applicant: Marcel Feld

Inventor： Marcel Feld

IPC: B01J31/04 ,  C07B61/00 ,  C07C51/00 ,  C07C51/265 ,  C07C51/47 ,  C07C63/04 ,  C07C63/70 ,  C07C65/21 ,  C07C67/00 ,  C07C201/12 ,  C07C201/16 ,  C07C205/57

CPC classification number: C07C201/12 ,  C07C201/16 ,  C07C51/265

Abstract: In a process for preparing aromatic monocarboxylic acids by oxidation of toluene or of toluenes substituted in the nucleus, the starting substances are reacted in the liquid phase with oxygen or with a gas containing oxygen, at a temperature of 80.degree.-180.degree. C. and a pressure of 5 to 50 bar in the presence of acetic acid as diluent and a soluble cobalt and/or manganese salt in combination with a bromide, and the aromatic monocarboxylic acids are then obtained by solid-liquid separation of the cooled reaction mixture.To reduce the dimensions of the oxidation reactor, for which particularly corrosion-resistant materials are necessary, and to isolate the target products in high yield and purity, as well as to reduce the technical complexity and cost of the treatment of the amounts of solvents that are yielded, relatively small amounts of acetic acid are used as solvents or diluents, namely at a ratio by weight of the alkyl aromatic being oxidized and acetic acid of 0.5:1 to 6:1. Not until the reaction has ended is the dilution, which is necessary for the isolation of the target product by solid-liquid separation of the cooled reaction mixture, performed by the addition of dilute aqueous acetic acid or of the washing filtrate from a preceding oxidation run. A typical example is the preparation of p-tert-butylbenzoic acid from p-tert-butyltoluene by the method described.

Abstract translation: 在通过甲苯或核中取代的甲苯的氧化制备芳族单羧酸的方法中，起始物质在液相中与氧气或含氧气体在80-180℃的温度下反应， 在乙酸作为稀释剂存在下，压力为5至50巴，与溴化物结合使用可溶性钴和/或锰盐，然后通过冷却的反应混合物的固液分离获得芳族单羧酸。 为了减小需要特别耐腐蚀材料的氧化反应器的尺寸，并以高产率和纯度分离目标产物，以及降低处理溶剂量的技术复杂性和成本， 使用相对少量的乙酸作为溶剂或稀释剂，即以氧化的烷基芳族化合物的重量比为0.5:1至6:1的乙酸。 直到反应结束为止，稀释是通过冷却的反应混合物的固液分离来分离目标产物所必需的，其通过加入稀乙酸水溶液或从先前的氧化运行中洗涤滤液进行 。 典型的实例是通过所述方法从对叔丁基甲苯制备对叔丁基苯甲酸。

公开(公告)号：US06580004B1

公开(公告)日：2003-06-17

申请号：US09668299

申请日：2000-09-25

Applicant: Juergen Muhr ,  Marcel Feld

Inventor： Juergen Muhr ,  Marcel Feld

IPC: C07C6938

CPC classification number: C07C69/38 ,  C07C67/30

Abstract: A process for preparing potassium monoethyl malonate by selective saponification of malonic acid diethyl ester with potassium hydroxide, in which the potassium hydroxide is added to the malonic acid diethyl ester, malonic acid diethyl ester and potassium hydroxide are used in a molar ratio of at least 1.5 and the potassium hydroxide is effectively distributed into the malonic acid diethyl ester.

Abstract translation: 使用氢氧化钾选择性皂化丙二酸二乙酯制备丙二酸钾的方法，其中将氢氧化钾加入到丙二酸二乙酯，丙二酸二乙酯和氢氧化钾中，摩尔比为至少1.5 并且氢氧化钾有效地分配到丙二酸二乙酯中。

公开(公告)号：US6156214A

公开(公告)日：2000-12-05

申请号：US21170

申请日：1998-02-10

Applicant: Marcus Bongen ,  Marcel Feld ,  Guenter Zoche

Inventor： Marcus Bongen ,  Marcel Feld ,  Guenter Zoche

IPC: C07C29/76 ,  C07C29/94 ,  C02F1/42 ,  C22B43/00

CPC classification number: C07C29/76 ,  C07C29/94

Abstract: A three-stage process for removing mercury contaminants from alcoholic alkali metal alkoxide solutions is provided, in which mercury is depleted in a first filtration through inert fibrous material, followed by a second filtration through pulverized coal, and then by concentration by distillation, to preferably provide a mercury content below 0.1 ppm.

Abstract translation: 提供了从醇类碱金属醇盐溶液中除去汞污染物的三阶段方法，其中通过惰性纤维材料首先过滤汞，随后通过粉煤进行第二次过滤，然后通过蒸馏浓缩至优选 提供低于0.1ppm的汞含量。

公开(公告)号：US5481019A

公开(公告)日：1996-01-02

申请号：US224151

申请日：1994-04-07

Applicant: Jurgen Muhr ,  Marcel Feld

Inventor： Jurgen Muhr ,  Marcel Feld

IPC: C07C253/30 ,  C07C255/15

CPC classification number: C07C253/30

Abstract: Alkali metal salts of cyanoacetone are prepared by reacting an acetonitrile, an acetic acid ester and an alkali metal alkoxide without distilling off the alcohol formed during the reaction. The reaction products are obtained with high yields and high purity.

Abstract translation: 氰基丙酮的碱金属盐通过使乙腈，乙酸酯和碱金属醇盐反应而不蒸发反应中形成的醇来制备。 以高产率和高纯度获得反应产物。

公开(公告)号：US5097030A

公开(公告)日：1992-03-17

申请号：US559635

申请日：1990-07-30

Applicant: Marcel Feld ,  Friedrich Goerentz

Inventor： Marcel Feld ,  Friedrich Goerentz

IPC: C07D239/60 ,  C07D239/62 ,  C07D239/02

CPC classification number: C07D239/60

Abstract: 2-(methylthio)barbituric acid is obtained with high yields and degree of purity by reacting a solution or suspension of an alkali metal salt or alkaline earth metal salt of 2-thiobarbituric acid with methyl bromide at a pressure of 1.5 to 5 bar.

Abstract translation: 通过在1.5至5巴的压力下使2-硫代巴比妥酸的碱金属盐或碱土金属盐的溶液或悬浮液与甲基溴反应，以高产率和纯度获得2-（甲硫基）巴比妥酸。

公开(公告)号：US06613934B1

公开(公告)日：2003-09-02

申请号：US08872057

申请日：1997-06-10

Applicant: Udo Jegelka ,  Wolfgang Kleemiss ,  Bruno Klotz-Berendes ,  Marcel Feld

Inventor： Udo Jegelka ,  Wolfgang Kleemiss ,  Bruno Klotz-Berendes ,  Marcel Feld

IPC: C07C6976

CPC classification number: C12P41/005 ,  C07C69/34 ,  C12P7/62

Abstract: The invention relates to enantiomerically enriched malonic acid monoesters &agr;-monosubstituted by a tertiary hydrocarbon radical, or their salts, of the general formula I: in which R1, R3, R4 and R5 are identical or different hydrocarbon radicals, and wherein any two of the radicals R3, R4 and R5 may alternatively be present as a carbocyclic ring together with the quaternary carbon atom which they substitute, and M is hydrogen, one equivalent of a metal or an optionally substituted ammonium ion. The invention further relates to a process for the preparation of the enantiomerically enriched &agr;-monosubstituted malonic acid monoesters, or their salts, by enzymatic partial hydrolysis of the corresponding diesters.

Abstract translation: 本发明涉及通过通式I的叔烃基或其盐进行α-单取代的对映体富集的丙二酸单酯：其中R 1，R 3，R 4和R 5是相同或不同的烃基，并且其中任何两个 基团R 3，R 4和R 5可以可替代地作为碳环与它们取代的季碳原子一起存在，M是氢，一当量的金属或任选取代的铵离子。 本发明还涉及通过相应的二酯的酶促部分水解制备对映体富集的α-单取代的丙二酸单酯或其盐的方法。