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公开(公告)号：US08456733B2
公开(公告)日：2013-06-04
申请号：US12083884
申请日：2006-10-16
申请人： Margherita Fontana , Gabriele Baisch , Thomas Giesenberg , Laurent Michau , Reinhold Öhrlein , Andreas Mühlebach
发明人： Margherita Fontana , Gabriele Baisch , Thomas Giesenberg , Laurent Michau , Reinhold Öhrlein , Andreas Mühlebach
IPC分类号： G02B26/00
CPC分类号： G02F1/167 , B82Y30/00 , C01P2002/88 , C01P2004/62 , C01P2004/64 , C09C1/3081 , C09C1/407 , C09C3/12
摘要： The present invention discloses the use of functionalized particles as electrophoretic displaying particles, wherein the functionalized particles are SiO2, Al2O3 or mixed SiO2 and Al2O3 particles comprising, covalently bound to an oxygen atom on the surface, a radical of formula (1), wherein R1 and R2 are independently of each other hydrogen, particle surface-O—, or a substituent, n is 1, 2, 3, 4, 5, 6, 7 or 8, B is the direct bond or a bridge member, and D is the residue of an organic chromophore.
摘要翻译： 本发明公开了使用官能化颗粒作为电泳显示颗粒，其中官能化颗粒是SiO 2，Al 2 O 3或混合SiO 2和Al 2 O 3颗粒，其包含与表面上的氧原子共价结合的式（1）基团，其中R 1 和R2彼此独立地为氢，颗粒表面-O-或取代基，n为1,2,3,4,5,6,7或8，B为直接键或桥构件，D为 有机发色团的残留物。
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公开(公告)号：US20090296195A1
公开(公告)日：2009-12-03
申请号：US12083884
申请日：2006-10-16
申请人： Margherita Fontana , Gabriele Baisch , Thomas Giesenberg , Laurent Michau , Reinhold Öhrlein , Andreas Mühlebach
发明人： Margherita Fontana , Gabriele Baisch , Thomas Giesenberg , Laurent Michau , Reinhold Öhrlein , Andreas Mühlebach
CPC分类号： G02F1/167 , B82Y30/00 , C01P2002/88 , C01P2004/62 , C01P2004/64 , C09C1/3081 , C09C1/407 , C09C3/12
摘要： The present invention discloses the use of functionalized particles as electrophoretic displaying particles, wherein the functionalized particles are SiO2, Al2O3 or mixed SiO2 and Al2O3 particles comprising, covalently bound to an oxygen atom on the surface, a radical of formula (1), wherein R1 and R2 are independently of each other hydrogen, particle surface-O—, or a substituent, n is 1, 2, 3, 4, 5, 6, 7 or 8, B is the direct bond or a bridge member, and D is the residue of an organic chromophore.
摘要翻译： 本发明公开了使用官能化颗粒作为电泳显示颗粒，其中官能化颗粒是SiO 2，Al 2 O 3或混合SiO 2和Al 2 O 3颗粒，其包含与表面上的氧原子共价结合的式（1）基团，其中R 1 和R2彼此独立地为氢，颗粒表面-O-或取代基，n为1,2,3,4,5,6,7或8，B为直接键或桥构件，D为 有机发色团的残留物。
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公开(公告)号：US08610998B2
公开(公告)日：2013-12-17
申请号：US12308594
申请日：2007-06-25
申请人： Gabriele Baisch , Reinhold Öhrlein , Peter Simmendinger , Gerardus De Keyzer , Margherita Fontana , Vilas N. Mumbaikar
发明人： Gabriele Baisch , Reinhold Öhrlein , Peter Simmendinger , Gerardus De Keyzer , Margherita Fontana , Vilas N. Mumbaikar
CPC分类号： C09B69/103 , C08K5/0041 , C09B69/106 , C09B69/107 , C09B69/109 , Y10T29/49002
摘要： The present invention relates to the preparation and use of (colored) organic particles carrying electric charge as electrophoretic (image) displaying particles, to electrophoretic dispersions comprising the organic particles carrying electric charge, electrophoretic (image) devices (especially displays) comprising the colored organic particles carrying electric charge, to the novel functionalized particles, and to their use. The particles are obtainable according to a method represented by the reaction scheme as given in FIG. 1.
摘要翻译： 本发明涉及携带电荷的（着色）有机颗粒作为电泳（图像）显示颗粒的制备和使用，包括带有带电荷的有机颗粒的电泳分散体，包含着色有机物的电泳（图像）装置（尤其是显示器） 携带电荷的颗粒，到新的功能化颗粒，以及它们的用途。 颗粒可以根据图1中给出的反应方案表示的方法获得。 1。
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公开(公告)号：US20110216392A1
公开(公告)日：2011-09-08
申请号：US12308594
申请日：2007-06-25
申请人： Gabriele Baisch , Reinhold Öhrlein , Peter Simmendinger , Gerardus De Keyzer , Margherita Fontana , Vilas N. Mumbaikar
发明人： Gabriele Baisch , Reinhold Öhrlein , Peter Simmendinger , Gerardus De Keyzer , Margherita Fontana , Vilas N. Mumbaikar
IPC分类号： G02F1/167 , C07C225/22 , C07F7/18 , C07C49/796 , C08F8/32 , C08F8/34 , C08F216/36 , C08F226/02 , H01B1/12 , H05K13/00
CPC分类号： C09B69/103 , C08K5/0041 , C09B69/106 , C09B69/107 , C09B69/109 , Y10T29/49002
摘要： The present invention relates to the preparation and use of (colored) organic particles carrying electric charge as electrophoretic (image) displaying particles, to electrophoretic dispersions comprising the organic particles carrying electric charge, electrophoretic (image) devices (especially displays) comprising the colored organic particles carrying electric charge, to the novel functionalized particles, and to their use. The particles are obtainable according to a method represented by the reaction scheme as given in FIG. 1.
摘要翻译： 本发明涉及携带电荷的（着色）有机颗粒作为电泳（图像）显示颗粒的制备和使用，包括带有带电荷的有机颗粒的电泳分散体，包含着色有机物的电泳（图像）装置（尤其是显示器） 携带电荷的颗粒，到新的功能化颗粒，以及它们的用途。 颗粒可以根据图1中给出的反应方案表示的方法获得。 1。
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5.发明授权Process for the preparation of intermediates useful in the synthesis of statin derivatives especially 7-amino-3.5-dihydroxyhepanoic acid derivatives and intermediates thereof 有权制备可用于合成他汀类衍生物，特别是7-氨基-3,5-二羟基庚酸衍生物的中间体的方法及其中间体公开(公告)号：US07855302B2
公开(公告)日：2010-12-21
申请号：US12220390
申请日：2008-07-24
IPC分类号： C07C69/66 , C07C259/06 , C07C69/22
CPC分类号： C07C235/74 , C07C69/67 , C07C69/716 , C07C69/732 , C07C69/738 , C07C227/32 , C07C229/22 , C07C235/06 , C12P7/62 , Y02P20/55
摘要： The invention relates to novel synthesis methods for the preparation of statin derivatives, which methods proceed by way of a key intermediate of formula I wherein X is halogen, acyloxy, activated hydrocarbyloxy, activated hydrocarbylthio or —N(CH3)OCH3, Ra is a hydroxy-protecting group and Rb is a carboxy-protecting group, and, as well as to the compound of formula I, to further new intermediates and methods for their preparation by Friedel-Crafts acylation.
摘要翻译： 本发明涉及用于制备他汀类衍生物的新型合成方法，该方法通过式I的关键中间体进行，其中X是卤素，酰氧基，活化的烃氧基，活化的烃基硫基或-N（CH 3）OCH 3，R a是羟基 保护基团，Rb是羧基保护基团，以及式I化合物，用于通过Friedel-Crafts酰化进一步制备新的中间体及其制备方法。
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6.发明授权公开(公告)号：US07507853B2
公开(公告)日：2009-03-24
申请号：US10529802
申请日：2003-10-02
申请人： Reinhold Öhrlein , Gabriele Baisch , Kai-Uwe Schöning , Jemima Schmidt , Sandra Franziska Mayer
发明人： Reinhold Öhrlein , Gabriele Baisch , Kai-Uwe Schöning , Jemima Schmidt , Sandra Franziska Mayer
CPC分类号： C12P7/62 , C12P7/6436 , C12P11/00 , C12P13/02 , C12P17/10
摘要： The present invention relates to an improved process for the preparation of phenolic carboxylic acid derivatives catalysed by biocatalytic esterification, transesterification or amidation of a corresponding lower alkyl ester. Biocatalysis is performed in the presence of suitable enzymes, e.g. hydrolases, especially esterases, amidases, lipases and proteases.
摘要翻译： 本发明涉及通过相应的低级烷基酯的生物催化酯化，酯交换或酰胺化催化的酚羧酸衍生物的制备方法。 在合适的酶存在下进行生物催化，例如 水解酶，特别是酯酶，酰胺酶，脂肪酶和蛋白酶。
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7.发明授权Process for the preparation of 7-amino syn 3,5-dihydroxy heptanoic acid derivatives, intermediates thereof and methods for their preparation 失效7-氨基顺式3,5-二羟基庚酸衍生物的制备方法，其中间体及其制备方法公开(公告)号：US07504532B2
公开(公告)日：2009-03-17
申请号：US11941347
申请日：2007-11-16
申请人： Reinhold Öhrlein , Gabriele Baisch , Hans Jörg Kirner , Stephan Burkhardt , Martin Studer , Frank Bienewald
发明人： Reinhold Öhrlein , Gabriele Baisch , Hans Jörg Kirner , Stephan Burkhardt , Martin Studer , Frank Bienewald
IPC分类号： C07C229/00 , C07C291/00 , C07C59/10
CPC分类号： C07C69/67 , C07C69/716 , C07C69/732 , C07C69/738 , C07C227/32 , C07C229/22 , C07C235/06 , C07C235/74 , C12P7/62 , Y02P20/55
摘要： Synthesis methods for the preparation of intermediates which are suitable for the preparation of statin derivatives, and especially to synthesis methods for the intermediate of formula (VI) wherein Ra′ and Rc′ are each independently of the other hydrogen or hydroxy-protecting group, or together are a bridging hydroxy-protecting group; and Rb is a carboxy-protecting group.
摘要翻译： 用于制备适于制备他汀类衍生物的中间体的合成方法，特别是其中R a'和R c'各自独立于其它氢或羟基保护基的式（Ⅵ）中间体的合成方法，或 一起是桥接羟基保护基团; 并且Rb是羧基保护基。
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8.发明授权Process for the preparation of 7-amino syn 3,5-dihydroxy heptanoic acid derivatives via 6-cyano syn 3,5-dihydroxy hexanoic acid derivatives 失效通过6-氰基顺式3,5-二羟基己酸衍生物制备7-氨基顺式3,5-二羟基庚酸衍生物的方法公开(公告)号：US07692034B2
公开(公告)日：2010-04-06
申请号：US11657808
申请日：2007-01-24
申请人： Reinhold Öhrlein , Gabriele Baisch , Hans Jürg Kirner , Frank Bienewald , Stephan Burkhardt , Martin Studer
发明人： Reinhold Öhrlein , Gabriele Baisch , Hans Jürg Kirner , Frank Bienewald , Stephan Burkhardt , Martin Studer
IPC分类号： C07C229/00
CPC分类号： C07C69/67 , C07C69/716 , C07C69/732 , C07C69/738 , C07C227/32 , C07C229/22 , C07C235/06 , C07C235/74 , C12P7/62 , Y02P20/55
摘要： The invention relates to novel synthesis methods for the preparation of the intermediates, which are suitable for the preparation of statin derivatives, especially to novel synthesis methods of the intermediate of formula VI wherein Ra and Rc are each independently of the other hydrogen or a hydroxy-protecting group or together are a bridging hydroxy-protecting group, and Rb is a carboxy-protecting group, which methods are carried out by conversion of the intermediate of formula XIX wherein Ra and Rc are each independently of the other hydrogen or a hydroxy-protecting group, and Rb is a carboxy-protective group.
摘要翻译： 本发明涉及适用于制备他汀类衍生物的中间体的新型合成方法，特别是式VI中间体的新合成方法，其中R a和R c各自独立地为氢或羟基 - 保护基或一起是桥接羟基保护基，Rb是羧基保护基，该方法通过式XIX的中间体转化而进行，其中R a和R c各自独立地为氢或羟基保护基 基团，Rb是羧基保护基。
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9.发明授权Process for the preparation of intermediates useful in the synthesis of statin derivatives especially 7-amino 3,5-dihydroxy heptanoic acid derivatives, and intermediates thereof 有权制备可用于合成他汀类衍生物，特别是7-氨基3,5-二羟基庚酸衍生物的中间体的方法及其中间体公开(公告)号：US07420078B2
公开(公告)日：2008-09-02
申请号：US10482463
申请日：2002-07-02
IPC分类号： C07C69/66 , C07C259/06 , C07C69/22
CPC分类号： C07C235/74 , C07C69/67 , C07C69/716 , C07C69/732 , C07C69/738 , C07C227/32 , C07C229/22 , C07C235/06 , C12P7/62 , Y02P20/55
摘要： The invention relates to synthesis methods for the preparation of statin derivatives, which methods proceed by way of a key intermediate of formula I wherein X is halogen, acyloxy, activated hydrocarbyloxy, activated hydrocarbylthio or N(CH3)OCH3, Ra is a hydroxy-protecting group, and Rb is a carboxy-protecting group, and, as well as to the compound of formula I, to further intermediates and methods for their preparation by Friedel-Crafts acylation.
摘要翻译： 本发明涉及用于制备他汀类衍生物的合成方法，该方法通过式I的关键中间体进行，其中X是卤素，酰氧基，活化的烃氧基，活化的烃基硫基或N（CH 3） OCH 3，R a是羟基保护基，R b是羧基保护基，以及对于 式I化合物，其进一步的中间体及其通过Friedel-Crafts酰化制备的方法。
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10.发明授权Process for preparation of 7-amino syn 3,5-dihydroxy heptanoic acid derivatives, intermediates thereof and methods for their preparation 失效7-氨基顺式3,5-二羟基庚酸衍生物的制备方法，其中间体及其制备方法公开(公告)号：US07317123B2
公开(公告)日：2008-01-08
申请号：US10482946
申请日：2002-07-02
申请人： Reinhold Öhrlein , Gabriele Baisch , Hans Jörg Kirner , Stephan Burkhardt , Martin Studer , Frank Bienewald
发明人： Reinhold Öhrlein , Gabriele Baisch , Hans Jörg Kirner , Stephan Burkhardt , Martin Studer , Frank Bienewald
IPC分类号： C07C229/00 , C07C233/00
CPC分类号： C07C69/67 , C07C69/716 , C07C69/732 , C07C69/738 , C07C227/32 , C07C229/22 , C07C235/06 , C07C235/74 , C12P7/62 , Y02P20/55
摘要： The invention relates to novel synthesis methods for the preparation of the intermediates, which are suitable for the preparation of statin derivatives, especially to novel synthesis methods of the intermediate of formula VI wherein Ra′ and Rc′ are each independently of the other hydrogen or a hydroxy-protecting group or together are a bridging hydroxy-protecting group, and Rb is a carboxy-protecting group, which methods are carried out by conversion of the intermediate of formula XVI wherein Ra′ and Rc′ are each independently of the other hydrogen or a hydroxy-protecting group, R* and R** are each independently of the other hydrogen or an amide-protecting group, and Rb is a carboxy-protecting group; which methods proceed to further new intermediates and methods for their preparation
摘要翻译： 本发明涉及用于制备适于制备他汀类衍生物的中间体的新型合成方法，特别涉及式VI中间体的新型合成方法，其中R a'和R“ > C独立地是氢或羟基保护基，或者一起是桥接羟基保护基，R b是羧基保护基，这些方法是 通过式XVI的中间体的转化而进行，其中R a a和R c'各自独立地是氢或羟基保护基，R *和R **各自独立地为另一个氢或酰胺保护基团，并且R b为羧基保护基团; 哪些方法进行进一步的新中间体及其制备方法
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