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公开(公告)号：US20130143223A1
公开(公告)日：2013-06-06
申请号：US13696215
申请日：2011-05-04
申请人： Maria Hernandez-Fuentes , Irene Rebollo-Mesa , Uwe Janssen , Stefan Tomiuk , Birgit Sawitzki , Hans-Dieter Volk , Robert Lechler
发明人： Maria Hernandez-Fuentes , Irene Rebollo-Mesa , Uwe Janssen , Stefan Tomiuk , Birgit Sawitzki , Hans-Dieter Volk , Robert Lechler
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6876 , C12Q1/6837 , C12Q1/6883 , C12Q2600/158
摘要： The present invention relates to a method of determining an individual's transplantation tolerance by determining the level of a number of biomarkers. The present invention also relates to a kit comprising reagents for detecting the levels of the biomarkers. The present invention also relates to a sensor for detecting the expression levels of a plurality of genes that can be used to determine an individual's transplantation tolerance.
摘要翻译： 本发明涉及通过确定多个生物标志物的水平来确定个体的移植耐受性的方法。 本发明还涉及包含用于检测生物标志物水平的试剂的试剂盒。 本发明还涉及用于检测可用于确定个体移植耐受性的多种基因的表达水平的传感器。
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公开(公告)号：US20050255550A1
公开(公告)日：2005-11-17
申请号：US11018106
申请日：2004-12-20
IPC分类号： A01K67/027 , A61K35/12 , A61K48/00 , A61L27/00 , C07K14/47 , C07K16/28 , C07K19/00 , C12N5/06 , C12N5/10 , C12N15/09 , C07H21/04 , C12P21/06 , C07K16/18
CPC分类号： C07K16/2836 , A01K2217/05 , A61K48/00 , A61K2035/122 , C07K14/47 , C07K2317/21 , C07K2317/622 , C07K2317/81 , C07K2319/00 , C07K2319/04
摘要： This invention relates to the suppression of graft rejection, particularly to the suppression of xenograft rejection. In particular, the invention relates to biological tissues that contain endothelial cells that may be induced to generate a compound which down-regulates the expression of a cell adhesion molecule in these cells.
摘要翻译： 本发明涉及抑制移植排斥反应，特别涉及抑制异种移植排斥。 特别地，本发明涉及含有内皮细胞的生物组织，所述内皮细胞可被诱导以产生下调这些细胞中细胞粘附分子表达的化合物。
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公开(公告)号：US20070157328A1
公开(公告)日：2007-07-05
申请号：US11635968
申请日：2006-12-08
IPC分类号： A01K67/027 , C07H21/04 , C12P21/06 , A61K48/00 , C07K14/705
CPC分类号： C07K16/2836 , A01K2217/05 , A61K48/00 , A61K2035/122 , C07K14/47 , C07K2317/21 , C07K2317/622 , C07K2317/81 , C07K2319/00 , C07K2319/04
摘要： This invention relates to the suppression of graft rejection, particularly to the suppression of xenograft rejection. In particular, the invention relates to biological tissues that contain endothelial cells that may be induced to generate a compound which down-regulates the expression of a cell adhesion molecule in these cells.
摘要翻译： 本发明涉及抑制移植排斥反应，特别涉及抑制异种移植排斥。 特别地，本发明涉及含有内皮细胞的生物组织，所述内皮细胞可被诱导以产生下调这些细胞中细胞粘附分子表达的化合物。
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公开(公告)号：US20060134124A1
公开(公告)日：2006-06-22
申请号：US11170797
申请日：2005-06-28
申请人： Robert Lechler , Nichola Rogers , Anthony Dorling
发明人： Robert Lechler , Nichola Rogers , Anthony Dorling
IPC分类号： A61K39/00
CPC分类号： A61K39/001 , A61K2039/6081 , C07K14/70532 , C07K14/70578 , C07K16/2827 , C07K2317/34 , C07K2319/00
摘要： The invention herein described relates to a method to improve the tolerance of a mammal, preferably a human, to a xenograft through immunisation of the recipient mammal with an immunogen comprising both a B cell epitope derived from porcine polypetides and T cell epitope. The invention also encompasses immunogenic compositions comprising said immunogens and methods to monitor the status of the xenograft.
摘要翻译： 本文描述的本发明涉及通过用包含来自猪多肽和T细胞表位的B细胞表位的免疫原免疫接受哺乳动物来改善哺乳动物，优选人类对异种移植物的耐受性的方法。 本发明还包括包含所述免疫原的免疫原性组合物和监测异种移植物状态的方法。
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公开(公告)号：US20050118160A1
公开(公告)日：2005-06-02
申请号：US10101523
申请日：2002-03-18
IPC分类号： A01K67/027 , A61K38/00 , A61K48/00 , A61P7/02 , A61P37/06 , C07K14/705 , C07K14/73 , C07K14/74 , C07K14/81 , C07K14/815 , C07K19/00 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N9/64 , C12N15/09 , C12N15/62 , C12N15/85 , H04W4/00 , C07H21/04 , A61K38/48
CPC分类号： C12N15/62 , A01K2207/15 , A01K2217/00 , A01K2217/05 , A01K2217/072 , A01K2227/10 , A01K2227/103 , A01K2227/108 , A01K2267/01 , A01K2267/02 , A01K2267/025 , A61K38/00 , A61K48/00 , C07H21/04 , C07K14/70514 , C07K14/70539 , C07K14/70564 , C07K14/70571 , C07K14/8114 , C07K14/815 , C07K2319/00 , C07K2319/03 , C07K2319/033 , C07K2319/32 , C07K2319/74 , C12N9/6418 , C12N15/63 , C12N15/8509 , C12N2799/027
摘要： The invention relates to the inhibition of blood coagulation, especially during organ rejection, and in particular the inhibition of delayed vascular rejection. The invention provides anticoagulant proteins which are anchored to cell membranes. The anticoagulant function preferably provided by heparin, antithrombin, hirudin, TFPI, tick anticoagulant peptide, or a snake venom factor. These anticoagulant proteins are preferably prevented from being constitutively expressed at the cell surface. In particular, expression at the cell surface is regulated according to cell activation, for instance by targeting the protein to a suitable secretory granule. Expression of these proteins renders cells, tissues and organs less vulnerable to rejection after transplantation (e.g. after xenotransplantation).
摘要翻译： 本发明涉及抑制血液凝固，特别是在器官排斥期间，特别是对延迟血管排斥的抑制。 本发明提供了锚定于细胞膜的抗凝血蛋白。 抗凝血功能优选由肝素，抗凝血酶，水蛭素，TFPI，蜱抗凝肽或蛇毒因子提供。 优选地防止这些抗凝血蛋白在细胞表面组成型表达。 特别地，细胞表面的表达根据细胞活化来调控，例如通过将蛋白质靶向合适的分泌颗粒。 这些蛋白质的表达使细胞，组织和器官在移植后不易受到排斥（例如在异种移植后）。
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