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    Esters of acyl l-carnitines with gamma-hydroxybutyric acid and pharmaceutical compositions containing them for inhibiting neuronal degeneration and for the treatment of coma
    1.
    发明授权
    Esters of acyl l-carnitines with gamma-hydroxybutyric acid and pharmaceutical compositions containing them for inhibiting neuronal degeneration and for the treatment of coma 失效
    具有γ-羟基丁酸的酰基l-肉碱的酯和含有它们的药物组合物用于抑制神经元变性和治疗昏迷

    公开(公告)号：US5543556A

    公开(公告)日：1996-08-06

    申请号：US317750

    申请日：1994-10-04

    申请人： Maria O. Tinti ,  Domenico Misiti ,  Claudio Cavazza ,  Nazareno Scafetta

    发明人： Maria O. Tinti ,  Domenico Misiti ,  Claudio Cavazza ,  Nazareno Scafetta

    IPC分类号： A61K31/22 ,  A61P25/00 ,  A61P25/28 ,  C07C219/22 ,  C07C229/22 ,  C07C229/00

    CPC分类号： C07C219/22

    摘要： The esters of acyl L-carnitines with gamma-hydroxybutyric acid in the form of pharmacologically acceptable salts of formula (I) ##STR1## wherein X.sup.- is the anion of a pharmacologically acceptable salt, e.g. chloride, bromide, orotate, acid aspartate, acid citrate, acid phosphate, acid fumarate, lactate, acid maleate, acid oxalate, acid sulfate and glucosephosphate or in the form of inner salts of formula (I') ##STR2## wherein R is a straight or branched acyl group having from 2 to 5 carbon atoms, such as e.g. acetyl, propionyl, n-butyryl, isobutyryl and isovaleryl, are active in inhibiting neuronal degeneration (as it occurs in Alzheimer's senile dementia and Parkinson's disease) and in the treatment of coma.

    摘要翻译： 酰基L-肉碱与式（I）的药理学上可接受的盐形式的γ-羟基丁酸的酯，其中X是药理学上可接受的盐的阴离子，例如， 氯化物，溴酸盐，乳清酸，天冬氨酸，酸式柠檬酸盐，酸式磷酸盐，富马酸酸盐，乳酸盐，酸性马来酸盐，酸性草酸盐，酸式硫酸盐和磷酸二氢盐或以式（I'）的内盐形式。 其中R是具有2至5个碳原子的直链或支链酰基，例如 乙酰基，丙酰基，正丁酰基，异丁酰基和异戊酰基在抑制神经元变性（如在阿尔茨海默病老年痴呆和帕金森病中发生）和在昏迷的治疗中是有活性的。

    Easters of acyl L-carnitines with gamma-hydroxybutyric acid and pharmaceutical compositions containing them for inhibiting neuronal degeneration and for the treatment of coma
    2.
    发明授权
    Easters of acyl L-carnitines with gamma-hydroxybutyric acid and pharmaceutical compositions containing them for inhibiting neuronal degeneration and for the treatment of coma 失效
    含有γ-羟基丁酸的酰基L-肉碱的东方人和含有它们的药物组合物用于抑制神经元变性和治疗昏迷

    公开(公告)号：US5534549A

    公开(公告)日：1996-07-09

    申请号：US395914

    申请日：1995-02-28

    申请人： Maria O. Tinti ,  Domenico Misiti ,  Claudio Cavazza ,  Nazareno Scafetta

    发明人： Maria O. Tinti ,  Domenico Misiti ,  Claudio Cavazza ,  Nazareno Scafetta

    IPC分类号： A61K31/22 ,  A61P25/00 ,  A61P25/28 ,  C07C219/22 ,  C07C229/22

    CPC分类号： C07C219/22

    摘要： The esters of acyl L-carnitines with gamma-hydroxybutyric acid in the form of pharmacologically acceptable salts of formula (I) ##STR1## wherein X.sup.- is the anion of a pharmacologically acceptable salt, e.g. chloride, bromide, orotate, acid aspartate, acid citrate, acid phosphate, acid fumarate, lactate, acid maleate, acid oxalate, acid sulfate and glucosephosphate or in the form of inner salts of formula (I') ##STR2## wherein R is a straight or branched acyl group having from 2 to 5 carbon atoms, such as e.g. acetyl, propionyl, n,butyryl, isobutyryl and isovaleryl, are active in inhibiting neuronal degeneration (as it occurs in Alzheimer's senile dementia and Parkinson's disease) and in the treatment of coma.

    摘要翻译： 酰基L-肉碱与式（I）的药理学上可接受的盐形式的γ-羟基丁酸的酯，其中X是药理学上可接受的盐的阴离子，例如， 氯化物，溴酸盐，乳清酸，天冬氨酸，酸式柠檬酸盐，酸式磷酸盐，富马酸酸盐，乳酸盐，酸性马来酸盐，酸性草酸盐，酸式硫酸盐和磷酸二氢盐或以式（I'）的内盐形式。 其中R是具有2至5个碳原子的直链或支链酰基，例如 乙酰基，丙酰基，n，丁酰基，异丁酰基和异戊酰基在抑制神经元变性（如阿尔茨海默病老年性痴呆和帕金森病）中发挥作用，并且在昏迷的治疗中具有活性。

    Esters of acyl carnitines with long-chain aliphatic alcohols and pharmaceutical compositions containing same having antimycotic activity
    10.
    发明授权
    Esters of acyl carnitines with long-chain aliphatic alcohols and pharmaceutical compositions containing same having antimycotic activity 失效
    具有长链脂肪醇的酰基肉碱的酯和含有它们的具有抗真菌活性的药物组合物

    公开(公告)号：US5519056A

    公开(公告)日：1996-05-21

    申请号：US250108

    申请日：1994-05-26

    申请人： Mose Santaniello ,  Maria O. Tinti ,  Domenico Misiti ,  Piero Foresta

    发明人： Mose Santaniello ,  Maria O. Tinti ,  Domenico Misiti ,  Piero Foresta

    IPC分类号： A61K31/22 ,  A61P31/04 ,  A61P31/10 ,  C07C229/22 ,  A61K31/225

    CPC分类号： C07C229/22

    摘要： Esters of acyl L-carnitines of general formula (I) ##STR1## wherein R is a straight or branched acyl group having 2 to 16 carbon atoms, in particular isobutyryl and isovaleryl;n is an integer comprised between 7 and 15, particularly 10; and,X.sup.- is the anion of a pharmacologically acceptable acid are endowed with potent antimycotic activity particularly against yeast like fungi, such as Candida albicans, the aetiologic agent of candidiasis and against filamentous fungi, such as Aspergillus fumigatus, the aetiologic agent of aspergillosis.Orally or parenterally administrable or topically applicable pharmaceutical compositions comprise an ester of formula (I) as active ingredient.

    摘要翻译： （I）的酰基L-肉碱的酯其中R是具有2至16个碳原子的直链或支链酰基，特别是异丁酰基和异戊酰基; n是7和15之间的整数，特别是10; X-是药理学上可接受的酸的阴离子，特别是对酵母样真菌如白色假丝酵母，念珠菌病的病原体和丝状真菌如烟曲霉，曲霉病的病原体具有有效的抗真菌活性。 口服或肠胃外给药或局部适用的药物组合物包含式（I）的酯作为活性成分。